Tight junction proteins in inflammatory bowel disease
Project/Area Number |
18590695
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Osaka City University |
Principal Investigator |
OSHITANI Nobuhide Osaka City University, 大学院・医学研究科, 准教授 (20231235)
|
Project Period (FY) |
2006 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,830,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
Keywords | 炎症性腸疾患 / クローン病 / 潰瘍性大腸炎 / 細胞間接着蛋白 / 上皮間細胞接着蛋白 |
Research Abstract |
クローン病、潰瘍性大腸炎、対照大腸組織を用いて細胞間接着蛋白の免疫染色法における局在を検討した。細胞間接着蛋白に対する抗Rab13 抗体、抗VASP 抗体、抗リン酸化VASP 抗体、抗ZO-1 抗体を使用した。対照正常粘膜ではZO-1、VASP、Rab13 はタイトジャンクションに一致して染色されたが、クローン病ではZO-1、VASP、Rab13 ともに細胞質側への変位をみとめ、Rab13、ZO-1 は杯細胞内の粘液も染色された。潰瘍性大腸炎では変位は認められず、対照正常粘膜と同様に染色された。これらにより、クローン病において、細胞間接着蛋白であるRab13、VASP の変位はクローン病の腸管粘膜の透過性亢進に関与し、クローン病の病態に寄与していることが示唆された
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Development of pouchitis with combination therapy with Peg-int erferon alpha-2b and ribavirin for chronic hepatitis C in a patient with ulcerative colitis who underwent pouch surgery2009
Author(s)
K Morimoto, H Yamagami, S Hosomi, M Ohira, T Suekane, N Kamata, M Sogawa, K Watanabe, K Tominaga, T Watanabe, Y Fujiwara, A Tamori, N Oshitani, T Arakawa
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Journal Title
Am J Gastroenterol. (In press)
Related Report
Peer Reviewed
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[Journal Article] Proliferation of immature plasma cells in pouchitis mucosa in patients with ulcerative colitis.2008
Author(s)
Hirata N, Oshitani N, Kamata N, Sogawa M, Yamagami H, Watanabe K, Watanabe T, Tominaga K, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T.
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Journal Title
Inflamm Bowel Dis. 14(8) :
Pages: 1084-1090
Related Report
Peer Reviewed
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[Journal Article] Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn' s disease.2008
Author(s)
Hosomi S, Oshitani N, Kamat a N, Sogawa M, Yamagami H, Watanabe K, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T.
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Journal Title
Inflamm Bowel Dis. 14(9) :
Pages: 1205-1213
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Peer Reviewed
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[Journal Article] Usefulness of Double-Balloon Endoscopy in the Diagnosis of Mal ignant Small-Bowel Tumors2008
Author(s)
Yamagami H, Oshitani N, Hosomi S, Suekane T, Kamata N, Sogawa M, Okazaki H, Watanabe K, Tominaga K, Watanabe T, Fujiwara Y, Arakawa T
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Journal Title
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 6(18)
Pages: 1202-1205
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Peer Reviewed
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[Journal Article] Control of cell wall assembly by a histone-like protein in mycobacteria2007
Author(s)
Katsube T, Matsumoto S, Takatsuka M, Okuyama M, Ozeki Y, Naito M, Nishiuchi Y, Fujiwara N, Yoshiimura M, Tsuboi T, Torii M, Oshitani N, Arakawa T, Kobayashi K.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Enhanced expressions of endothelin-converting enzyme and endothelin receptors in human colonic tissues of Crohn's disease.2007
Author(s)
Suekane T, Ikura Y, Arimot J, Nakagawa M, Kitabayashi C, Naruko T, Watanabe T, Fujiwara Y, Oshitani N, Maeda Kiyoshi, Tanzawa K, Hirakawa K, Arakawa T, Ue
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Journal Title
J Clin Biochem Nutr (In press)
NAID
Related Report
Peer Reviewed
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[Journal Article] Close association between activated platelets and neutrophils in the active phase of ulcerative colitis in humans.2006
Author(s)
Kayo S, Ikura Y, Suekane T, Shirai N, Sugama Y, Ohsawa M, Adachi K, Watanabe K, Nakamura S, Fujiwara Y, Oshitani N, Higuchi K, Maeda K, Hirakawa K, Arakawa T, Ueda M.
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Journal Title
Inflamm Bowel Dis 12
Pages: 727-735
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[Presentation] Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn's disease2008
Author(s)
Hosomi S, Watanabe K, Hirata N, Suekane T, Kamata N, Sogawa M, Yamagami H, Tominaga K, Watanabe T, Fujiwara Y, Oshitani N, Arakawa T
Organizer
Digestive Disease Week 2009 AGA
Place of Presentation
アメリカサンディェゴ
Year and Date
2008-05-25
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[Presentation] The efficacy of "Mother-Baby Technique" enteroscopy for patients with small bowel strictures of Crohn's disease2008
Author(s)
Hosomi S, Watanabe K, HiTata N, Suekane T, Kamata N, Sogawa M, Yamagami H, Tominaga K, Watanabe T, Fujiwara Y, Oshitani N, Arakawa T
Organizer
Digestive Disease Week 2009 ASGE
Place of Presentation
アメリカサンディェゴ
Year and Date
2008-05-25
Related Report
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[Presentation] The efficacy of infliximab for small bowel lesions of patients with Crohn's disease according to the evaluation by using capsule endoscopy and double balloon enteros copy2008
Author(s)
Watanabe K, Hosomi S, Suekane T, Kamata N, Sogawa M, Yamagami H, Tominaga K, Watanabe T, Fujiwara Y, Oshitani N, Arakawa T
Organizer
Digestive Di sease Week 2009 ASGE
Place of Presentation
アメリカサンディェゴ
Year and Date
2008-05-25
Related Report
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[Presentation] Clinical impact of double balloon endoscopy on the diagnosis of malignant Small bowel tumors : A single center experience2008
Author(s)
Yamagami H, Oshitani N, Suekane T, Kamata N, Sogawa M, Okazaki H, Watanabe K, Tominaga K, Watanabe T, Fujiwara Y, Arakawa T
Organizer
Digestive Disease Week 2009 ASGE
Place of Presentation
アメリカサンディェゴ
Year and Date
2008-05-25
Related Report
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[Presentation] Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases.2007
Author(s)
Aomatsu K, Kato T, Fujita H, Hato F, Tamura T, Suekane T, Kamata N, Sobawa M, Yamagami H, Watanabe K, Oshitani N, Arakawa T, Kitagawa S.
Organizer
12th World Congress on advanced in Oncology and 10th International Symposium on Molecular Medicine
Place of Presentation
ギリシャ
Related Report
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[Presentation] Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn's disease.2007
Author(s)
Hosiomi S, Oshitani N, Kamata N, Sogawa M, Yamagami H, Watanabe K, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T.
Organizer
The 2nd Korea-Japan IBD Symposium
Place of Presentation
東京
Related Report