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Coupling of protein kinase C and Ca/calmodulin dependent protein kinase II in cardiac muscle

Research Project

Project/Area Number 18590789
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionJikei University School of Medicine

Principal Investigator

KOMUKAI Kimiaki  Jikei University School of Medicine, 医学部, 講師 (60360145)

Co-Investigator(Kenkyū-buntansha) HONGO Kenichi  東京慈恵会医科大学, 医学部, 准教授 (00256447)
KAWAI Makoto  東京慈恵会医科大学, 医学部, 講師 (40277025)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,110,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Keywordsエンドセリン / カルシウム電流 / 心筋 / シグナル伝達 / CaMKII / プロテインキナーゼC / パッチクランプ法 / ETA受容体 / プロテインキナーゼ / ラット / カルシウム / ETB受容体 / 生理活性 / α受容体 / アンギオテンシン / KN-93
Research Abstract

We investigated the effect of endothelin-1 (ET-1) on L-type Ca current (ICa) of rat ventricular myocytes using perforated patch clamp technique. ET-1 (10nM) increased ICa. This increase was blocked by a selective ETA antagonist BQ-123 but not by a selective ETB antagonist BQ-788. The increase was blocked by a PKC inhibitor chelerythrine and a CaMKII inhibitor KN-93 but not by its inactive analogue KN-92. The increase was blocked by another CaMKII inhibitor AIP. These results suggested that ET-1 increased ICa via an ETA-PKC-CaMKII pathway.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (64 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (38 results) (of which Peer Reviewed: 20 results) Presentation (26 results)

  • [Journal Article] Difference in risk factors between acute coronary syndrome and stableangina pectoris in the Japanese : smoking as a crucial risk factor of acute coronary syndrome2010

    • Author(s)
      Yagi H, et al
    • Journal Title

      Journal of Cardiology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Ca2+/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca current during endothelin-1 stimulation2010

    • Author(s)
      Komnkai K, et al
    • Journal Title

      American Journal of Physiology Heart and Circulatory Physiology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergic inhibitory effect of angiotensin II receptor blocker and thiazide Diuretic on the tissue renin-angiotensin-aldosterone system2010

    • Author(s)
      Yoshimura M, et al
    • Journal Title

      Journal of Renin-Angiotensin-Aldosterone System (In Press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 冠動脈疾患2010

    • Author(s)
      小武海公明, 他
    • Journal Title

      日本臨床 68(増刊2)

      Pages: 388-92

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Caと平滑筋収縮の関係(CaシグナルとRhoキナーゼ系を含めて)2010

    • Author(s)
      本郷賢一, 他
    • Journal Title

      Modern Physician 30

      Pages: 343-5

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ACE阻害薬の臨床上の効能と副作用2010

    • Author(s)
      小武海公明, 他
    • Journal Title

      Modern Physician 30

      Pages: 387-90

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ACE阻害薬と利尿薬併用の意義2010

    • Author(s)
      川井真, 他
    • Journal Title

      Modern Physician 30

      Pages: 412-6

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increase Ca(2+) leak in mouse heart.2009

    • Author(s)
      Morimoto S, O-Uchi J, Kawai M, Hosh T, Kusakari Y, Komukai K, Sasaki H, Hongo K, Kurihara S.
    • Journal Title

      Biochem Biophys Res Commun 390

      Pages: 87-92

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy2009

    • Author(s)
      Kawai M, Hongo K, Komukai K, Morimoto S, Nagai M, Seki S, Taniguchi I, Mochizuki S, Yoshimura M.
    • Journal Title

      in renovascular hypertensive rats. Hypertens Res 32

      Pages: 604-610

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Infiltration of macrophages through the atrial endocardium in inflammation-induced rats: the contribution of fractalkine.2009

    • Author(s)
      Date T, Yamashita T, Iwasaki Y, Aizawa T, Aramaki Y, Komukai K, Taniguchi I, Yoshimura M.
    • Journal Title

      Circ J 73

      Pages: 932-937

    • NAID

      10025930542

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Infiltration of macrophages through the atrial endocardium in inflammation-induced rats : the contribution of fractalkine.2009

    • Author(s)
      Date T, et al
    • Journal Title

      Circulation Journal 73

      Pages: 932-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats.2009

    • Author(s)
      Kawai M, et al
    • Journal Title

      Hypertension Research 32

      Pages: 604-10

    • NAID

      10025164290

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increases Ca(2+) leak in mouse heart.2009

    • Author(s)
      Morimoto S, et al
    • Journal Title

      Biochemical and Biophysical Research Communications 390

      Pages: 87-92

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ACE阻害薬・ARB・抗アルドステロン薬の共通点と相違点2009

    • Author(s)
      小武海公明, 他
    • Journal Title

      診断と治療 97

      Pages: 694-700

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ACE阻害薬2009

    • Author(s)
      小武海公明, 他
    • Journal Title

      循環器科 66

      Pages: 24-31

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 神経体液因子からわかること2009

    • Author(s)
      川井真, 他
    • Journal Title

      Medicina 46

      Pages: 1238-41

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 薬物療法・ACE阻害薬2009

    • Author(s)
      小武海公明, 他
    • Journal Title

      Medicina 46

      Pages: 1284-6

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 選択的抗アルドステロン薬2009

    • Author(s)
      小武海公明, 他
    • Journal Title

      日本臨床 67(増刊7)

      Pages: 359-62

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats2009

    • Author(s)
      Kawai M, Hongo K, Komukai K, Morimoto S, Nagai M, Seki S, Taniguchi I Mochizuki S. Yoshimura M.
    • Journal Title

      Hypertension Res 32

      Pages: 604-10

    • NAID

      10025164290

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Infiltration of macrophages through the atrial endocardium in inflammation-induced rats : the contribution of fractalkine2009

    • Author(s)
      Date T, Yamashita T, Iwasaki Y, Aizawa T, Aramaki Y, Komukai K, Taniguchi I, Yoshimura M.
    • Journal Title

      Circ J 75

      Pages: 923-7

    • NAID

      10025930542

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] High incidence of anginal re-attacks despite the treatment of Ca-channel blockers in patients with coronary spastic angina2009

    • Author(s)
      Ogawa, et al
    • Journal Title

      Circulation Journal 73

      Pages: 512-515

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of {alpha}1-Adrenoceptor Subtypes With Different G Proteins Induces Opposite Effects on Cardiac L-type Ca(2+) Channel.2008

    • Author(s)
      O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S.
    • Journal Title

      Circ Res 102

      Pages: 1378-1388

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of the renin-angiotensin system prevents re-hospitalization in heart failure patients with preserved ejection fraction2008

    • Author(s)
      Komukai K, Yagi H, Ogawa T, Date T, Morimoto S, Kawai M, Hongo K, Taniguchi I, Yoshimura M.
    • Journal Title

      Circ J 72

      Pages: 2004-8

    • NAID

      110006987355

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca^<2+> channel2008

    • Author(s)
      O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S.
    • Journal Title

      Circ Res 102

      Pages: 1378-88

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Decreased renal function as an independent predictor of re-hospitalization for congestive heart failure2008

    • Author(s)
      Komukai, et al
    • Journal Title

      Circulation Journal 72

      Pages: 1152-1157

    • NAID

      110006792071

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of the renin-angiotensin system prevents r-hospitalization in heart failure patients with peserved ejection fraction2008

    • Author(s)
      Komukai, et al
    • Journal Title

      Circulation Journal 72

      Pages: 2004-2008

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心不全とアルドステロン2008

    • Author(s)
      小武海ら
    • Journal Title

      最新医学 63

      Pages: 854-857

    • NAID

      40015976195

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Renal insufficiency is related to painless myocardial infarction2007

    • Author(s)
      Komukai, et. al.
    • Journal Title

      Circulation Journal 71

      Pages: 1366-1369

    • NAID

      110006399679

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 交感神経受容体(カテコールアミン受容体)からのシグナル伝達の変化2007

    • Author(s)
      川井, ら
    • Journal Title

      日本臨床 65(Suppl4)

      Pages: 262-266

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Use of the Ca-shortening curve to estimate the myofilament responsiveness to Ca2+ in tetanized rat ventricular myocytes.2006

    • Author(s)
      Kusakari Y, Hongo K, Kawai M, Konishi M, Kurihara S.
    • Journal Title

      J Physiol Sci 56

      Pages: 219-226

    • NAID

      10020331576

    • Related Report
      2009 Final Research Report
  • [Journal Article] Intracellular mechanism of the negative inotropic effect induced by alpha1-adrenoceptor stimulation in mouse myocardium.2006

    • Author(s)
      Hirano S, Kusakari Y, O-Uchi J, Morimoto S, Kawai M, Hongo K, Kurihara S.
    • Journal Title

      J Physiol Sci 56

      Pages: 297-304

    • NAID

      130004466859

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated plasma brain natriuretic peptide level in cardiac sarcoidosis patients with preserved ejection fraction.2006

    • Author(s)
      Date et al.
    • Journal Title

      Heart 107・4

      Pages: 277-80

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Intracellular mechanism of the negative inotropic effect induced by alphal-adrenoceptor stimulation in a mouse myocardium.2006

    • Author(s)
      Hirano et al.
    • Journal Title

      J Physiol Sci 56・4

      Pages: 297-304

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Use of the Ca-shortening curve to estimate the myofilament responsiveness to Ca in tetanized rat ventricular myocytes.2006

    • Author(s)
      Kusakari et al.
    • Journal Title

      J Physiol Sci 56・3

      Pages: 219-26

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of spironolactone during an angiotensin II receptor blocker treatment on the left ventricular mass reduction in hypertensive patients with concentric left ventricular hypertrophy.2006

    • Author(s)
      Taniguchi et al.
    • Journal Title

      Circ J 70・8

      Pages: 995-1000

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 大動脈解離と酸素化障害(総説)2006

    • Author(s)
      小武海 公明 ら
    • Journal Title

      呼吸と循環 54・7

      Pages: 739-43

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ACE阻害薬による糖尿病発症予防効果(総説)2006

    • Author(s)
      川井 真 ら
    • Journal Title

      呼吸と循環 54・4

      Pages: 355-63

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of Ca2+/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca2+ current durinendothelin-1 stimulation.

    • Author(s)
      Komukai K, O-Uchi J, Morimoto S, KaM, Hongo K, Yoshimura M, Kurihara S.
    • Journal Title

      Am Physiol Heart Circ Physiol 2010 press

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Factors modulating the effect of endothelin-1 on L-type Ca current.2010

    • Author(s)
      Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S.
    • Organizer
      第73回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Factors modulating the effect of endothelin-1 on L-type Ca current2010

    • Author(s)
      Komukai K, et al
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Endothelin-1 increases L-type Ca current of rat ventricular myocytesvia an activation of protein kinase C and Ca/calmodulin dependent protein kinase II2009

    • Author(s)
      Komukai K, et al
    • Organizer
      American Heart Association Scientific Session 2009
    • Place of Presentation
      Orlando, Florica
    • Year and Date
      2009-11-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Renin-angiotensin system plays an important role in the pathogenesis of DCM in mice2009

    • Author(s)
      Hongo K, et al
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Endothelin-1 potentiates L-type Ca current by activating CaMKII in rat ventricular myocytes.2009

    • Author(s)
      Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S.
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences.
    • Year and Date
      2009-07-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Endothelin-1 potentiates L-type Ca current by activating CaMKII in rat Ventricular myocytes2009

    • Author(s)
      Komukai K, et al
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Beta-adrenoceptor stimulation increased Ca leak from sarcoplasmic Reticulum without dissociation of FKBP12.6 under physiological condition2009

    • Author(s)
      Morimoto S, et al
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Angiotensin II type l receptor blockade rescued the mouse model of dilated cardiomyopathy from sudden cardiac death.2009

    • Author(s)
      Hongo, et al
    • Organizer
      第73回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cardiac alphala-adrenoceptor stimulation inhibits L-type Ca2+ current in the presence of beta-adrenoceptor stimulation through tyrosine kinase.2009

    • Author(s)
      0-Uchi, et al
    • Organizer
      Biophysical Society 53rd Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, USA
    • Year and Date
      2009-03-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Endothelin-1 increases L-type Ca current of rat ventricular myocytes via an activation of protein kinase C and Ca/calmodulin dependt protein kinase II.2009

    • Author(s)
      Komukai K, O-Uchi J, Hongo K, Kawai M, Morimoto S, Yoshimura M, Kurihara S.
    • Organizer
      American Heart Association Scientific Session 2009
    • Place of Presentation
      Orlando, Florida
    • Related Report
      2009 Final Research Report
  • [Presentation] Ca2+ leak from sarcoplasmic reticulum is increased by beta-adrenergic stimulation.2008

    • Author(s)
      Morimoto, et al
    • Organizer
      第25回国際心臓研究会日本部会
    • Place of Presentation
      横浜
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Decreased Ca2+ affinity of thin filament is a important factor for the development of cardiac dysfunction in mouse model of dilated cardiomyopathy.2008

    • Author(s)
      O-Uchi, et al
    • Organizer
      Thick and Thin Filament Regulation in Striated Muscle.
    • Place of Presentation
      Wisconsin, MadisonUSA
    • Year and Date
      2008-05-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Endothelin-1 increases L-type Ca current via an activation of Ca/calmodulin dependent protein kinase II in rat ventricular myocytes2008

    • Author(s)
      Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Endothelin-1 increases L-type Ca current via an activation of Ca/calmodulin protein kinase II in rat ventricular myocytes2008

    • Author(s)
      Komukai, et. al.
    • Organizer
      第72回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Decreased Ca2+ sensitivity of the myofilament is critical for the development of cardiac dysfunction in mouse model of dilated cardiomyopathy2008

    • Author(s)
      Hongo, et. al.
    • Organizer
      第72回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Beta-adrenoceptor stimulation accelerates Ca2+ turnover through PKA-dependent phosphorylation in saponin-treated mouse myocardium2008

    • Author(s)
      Morimoto, et. al.
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cardiac alphal-adrenoceptor stimulation inhibits L-type Ca2+ current in the presence of beta-adrenoceptor stimulation2008

    • Author(s)
      O-Uchi, et. al.
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Inhibitory effect of alphal-adrenoceptor stimulation on cardiac L-type Ca current in the presence of beta-adrenoceptor agonist in rat ventricular myocytes2008

    • Author(s)
      O-Uchi, et. al.
    • Organizer
      52nd Biophysical Society Annual Meeting
    • Place of Presentation
      Long Beech,US
    • Year and Date
      2008-02-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Endothelin-1 increases L-type Ca current via an activation of Ca/calmodulin- dependent protein kinase II in rat ventricular myocytes2008

    • Author(s)
      Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S.
    • Organizer
      第72回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of endothelin-I on L-type Ca current in rat ventricular myocytes2007

    • Author(s)
      Komukai, et. al.
    • Organizer
      第11回日本心不全学会学術集会
    • Place of Presentation
      浦安
    • Year and Date
      2007-09-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ca2+ content and Ca2+ leakage at a steady state are not influnenced by genetic modulation of Ca2+ uotake rate of SR2007

    • Author(s)
      Morimoto, et. al.
    • Organizer
      第11回日本心不全学会学術集会
    • Place of Presentation
      浦安
    • Year and Date
      2007-09-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Altered Ca2+ handling could contribute to the cardiac sudden deathin Knock-in mouse of dilated cardiomyopathy2007

    • Author(s)
      Hongo, et. al.
    • Organizer
      第30回心筋代謝研究会
    • Place of Presentation
      京都
    • Year and Date
      2007-07-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Modulation of Ca2+ uptake rate in SR does not affect Ca2+ content and Ca leakage in saponin-treated mouse myocardium2007

    • Author(s)
      Morimoto, et. al.
    • Organizer
      XIX World Congress of ISHR
    • Place of Presentation
      Bologna,Italy
    • Year and Date
      2007-06-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Changes in Ca2+ transient and contraction of left ventricular papillary muscles in mouse model of dilated cardiomyopathy2007

    • Author(s)
      Hongo, et. al.
    • Organizer
      The 24th Annual Meeting of ISHR Japanese Section
    • Place of Presentation
      Ferrara,Italy
    • Year and Date
      2007-06-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] The novel angiotensin receptor blocker,telmisartan prevents myocardial hypertrophy and fibrosis in renovascular hypertensive(Goldblatt)rat2007

    • Author(s)
      Kawai, et. al.
    • Organizer
      The 24th Annual Meeting of ISHR Japanese Section
    • Place of Presentation
      Ferrara,Italy
    • Year and Date
      2007-06-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of endothelin-1 on L-type Ca current in rat ventricular myocytes.2007

    • Author(s)
      Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Kurihara S.
    • Organizer
      第11回日本心不全学会学術集会
    • Place of Presentation
      浦安
    • Related Report
      2009 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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