| Project/Area Number |
18590778
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MIURA Toshiro Yamaguchi University, Graduate School of Medicine, Associate Professor (00243634)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Yasuhiro Yamaguchi University, School of Medicine, Associate Professor (00260349)
HAMANO Koichi Yamaguchi University, Graduate School of Medicine, Professor (60263787)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | tissue stem cell / myocardial regeneration / tongue derived stem cell / cardiac function / 舌 / 大腿筋 / 遺伝子発現 / 心筋梗塞 |
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| Research Abstract |
This project demonstrates the various muscle-derived stem cells using the cell surface marker SCA-1, and compared the efficiency to differentiate into cardiac myocytes. The newly identified tongue muscle-derived stem cells most efficiently differentiates into contractile muscle cells which express NKX2.5 and Connexin 43. This cell was cultured and injected into infarcted heart of the C57/B16 mice and the long term survival and the event of arrhythmia were investigated. The long term survival was improved by the tongue derived stem cells group than that of myoblast transplanted group. The arrhythmogenic effect was not observed by the implantation of the tongue derived stem cells. Thus, the transplantation of the tongue derived stem cells are the promising therapeutic strategy for the treatment of heart failure induced by myocardial infarction.
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