• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Personalized prevention using the information of longevity-associated mitochondrial DNA polymorphism

Research Project

Project/Area Number 18590572
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionShowa University (2007-2008)
Kyorin University (2006)

Principal Investigator

KOKAZE Akatsuki  Showa University, 医学部, 教授 (70271583)

Co-Investigator(Kenkyū-buntansha) 高島 豊  杏林大学, 医学部, 教授 (20163199)
吉田 正雄  杏林大学, 医学部, 助教 (10296543)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Keywords遺伝子多型 / ミトコンドリア / 長寿 / 生活習慣 / 予防医学 / ミトコンドリアDNA / 喫煙習慣 / コーヒー飲用 / 交互作用 / テーラーメイド予防医学
Research Abstract

長寿関連ミトコンドリア遺伝子多型(Mt5178C/A多型)と飲酒習慣との高血圧症リスクおよび高尿酸血症リスクへの交互作用、Mt5178C/A多型と喫煙習慣との呼吸機能への交互作用、Mt5178C/A多型とコーヒー飲用との高血圧症リスクおよび耐糖能異常リスクへの交互作用を論文発表した. また、Mt5178C/A多型と心血管疾患の危険因子の重積との関連について検討し、Mt5178C型の男性においては毎日の飲酒が心血管疾患危険因子の重積と関連することを学会報告した.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (18 results)

All 2008 2007 2006 Other

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (8 results) Book (2 results)

  • [Journal Article] Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men2007

    • Author(s)
      Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Masao Yoshida, Masao Satoh, Koji Teruya, Rie Honmyo, Takako Shirasawa, Hiromi Hoshino, Yutaka Takashima
    • Journal Title

      J. Hum. Genet 52

      Pages: 680-685

    • NAID

      10019812879

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies the effects of alcohol consumption on risk for hypertension in middle-aged Japanese men2007

    • Author(s)
      Akatsuki Kokaze, Mamoru Ishikawa, Naomi atsunaga, Masao Yoshida, Masao Satoh, Koji Teruya, Yumi Matsuda, Rie Honmyo, Yoshiko Uchida, Yutaka Takashima
    • Journal Title

      Hypertens. Res 30

      Pages: 213-218

    • NAID

      10018830548

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Longevity-associated mitochondrial DNA 5178C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged2007

    • Author(s)
      Kokaze A, et. al.
    • Journal Title

      Journal of Human Genetics 52

      Pages: 680-685

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies the effects of alcohol consumption on risk for hypertension in middle-aged Jananese men.2007

    • Author(s)
      Kokaze A et al.
    • Journal Title

      Hypertension Research 30・3

      Pages: 213-218

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men2006

    • Author(s)
      Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Masao Yoshida, Masao Satoh, Koji Teruya, Rie Honmyo, Misako Yorimitsu, Yumi Masuda, Yoshiko Uchida, Yutaka Takashima
    • Journal Title

      J. Hum. Genet 51

      Pages: 765-771

    • NAID

      10018765473

    • Related Report
      2008 Final Research Report
  • [Journal Article] Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men.2006

    • Author(s)
      Kokaze A et al.
    • Journal Title

      Journal of Human Genetics 51・9

      Pages: 756-771

    • NAID

      10018765473

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on reduced risk of hypertension in middle-aged Japanese men

    • Author(s)
      Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Kanae Karita, Masao Yoshida, Tadahiro Ohtsu, Takako Shirasawa, Hideaki Sekii, Taku Ito, Teruyoshi Kawamoto, Yutaka Takashima
    • Journal Title

      J. Epidemiol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on reduced risk of hypertension in middle-aged Japanese men.

    • Author(s)
      Kokaze A, et al.
    • Journal Title

      Journal of Epidemiology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 長寿関連ミトコンドリアDNA多型と心血管疾患危険因子の重積との関連解析2008

    • Author(s)
      小風 暁 等
    • Organizer
      第67回日本公衆衛生学会総会
    • Place of Presentation
      福岡市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 長寿関連ミトコンドリアDNA多型におけるコーヒー飲用と耐糖能異常との関係解析2008

    • Author(s)
      小風 暁, 等
    • Organizer
      第78回日本衛生学会総会
    • Place of Presentation
      熊本市
    • Year and Date
      2008-03-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] 長寿関連ミトコンドリアDNA多型と心血管疾患危険因子の重積との関連解析2008

    • Author(s)
      小風暁、苅田香苗、吉田正雄、大津忠弘、白澤貴子、櫨場八裕、星野裕美、照屋浩司
    • Organizer
      第67回日本公衆衛生学会総会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] 長寿関連ミトコンドリアDNA多型におけるコーヒー飲用と耐糖能異常との関係解析2008

    • Author(s)
      小風暁、石川守、白澤貴子、吉田正雄、本名理恵、照屋浩司、高島豊
    • Organizer
      第78回日本衛生学会総会
    • Place of Presentation
      熊本
    • Related Report
      2008 Final Research Report
  • [Presentation] 長寿関連ミトコンドリアDNA5178C/A多型と飲酒・喫煙習慣との交互作用2007

    • Author(s)
      小風暁
    • Organizer
      第3回東京抗加齢医学研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-02-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 長寿関連ミトコンドリアDNA5178C/A多型と呼吸機能との関連解析2007

    • Author(s)
      小風暁、石川守、松永直美、吉田正雄、佐藤正夫、照屋浩司、増田由美、本名理恵、阿部淑子、高島豊
    • Organizer
      第17回日本疫学会学術総会
    • Place of Presentation
      広島
    • Year and Date
      2007-01-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 長寿関連ミトコンドリアDNA多型におけるコーヒー飲用と高血圧症との関係解析2007

    • Author(s)
      小風暁、石川守、吉田正雄、増田由美、本名理恵、佐藤正夫、照屋浩司、高島豊
    • Organizer
      第77回日本衛生学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 長寿関連ミトコンドリアDNA5178C/A多型と高血圧症との関連解析2006

    • Author(s)
      小風暁、石川守、吉田正雄、増田由美、本名理恵、照屋浩司、高島豊
    • Organizer
      第71回日本民族衛生学会総会
    • Place of Presentation
      那覇
    • Related Report
      2008 Final Research Report
  • [Book] In : Columbus F editor. Longevity : Genetics, Diet and Disease

    • Author(s)
      Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Kanae Karita, Masao Yoshida, Tadahiro Ohtsu, Takako Shirasawa, Yahiro Haseba, Masao Satoh, Koji Teruya, Hiromi Hoshino, Yutaka Takashima
    • Publisher
      Longevityassociated mitochondrial DNA 5178 C/A polymorphism modifies the effect of coffee consumption on glucose tolerance in middleaged Japanese men((in press))
    • Related Report
      2008 Final Research Report
  • [Book] Handbook on Longevity : Genetics, Diet & Disease

    • Author(s)
      Kokaze A, et al.
    • Publisher
      Nova Science(in press)
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi