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IMMUNO-EPIDEMIOLOGICAL STUDY FOR JAPANESE CEDAR POLLINOSIS

Research Project

Project/Area Number 18590608
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

OZASA Kotaro  Kyoto Prefectural University of Medicine, GRADUATE SCHOOL OF MEDICAL SCIENCE, ASSOCIATE PROFESSOR (20204191)

Co-Investigator(Kenkyū-buntansha) TAKENAKA Hiroshi  OSAKA MEDICAL COLLEGE, FACULTY OF MEDICINE, PROFESSOR (40137162)
HAMA Takemitsu  KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, GRADUATE SCHOOL OF MEDICAL SCIENCE, ASSISTANT PROFESSOR (90315953)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,160,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsJapanese cedar pollinosis / Immunity / Allergic diseases / Epidemiology / IgE antibody / サイトカイン
Research Abstract

We investigated the prevalence of Japanese cedar pollinosis among schoolchildren in a small rural town in Kyoto prefecture during 1994-2007. Diagnosis was determined using a self-administered questionnaire and measuring serum antigen-specific IgE. Prevalence of being positive to Japanese cedar pollen antigen (>1 of CAP score) was around 40% to 60% according to the amount of dispersed pollen. Those to house dust mite was around 40% to 50%. Japanese cedar pollinosis was defined as being positive to Japanese cedar pollen and having any nasal or conjunctival symptom (sneeze, nasal discharge, nasal obstruction, itching of nasal mucosa, itching of eye conjunctiva, watering eyes, or eye irritation) lasting 3 week or longer in March or April. Prevalence of Japanese cedar pollinosis was around 15% to more than 20% according to the dispersion. Those who having the symptoms not lasting 3 weeks were 16% to 21 % of the subjects, and the prevalence was scarcely associated with the dispersion, so those symptoms seemed to be non-specific.
Disease-specific scale of quality of life (QOL) was measured since 2001. The scale was strongly related to the level of Japanese cedar pollen-specific IgE concentration. Using the over-the-counter medicine, mask, or goggles seemed to be slightly effective to release the symptoms, and medicines prescribed at medical clinics seemed to be well effective.
An individually longitudinal observation of association between amount of dispersed pollen and individual fluctuation of antigens-specific IgE level to house dust mite during these 14 years showed that exposure to Japanese cedar pollen produced the other antigen-specific IgE antibody in addition to Japanese cedar pollen. This tendency was stronger among those who were strongly sensitized to Japanese cedar pollen.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (13 results)

All 2008 2007 2006

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] A 13-year study of Japanese Cedar Pollinosis in Japanese Schoolchildren2008

    • Author(s)
      Ozasa K, Hama T, Dejima K, Watanabe Y, Hyo S, Terada T, Araki N, Takenaka H
    • Journal Title

      Allergol Int 57

      Pages: 175-180

    • NAID

      10021246646

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A 13-year study of Japanese cedar pollinosis in Japanese schoolchildren2008

    • Author(s)
      Ozasa, K., Hama, T., Dejima, K., Watanabe, Y., Hyo, S., Terada, T., Araki, N., Takenaka, H
    • Journal Title

      Allergology International 57

      Pages: 175-180

    • NAID

      10021246646

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A 13-year study of Japanese Cedar Pollinosis in Japanese Schoolchildren2008

    • Author(s)
      Ozasa K, Hama T, Dejima K, Watanabe Y, Hyo S, Terada T, Araki N, Takenaka H
    • Journal Title

      Allergol Int 57(in press)

    • NAID

      10021246646

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] スギ花粉特異的IgE抗体および症状発現に関わる要因2007

    • Author(s)
      小笹晃太郎, 三谷智子, 林恭平, 渡邊能行, 出島健司, 浜雄光, 荒木南都子, 竹中洋
    • Journal Title

      Journal of Epidemiology 10・1Suppl

      Pages: 65-65

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 学童検診におけるスギ花粉症とFcεRIα,IL-13 mRNA発現についての検討2006

    • Author(s)
      本田隆幸, 寺田哲也, 中川俊正, 小笹晃太郎, 田中一彦, 竹中洋
    • Journal Title

      アレルギー 55・8-9

      Pages: 1157-1157

    • Related Report
      2006 Annual Research Report
  • [Presentation] スギ花粉飛散量がスギ花粉以外の抗原特異的IgE抗体価に与える影響2008

    • Author(s)
      小笹 晃太郎、浜 雄光、竹中 洋, 他
    • Organizer
      第18回日本疫学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2008-01-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Influence of exposure to Japanese cedar pollen on production of the other antigen-specific IgE antibody in addition to Japanese cedar pollen2008

    • Author(s)
      Ozasa, K., Hyo, S., Terada, T., Mitani, S., Hayashi, K., Watanabe, Y., Dejima, K., Hama, T., Araki, N., Takenaka, H
    • Organizer
      The 18th Scientific Meeting of Japan Epidemiological Association
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-01-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] スギ花粉症への疫学的縦断的解析の試み2007

    • Author(s)
      小笹 晃太郎
    • Organizer
      第3回京都気道疾患研究会
    • Place of Presentation
      京都
    • Year and Date
      2007-10-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] スギ花粉症への疫学的アプローチ2007

    • Author(s)
      小笹 晃太郎
    • Organizer
      第27回日本医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Epidemiological approach to Japanese cedar pollinosis2007

    • Author(s)
      Ozasa, K
    • Organizer
      The 27th General Assembly of the Japan Medical Congress
    • Place of Presentation
      Osaka
    • Year and Date
      2007-04-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] スギ花粉特異的IgE抗体および症状発現に関わる要因2007

    • Author(s)
      小笹 晃太郎、浜 雄光、竹中 洋, 他
    • Organizer
      第17回日本疫学会学術総会
    • Place of Presentation
      広島
    • Year and Date
      2007-01-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Factors associated with production of Japanese cedar pollen-specific IgE antigen and symptoms of Japanese cedar pollinosis2007

    • Author(s)
      Ozasa, K., Mitani, S., Hayashi, K., Watanabe, Y., Dejima, K., Hama, T., Araki, N., Takenaka, H
    • Organizer
      The 17th Scientific Meeting of Japan Epidemiological Association
    • Place of Presentation
      Hiroshima
    • Year and Date
      2007-01-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Association of Japanese cedar pollinosis and expression of FcERIa, IL-13 mRNA2006

    • Author(s)
      Honda ,T., Terada, T., Nakagawa, T., Ozasa, K., Tanak, K., Takenaka, H
    • Organizer
      The 56th Autumn-Scientific Meeting of Japanese Society of Allergology
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-11-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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