Investigative of diffentiation of pancreatic cells and application for treatments for chronic pancreatitis
| Project/Area Number |
18590750
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Tokai University |
|---|
Principal Investigator |
MINE Tetsuya Tokai University, School of Medicine, Professor (20157572)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HABU Sonoko Tokai University, School of Medicine, Professor (30051618)
HOZUMI Katsuto Tokai University, School of Medicine, Associate Professor (30246079)
|
|---|
| Project Period (FY) |
2006 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
|---|
| Keywords | Noctch / Transgenicmouse / D111 / Jagged / exocrine / endocrine / knockout mouse / Ptfla-Cre / トランスジェニックマウス / Jagged / 外分泌細胞 / 内分泌細胞 / 膵 / Dll1 / Pdx-Cre / ER / 膵幹細胞 / リガンド |
|---|
| Research Abstract |
Appearance of Jagged1 was confirmed in pancreatic tissue at E15. 5 Pancreas-specific Jaggedl-floxed knock-out mice were made.
In pancreas-specific. jaggedl floxed knock-out mice, the cells in which function of amylase secretion was made and secretion of insulin and glucagon were demonstrated. In part, exocrine tissues were changed to fatty tissues
|
Report
(3 results)
Research Products
(23 results)
-
-
[Journal Article] Eight-week oral administration of meloxicam,a non-steroidal anti-inflammatory drug,prevents dose reduction of pegylated interferon alpha-2a in the treatment of chronic hepatitis C2008
Author(s)
Kagawa T, Shiozawa H, Kojima SI, Takashimizu S, Nagata N, Numata M, Morino F, Nishizaki Y, Mochizuki K, Watanabe N, Watanabe T, Matsuzaki S, Mine T.
-
Journal Title
Hepatol Res 38
Pages: 259-66
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] A liver-derived immunosuppressive factor is an arglnase:identification and mechanism of immunosuppression2007
Author(s)
Ohtani Y, Hiyoshi M, Ohkubo T, Tsuji K, Hagihara M, Nakasaki H, Makuuchi H, Nagata N, Mine T, Takada S, Yamamura M, Tsuda M.
-
Journal Title
Riomed Res 28
Pages: 17-2
Related Report
Peer Reviewed
-
-
-
-
-
-
-
