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Investigative of diffentiation of pancreatic cells and application for treatments for chronic pancreatitis

Research Project

Project/Area Number 18590750
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTokai University

Principal Investigator

MINE Tetsuya  Tokai University, School of Medicine, Professor (20157572)

Co-Investigator(Kenkyū-buntansha) HABU Sonoko  Tokai University, School of Medicine, Professor (30051618)
HOZUMI Katsuto  Tokai University, School of Medicine, Associate Professor (30246079)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsNoctch / Transgenicmouse / D111 / Jagged / exocrine / endocrine / knockout mouse / Ptfla-Cre / トランスジェニックマウス / Jagged / 外分泌細胞 / 内分泌細胞 / 膵 / Dll1 / Pdx-Cre / ER / 膵幹細胞 / リガンド
Research Abstract

Appearance of Jagged1 was confirmed in pancreatic tissue at E15. 5 Pancreas-specific Jaggedl-floxed knock-out mice were made.
In pancreas-specific. jaggedl floxed knock-out mice, the cells in which function of amylase secretion was made and secretion of insulin and glucagon were demonstrated. In part, exocrine tissues were changed to fatty tissues

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (23 results)

All 2008 2007 2006

All Journal Article (21 results) (of which Peer Reviewed: 11 results) Book (2 results)

  • [Journal Article] Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells2008

    • Author(s)
      Kagawa T, Watanabe N, Mochizuki K, Numari A, Ikeno Y, Itoh J, Tanaka H, Arias IM, Mine T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 294

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eight-week oral administration of meloxicam,a non-steroidal anti-inflammatory drug,prevents dose reduction of pegylated interferon alpha-2a in the treatment of chronic hepatitis C2008

    • Author(s)
      Kagawa T, Shiozawa H, Kojima SI, Takashimizu S, Nagata N, Numata M, Morino F, Nishizaki Y, Mochizuki K, Watanabe N, Watanabe T, Matsuzaki S, Mine T.
    • Journal Title

      Hepatol Res 38

      Pages: 259-66

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the effectiveness of geranylgeranylacetone with cimetidine in gastritis patients with dyspeptic symptoms and gastric lesions2007

    • Author(s)
      Sakamoto C
    • Journal Title

      Digestion 75

      Pages: 215-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis2007

    • Author(s)
      Watanabe N
    • Journal Title

      Hepatol Res 37

      Pages: 598-607

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinical utility of double-balloon enteroscopy for small intestinal bleeding2007

    • Author(s)
      Suzuki T
    • Journal Title

      Dig Dis Sci. 52

      Pages: 1914-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A liver-derived immunosuppressive factor is an arginase:identification and mechanism of immunosuppression2007

    • Author(s)
      Ohtani Y
    • Journal Title

      Biomed Res 28

      Pages: 17-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells2007

    • Author(s)
      Mochizuki K
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 292

      Pages: 818-28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comparison of the effectiveness of geranylgeranylacetone with cimetidine in gastritis patients with dyspeptic symptoms and gastric lesions2007

    • Author(s)
      Sakamoto, C
    • Journal Title

      Digestion 75(4)

      Pages: 215-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis2007

    • Author(s)
      Watanabe, N
    • Journal Title

      Hepatol Res 37

      Pages: 598-607

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clinical utility of double-balloon enteroscopy for small intestinal bleeding2007

    • Author(s)
      Suzuki, T
    • Journal Title

      Dig Dis Sci 52(8)

      Pages: 1914-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A liver-derived immunosuppressive factor is an arginase : identification and mechanism of immunosuppression2007

    • Author(s)
      Ohtani, Y
    • Journal Title

      Biomed Res 28(1)

      Pages: 17-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Two N-linked glycans are required to maintain the transport activity of the bile salt export pump(ABCB11) in MDCK II cells2007

    • Author(s)
      Mochizuki, K
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 292(3)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Reconsidering the increase of expression of GGT in alcoholic liver diseases2007

    • Author(s)
      Mine T.
    • Journal Title

      Hepatol res 37

      Pages: 904-5

    • NAID

      10019773701

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis2007

    • Author(s)
      Watanabe N, Takashimizu S, Kojima S, Kagawa T, Nishizaki Y, Mine T, Matsuzaki S.
    • Journal Title

      Hepatol Res 37

      Pages: 598-607

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is post-endoscopic retrograde cholangiopancreatography pancreatitis the same as acute clinical pancreatitis?2007

    • Author(s)
      Mine T
    • Journal Title

      J Gastroenterol 42

      Pages: 265-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A liver-derived immunosuppressive factor is an arglnase:identification and mechanism of immunosuppression2007

    • Author(s)
      Ohtani Y, Hiyoshi M, Ohkubo T, Tsuji K, Hagihara M, Nakasaki H, Makuuchi H, Nagata N, Mine T, Takada S, Yamamura M, Tsuda M.
    • Journal Title

      Riomed Res 28

      Pages: 17-2

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two N-linked glycansare required to maintain transport activity of the bile salt export pump in MDCK II cells2006

    • Author(s)
      Mochizuki K et al.
    • Journal Title

      Am J Physiol 2

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Eupathili has an antiapopotic action on hepatocytes, in contrast to apoptotic actions on other cells2006

    • Author(s)
      Mine T
    • Journal Title

      J Gastroenterol 41

      Pages: 818-819

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Taurolithocholate impairs bile canalicular motility and canalicular bile secretion in isolated rat hehatocyte couplets2006

    • Author(s)
      Watanabe N
    • Journal Title

      World J Gastroenterol 7

      Pages: 5320-5325

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Primary biliary cirrhosis with multinucleated hepatocellular Giant cells2006

    • Author(s)
      Watanabe N
    • Journal Title

      Eur J Gastroenterol Hepatol 18

      Pages: 1023-1027

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ductal plate malformation, congenital hepatic fibrosis and Calori's disease are same entities or not?2006

    • Author(s)
      Mine T
    • Journal Title

      Hepatol Res 35

      Pages: 77-78

    • NAID

      10020329843

    • Related Report
      2006 Annual Research Report
  • [Book] 消化器病シークレット2007

    • Author(s)
      峯徹 哉, 幕内 博康
    • Total Pages
      871
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2007 Annual Research Report
  • [Book] サイトプロテクション2006

    • Author(s)
      峯 徹哉
    • Total Pages
      164
    • Publisher
      癌と化学療法社
    • Related Report
      2006 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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