| Project/Area Number |
18590785
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
YOSHIYAMA Minoru Osaka City University, Department of Internal Medicine and Cardiology, Professor (30240956)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Side Population Cell / Transplantation / Regenerative Medicin |
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| Research Abstract |
Despite the advance in pharmacotherapeutics and mechanical interventions, the cardiomyocytes lost during myocardial infarction (MI) cannot be regenerated. Consequently, the loss of cardiomyocytes in MI is a major cause of heart failure. As a potential method, cell transplantation to myocardium has been studied for a decade. Side Population Cell in Skeletal Muscle transplantation could be potential therapy for heart damage in experimentally. However, the safety, efficacy of their transplantation are controversial. In this study, we investigate that whether Side Population' Cell in Skeletal Muscle can be a good cell source. In the present study, we transplanted Side Population Cell in Skeletal Muscle into infracted mouse hearts and investigate that (1) whether engrafted Side Population Cell in Skeletal Muscle improve post infarcted cardiac function, (2) whether Side Population Cell in Skeletal Muscle myoblasts can transdifferentiate into cardiomyocytes in vitro and in vivo.
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