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A case-control study of factors contributing to the progression of chronic hepatitis using stored sera

Research Project

Project/Area Number 18590626
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionRadiation Effects Research Foundation

Principal Investigator

OHISHI Waka  Radiation Effects Research Foundation, Department of Clinical Studies, Division of Clinical Laboratories, Chief (20393423)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Saeko  Radistion Effects Research Foundation, Department of Clinical Studies, Chief (70359454)
JOHN Cologne  Radistion Effects Research Foundation, Department of Statistics, Consultant (50344411)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,870,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordshepatitis B virus / hepatitis C virus / chronic hepatitis / liver fibrosis / hepatocellular carcinoma / lifestyle habit / obesity / nested case-control study
Research Abstract

The objectives of this study is to investigate the contribution of risk factors, such as hepatitis B(HBV) or C virus(HCV) infection, severity of liver fibrosis, and lifestyle-related factors in the etiology of hepatocellular carcinoma(HCC). We conducted a nested case-control study using sera stored before HCC diagnosis in the Adult Health Study longitudinal cohort followed up since 1958. We selected 224 HCC cases and 644 controls that were matched to the cases on gender, age, city, time of serum storage, and method of serum storage, and countermatched on radiation dose.
We investigated usefulness of frozen and freeze-dried sera for serological and molecular biological detection of hepatitis B and C viruses. The results indicated that frozen and freeze-dried sera were available for use interchangeably.
Multivariate relative risks(RRs) of HCC(95% confidence intervals) were 45.8(15.2-13.8), 101(38.7-263), 70.7(8.3-601), 4.36 (1.48-13.0), and 4.57(1.85-11.3), for HBV infection alone, HCV infection alone, both HBV and HCV infections, alcohol consumption of 〓 40 g of ethanol/day, and body mass index(BMI) of > 25.0 kg/m^2(obesity) 10 years prior to diagnosis, respectively. HBV and HCV infection and BMI of > 25.0 kg/m^2 remained independent risk factors even after adjusting for severity of liver fibrosis. Among HCV infected individuals, the RR of HCC for a 1kg/m^2 increase in BMI was 1.39(P=0.003), significant multiplicative interaction in HCC risk between HCV infection and increased BMI was observed. Our findings indicated that control of excess weight(especially those with chronic hepatitis C) and antialcoholism may contribute to preventing patients with chronic liver disease from HCC occurrence.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (37 results)

All 2008 2007 2006 Other

All Journal Article (13 results) (of which Peer Reviewed: 4 results) Presentation (13 results) Book (3 results) Remarks (8 results)

  • [Journal Article] Risk factors for hepatocellular carcinoma in a Japanese population:a nested case-control study.2008

    • Author(s)
      Waka Ohishi
    • Journal Title

      Cancer Epidemiology Biomarkers & Prevention 17

      Pages: 846-854

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] B型肝炎.診療ガイドライン.2008

    • Author(s)
      大石和佳
    • Journal Title

      診断と治療 96

      Pages: 481-487

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Risk factors for hepatocellular carcinoma in a Japanese population : a nested case-control study.2008

    • Author(s)
      Waka Ohishi
    • Journal Title

      Cancer Epidemiology Biomarkers & Prevention 17

      Pages: 846-854

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Guidelines for management of hepatitis B.2008

    • Author(s)
      Waka Ohishi
    • Journal Title

      Dignosis and Treatment 96

      Pages: 481-487

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Risk factors for hepatocellular carcinoma in a Japanese population : A nested case-control study2008

    • Author(s)
      Waka Ohishi
    • Journal Title

      Cancer Epidemiology Biomarkers & Prevention 17

      Pages: 846-854

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of the use of freeze-dried sera for diagnosis of hepatitis B and C virus infections2007

    • Author(s)
      Waka Ohishi
    • Journal Title

      a longitudinal study cohort., Research Advances in Microbiology 7,Global Researc

      Pages: 1-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Validation of the use of freeze-dried sera for diagnosis of hepatitis B and C virus infections in a longitudinal study cohort.2007

    • Author(s)
      Waka Ohishi
    • Journal Title

      Research Advances in Microbiology7. Ed by Mohan RM. Kerala, Global Research Network

      Pages: 1-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Feasibility of freeze-dried sera for serological and molecular biological detection of hepatitis B and C viruses.2006

    • Author(s)
      Waka Ohishi
    • Journal Title

      Journal of Clinical Microbiology 44

      Pages: 4593-4595

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Evolution of hepatitis C virus quasispecies during ribavirin and interferon alpha-2b combination therapy and interferon alpha-2b monotherapy.2006

    • Author(s)
      Keiko Arataki
    • Journal Title

      Intervirology 49

      Pages: 352-361

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Feasibility of freeze-dried Sera for Serological and Molecular Biological Detection of Hepatitis B and C Viruses.2006

    • Author(s)
      Waka Ohishi
    • Journal Title

      Journal of Clinical Microbiology 44

      Pages: 4593-4595

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Diagnosis of and countermeasures for variant strain development.2006

    • Author(s)
      Waka Ohishi
    • Journal Title

      Modem Medical Tretment of Liver Diseases. Ed by Tode G, et. al. Tokyo, Advanced Medical Technology Research Institute

      Pages: 164-169

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evolution of hepatitis C virus quasispecies during ribavirin and interferon alpha-2b combination therapy and interferon alpha-2b monotherapy.2006

    • Author(s)
      Arataki K
    • Journal Title

      Intervirology 49

      Pages: 352-361

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Feasibility of Freeze-dried Sera for Serological and Molecular Biological Detection of Hepatitis B and C Viruses.2006

    • Author(s)
      Ohishi W
    • Journal Title

      Journal of Clinical Microbiology 44

      Pages: 4593-4595

    • Related Report
      2006 Annual Research Report
  • [Presentation] Immunological profiles in the persistence and disease progression of hepatitis C virus infection2008

    • Author(s)
      Waka Ohishi
    • Organizer
      The 18^<th> Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      ソウル
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Immunological profiles in the persistence and disease progression of hepatitis C virus infection.2008

    • Author(s)
      Waka Ohishi
    • Organizer
      18th Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Seoul
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Immunological profiles in the persistence and disease progression of hepatitis C virus infection2008

    • Author(s)
      Waka Ohishi
    • Organizer
      The 18th Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] C型肝炎ウイルス感染におけるサイトカイン産生と肝病態2007

    • Author(s)
      大石和佳
    • Organizer
      第43回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Relationship between production of cytokines and disease progression in hepatitis C virus infection2007

    • Author(s)
      Waka Ohishi
    • Organizer
      43rd Annual Meeting of Japan Society of Hepatology
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-05-31
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Environmental factors and risk of hepatocellular carcinoma2006

    • Author(s)
      Waka Ohishi
    • Organizer
      The 57^<th> Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      ボストン
    • Year and Date
      2006-10-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Environmental factors and risk of hepatocellular carcinoma.2006

    • Author(s)
      Waka Ohishi
    • Organizer
      57th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston
    • Year and Date
      2006-10-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 非B非C型肝細胞癌のリスク要因の検討2006

    • Author(s)
      大石和佳
    • Organizer
      第10回日本肝臓学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2006-10-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A study of risk factors contributing to the development of non-B, non-C, hepatocellular carcinoma.2006

    • Author(s)
      Waka Ohishi
    • Organizer
      10th Annual Meeting of the Japanese Society of Hepatology
    • Place of Presentation
      Sapporo
    • Year and Date
      2006-10-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] コホート内症例対照研究による環境要因と肝細胞がんリスクとの関連2006

    • Author(s)
      大石和佳
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Relationship between environmental factors and risk of hepatocellular carcinoma based on a nested case-control study.2006

    • Author(s)
      Waka Ohishi
    • Organizer
      65th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝細胞癌発症における生活習慣と肥満の影響について2006

    • Author(s)
      大石和佳
    • Organizer
      第92回日本消化器病学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2006-04-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of lifestyle and obesity in the development of hepatocellular carcinoma2006

    • Author(s)
      Waka Ohishi
    • Organizer
      92nd Annual Meeting of Japanese Society of Gastroenterology
    • Place of Presentation
      Kitakyushu
    • Year and Date
      2006-04-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Validation of the use of freeze-dried sera for diagnosis of hepatitis B and C virus infections in a longitudinal study cohort2007

    • Author(s)
      Waka Ohishi
    • Publisher
      Research Advances in Microbiology 7,Global Researc Network
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Validation of the use of freeze-dried sera for diagnosis of hepatitis B and C virus infections in a longitudinal study cohort2007

    • Author(s)
      Waka Ohishi
    • Total Pages
      9
    • Publisher
      Research Advances in Microbiology 7, Global Research Network
    • Related Report
      2007 Annual Research Report
  • [Book] 変異株の出現の診断とその対策2006

    • Author(s)
      大石和佳
    • Publisher
      先端医療技術研究所
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.rerf.jp/programs/rparchiv/rp01-04.htm

    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.rerf.jp/library/rr/rr0508.htm

    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.rerf.jp/library/scidata/cr_e/cr0702.htm

    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.rerf.jp/library/rr_e/rr0716.htm

    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 研究内容

    • URL

      http://www.rerf.jp/programs/rparchiv/rp01-04.htm

    • Related Report
      2007 Annual Research Report
  • [Remarks] 研究成果

    • URL

      http://www.rerf.jp/library/rr/rr0508.htm

    • Related Report
      2007 Annual Research Report
  • [Remarks] 研究成果

    • URL

      http://www.rerf.jp/library/scidata/cr_e/cr0702.htm

    • Related Report
      2007 Annual Research Report
  • [Remarks] 研究成果

    • URL

      http://www.rerf.jp/library/rr_e/rr0716.htm

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2021-04-07  

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