• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of cytosolic phospholipase A2 gene for intestinal diseases

Research Project

Project/Area Number 18590687
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKyushu University

Principal Investigator

MATSUMOTO Takayuki  Kyushu University, Hospital, Assistant Professor (10278955)

Co-Investigator(Kenkyū-buntansha) IIDA Mitsuo  Kyushu University, Medical Sciences, Professor (00127961)
ESAKI Motohiro  Kyushu University, Hospital, Assistant Professor (50335957)
YADA Shinichiro  Kyushu University, Hospital, Assistant Professor (00346800)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,670,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsPhosnholinase A2 / adenomatous polyposis / disease modifier gene / フォスフォリパーゼ / 小腸潰瘍 / 大腸腫瘍 / アラキドン酸
Research Abstract

Cytosolic phospholipase A2 (cPLA2a) has been shown to regulate arachidonic acid release from phospholipids of the cellular membrane. It has also been shown to contribute to the polyp formation in humans and in experimental animals. Adenomatous polyposis, a hereditary condition characterized by the development of numerous colorectal adenomas, has heterogeneity in the clinical manifestations even in an identical family pedigree. We thus aimed to elucidate whether cPLA2a is a disease modifier gene in our 73 patients with adenomatous polyposis. We analyzed seven types of single nucleotide polymorphism (SNP) in genomic DNA of the subjects by means of direct sequencing and compared the results with the clinical manifestations. Severity of colorectal adenomatosis, colorectal cance4 fundic gland polyps, gastroduodenal adenomas, congenital hypertrophy of the retinal pigment epithelium, osteomas and desmoids were the target clinical manifestations. As a result, we could show that an allele C in rs12746200 (odds ratio [O!R] 2.5, 95% confidence interval [CI] 1.27-4.48, p=0.011) and an allele G in rs12746200(OR 2.59, 95% CI 1.06-6.3,p=0.034) were the SNPs, which contributed to gastric fundic gland polyps. However, the contribution of those alleles for the gastric polyp was insignificant when infection of Helicobacter pylori was taken into account. These findings suggest that cPLA2 does not seem to be a strong disease modifier gene for adenomatous polypasis. However, it seems to be related to the proliferation of gastric mucosa via Helicobacter pylori.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (22 results)

All 2008 2007 2006 Other

All Journal Article (20 results) (of which Peer Reviewed: 11 results) Presentation (2 results)

  • [Journal Article] Sman intestinal involvemellt in famalial adenomatous polyposis. Evaluation by double-balloone endoscopy and intraoperative enteroscopy2008

    • Author(s)
      Matsumoto T, et. al.
    • Journal Title

      Gastrointestnal Endoscopy 67(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genomic and functional analysis of MUTYH in Japanese patients with adenomatous polyposis. Chnical Genetics73(6)2008

    • Author(s)
      Yanaru-Fujisawa R, et. al.
    • Journal Title

      Chnical Genetics 73

      Pages: 545-53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prevalence of nonsteroidal anti-inflammatory drug-induced enteropathy in humans. An analysis of Japanese study group for double balloon endoscopy2008

    • Author(s)
      Matsumoto T, et. al.
    • Journal Title

      Scandinavian Journal of Gastroenterology 43

      Pages: 490-496

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Impact of phospholipase A2 group IIa genepolymorphism on phenotypic features of patients with familial adenomatous polyposis2008

    • Author(s)
      Yanaru-Fujisawa R, et. al.
    • Journal Title

      Diseases of the Colon & Rectum 50

      Pages: 223-231

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prevalence of nonsteroidal anti-inflammatory drug-induced enteropathy in humans. An analysis of Japanese study group for double balloon endoscopy2008

    • Author(s)
      Matsumoto, T., et. al.
    • Journal Title

      Scand J Gastroenterol 43

      Pages: 490-496

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Genomic and functional analysis of MUTYH in Japanese patients with adenomatous polyposis2008

    • Author(s)
      Yanaru-Fujisawa, R., et. al.
    • Journal Title

      Clin Genet 73

      Pages: 545-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Small intestinal involvement in familial adenomatous polyposis. Evalua tion by double balloon endoscopy and intraoperative enteroscopy2008

    • Author(s)
      Matsumoto T, et. al.
    • Journal Title

      Gastrointestnal Endoscopy 67 (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 家族性大腸腺腫症の消化管病変に対するスリンダクの効果2007

    • Author(s)
      松本 主之, 他
    • Journal Title

      胃と腸 42

      Pages: 1767-1780

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Chronic nonspecific multiple ulcers of the small intestine. A proposal of the entity from Japanse gastroenterologists to Western enteroscopists2007

    • Author(s)
      Matsumoto T, et. al.
    • Journal Title

      Gastrointestnal Endoscopy 66

      Pages: 99-107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 非特異性多発性小腸潰瘍症の小腸内視鏡所見非ステロイド性抗炎症剤起因性小腸潰瘍症との比較2007

    • Author(s)
      松本 主之, 他
    • Journal Title

      胃と腸 41

      Pages: 1637-1648

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Chronic nonspecific multiple ulcers of the small intestine. A proposal of the entity from Japanese gastroenterologists to Western enteroscopists2007

    • Author(s)
      Matsumoto, T., et. al.
    • Journal Title

      Gastrointest Endosc 66

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Impact of phospholipase A2 group IIa gene polymorphism on phenotypic features of patients with familial adenomatous polyposis2007

    • Author(s)
      Yanaru-Fujisawa, R., et. al.
    • Journal Title

      Dis Colon Rectum 50

      Pages: 223-231

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Chronic nonspecific multiple ulcers of the small intestine. A proposal from Japanese enteroscopists to Western gastroenterologists2007

    • Author(s)
      Matsumoto T, et. al.
    • Journal Title

      Gastrointest Endosc 66

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 家族性大腸腺腫症の消化管病変に対するsulindacの効果2007

    • Author(s)
      松本 主之, 他
    • Journal Title

      胃と腸 42

      Pages: 1767-1780

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic nonspecific multiple ulcers of the small intestine. A proposal of the entity from Japanese gastroenterologists to Western enteroscopists2007

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      Gastrointestinal Endoscopy (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Endoscopic features of chronic nonspecific multiple ulcers of the small intestine: Comparison with NSAID-enteropathy2006

    • Author(s)
      Matsumoto T, et. al.
    • Journal Title

      Digestive Disease & Sciences 51

      Pages: 1357-1363

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Endoscopic features of chronic nonspecific multiple ulcers of the small intestine : Comparison with NSAID-enteropathy2006

    • Author(s)
      Matsumoto, T., et. al.
    • Journal Title

      Dig Dis Sci 51

      Pages: 1357-1363

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Endoscopic features of chronic nonspecific multiple ulcers of the small intestine : Comparison with NSAID-enteropathy2006

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      Digestive Diseases and Science 51

      Pages: 1357-1363

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 非特異性多発性小腸潰瘍症の小腸内視鏡所見.非ステロイド性抗炎症剤起因性小腸潰瘍症との比較2006

    • Author(s)
      松本主之, 他
    • Journal Title

      胃と腸 41

      Pages: 1637-1648

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Small intestinal involvement in familial adenomatous polyposis : Evaluation by intraoperative enteroscopy and double-balloon endoscopy

    • Author(s)
      Matsumoto, T., et. al.
    • Journal Title

      Gastrointest Endosc (accepted)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 家族性大腸腺腫症細胞質ホスホリパーゼAa遺伝子多型の解析2008

    • Author(s)
      梅野 淳嗣, 他
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] An analysis of cytosolic phospholipase A2 poymorphism in patients with adenomatous polyposis2008

    • Author(s)
      Umeno, J., et. al.
    • Organizer
      Annual meeting of Japanse Society of Gastroenterology
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2008-05-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi