Role of dbpA in hepatocarcinogenesis
| Project/Area Number |
18590748
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Juntendo University |
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Principal Investigator |
KAJINO Kazunori Juntendo University, School of Medicine, Assistant Professor (80260066)
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| Co-Investigator(Kenkyū-buntansha) |
HINO Okio Juntendo University, School of Medicine, Professor (90127910)
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| Project Period (FY) |
2006 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | hepatocarcinogenesis / genomic instability / dbpA / Y box binding protein / アシルCoA合成酵素 / 脂肪酸代謝 |
|---|
| Research Abstract |
We consider dbpA to be the candidate molecule which connects the chronic inflammation and carcinogenesis. In 2006 and 2007 when we received Grant-in-aid (C), we clarified the following five points.
1. Expression of dbpA in hepatocellular carcinoma (HCC) was associated with the dbpA promoter methylation in the adjacent non-HCC tissues.
2. In the liver of dbpA transgenic mice, expression of cellular genes accerelating the cell proliferation was enhanced, even before the stage when the .morphological liver change occurred.
3. The ischemic stress induced expression of dbpA in the liver.
4. In vitro, transient overexpression of dbpA accerelated the proliferation of cultured cells.
5. In the well-differentiated stomach cancer tissue, the expression of dpbA was localized in the bottom of the tubular structures. This finding suggested that, in well-differentiated stomach cancer, the dividing cells are located in the bottom of the tubular structures, as if in the bottom of crypt in normal gastric mucosa. The finding also suggested the possibility that dbpA might be the markers of canncer stem cells.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Establishment of the enzyme-linked immunosorbent assay system to detect the amino terminal secretory form of rat Erc/Mesothelin2007
Author(s)
Nakaishi, M., Kajino, K., Ikesue, M., Hagiwara, Y., Kuwahara, M., Mitani, H., Horikoshi-Sakuraba, Y., Segawa, T., Kon, S., Maeda, M., Wang, T., Abe, M., Yokoyama, M., Hino, O
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Journal Title
Cancer Sci 98
Pages: 659-64
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Gene Expression Profile of dbpA(DNA Binding Protein A)transgenic mice2006
Author(s)
Tobita, H., Kajino, K., Inami, I., Kano, S., Yasen, M., Imamura, O., Kinoshita, Y., Hino, O
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Journal Title
Int J Oncol 29
Pages: 673-679
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis2006
Author(s)
Matsumoto, F., Fujii, H., Abe, M., Kajino, K., Kobayashi, T., Matsumoto, T., Ikeda, K., Hino, O
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Journal Title
Hum Pathol 37
Pages: 1592-600
Description
「研究成果報告書概要(欧文)」より
Related Report
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