| Project/Area Number |
18590650
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
KANAZAWA Motoyori Tohoku University, Tohoku University, Graduate School of Medicine, Assistant Professor (70323003)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDO Shin Tohoku University, Graduate School of Medicine, Professor (80199249)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥2,270,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | irritable bowel syndrome (IBS) / abdominal bloating / abdominal gas / visceral hypersensitivity / QOL / 内臓知覚過敏 |
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| Research Abstract |
0785636
Little has been known about abdominal bloating observed in patients with irritable bowel syndrome (IBS). We investigated the hypotheses that IBS patients show more severe abdominal bloating than healthy subjects and that severity of abdominal bloating is not associated with visceral hypersensitivity in the colon or abdominal gas volume but with subjective symptoms.
Thirty seven patients with IBS and 18 healthy subjects were participated in the study. Validated questionnaires of IBS severity index (IBSSI), gastrointestinal rating scale (GSRS) and IBS-QOL were used to score IBS symptom severity and health related QOL. Pain sensitivity to intraluminal distention and smooth muscle tone in the rectum using with a barostat device and percent of abdominal gas volume in an abdominal plain x-ray film were also assessed.
IBS patients had significantly higher scores on the severity of each symptom and lower score on the IBS-QOL compared with healthy controls. IBS showed significantly lower pain threshold to the rectal distention but no significant difference in rectal tone or abdominal gas volume was observed between the patients and controls. There was a significant positive correlation between severity of abdominal bloating and constipation. There were no significant relationships of severity of abdominal bloating with rectal pain perception, motility or abdominal gas volume.
The findings of the present study suggest that abdominal bloating in IBS patients per se may affect their daily activity and that the symptom severity may not be always determined by gas content in the gastrointestinal tract but by multiple factors including subjective feelings.
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