| Project/Area Number |
18590759
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
KUMAGAI Koji Tohoku University, Hospital, Lrcture (30400328)
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| Co-Investigator(Kenkyū-buntansha) |
SIMOKAWA Hiroaki Tohoku University, Graduate School of Medicine, Professor (00235681)
FUKUDA Koji Tohoku University, Hospital, Research Associate (20375083)
WAKAYAM Yuji Tohoku University, Hospital, Research Associate (10375082)
SUGAI Yoshinao Tohoku University, Hospital, Research Associate (90400340)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | shock wave / tachyarrhythmias / non-pharmacological therapy |
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| Research Abstract |
Radiofrequency catheter ablation (RFCA) has been established as an effective and safe non-pharmacological therapy for arrhythmias. The indication for RFCA has been rapidly widened, from supraventricular tachycardia a decade ago to ventricular tachyarrhythmias with underlying heart disease and atrial fibrillation in recent days. However, it is difficult to eliminate the origin located deep in the myocardial wall and the origin in the epicardium by RFCA because the delivery of radiofrequency has an effect only within a limited depth. In this study, we paid attention to shock wave as a new energy source of therapy for such tachyarrhythmias with the origin located deep in the myocardial wall. The extracorporeal shock wave lithotripsy has been established as an effective and safe therapy. In addition, the extracorporeal cardiac shock wave therapy for ischemic heart disease has been also evaluated as an effective and noninvasive therapeutic strategy in this hospital. Technically, it is possible to focus and deliver the shock wave to the tachyarrhythmias with the origin located deep in the myocardial wall. In this study, the aim is finally to develop the non invasive method using extracorporeal cardiac shock wave for the tachyarrhythmias with the origin located deep in the myocardial wall which was resistant to RFCA. At first we tried to make the catheter system equipped with apparatus which can deliver shock wave (shock wave catheter) and evaluate the effect of damage of tissue in the cardiac cavity of a porcine. We confirmed that shock wave could generate energy enough to destroy the tissue from a basic experiment.
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