Myocardial regeneration by redox regulation in myocarditis with heart failure

• Project/Area Number: 18590772
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto University
• Principal Investigator: KISHIMOTO Chiharu Kyoto University, 医学研究科, 助教 (70169845)
• Co-Investigator(Kenkyū-buntansha): 中村 肇 京都大学, 医学研究科, 准教授 (70303914)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,270,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: レドックス / 心不全 / 心筋再生療法 / 酸化ストレス / チオレドキシン

Research Abstract

We investigated the role of myocardial redox system using animal model of myocardial dysfunction. As a result, the important role for myocardial regeneration of redox system was clarified.

Research Products

• [Journal Article] Antioxidants reduce the severity of atherosclerosis (2010)
  • Author(s): Kishimoto C, Shimada K
  • Journal Title: Website of International Atherosclerosis Society, Jan. 8
  • Peer Reviewed
• [Journal Article] Pioglitazone modulates the balance of effector and regulatory Tcells in apolipoprotein E deficient mice (2010)
  • Author(s): Tian Yue
  • Journal Title: Nutrition, Metabolism & Cardiovascular Disease (in press)
  • Peer Reviewed
• [Journal Article] High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance (2010)
  • Author(s): Xue JH
  • Journal Title: Cardiovascular Research (in press)
  • Peer Reviewed
• [Journal Article] Olmesartan, a novel angiotensin II type 1 receptor antagonist, reduces severity of atherosclerosis in apolipoprotein E deficient mice associated with reducing superoxide production (2010)
  • Author(s): Shimada Kana
  • Journal Title: Nutrition, Metabolism & Cardiovascular Disease (in press)
  • Peer Reviewed
• [Journal Article] Therapy with granulocyte colony-stimulating factor in the chronic stage, but not in the acute stage, improves experimental autoimmune myocarditis in rats via nitric oxide (2010)
  • Author(s): Shimada Kana
  • Journal Title: J Moll Cell Cardiol (in press)
  • Peer Reviewed
• [Journal Article] Antioxidants reduce the severity of atherosclerosis (2010)
  • Author(s): Kishimoto Chiharu
  • Journal Title: Website of International Atherosclerosis Society
• [Journal Article] N-acetylcysteine reduces the severity of atherosclerosis in apolipoprotein E deficient mice via reducing superoxide production (2009)
  • Author(s): Shimada K, Murayama T, Yokode M, Kita T, Uzui H, Ueda T, Lee JD, Kishimoto C
  • Journal Title: Circ J 73 Pages: 1337-1341
  • Peer Reviewed
• [Journal Article] N-acetylcysteine reduces the severity of atherosclerosis in apolipoprotein E deficient mice via reducing superoxide production (2009)
  • Author(s): Shimada Kana
  • Journal Title: Circulation Journal 73 Pages: 1337-1341
  • Peer Reviewed
• [Journal Article] QRS voltages are transiently increased at the superacute stage of experimental myocarditis (2008)
  • Author(s): Kishimoto C, Ohmae M, Tomioka N
  • Journal Title: Exp Clin Cardiol 13 Pages: 15-18
  • Peer Reviewed
• [Journal Article] Naloxone, an opiate receptor antagonist, ameliorates acute experimental autoimmune myocarditis by reducing cytotoxic activities (2008)
  • Author(s): Kishimoto C, Okabe T, Hattori M, Yuan Z
  • Journal Title: J Cardiovasc Pharmacol 52 Pages: 445-451
  • Peer Reviewed
• [Journal Article] L-arginine ameliorates experimental autoimmune myocarditis by maintaining extracellular matrix and reducing cytotoxic activity of lymphocytes (2008)
  • Author(s): Okabe T, Hattori M, Yuan Z, Kishimoto C
  • Journal Title: Int J Exp Path 89 Pages: 382-388
  • Peer Reviewed
• [Journal Article] L-arginine ameliorates experimental autoimmune myocardiits by maintaining extracellular matrix and reducing cytotoxic activity of lymphocytes (2008)
  • Author(s): Okabe Taka-aki
  • Journal Title: International Journal of Experimental Pathology 89 Pages: 382-388
  • Peer Reviewed
• [Journal Article] Naloxone, an opiate receptor antagonist. ameliorates acute experimental autoimmune myocarditis by reducing cytotoxic activities (2008)
  • Author(s): Kishimoto Chiharu
  • Journal Title: Journal of Cardiovascular Pharmacology 52 Pages: 445-451
  • Peer Reviewed
• [Journal Article] QRS voltages are transiently increased at the superacute stage of experimental myocarditis (2008)
  • Author(s): Kishimoto Chiharu
  • Journal Title: Experimental and Clinical Cardiology 13 Pages: 15-18
  • Peer Reviewed
• [Journal Article] 実験的自己免疫性心筋炎に対するG-CSFの効果 (2008)
  • Author(s): 島田佳奈
  • Journal Title: 循環器科 64 Pages: 204-204
  • Peer Reviewed
• [Journal Article] PPAR gamma gene C161T substitution is associated with reduced risk of coronary artery disease and decreased proinflammatory cytokine expression (2007)
  • Author(s): Liu Y, Yuan Z, Liu Y, Zhang J, Yin P, Wang D, Wang Y, Kishimoto C, Ma A
  • Journal Title: Am Heart J 154 Pages: 718-724
  • Peer Reviewed
• [Journal Article] Exercise training reduces severity of atherosclerosis in apolipoprotein E knockout mice via nitric oxide (2007)
  • Author(s): Shimada K, Kishimoto C, Okabe T, Hattori M, Murayama T, Yokode M, Kita T
  • Journal Title: Circ J 71 Pages: 1147-1151
  • NAID: 110006318420
  • Peer Reviewed
• [Journal Article] Swimming reduces the severity of atherosclerosis in apolipoprotein E deficient mice by antioxidant effects (2007)
  • Author(s): Okabe T, Shimada K, Hattori M, Murayama T, Yokode M, Kita T, Kishimoto C
  • Journal Title: Cardiovasc Res 74 Pages: 537-545
  • Peer Reviewed
• [Journal Article] Immunoglobulin therapy, myocardial diseases and atherosclerosis: Recent experimental and clinical studies (2007)
  • Author(s): Kishimoto C
  • Journal Title: Curr Cardiol Rev 3 Pages: 15-21
  • Peer Reviewed
• [Journal Article] NG-nitro-L-arginine methyl ester (L-NAME)の投与は運動による動脈硬化抑制効果を阻害する (2007)
  • Author(s): 島田佳奈, 岸本千晴, 岡部孝明, 村山敏典, 横出正之, 北徹
  • Journal Title: 呼吸と循環 55 Pages: 1-5
  • NAID: 40015528184
  • Peer Reviewed
• [Journal Article] Immunoglobulin therapy, myocardial diseases and atherosclerosis: Recent experimental and clinical studies (2007)
  • Author(s): Kishimoto Chiharu
  • Journal Title: Current Cardiology 3 Pages: 15-21
  • Peer Reviewed
• [Journal Article] Swimming reduces the severity of atherosclerosis in apolipoprotein E deficient mice by antioxidant effects (2007)
  • Author(s): Okabe Taka-aki
  • Journal Title: Cardiovascular Research 74 Pages: 537-545
  • Peer Reviewed
• [Journal Article] Exercise training reduces severity of atherosclerosis in apolipoprotein E knockout mice via nitric oxide (2007)
  • Author(s): Shimada Kana
  • Journal Title: Circulation Journal 71 Pages: 1147-1151
  • Peer Reviewed
• [Journal Article] PPAR gamma gene C161T substitution is associated with reduced risk of coronary artery disease and decreased proinflammatory cytokine expression (2007)
  • Author(s): Liu Y
  • Journal Title: American Heart Journal 154 Pages: 718-724
  • Peer Reviewed
• [Journal Article] N^G-nitro-L-arginine methyl ester(L-NAME)の投与は運動による動脈硬化抑制効果を阻害する (2007)
  • Author(s): 島田佳奈
  • Journal Title: 呼吸と循環 55 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Effects of exercise on the development of atherosclerosis in apolipoprotein E-deficient mice (2006)
  • Author(s): Okabe T, Kishimoto C, Murayama T, Yokode M, Kita T
  • Journal Title: ExpClin Cardiol 11 Pages: 276-279
  • Peer Reviewed
• [Journal Article] Effects of MCI-186 (edaravone), a novel free radical scavenger, upon experimental atherosclerosis in apolipoprotein E-deficient mice (2006)
  • Author(s): Okabe T, Kishimoto C, Shimada K, Murayama T, Yokode M, Kita T
  • Journal Title: Circ J 70 Pages: 1216-1219
  • NAID: 110004814901
  • Peer Reviewed
• [Journal Article] Revelance of inflammatory cells infiltrates for complete AV-block in experimental murine myocarditis (2006)
  • Author(s): Kishimoto C, Ohmae M, Tomioka N
  • Journal Title: Cardiovasc Pathol 15 Pages: 139-143
  • Peer Reviewed
• [Journal Article] Carotid intima-media thickness is increased in subjects with ischemic heart disease having a familial incidence (2006)
  • Author(s): Kishimoto C, Hirata M, Hama K, Tanaka M, Nishimura K, Kubo S, Veda K, Fujioka T, Tamaki S
  • Journal Title: Exp & Clin Cardiol 11 Pages: 8-10
  • Peer Reviewed
• [Journal Article] A novel approach to the suppression of atherosclerosis by Fcγreceptor blockade (2006)
  • Author(s): Kishimoto C
  • Journal Title: Circ Res 99 Pages: 1154-1155
  • Peer Reviewed
• [Journal Article] FcγIIB and cardiovascular inflammatory disease (2006)
  • Author(s): Kishimoto C, Shioji K, Yuan Z
  • Journal Title: Circ Res 98
  • Peer Reviewed
• [Journal Article] 免疫グロブリンはFc部分を介して実験的動脈炎・硬化病変を改善する (2006)
  • Author(s): 二又正臣, 岸本千晴, 袁祖貽, 塩路圭介, 北徹, 佐野秀人, 許揚, 横出正之
  • Journal Title: Trend of IVIg (3) Pages: 11-11
  • Peer Reviewed
• [Journal Article] 心房細・粗動を有する陳旧性心筋梗塞患者のジピリダモール負荷心筋シンチグラフィー時にみられた規則的R-Rについて (2006)
  • Author(s): 岸本千晴, 吉田由紀, 全栄和, 中村玲雄, 伊藤一貴
  • Journal Title: J Cardiol 48 Pages: 285-288
  • Peer Reviewed
• [Journal Article] Immunoglobulin stabilizes plaque formation in experimental atherosclerosis (2006)
  • Author(s): Shimada K, Kishimoto C, Okabe T, Murayama T, Yokode M, Kita T
  • Journal Title: J Cardiol 47 Pages: 293-297
  • NAID: 10019253864
  • Peer Reviewed
• [Journal Article] アポリポプロテインEノックアウトマウスにおける後期免疫グロブリン治療は脂肪プラークを安定させ動脈効果を抑制する (2006)
  • Author(s): 島田佳奈, 岸本千晴, 岡部孝明, 村山敏典, 横出正之, 北徹
  • Journal Title: 呼吸と循環 54 Pages: 663-667
  • Peer Reviewed
• [Journal Article] Carotid intima-media thickness is increased in subjects with ischemic heart disease having a familial incidence (2006)
  • Author(s): Kishimoto C et al.
  • Journal Title: Experimental ＆ Clinical Cardiology 11 Pages: 8-10
• [Journal Article] Effects of MCI-186 (edaravone), a novel free radical scavenger, upon experimental atherosclerosis in apolipoprotein E-deficient mice (2006)
  • Author(s): Okabe T et al.
  • Journal Title: Circulation Journal 70 Pages: 1216-1219
• [Journal Article] Revelance of inflammatory cells infiltrates for complete AV-block in experimental murine myocarditis (2006)
  • Author(s): Kishimoto C et al.
  • Journal Title: Journal of Cardiovascular Pharmacology 15 Pages: 139-143
• [Journal Article] FcγIIB and cardiovascular inflammatory disease (2006)
  • Author(s): Kishimoto C et al.
  • Journal Title: Circulation Research 98 Pages: 26-26
• [Journal Article] A novel approach to the suppression of atherosclerosis by Fcγ receptor blockade (2006)
  • Author(s): Kishimoto C
  • Journal Title: Circulation Research 99 Pages: 1154-1155
• [Journal Article] Effects of exercise on the development of atherosclerosis in apolipoprotein E-deficient mice (2006)
  • Author(s): Okabe et al.
  • Journal Title: Experimental ＆ Clinical Cardiology 11 Pages: 276-279
• [Journal Article] Therapy with granulocyte colony-stimulating factor in the chronic stage, but not in the acute stage, improves experimental autoimmune myocarditis in rats via nitric oxide
  • Author(s): Shimada K, Okabe T, Mikami Y, Hattori M, Fujita M, Kishimoto C
  • Journal Title: J Moll Cell Cardiol (in press)
  • Peer Reviewed
• [Journal Article] Olmesartan, a novel angiotensin II type 1 receptor antagonist, reduces severity of atherosclerosis in apolipoprotein E deficient mice associated with reducing superoxide production
  • Author(s): Shimada K, Murayama T, Yokode M, Kita T, Fujita M, Kishimoto C
  • Journal Title: Nutrition, Metabolism & Cardiovascular Disease (in press)
  • Peer Reviewed
• [Journal Article] High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance
  • Author(s): Xue JH, Yuan Z, Wu Y, Liu Y, Zhao Y, Zhang WP, Tian YL, Liu WM, Liu Y, Kishimoto C
  • Journal Title: Cardiovasc Res (in press)
  • Peer Reviewed
• [Journal Article] Pioglitazone modulates the balance of effector and regulatory T cells in apolipoprotein Edeficient mice
  • Author(s): Tian Y, Yuan Z, Liu Y, Liu W, Zhang W, Xue J, Shen Y, Liang X, Chen T, Kishimoto C
  • Journal Title: Nutrition, Metabolism & Cardiovascular Disease (in press)
• [Presentation] Activation of Cannabinoid-2 receptor ameliorates atherosclerosis associated with suppression of proinflammatory responses (2010)
  • Author(s): Kishimoto C
  • Organizer: 第74回日本循環器学会・学術集会
  • Place of Presentation: 京都
• [Presentation] Inhibitory Fcγreceptor protects against the development of myocarditis in mice (2010)
  • Author(s): Kishimoto C
  • Organizer: 第74回日本循環器学会・学術集会
  • Place of Presentation: 京都
• [Presentation] Erythromycin treatment suppressed myocardial injury in autoimmune myocarditis (2010)
  • Author(s): Shimada K
  • Organizer: 第74回日本循環器学会・学術集会
  • Place of Presentation: 京都
• [Presentation] Inhibitory Fcy receptor protects against the development of myocarditis in mice (2010)
  • Author(s): Kishimoto Chiharu
  • Organizer: 第74回日本循環器学会・学術集会
  • Place of Presentation: 京都
• [Presentation] 自己免疫性心筋炎に対するErythromycinの効果 (2009)
  • Author(s): 島田佳奈
  • Organizer: 第31回心筋生検研究会
  • Place of Presentation: 大阪
• [Presentation] Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression (2009)
  • Author(s): Kishimoto C, Yuan Z, Shioji K, Nakamura H, Yodoi J
  • Organizer: The American Heart Association's Scientific Sessions 2009
  • Place of Presentation: Orlando
• [Presentation] Olmesartan, an angiotensin II receptor type 1 antagonist, suppresses cytotoxic myocardial injury in autoimmune heart failure (2009)
  • Author(s): Kishimoto C, Nimata M, Okabe T, Shioji K, Yuan Z
  • Organizer: The American Heart Association's Scientific Sessions 2009
  • Place of Presentation: Orlando
• [Presentation] テモカプリルは抗酸化効果により心筋炎・心不全を改善する (2009)
  • Author(s): 岸本千晴
  • Organizer: 第57回日本心臓病学会学術集会
  • Place of Presentation: 札幌
• [Presentation] NO前駆物質L-アルギニンは心筋炎・心不全を改善する (2009)
  • Author(s): 岸本千晴
  • Organizer: 第57回日本心臓病学会学術集会
  • Place of Presentation: 札幌
• [Presentation] 心筋炎発症の超急性期にはQRS電位は増加する (2009)
  • Author(s): 岸本千晴
  • Organizer: 第57回日本心臓病学会学術集会
  • Place of Presentation: 札幌
• [Presentation] 発症直後にNK-T細胞の著明な低下を示した心筋炎の一例 (2009)
  • Author(s): 岸本千晴
  • Organizer: 第57回日本心臓病学会学術集会
  • Place of Presentation: 札幌
• [Presentation] Pioglitazone ameliorates atherosclerosis in apolipoprotein E deficient mice by modulating the balance of effector and regulatory T cells (2009)
  • Author(s): Kishimoto C
  • Organizer: 第73回日本循環器学会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Induction of vulnerable plaques by marble-burying behavior and their stabilization by exercise training in experimental atherosclerosis (2009)
  • Author(s): Shimada K
  • Organizer: 第73回日本循環器学会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Naloxone, an opiate receptor antagonist, ameliorates acute heart failure in experimental autoimmune myocarditis by reducing cytotoxic activities (2009)
  • Author(s): Kishimoto C
  • Organizer: 第73回日本循環器学会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Immunoglobulin treatment ameliorates murine myocarditis associated with reduction of neurohumoral activity and improvement of extracellular matrix change (2009)
  • Author(s): Kishimoto C
  • Organizer: 第73回日本循環器学会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Olmesartan, an angiotensin II receptor type 1 antagonist, suppresses cytotoxic myocardial injury in autoimmune heart failure (2009)
  • Author(s): Kishimoto Chiharu
  • Organizer: The American Heart Association's Scientific Sessions 2009
  • Place of Presentation: America, Orlando
• [Presentation] Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression (2009)
  • Author(s): Kishimoto Chiharu
  • Organizer: The American Heart Association's Scientific Sessions 2009
  • Place of Presentation: America, Orlando
• [Presentation] Naloxone, an opiate receotor antagonist, ameliorates acute heart failure in experimental autoimmune myocarditis by reducing cytotoxic activites (2009)
  • Author(s): Kishimoto Chiharu
  • Organizer: 第73回日本循環器学会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Pioglitazone ameliorates atherosclerosis in apolipoprotein E deficient mice by modulating the balance of effector and regulatory Tcells (2009)
  • Author(s): Kishimoto Chiharu
  • Organizer: 第73回日本循環器学会・学術集会
  • Place of Presentation: 大阪
• [Presentation] No前駆物質L-アルギニンは心筋炎・心不全を改善する (2009)
  • Author(s): 岸本千晴
  • Organizer: 第57回日本心臓病学会学術集会
  • Place of Presentation: 札幌
• [Presentation] マウスの動脈硬化に対するガラス玉覆い隠し行動と運動の影響 (2008)
  • Author(s): 島田佳奈
  • Organizer: 第106回日本循環器学会・近畿地方会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-29
• [Presentation] 下肢咬創による長期の安静臥床により症状が悪化した心不全の一例 (2008)
  • Author(s): 岸本千晴
  • Organizer: 第106回日本循環器学会・近畿地方会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-29
• [Presentation] 炎症性心臓・血管病に対する治療戦略 (2008)
  • Author(s): 岸本千晴
  • Organizer: 藤枝市立総合病院主催・学術講演会
  • Place of Presentation: 静岡県
  • Year and Date: 2008-09-26
• [Presentation] 「炎症性心臓・血管病に対する治療戦略」〜特にARBを中心に〜 (2008)
  • Author(s): 岸本千晴
  • Organizer: 藤枝市立総合病院主催・学術講演会
  • Place of Presentation: 静岡
  • Year and Date: 2008-09-26
• [Presentation] カルペジロールはβ-遮断効果というよりも抗酸化効果によって自己免疫性心筋炎を改善する (2008)
  • Author(s): 岸本千晴
  • Organizer: 第56回日本心臓病学会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-08
• [Presentation] 家族歴を有する虚血性心疾患患者における頚動脈内膜中膜肥厚の重要性 (2008)
  • Author(s): 岸本千晴
  • Organizer: 第56回日本心臓病学会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-08
• [Presentation] 家族歴を有する虚血性心疾患患者における頸動脈内膜中膜肥厚の重要性 (2008)
  • Author(s): 岸本千晴
  • Organizer: 第56回日本心臓病学会・学術集会
  • Place of Presentation: 東京
• [Presentation] カルベジロールはβ-遮断効果というよりも抗酸化効果によって自己免疫性心筋炎を改善する (2008)
  • Author(s): 岸本千晴
  • Organizer: 第56回日本心臓病学会・学術集会
  • Place of Presentation: 東京
• [Presentation] Immunoglobulin treatment suppresses oxidative stress-mediated myocardial injury (2008)
  • Author(s): Kishimoto C
  • Organizer: 第72回日本循環器学会・学術集会
  • Place of Presentation: 福岡
• [Presentation] Post-myocarditic G-CSF therapy improves the severity of the disease in experimental autoimmune myocarditis in rats (2008)
  • Author(s): Kishimoto C
  • Organizer: 第72回日本循環器学会・学術集会
  • Place of Presentation: 福岡
• [Presentation] Therapy with immunoglobulin prevents acute death in patients with fulminant myocarditis (2008)
  • Author(s): Kishimoto C
  • Organizer: 第72回日本循環器学会・学術集会
  • Place of Presentation: 福岡
• [Presentation] Swimming reduces the severity of atherosclerosis in apolipoprotein E deficient mice by antioxidant effects (2008)
  • Author(s): Kishimoto C
  • Organizer: 第72回日本循環器学会・学術集会
  • Place of Presentation: 福岡
• [Presentation] フリーラジカル・スカベンジャー、MCH-186(エダラボン)は自己免疫性心筋炎を改善する (2007)
  • Author(s): 岸本千晴
  • Organizer: 第55回日本心臓病学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2007-09-10
• [Presentation] 低容量のべネディピンは急性自己免疫性心筋炎を改善する (2007)
  • Author(s): 岸本千晴
  • Organizer: 第55回日本心臓病学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2007-09-10
• [Presentation] 新規AT1拮抗剤オルメサルタンは自己免疫性心筋炎を改善する (2007)
  • Author(s): 岸本千晴
  • Organizer: 第55回日本心臓病学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2007-09-10
• [Presentation] PPAR-γリガンドは自己免疫性心筋炎を改善する (2007)
  • Author(s): 岸本千晴
  • Organizer: 第55回日本心臓病学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2007-09-10
• [Presentation] An experimental model of in vitro autoimmune-mediated myocardial damage in myocarditis (2007)
  • Author(s): Chiharu Kishimoto
  • Organizer: 第71回日本循環器学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2007-03-15
• [Presentation] Antibody-mediated infections enhancement via Fc receptors in murine coxsackievirus B3 myocarditis (2007)
  • Author(s): Chiharu Kishimoto
  • Organizer: 第71回日本循環器学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2007-03-15
• [Presentation] Generalized oxidative stress overload is present in patients with heart failure (2007)
  • Author(s): Chiharu Kishimoto
  • Organizer: 第71回日本循環器学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2007-03-15
• [Presentation] Effects of MCI-186 (edaravone), a novel free radical scavenger, uponexperimental atherosclerosis in apolipoprotein E-deficient mice (2007)
  • Author(s): Kana Shimada
  • Organizer: 第71回日本循環器学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2007-03-15
• [Presentation] Immunoglobulin suppresses experimental atherosclerosis via the Fc portion independent of hypercholesterolemia (2007)
  • Author(s): Kana Shimada
  • Organizer: 第71回日本循環器学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2007-03-15
• [Presentation] 実験的自己免疫性心筋炎に対するG-CSFの効果 (2007)
  • Author(s): 島田佳奈, 三神優, 岡部孝明, 藤田正俊, 岸本千晴
  • Organizer: 第29回心筋生検研究会
  • Place of Presentation: 名古屋
• [Presentation] PPAR-γリガンドは自己免疫性心筋炎を改善する (2007)
  • Author(s): 岸本千晴, 袁祖胎, 塩路圭介, 北徹
  • Organizer: 第55回日本心臓学会学術集会
  • Place of Presentation: 千葉
• [Presentation] 新規AT1拮抗剤オルメサルタンは自己免疫性心筋炎を改善する (2007)
  • Author(s): 岸本千晴, 岡部孝明, 塩路圭介, 島田佳奈, 北徹
  • Organizer: 第55回日本心臓学会学術集会
  • Place of Presentation: 千葉
• [Presentation] 低用量のベネディピンは急性自己免疫性心筋炎を改善する (2007)
  • Author(s): 岸本千晴, 塩路圭介, 袁祖胎, 北徹
  • Organizer: 第55回日本心臓病学会学術集会
  • Place of Presentation: 千葉
• [Presentation] MCI-186(エダラボン)は自己免疫性心筋炎を改善する (2007)
  • Author(s): 岸本千晴、岡部孝明、服部美樹、島田佳奈、袁祖胎、塩路圭介
  • Organizer: 第55回日本心臓病学会学術集会
  • Place of Presentation: 千葉
• [Presentation] 水泳トレーニングは抗酸化効果により動脈硬化の進展を阻止する (2007)
  • Author(s): 島田佳奈, 岸本千晴, 岡部孝明, 村山敏典, 横出正之, 北徹
  • Organizer: 第55回日本心臓病学会学術集会
  • Place of Presentation: 千葉
• [Presentation] Immunoglobulin suppresses experimental atherosclerosis via the Fc portion independent of hypercholesterolemia (2007)
  • Author(s): Shimada K, Kishimoto C, Yuan Z, Sano H, Shioji K, Xu Y, Yokode M, Kita T
  • Organizer: 第71回日本循環器学会・学術集会
  • Place of Presentation: 神戸
• [Presentation] Effects of MCI-186 (edaravone), a novel free radical scavenger, upon experimental atherosclerosis in apolipoprotein E-deficient mice (2007)
  • Author(s): Shimada K, Kishimoto C, Okabe T, Murayama T, Yokode M, Kita T
  • Organizer: 第71回日本循環器学会・学術集会
  • Place of Presentation: 神戸
• [Presentation] Antibody-mediated infections enhancement via Fc receptors in murine coxsackievirus B3 myocarditis (2007)
  • Author(s): Kishimoto C, Shioji K, Yuan Z
  • Organizer: 第71回日本循環器学会・学術集会
  • Place of Presentation: 神戸
• [Presentation] An experimental model of in vitro autoimmune-mediated myocardial damage in myocarditis (2007)
  • Author(s): Kishimoto C, Nimata M, Yuan Z
  • Organizer: 第71回日本循環器学会・学術集会
  • Place of Presentation: 神戸
• [Presentation] 心房細動を合併した心筋梗塞患者でのジピリダモール負荷心筋シンチ時にみられた興味ある心拍変動について (2006)
  • Author(s): 吉田由紀, 岸本千晴, 全栄和, 中村玲雄, 伊藤一貴
  • Organizer: 第101回日本循環器学会近畿地方会
  • Place of Presentation: 神戸
  • Year and Date: 2006-06-24
• [Presentation] NG-nitro-L-arginine methyl ester (L-NAME)の投与は運動による動脈硬化抑制を阻害する (2006)
  • Author(s): 島田佳奈, 岸本千晴, 岡部孝明, 村山敏典, 横出正之, 北徹
  • Organizer: 第28回心筋生検研究会
  • Place of Presentation: 高槻
• [Presentation] 心筋炎標本サンプルよりのリンパ球培養の試み (2006)
  • Author(s): 岸本千晴, 二又正臣, 袁祖貽
  • Organizer: 第54回日本心臓病学術集会
  • Place of Presentation: 鹿児島
• [Presentation] 急性心筋炎に対する免疫グロブリン療法:多施設共同研究と血中のサイトカイン分析 (2006)
  • Author(s): 岸本千晴, 塩路圭介, 橋本哲男, 田巻俊一, 河合忠一, 安田聡, 野々木宏, 李鍾大, 加藤茂, 平光伸也, 森本紳一郎
  • Organizer: 第54回日本心臓病学術集会
  • Place of Presentation: 鹿児島
• [Presentation] Systemic oxidative stress is increased in patients with heart failure (2006)
  • Author(s): Kishimoto C, Shioji K, Tamaki S, Hashimoto T
  • Organizer: 第54回日本心臓病学術集会
  • Place of Presentation: 鹿児島
• [Presentation] Inflammatory cell infiltrates and edema in the conduction system cause complete AV block in experimental murine myocarditis (2006)
  • Author(s): Kishimoto C, Ohmae M, Tomioka N
  • Organizer: 第54回日本心臓病学術集会
  • Place of Presentation: 鹿児島
• [Presentation] Systemic oxidative stress is increased in patients with heart failure (2006)
  • Author(s): Kishimoto C, Shioji K, Nimata M, Nakamura H, Yodoi J, Tamaki S, Hashimoto T, Kawai C
  • Organizer: The American Heart Association's Scientific Sessions 2006
  • Place of Presentation: Chicago
• [Presentation] Peroxisome proliferation-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis (2006)
  • Author(s): Kishimoto C, Yuan Z, Shioji K
  • Organizer: The American Heart Association's Scientific Sessions
  • Place of Presentation: Chicago
• [Presentation] Supplementation of L-NAME restores suppressive effects of exercise upon experimental murine atherosclerosis (2006)
  • Author(s): Shimada K, Kishimoto C, Okabe T, Murayama T, Yokode M, Kita T
  • Organizer: 2nd Congress of International Academy of Cardiovascular Sciences
  • Place of Presentation: Sapporo
• [Book] わかりやすい内科学 (2008)
  • Author(s): 岸本千晴
  • Publisher: 文光堂
• [Book] わかりやすい内科学 (2008)
  • Author(s): 岸本千晴、文光堂
• [Book] わかりやすい内科学.第3版.「心筋炎」(p.202〜206) (2008)
  • Author(s): 岸本 千晴
  • Total Pages: 1481
  • Publisher: 文光堂
• [Book] 心筋炎における酸化ストレス、酸化ストレスVer. 2フリーラジカル医学生物学の最前線(ed by吉川敏一) (2006)
  • Author(s): 岸本千晴
  • Publisher: 医歯薬出版株式会社
• [Remarks] ホームページ等
  • URL: http://kyoto-u-cardio.jp/
• [Remarks]
  • URL: http://www.athero.org/