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High-mobility group box 1 restores cardiac dysfunction after myocardial infarction in transgenic mice

Research Project

Project/Area Number 18590760
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionYamagata University

Principal Investigator

KUBOTA Isao  Yamagata University, School of Medicine, Professor (30161673)

Co-Investigator(Kenkyū-buntansha) TAKEISHI Yasuchika  Yamagata University, School of Medicine, Associate Professor (40272067)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,980,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsHMBG1 / cardiac remodeling / myocardial infarction / angiogenesis / inflammation / immunity / heart failure
Research Abstract

Background: High-mobility group box 1 (HMGB1) is a nuclear DNA-binding protein and is released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. To test the hypothesis that HMGB1 enhances angiogenesis and restores cardiac dysfunction after myocardial infarction, we generated transgenic mouse with cardiac specific overexpression of HMGB1 (HMGB1-Tg) using α-myosin heavy chain (MHC) promoter.
Methods and Results: The left anterior descending coronary artery was ligated in HMGB1-Tg and wild-type littermate (Wt) mice. After coronary artery ligation, HMGB1 was released into circulation from the necrotic cardiomyocytes of HMGB1 overexpressing hearts. The size of myocardial infarction was smaller in HMGB1-Tg than in Wt mice. Echocardiography and cardiac catheterization demonstrated that cardiac remodeling and dysfunction after myocardial infarction were prevented in HMGB1-Tg mice compared to Wt mice. Furthermore, survival rate after myocardial infarction of HMGB1-Tg mice was higher than that of Wt mice. Immunohistochemical staining revealed that capillary and arteriole formations after myocardial infarction were enhanced in HMGB1-Tg mice.
Conclusions: We demonstrated the first in vivo evidence that HMGB1 enhances angiogenesis, restores cardiac dysfunction, and improves survival after myocardial infarction. These results may provide a novel therapeutic approach for left ventricular dysfunction after myocardial infarction.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (80 results)

All 2008 2007 2006

All Journal Article (32 results) (of which Peer Reviewed: 16 results) Presentation (48 results)

  • [Journal Article] Diacylglycerol kinase ζ rescues G alpha q-induced heart failure in transgenic mice.2008

    • Author(s)
      Niizeli, T, et. al.
    • Journal Title

      Circ J 72

      Pages: 309-317

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in sterptozotocin-induced diabetes mellitus.2008

    • Author(s)
      Bilim, O, et. al.
    • Journal Title

      Cardiovasc Diabetol 7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Diacylglycerol kinase ε rescues G alpha q-induced heart failure in transgenic mice2008

    • Author(s)
      Niizeki T, et. al.
    • Journal Title

      Circ J 72

      Pages: 309-317

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus2008

    • Author(s)
      Bilim O, et. al.
    • Journal Title

      Cardiovasc Diabetol 7

      Pages: 2-2

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus.2008

    • Author(s)
      Bilim O
    • Journal Title

      Cardiovasc Diabetol 7

      Pages: 2-2

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.2008

    • Author(s)
      Niizeki T
    • Journal Title

      Circ J 72

      Pages: 309-309

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Azelnidipine inhibits H2O2-induced cell death in neonatal rat cardiomyocytes.2008

    • Author(s)
      Koyama Y
    • Journal Title

      Cardiovasc Drugs Ther 21

      Pages: 89-89

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diacylglycerol kinase ζ attenuates pressure overload-induced cardiachypertrophy.2007

    • Author(s)
      Harada, M, et. al.
    • Journal Title

      Circ J 71

      Pages: 276-282

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cardiac-specific overxperssion of diacylglycerol kinase ζ attenuates left ventricular remodeling and improves survival after myocardial infarction.2007

    • Author(s)
      Niiceki, T, et. al.
    • Journal Title

      Am J Physilo Heart Circ Physiol 292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cardiac sympathetic denervation and ongoin myocardial damage for prognosis in heart failure.2007

    • Author(s)
      Arimoto, T, et. al.
    • Journal Title

      J Card Fail 13

      Pages: 34-41

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Azelnidipine inhibits H202-induced cell death in neonatal rat cardiompycytes.2007

    • Author(s)
      Koyam, T., et. al.
    • Journal Title

      Cardiovasc Drugs Ther 21

      Pages: 69-72

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pentraxin 3, a new marker for vascular inflammation, predicts adverseclinical outcomes in patients with heart failure.2007

    • Author(s)
      Suzuki, S, et. al.
    • Journal Title

      Am Heart J 155

      Pages: 75-81

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Diacylglycerol kinase ε attenuates pressure overload-induced cardiac hypertrophy2007

    • Author(s)
      Harada M, et. al.
    • Journal Title

      Circ J 71

      Pages: 276-282

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cardiac-specific overexpression of diacylglycerol kinase ε attenuates left ventricular remodeling and improves survival after myocardial infarction2007

    • Author(s)
      Niizeki T, et. al.
    • Journal Title

      Am J Physiol Heart Circ Physiol 292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cardiac sympathetic denervation and ongoing myocardial damage for prognosis in heart failure2007

    • Author(s)
      Arimoto T, et. al.
    • Journal Title

      J Card Fail 13

      Pages: 34-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Azelnidipine inhibits H202-induced cell death in neonatal rat cardiomyocytes2007

    • Author(s)
      Koyama Y, et. al.
    • Journal Title

      Cardiovasc Drugs Ther 21

      Pages: 69-72

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure2007

    • Author(s)
      Suzuki S, et. al.
    • Journal Title

      Am Heart J 155

      Pages: 75-81

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy.2007

    • Author(s)
      Harada M
    • Journal Title

      Circ J 71

      Pages: 276-276

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac-specific overexpression of diacylglycerl kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction.2007

    • Author(s)
      Niizeki T
    • Journal Title

      Am J Physiol Heart Circ Physiol 292

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure.2007

    • Author(s)
      Suzuki S
    • Journal Title

      Am Heart J 155

      Pages: 75-75

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diacylglycerol kinase ζ attenuates pressure overload-induced cardiac hypertrophy.2007

    • Author(s)
      Harada M, et al.
    • Journal Title

      Circ J 71

      Pages: 276-282

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Diacylglycerol kinase ζ attenuates left ventricular remodeling and improves survival after myocardial infarction.2007

    • Author(s)
      Niizeki T, et al.
    • Journal Title

      Am J Physiol Heart Circ Physiol 292

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cardiac sympathetic denervation and ongoing myocardial damage for prognosis in heart failure.2007

    • Author(s)
      Arimoto T, et al.
    • Journal Title

      J Card Fail 13

      Pages: 34-41

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gentral role of endogenous TLR-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury.2006

    • Author(s)
      Shishido, T, et, al.
    • Journal Title

      Biochem Biophys Res Commun 345

      Pages: 1446-1453

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hyperuricemia is associated with high cardiac event rates in the elderly person with chronic heart failure.2006

    • Author(s)
      Niizeki, T, et, al.
    • Journal Title

      J Cardiol 47

      Pages: 219-228

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A single nucleotide polymorphism in the CCL1 gene predicts acute exacerbations in chronic obstructive pulmonary disease.2006

    • Author(s)
      Takabatake, N, et. al.
    • Journal Title

      Am J Respir Crit Care Med 174

      Pages: 875-885

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Central role of endogenous TLR-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury2006

    • Author(s)
      Shishido T, et. al.
    • Journal Title

      Biochem Biophys Res Commun 345

      Pages: 1446-1453

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hyperuricemia is associated with high cardiac event rates in the elderly person with chronic heart failure2006

    • Author(s)
      Niizeki T, et. al.
    • Journal Title

      J Cardiol 47

      Pages: 219-228

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A single nucleotide polymorphism in the CCL1 gene perdicts acute exacerbations in chronic obstructive pulmonary disease2006

    • Author(s)
      Takabatake N, et. al.
    • Journal Title

      Am J Respir Crit Care Med 174

      Pages: 8575-885

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Central role of endogenous TLR-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injurv.2006

    • Author(s)
      Shishido T, et al.
    • Journal Title

      Biochem Biophys Res Commun 345

      Pages: 1446-1453

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hyperuricemia is associated with high cardiac event rates in the elderly person with chronic heart failure.2006

    • Author(s)
      Niizeki T, et al.
    • Journal Title

      J Cardiol 47

      Pages: 219-228

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A single nucleotide polymorphism in the CCL1 gene predicts acute exacerbations in chronic obstructive pulmonary disease.2006

    • Author(s)
      Takabatake N, et al.
    • Journal Title

      Am J Respir Crit Care Med 174

      Pages: 875-885

    • Related Report
      2006 Annual Research Report
  • [Presentation] Diacylglycerol kinase α exacerbates cardiac injury after ischemia/reperfusion in transgenic mouse hearts.2007

    • Author(s)
      Sasaki, T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diacylglycerol kinase-ε prevents cardiac hypertrophy and fibrosis induced by aortic banding: A new specific regulator of Gαq singalingcascade.2007

    • Author(s)
      Niizeki, T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diacylglycerol kinase-ζrescues Gaq-induced heart failure.2007

    • Author(s)
      Niizeki, T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Soluble receptor for advanced glycation end products (RAGE) is a prognostic factor for heart failure.2007

    • Author(s)
      Koyama, Y, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Multiple biomarkers for the prediction of eardiac events in chronic heart failure patients.2007

    • Author(s)
      Niizeki, T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Persistently increased serum concentrations of heart-type fatty acid-biniding protein predict adverse outcomes in patients with chronic heart failure.2007

    • Author(s)
      Niizeki, T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diacylglycerol kinase a exacerbates cardiac injury after ischemia/reperfusion in transgenic mouse hearts2007

    • Author(s)
      Sasaki T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diacylglycerol kinase-ε prevents cardiac hypertrophy and fibrosis induced by aortic banding : A new specific regulator of Gqα signaling cascade2007

    • Author(s)
      Niizeki T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diacylglycerol kinase-ε rescues Gaq-induced heart failure2007

    • Author(s)
      Niizeki T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Soluble receptor for advanced glycation end products(RAGE) is a prognostic factor for heart failure2007

    • Author(s)
      Koyama Y, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Multiple biomarkers for the prediction of cardiac events in chronic heart failure patients2007

    • Author(s)
      Niizeki T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Persistently increased serum concentrations of heart-type fatty acid-binding protein predict adverse outcomes in patients with chronic heart failure2007

    • Author(s)
      Niizeki T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diacylglycerol kinase α exacerbates cardiac injury after ische mia/reperfusion in transgenic mouse hearts.2007

    • Author(s)
      Sasaki T
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orlando
    • Related Report
      2007 Annual Research Report
  • [Presentation] Diacylglycerol kinase-ε prevents cardiac hypertrophy and fibrosis induced by aortic banding: A new Specific regulator of Gαq signaling cascade.2007

    • Author(s)
      Niizeki T
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orlando
    • Related Report
      2007 Annual Research Report
  • [Presentation] Diacylglycerol kinase-ζ rescues Gaq-induced heart failure.2007

    • Author(s)
      Niizeki T
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orlando
    • Related Report
      2007 Annual Research Report
  • [Presentation] Soluble receptor for advanced glycation end products (RAGE) is a prognostic factor for heart failure.2007

    • Author(s)
      Koyama Y
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orlando
    • Related Report
      2007 Annual Research Report
  • [Presentation] Multiple biomarkers for the prediction of cardiac events in chronic heart failure patients.2007

    • Author(s)
      Niizeki T
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orlando
    • Related Report
      2007 Annual Research Report
  • [Presentation] Persistently increased serum concentrations of heart-type fatty acid-binding protein predict adverse outcomes in patients with chronic heart failure.2007

    • Author(s)
      Niizeki T
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orlando
    • Related Report
      2007 Annual Research Report
  • [Presentation] Diacylglycerol kinaseζprevents cardiac remodeling by mechanical overload.2006

    • Author(s)
      Takeishi, Y, et. al.
    • Organizer
      3rd Annual symlposium of the American Heart Association Council on Basic Cardiovascular Sciences - Translation of Basic Insights Into Clinical Practice
    • Place of Presentation
      Keystone, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A combination of heart-type fatty acid binding protein and brainnatriuretic peptide can reliably risk stratify patients hospitalized for chronic heart failure.2006

    • Author(s)
      Niizeki, T, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Serum pentosidine, an advanced glycation end product (AGE), is a risk factor for heart failure.2006

    • Author(s)
      Koyama, Y, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diacylglycerol kinase zeta Prevents cardiac remodeling by mechanical overload.2006

    • Author(s)
      Takeishi, Y, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Serum carboxy-terminal telopeptide of type I collagen (ICTP) predicts cardiac events in patients with preserved left ventricular systolic function.2006

    • Author(s)
      Kitahara, T, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Heart-type fatty scid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage.2006

    • Author(s)
      Niizeki, T, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Serum resistin is associated with high risk in patients with heart failure.2006

    • Author(s)
      Takeishi, Y, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diacylglycerol kinase-ε prevents cardiac hypertrophy induced by continuous administration of phenylephrine: A new specific regulator of Gqα signaling cascade.2006

    • Author(s)
      Niizeki, T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DGK zeta prevents pressure overload-induced cardiac hypertrophy and progression to heart failure.2006

    • Author(s)
      Harada, M, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The circulating levels of heart-type fatty acid-binding protein (H-FABP) and brain natriuretic peptide (BNP) in general japanese population: Effects of age, sex, and other physiologic characteristics.2006

    • Author(s)
      Niizeki, T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] High serum level of pentosidine, an advanced glycation end product (AGE), is a risk factor of patients with heart failure.2006

    • Author(s)
      Koyama, Y, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Serum carboxy-terminal telopeptide of type I collagen (ICTP) predicts cardiac events in hypatensive heart failure patients with preserved left ventricular systolic function.2006

    • Author(s)
      Kitahara, T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cardiac sympathetic denervation and ongoing myocardial damage for prognosis in heart failure.2006

    • Author(s)
      Arimoto, T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pentraxin 3, a new inflammatory maker for endothelial cells, predicts cardiac events in patients with heart failure.2006

    • Author(s)
      Suzuki, S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Olmesartan attenuates carbonyl stress in renal injury induced by subtotal nephrectomy.2006

    • Author(s)
      Takahashi, T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diacylglycerol kinase ε prevents cardiac remodeling by mechanical overload2006

    • Author(s)
      Takeishi Y, et. al.
    • Organizer
      3rd Annual symposium of the American Heart Association Council on Basic Cardiovascular Sciences-Translation of Basic Insights Into Clinical Practice
    • Place of Presentation
      Keystone, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A combination of heart-type fatty acid binding protein and brain natriuretic peptide can reliably risk stratify patients hospitalized for chronic heart failure2006

    • Author(s)
      Niizeki T, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Serum pentosidine, an advanced glycation end product(AGE), is a risk factor for heart failure2006

    • Author(s)
      Koyama Y, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diacylglycerol kinase zeta prevents cardiac remodeling by mechanical overload2006

    • Author(s)
      Takeishi Y, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Serum carboxy-terminal telopeptide of type I collagen(ICTP) predicts cardiac events in patients with preserved left ventricular systolic function2006

    • Author(s)
      Kitahara T, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage2006

    • Author(s)
      Niizeki T, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Serum resistin is associated with high risk in patients with heart failure2006

    • Author(s)
      Takeishi Y, et. al.
    • Organizer
      European Society of Cardiology 2006 World Congress
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diacylglycerol kinase-ε prevents cardiac hypertrophy induced by continuous administration of phenylephrine : A new specific regulator of Gqα signaling cascade2006

    • Author(s)
      Niizeki T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DGK zeta prevents pressure overload-induced cardiac hypertrophy and progression to heart failure2006

    • Author(s)
      Harada M, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The circulating levels of heart-type fatty acid-binding protein(H-FABP) and brain natriuretic peptide(BNP) in general japanese population : Effects of age, sex, and other physiologic characteristics2006

    • Author(s)
      Harada M, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] High serum level of pentosidine, an advanced glycation end product(AGE), is a risk factor of patients with heart failure2006

    • Author(s)
      Niizeki T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Serum carboxy-terminal telopeptide of type I Collagen(ICTP) predicts cardiac events in hypertensive heart failure patients with preserved left ventricular systolic function2006

    • Author(s)
      Kitahara T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cardiac sympathetic denervation and ongoing myocardial damage for prognosis in heart failure2006

    • Author(s)
      Arimoto T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pentraxin 3, a new inflammatory maker for endothelial cells, predicts cardiac events in patients with heart failure2006

    • Author(s)
      Suzuki S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Olmesartan attenuates carbonyl stress in renal injury induced by subtotal nephrectomy2006

    • Author(s)
      Takahashi T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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