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Association with occult hepatitis C virus in the patients with non-alcoholic steatohepatitis

Research Project

Project/Area Number 18590734
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionShimane University

Principal Investigator

SATO Shuichi  Shimane University, Medicine, Associate Professor (10332785)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,270,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsNon alcoholic steatohenatitis / occult henatitis C virus / hepatocarcinogenesis / 滞在性HCV
Research Abstract

In order to qualitatively and quantitatively detect the occult hepatitis C virus (HCV) in the patients with non-alcoholic steatohepatitis (NASH) , we underwent real-time PCR for HCV-RNA in the patients whose serum HCV RNA were positive (positive control, n=6) , with NASH whose serum HCV-RNA were negative (n=47) and the patients with other diseases example for benign tumor, metastatic liver tumor, drug-induced liver injury and cholangioma whose serum HCV-RNA were negative as well as NASH (negative control, n=14). lassay of real time PCR was necessary for 10 mg of liver tissue. The results in real time PCR were positive in all of the patients with chronic hepatitis C (4.7±6.5x10^5 copies/assay, mean±SD, range: 1.1-8.5x10^5 copies/assay. The viral load in 10mg of liver tissue estimated by Real time PCR significantly related to serum viral load in identified patient with hepatitis C (p<0.05) . However, HCV-RNA was not detected in the patients with NASH and other diseases whose serum HCV-RNA were negative. In addition, we demonstrated the real-time PCR for HCV-RNA using by resected liver specimen in the four patients with burned out NASH and hepatocellular carcinoma. As well as the patients with NASH, the results in real time PCR were negative in all of the patients. This results suggested that occult HCV did not associated with second hit theory for NASH.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (10 results)

All 2008 2007 2006

All Journal Article (9 results) (of which Peer Reviewed: 5 results) Book (1 results)

  • [Journal Article] Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethyl nitrosamine-treated rats.2008

    • Author(s)
      Furuta K, Sato S, et. al.
    • Journal Title

      Oncology Report 19

      Pages: 361-368

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Abnormal liver function in Crohn's disease related to location of diseaselesions.2008

    • Author(s)
      Furuta K, Sato S, et. al.
    • Journal Title

      Inflammatory Bowel Diseases 14

      Pages: 138-139

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats2008

    • Author(s)
      Furuta, K., Sato, S., et. al.
    • Journal Title

      Oncology Report 19

      Pages: 361-368

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Abnormal liver function in Crohn's disease related to location of disease lesions2008

    • Author(s)
      Furuta, K., Sato, S., et. al.
    • Journal Title

      Inflammatory Bowel Diseases 14

      Pages: 138-139

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Abnormal liver function in Crohn's disease related to location of disease lesions.2008

    • Author(s)
      Furuta K, Sato S, et. al.
    • Journal Title

      Inflammatory Bowel Diseases 14

      Pages: 138-139

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ferucarbotran expands area treated by radiofrequency ablation in rabbit livers.2007

    • Author(s)
      Miyake T, Sato S, et. al.
    • Journal Title

      Journal of Gastroenterology and Hepatology 23(Epub)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ferucarbotran expands area treated by radiofrequency ablation in rabbit livers2007

    • Author(s)
      Miyake, T., Sato, S., et. al.
    • Journal Title

      Journal of Gastroenterology and Hepatology(Epub)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ferucarbotran expands area treated by radiofrequency ablation in rabbit livers.2007

    • Author(s)
      Miyake T, Sato S, et. al.
    • Journal Title

      Journal of Gastroenterology and Hepatology 23

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative measurement of hepatitis B virus DNA in2006

    • Author(s)
      Mishiro T, et al.
    • Journal Title

      Journal of Medical Virology 78

      Pages: 37-43

    • Related Report
      2006 Annual Research Report
  • [Book] 開けがわかる超音波ポケットアトラス2007

    • Author(s)
      木下芳一、佐藤秀一, 他
    • Total Pages
      281
    • Publisher
      南江堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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