| Budget Amount *help |
¥4,230,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Research Abstract |
Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrogenesis in chronic pancreatitis and in the desmoplastic reaction in pancreatic cancer. We demonstrated that PSCs are associated with phagocytosis and innate immunity via toll-like receptors, but not with acquired immunity via MHC class II. PSCs that engulfed dead cells inhibited proliferation, invasion, and chemotaxis by pancreatic cancer cells in a manner that was mediated by luminal factors released by PSCs, suggesting that the phagocytic function of PSCs modulates the epithelial-mesenchymal transition in pancreatic cancer.
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