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A Comparative Study of Past Medical History among the Oldest Old in Okinawa, Hawaii and U.S.A

Research Project

Project/Area Number 18590610
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionOkinawa International University (2007-2008)
Okinawa Prefectural College of Nursing (2006)

Principal Investigator

D・CRAIG Willcox  Okinawa International University, 総合文化学部, 准教授 (70316214)

Co-Investigator(Renkei-kenkyūsha) 鈴木 信  琉球大学, 医学部, 名誉教授
ブラッドリー ウィルコックス  Pacific Health Research Institute(*), 研究員
矢野 勝彦  Pacific Health Research Institute(*), 研究員
デビッド カーブ  Pacific Health Research Institute(*), 研究所長
トム パールズ  ボストン大学, 医学部・NECSディレクタ, 准教授
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,670,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords沖縄 / 長寿 / 国際保健 / 百寿者 / 病歴
Research Abstract

沖縄県(OCS)とハワイの日系アメリカ人(HHP)の百寿者を対象とし、加齢に伴う疾患の病歴および病態と罹患時の年齢を調査し全米(NECS)の百寿者と比較した。OCSの百寿者は加齢に伴う疾患が比較的少なかった。百寿者の共通点は癌の有病率が低くて、加齢に伴う感覚器の疾患(例えば、白内障)が多くみられること。糖尿病の有病率は、OCSとNECSは非常に低いが、HHPの百寿者には多かった。長寿の遺伝表現型(phenotype)が環境によって異なる可能性をしめしていると考えられる。また、百寿者に共通することは病気を遅らせる(delay)傾向があり、女性は男性より生存者(survivors)が多く、男性は女性より回避者(escapers)が多い、といった性差がみられる。超長寿者の遺伝子表現型は様々でありさらに研究する必要がある。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (41 results)

All 2008 2007 2006 Other

All Journal Article (18 results) (of which Peer Reviewed: 15 results) Presentation (18 results) Book (4 results) Remarks (1 results)

  • [Journal Article] They really are that old : A validation study of centenarian prevalence in Okinawa2008

    • Author(s)
      Willcox DC, Willcox BJ, He Q, Wang N-C, Suzuki M
    • Journal Title

      Journal of Gerontology : Biological and Medical Sciences 63(4)

      Pages: 338-349

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Life at the extreme limit : Phenotypic characteristics of supercentenarians in Okinawa2008

    • Author(s)
      Willcox DC, Willcox BJ, Wang N-C, Rosenbaum M, Suzuki M
    • Journal Title

      Journal of Gerontology : Biological and Medical Sciences 63(11)

      Pages: 1201-1208

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secrets of healthy aging and longevity from exceptional survivors around the globe : Lessons from octogenarians to supercentenarians2008

    • Author(s)
      Willcox BJ, Willcox DC, Ferrucci L
    • Journal Title

      Journal of Gerontology : Biological and Medical Sciences 63(11)

      Pages: 1181-1185

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Life at the extreme limit : Phenotypic characteristics of supercentenarians in Okinawa2008

    • Author(s)
      Willcox DC, Willcox BJ, Wang N-C, Rosenbaum M, Suzuki M
    • Journal Title

      Journal of Gerontology : Biological and Medical Sciences

      Pages: 1201-1208

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and environmental determinants of healthy aging. Editorial. Secrets of healthy aging and longevity from exceptional survivors around the globe : Lessons from octogenarians to supercentenarians2008

    • Author(s)
      Willcox BJ, Willcox DC, Ferrucci L.
    • Journal Title

      Journal of Gerontology : Biological and Medical Sciences 63(11)

      Pages: 1181-1185

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Why do women live longer than men? A demographic analysis of male-female mortality differences in Okinawa and Japan2007

    • Author(s)
      Willcox DC
    • Journal Title

      OIU Journal of Scientific Research 11(1)

      Pages: 1-16

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The biodemography of exceptional survivorship and the emergence of supercentenarians in Okinawa2007

    • Author(s)
      Willcox DC
    • Journal Title

      OIU Journal of Social Welfare and Psychology 6(1)

      Pages: 1-20

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aging gracefully : A retrospective analysis of functional status in Okinawan centenarians2007

    • Author(s)
      Willcox DC, Willcox BJ, Shimajiri S, Kurechi S, Suzuki M
    • Journal Title

      American Journal of Geriatric Psychiatry 15(3)

      Pages: 252-256

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The historical context of Okinawan longevity : Influence of U. S and Japan2007

    • Author(s)
      Suzuki M, Willcox DC, Willcox BJ
    • Journal Title

      Okinawa Journal of American Studies 4

      Pages: 46-61

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Why do women live longer than men? A demographic analysis of male-female mortality differences in Okinawa and Japan2007

    • Author(s)
      Willcox D. C.
    • Journal Title

      Okinawa International University Journal of Scientific Research 11.1

      Pages: 1-16

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The biodemography of exceptional survivorship and the emergence of supercentenarians in Okinawa2007

    • Author(s)
      Willcox D. C.
    • Journal Title

      Okinawa International University Journal of Social Welfare and Psychology 6.1

      Pages: 1-20

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caloric restriction, the traditional Okinawan diet and healthy aging:The diet of the world's longest-lived people and its potential impact on morbidity and lifespan2007

    • Author(s)
      Willcox BJ, Willcox DC, Todoriki H, et. al.
    • Journal Title

      Annuals of the N.Y. Academy of Sciences 1114

      Pages: 434-455

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caloric restriction, energy balance and healthy aging in Okinawans and Americans: Biomarker differences in septuagenarians2007

    • Author(s)
      Willcox BJ, Willcox DC, Todoriki H, et. al.
    • Journal Title

      Okinawan Journal of American Studies 4

      Pages: 62-74

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aging Gracefully : A retrospective Analysis of Functional Status in Okinawan Centenarians2007

    • Author(s)
      D.Willcox, B.Willcox, S.Shimajiri, S Kurechi, M.Suzuki
    • Journal Title

      American Journal of Geriatric Psychiatry 15・3

      Pages: 252-256

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetic determinants of exceptional human longevity : Insights from the Okinawa Centenarian Study2006

    • Author(s)
      Willcox DC, Willcox B, Hsueh W, Suzuki M
    • Journal Title

      Aging 28(4)

      Pages: 313-332

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Midlife risk factors and healthy survival in men2006

    • Author(s)
      Willcox BJ, He Q, Chen R, Yano K, Masaki KH, Grove JS, Donlon TA, Willcox DC, Curb JD
    • Journal Title

      Journal of the American Medical Association 296(19)

      Pages: 2343-2350

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic determinants of exceptional human longevity : insighs from the Okinawa Centenarian Study.2006

    • Author(s)
      D.Willcox, B.Willcox, W.Hsueh, M.Suzuki
    • Journal Title

      American Aging Association(AGE) 28・4

      Pages: 313-332

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Longevity and Gene-Environment Interactions in Okinawa : A Bio-Cultural Perspective2006

    • Author(s)
      D.Willcox, B.Willcox, J.Curb, M.Suzuki, W.Hsueh, Q.He
    • Journal Title

      The Gerontologist 46・1

      Pages: 137-137

    • Related Report
      2006 Annual Research Report
  • [Presentation] What do we know about exceptional longevity in Okinawa : Four decades of research on centenarians and super-centenarians2008

    • Author(s)
      Willcox DC, Willcox BJ, Wang N-C, He Q, Rosenbaum M, Suzuki M
    • Organizer
      7th International Workshop on Supercentenarians
    • Place of Presentation
      Montreal
    • Related Report
      2008 Final Research Report
  • [Presentation] What's new with the world' s longest lived people? A history and update from the Okinawa Centenarian Study2008

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M
    • Organizer
      20th Anniversary Celebration symposium of the Georgia Centenarian Study
    • Place of Presentation
      Atlanta
    • Related Report
      2008 Final Research Report
  • [Presentation] Health secrets of the Uchinanchuu : The world's longest lived people2008

    • Author(s)
      Willcox DC
    • Organizer
      World Uchinanchuu Centennial of Immigration to Brazil and Argentina Conference
    • Place of Presentation
      WUB and 県人会 of Brazil and Argentia
    • Related Report
      2008 Final Research Report
  • [Presentation] Secrets of healthy aging from the Okinawans, the world's longest lived people2008

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M
    • Organizer
      1st International Congress of Science in Nutrition
    • Place of Presentation
      Rome
    • Related Report
      2008 Final Research Report
  • [Presentation] Secrets of Healthy Aging from the Uchinanchuu2008

    • Author(s)
      Willcox DC
    • Organizer
      World Uchinanchu Centennial of Immigration to Brazil and Argentina Conference (WUB and 県人会)
    • Place of Presentation
      San Paulo, Brazil
    • Related Report
      2008 Annual Research Report
  • [Presentation] What's new with the world's longest lived people? A history and update from the Okinawa Centenarian Study2008

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M
    • Organizer
      Georgia Centenarian Study (20th Anniversary Celebration Conference)
    • Place of Presentation
      Athens, Georgia USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] What do we know from four decades of research on centenarians in Okinawa?2008

    • Author(s)
      Willcox DC, Willcox BJ, Wang N-C, Rosenbaum M, Suzuki M
    • Organizer
      7th I nternational Workshop on Supercentenarians
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] Life space mobility among rural Okinawan older adults2007

    • Author(s)
      Schell J, Al lman R, Sawyer-Baker P, Willcox B, Dodner E, Willcox DC
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] The genetic epidemiology of human longevity : Healthy aging around the globe2007

    • Author(s)
      Willcox BJ, Willcox DC, Curb J
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] The genetics of longevity in Okinawa and Hawaii2007

    • Author(s)
      Willcox DC, Willcox BJ, Hsueh W-C, He Q, Curb JD, Suzuki M
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Biological insights for healthy aging2007

    • Author(s)
      Willcox BJ, Willcox DC, He Q, Chen R, Yano K, et al
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Gene variants and healthy aging in Okinawa and Hawaii2007

    • Author(s)
      Willcox DC, Willcox BJ, Hsueh W-C, He Q, Curb JD, Suzuki M
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] Comparisons of genome diversity between the Okinawan and four Hap-Map populations2007

    • Author(s)
      Hsueh W-C, He Q, Willcox DC, Suzuki M, Curb JW, et al
    • Organizer
      American Society of Human Genetics
    • Place of Presentation
      San Diego
    • Related Report
      2008 Final Research Report
  • [Presentation] Multi-ethnic comparisons of life-space mobility II2007

    • Author(s)
      Schell J, Sawyer P, Willcox BJ, Willcox DC, Bodner EV, Allman RM
    • Organizer
      American Geriatrics Society
    • Place of Presentation
      Seattle
    • Related Report
      2008 Final Research Report
  • [Presentation] The genetic epidemiology of human longevity:Healthy aging around the globe2007

    • Author(s)
      Willcox BJ, Willcox DC, Curb J, et. al.
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      San Francisco
    • Related Report
      2007 Annual Research Report
  • [Presentation] The genetic epidemiology of healthy aging : disentangling the effects of genes, ethnicity and environment2006

    • Author(s)
      Willcox BJ, Willcox DC, Gondo Y, Yashin A, Hsueh W, Curb JD
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] Longevity and gene-environment interactions in Okinawa : A bio-cultural perspective2006

    • Author(s)
      Willcox DC, Willcox BJ, Curb J, Suzuki M, Hsueh W, He Q
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] Multi-ethnic Comparisons of Life-space Mobility I2006

    • Author(s)
      Schell J, Sawyer P, Willcox BJ, Willcox DC, Bodner EV, Allman RM
    • Organizer
      American Geriatrics Society
    • Place of Presentation
      Chicago
    • Related Report
      2008 Final Research Report
  • [Book] Okinawa L' Isola Dei Centenari2008

    • Author(s)
      Willcox BJ, Willcox DC, Suzuki M
    • Publisher
      Sperling & Kupfer
    • Related Report
      2008 Final Research Report
  • [Book] Okinawa ; L'isola Dei Centenari (Okinawa : Island of Centenarians)2008

    • Author(s)
      Willcox BJ, Willcox DC, Suzuki M
    • Publisher
      Sperling & Kupfer, Italy
    • Related Report
      2008 Annual Research Report
  • [Book] Exceptional Human Longevity In : Karasek, M. (Ed.). Aging and Age-Related Diseases : The Basics2006

    • Author(s)
      Willcox BJ, Willcox DC, Suzuki M
    • Publisher
      Nova Science Publishers Inc.
    • Related Report
      2008 Final Research Report
  • [Book] In : Aging and Age-Related Diseases2006

    • Author(s)
      B.Willcox, D.Willcox, M.Suzuki
    • Total Pages
      51
    • Publisher
      Nova Science Publishers Inc.
    • Related Report
      2006 Annual Research Report
  • [Remarks] Okinawa Centenarian Study website can be accessed at: www.okicent.org

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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