Personalized prevention using the information of longevity-associated mitochondrial DNA polymorphism
| Project/Area Number |
18590572
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Showa University (2007-2008)
Kyorin University (2006) |
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Principal Investigator |
KOKAZE Akatsuki Showa University, 医学部, 教授 (70271583)
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| Co-Investigator(Kenkyū-buntansha) |
高島 豊 杏林大学, 医学部, 教授 (20163199)
吉田 正雄 杏林大学, 医学部, 助教 (10296543)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | 遺伝子多型 / ミトコンドリア / 長寿 / 生活習慣 / 予防医学 / ミトコンドリアDNA / 喫煙習慣 / コーヒー飲用 / 交互作用 / テーラーメイド予防医学 |
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| Research Abstract |
長寿関連ミトコンドリア遺伝子多型(Mt5178C/A多型)と飲酒習慣との高血圧症リスクおよび高尿酸血症リスクへの交互作用、Mt5178C/A多型と喫煙習慣との呼吸機能への交互作用、Mt5178C/A多型とコーヒー飲用との高血圧症リスクおよび耐糖能異常リスクへの交互作用を論文発表した. また、Mt5178C/A多型と心血管疾患の危険因子の重積との関連について検討し、Mt5178C型の男性においては毎日の飲酒が心血管疾患危険因子の重積と関連することを学会報告した.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men2006
Author(s)
Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Masao Yoshida, Masao Satoh, Koji Teruya, Rie Honmyo, Misako Yorimitsu, Yumi Masuda, Yoshiko Uchida, Yutaka Takashima
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Journal Title
J. Hum. Genet 51
Pages: 765-771
NAID
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[Journal Article] Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on reduced risk of hypertension in middle-aged Japanese men
Author(s)
Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Kanae Karita, Masao Yoshida, Tadahiro Ohtsu, Takako Shirasawa, Hideaki Sekii, Taku Ito, Teruyoshi Kawamoto, Yutaka Takashima
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Journal Title
Related Report
Peer Reviewed
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[Book] In : Columbus F editor. Longevity : Genetics, Diet and Disease
Author(s)
Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Kanae Karita, Masao Yoshida, Tadahiro Ohtsu, Takako Shirasawa, Yahiro Haseba, Masao Satoh, Koji Teruya, Hiromi Hoshino, Yutaka Takashima
Publisher
Longevityassociated mitochondrial DNA 5178 C/A polymorphism modifies the effect of coffee consumption on glucose tolerance in middleaged Japanese men((in press))
Related Report
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