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Clinical and Basic Aspects of Interleukin-22

Research Project

Project/Area Number 18590676
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionShiga University of Medical Science

Principal Investigator

ANDOH Akira  Shiga University of Medical Science, 医学部, 講師 (90252395)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsサイトカイン / 炎症 / 腸炎 / IL-22 / IL-17 / 炎症性腸疾患 / 大腸炎モデル
Research Abstract

炎症性腸疾患の病因、病態において活性化T細胞が重要な役割をはたしている。インターロイキン(IL)-22は、比較的最近見いだされた活性化T 細胞に由来する炎症性サイトカインの一つである。本研究では、IL-22の生理作用についてヒト大腸筋線維芽細胞をもちいて検討するとともに、マウス大腸炎モデルを用いてin vivoにおけるIL-22の役割を明らかにした。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (4 results)

All 2009 2008 2007 2006

All Journal Article (4 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Fecal microbiota profile of crohn's disease determined by terminal restriction fragment length polymorphism (T-RFLP) analysis2009

    • Author(s)
      Andoh A, Tsujikawa T, Sasaki M, Mitsuyama K, Suzuki Y, Matsui T, Matsumoto T, Benno Y, Fujiyama Y.
    • Journal Title

      Aliment Pharmacol Ther 29

      Pages: 75-82

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis2008

    • Author(s)
      Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi A.
    • Journal Title

      J Clin Invest 118

      Pages: 534-544

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut2007

    • Author(s)
      Andoh, A, et. al.
    • Journal Title

      Pharmacol Ther 114

      Pages: 94-106

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic approaches targeting intestinal microflora in inflammatory bowel disease.2006

    • Author(s)
      Andoh, Fujiyama Y.
    • Journal Title

      World J Gastroenterol. 12

      Pages: 4452-4460

    • Related Report
      2006 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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