A study on validity of adiponectin for macro- and micro-vascular injury

• Project/Area Number: 18590780
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: KOJIMA Sunao Kumamoto University, 医学部附属病院, 助教 (50363528)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,990,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2008: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
• Keywords: 心臓病態学 / 血管病態学 / アディポネクチン / 虚血性心疾患 / 冠動脈プラーク / 血管内超音波 / Virtual Histology / 喫煙 / アディポクチン

Research Abstract

We demonstrated that patients with coronary artery disease had low levels of adiponectin. Low adiponectin levels were associated with poor prognosis in men, while a reduction in adiponectin concentration during hospitalization correlated with future cardiac events in women with acute myocardial infarction. Statin-use and necrotic core volume highly suggestive of coronary plaque vulnerability were closely associated with adiponectin levels. The flow pattern of ophthalmic artery representative of micro vessels was involved in the severity of coronary artery disease. Our studies clarified that adiponectin had an impact on macro- and micro-vascular injury and the increase of adiponectin levels may inhibit systemic atherosclerotic change.

Research Products

• [Journal Article] Waveform of ophthalmic artery Doppler flow predicts the severity of systemic atherosclerosis (2010)
  • Author(s): Hidetomo Maruyoshi, Sunao Kojima, Shinobu Kojima, Yasuhiro Nagayoshi, Yoko Horibata, Koichi Kaikita, Seigo Sugiyama, Hisao Ogawa
  • Journal Title: Circ J (in press)
  • NAID: 10026475144
  • Peer Reviewed
• [Journal Article] Hypercholesterolemia and hypoadiponectinemia are associated with necrotic core-rich coronary plaque (2010)
  • Author(s): Shinobu Kojima, Sunao Kojima, Hidetomo Maruyoshi, Yasuhiro Nagayoshi, Koichi Kaikita, Hitoshi Sumida, Seigo Sugiyama, Tohru Funahashi, Hisao Ogawa
  • Journal Title: Int J Cardiol (in press)
  • Peer Reviewed
• [Journal Article] Increased Density of the Liver and Amiodarone-Associated Phospholipidosis (2010)
  • Author(s): Sunao Kojima, Shinobu Kojima, Hirofumi Ueno, Motohiro Takeya, Hisao Ogawa
  • Journal Title: Cardiol Res Pract vol.2009 Pages: 3-3
  • Peer Reviewed
• [Journal Article] Smoking cessation is associated with increased plasma adiponectin levels in men (2009)
  • Author(s): Fumiyuki Otsuka, Sunao Kojima, Hidetomo Maruyoshi, Shinobu Kojima, Yasushi Matsuzawa, Tohru Funahashi, Koichi Kaikita, Seigo Sugiyama, Kazuo Kimura, Satoshi Umemura, Hisao Ogawa
  • Journal Title: J Cardiol 53 Pages: 219-225
  • NAID: 10025183122
  • Peer Reviewed
• [Journal Article] Increased Density of the Liver and Amiodarone-Associated Phospholipidosis (2009)
  • Author(s): Sunao Kojima
  • Journal Title: Cardiology Research and Practice 2009
  • Peer Reviewed
• [Journal Article] Smoking cessation is ssociated with increased plasma adiponectin levels in men (2009)
  • Author(s): Fumiyuki Otsuka, Sunao Kojima, Hidetomo Maruyoshi, Shinobu Kojima, Yasushi Matsuzawa, Tohru Funahashi, Koichi Kaikita, Seigo Sugiyama, Kazuo Kimura, Satoshi Umemura, Hisao Ogawa
  • Journal Title: J Cardiol 53 Pages: 219-225
  • Peer Reviewed
• [Journal Article] Smoking cessation is associated with increased plasma adiponectin levels in men. (2009)
  • Author(s): Fumiyuki Otsuka
  • Journal Title: Journal of Cardiology 53(2) Pages: 219-225
  • Peer Reviewed
• [Journal Article] Hypoadiponectinemia is associated with impaired glucose tolerance and coronary artery disease in non-diabetic men (2007)
  • Author(s): Fumiyuki Otsuka, Seigo Sugiyama, Sunao Kojima, Hidetomo Maruyoshi, Tohru Funahashi, Tomohiro Sakamoto, Michihiro Yoshimura, Kazuo Kimura, Satoshi Umemura, Hisao Ogawa
  • Journal Title: Circ J 71 Pages: 1703-1709
  • NAID: 110006448577
  • Peer Reviewed
• [Journal Article] Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction (2007)
  • Author(s): Sunao Kojima, Tohru Funahashi, Fumiyuki Otsuka, Hidetomo Maruyoshi, Takuro Yamashita, Ichiro Kajiwara, Hideki Shimomura, Yuji Miyao, Kazuteru Fujimoto, Seigo Sugiyama, Tomohiro Sakamoto, Michihiro Yoshimura, Hisao Ogawa
  • Journal Title: Atherosclerosis 194 Pages: 204-213
  • Peer Reviewed
• [Journal Article] Hypoadiponectinemia is associated with impaired glucose tolerance and coronary artery disease innon-diabetic men (2007)
  • Author(s): Fumiyuki Otsuka, Seigo Sugiyama, Sunao Kojima, Hidetomo Maruyoshi, Tohru Funahashi, Tomohiro Sakamoto, Michihiro Yoshimura, Kazuo Kimura, Satoshi Umemura, Hisao Ogawa
  • Journal Title: Circ J. 71 Pages: 1703-1709
  • Peer Reviewed
• [Journal Article] Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction. (2007)
  • Author(s): Sunao Kojima
  • Journal Title: Atherosclerosis 194 Pages: 204-213
  • Peer Reviewed
• [Journal Article] Hypoadiponectinemia is associated with impaired glucose tolerance and coronary artery disease in non-diabetic men. (2007)
  • Author(s): Fumiyuki Otsuka
  • Journal Title: Circulation Journal 71 Pages: 1703-1709
  • Peer Reviewed
• [Journal Article] Plasma adiponectin levels are associated with complex coronary plaque morphology in men with stable coronary artery disease (2006)
  • Author(s): Fumiyuki Otsuka, Seigo Sugiyama, Sunao Kojima, Hidetomo Maruyoshi, Tohru Funahashi, Tomohiro Sakamoto, Michihiro Yoshimura, Kazuo Kimura, Satoshi Umemura, Hisao Ogawa
  • Journal Title: J Am Coll Cardiol 48 Pages: 1155-1162
• [Journal Article] Plasma adiponectin levels are associated with complex coronary plaque morphology in men with stable coronary artery disease (2006)
  • Author(s): Fumiyuki Otsuka, Seigo Sugiyama, Sunao Kojima, detomo Maruyoshi, Tohru Funahashi, Tomohiro akamoto, Michihiro Yoshimura, Kazuo Kimura, Satoshi Umemura, Hisao Ogawa
  • Journal Title: J Am Coll Cardiol. 48 Pages: 1155-1162
  • Peer Reviewed
• [Journal Article] Plasma Adiponectin Levels Are Associated With Coronary Lesion Complexity in Men With Coronary Artery Disease (2006)
  • Author(s): Fumiyuki Otsuka
  • Journal Title: Journal of the American College of Cardiology 48(6) Pages: 1155-1162
• [Journal Article] Hypercholesterolemia and hypoadiponectinemia are associated with necrotic core-rich coronary plaque
  • Author(s): Shinobu Kojima
  • Journal Title: International Journal of Cardiology (In press)
  • Peer Reviewed
• [Journal Article] Waveform of ophthalmic artery Doppler flow predicts the severity of systemic atherosclerosis
  • Author(s): Hidetomo Maruyoshi
  • Journal Title: Circulation Journal (In press)
  • Peer Reviewed
• [Presentation] Active smoking has an impact on the morphological distribution of coronary arterial plaque visualized by intravascular ultrasound- Virtual Histology (2009)
  • Author(s): Sunao Kojima
  • Organizer: American Heart Association the 82nd Scientific Sessions Orlando, Florida, Orange County Convention Cente
  • Place of Presentation: Florida, Orange County Convention Center
• [Presentation] Hypercholesterolemia and hypoadiponectinemia are risk factors for coronary plaque vulnerability (2009)
  • Author(s): Shinobu Kojima, Sunao Kojima
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪大阪国際会議場
• [Presentation] Active smoking has an impact on the morphological distribution of coronary arterial plaque visualized by intravascular ultrasound-Virtual Histology (2009)
  • Author(s): Sunao Kojima
  • Organizer: American Heart Association the 82^<nd> Scientific Sessions
  • Place of Presentation: Orlando, Florida(アメリク合衆国)
• [Presentation] (2009)
  • Author(s): Kojima S, Kojima S, et.al.
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪市
• [Presentation] Hypercholesterolemia and hypoadiponectinemia are risk factors for coronary plaque vulnerability (2009)
  • Author(s): Shinobu Kojima
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪市
• [Presentation] Statin-use and increase of adiponectin enhance the stabilization and regression of coronary arterial plaques characterized by low- and high-density lipoprotein cholesterols (2008)
  • Author(s): Shinobu Kojima, Sunao Kojima
  • Organizer: American Heart Association the 81st Scientific Sessions Orlando, New Orleans, Louisiana
  • Place of Presentation: Ernest N Morial Convention Center
• [Presentation] HDLコレステロールやLDLコレステロールは冠動脈内プラークの体積や組成を反映する (2008)
  • Author(s): 小島淳
  • Organizer: 第81回日本超音波医学会学術集会
  • Place of Presentation: 戸神戸国際会議場
• [Presentation] (2008)
  • Author(s): 小島淳ら
  • Organizer: 第81回日本超音波医学会学術集会
  • Place of Presentation: 神戸市
• [Presentation] (2008)
  • Author(s): Kojima S, Kojima S, et.al.
  • Organizer: American Heart Association the 81^<st> Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] HDLコレステロールやLDLコレステロールは冠動脈内プラークの体積や組成を反映する (2008)
  • Author(s): 小島 淳
  • Organizer: 第81回日本超音波医学会学術集会
  • Place of Presentation: 神戸市
• [Presentation] Statin-use and increase of adiponectln enhance the stabilization and regression of coronary arterial plaques characterized by low-and high-density lipoprotein cholesterols (2008)
  • Author(s): Shinobu Kojima
  • Organizer: American Heart Association the 81^<st> Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] Metabolic syndrome enhances the formation of large coronary plaques with fibro-fatty lesions leading to impaired microcirculation and myocardial perfusion during coronary intervention (2007)
  • Author(s): Shinobu Kojima, Sunao Kojima
  • Organizer: American Heart Association the 80th Scientific Sessions Orlando
  • Place of Presentation: Florida, Orange County Convention Center
• [Presentation] (2007)
  • Author(s): Kojima S, et.al.
  • Organizer: American Heart Association the 80^<th> Scientific Sessions
  • Place of Presentation: Orlando, Florida.
• [Presentation] Metabolic syndrome enhances the formation of large coronary plaques with fibro-fatty lesions leading to impaired microcirculation and myocardial perfusion during coronary intervention (2007)
  • Author(s): Sunao Kojima
  • Organizer: American Heart Association the 80th Scientific Sessions.
  • Place of Presentation: Orlando,Florida
• [Presentation] Coronary Plaque characterization of culprit lesions assessed by in vivo intracoronary ultrasound radiofrequency data analysis can predict angiographic no-reflow or slow-flow phenomenon during coronary intervention (2006)
  • Author(s): Sunao Kojima
  • Organizer: American Heart Association the 79th Scientific Sessions Chicago, Illinois
  • Place of Presentation: Mc Cormick Place