Real-time imaging of inflammatory reactions and their related metabolic factors in vivo
| Project/Area Number |
18590805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YOSHIDA Masayuki Tokyo Medical and Dental University, Bioethics Research Center, Professor (80282771)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,740,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | vascular endothelial cells / cell adhesion molecules / metabolic syndrome / メタポリックシンドローム |
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| Research Abstract |
In this project, we established a novel intravital microscopic system to analyze leukocyte recruitment to the injured mouse femoral artery in vivo. We found that oxidative stress in leukocytes plays a major role in the development of the inflammation. Further, our observation points an important role for renin-angiotensin system in this process. As for the contribution of metabolic syndrome to atherosclerosis, we reported that inhibition of intestinal lipid absorption reduced hepatic steatosis and subsequent insulin resistance. Our results greatly enhance the knowledge of atherosclerosis and metabolic syndrome with various future clinical applications.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Functional impact of IgA nephropathy-associated selectin gene haplotype on leukocyte-endothelial interaction.2006
Author(s)
T. Takei, M. Hiraoka, K. Nitta, K. Uchida, M. Deushi, T, Yu, N. Nitta, K. Tsuchiya, W. Yumura, H. Nihei, Y. Nakamura, M. Yoshida
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Journal Title
Immunogenetics 58
Pages: 355-61
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Journal Article] Functional impact of IgA nephropathy-associated selectin gene haplotype on leukocyte-endothelial interaction.2006
Author(s)
T. Takei, M. Hiraoka, K. Nitta, K. Uchida, M. Deushi, T. Yu, N. Nitta, K. Tsuchiya, W. Yumura, H. Nihei, Y. Nakamura, M. Yoshida
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Journal Title
Immunogenetics 58
Pages: 355-61
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Functional impact of lgA nephropathy-associated selectin gene haplotype on leukocyte-endothelial interaction2006
Author(s)
T.Takei, M.Hiraoka, K.Nitta, K.Uchida, M.Deushi, T.Yu, N.Nitta, K.Tsuchida, W.Yumura, H.Nihei, Y.Nakamura, M.Yoshida
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Journal Title
Immunogentics 58
Pages: 355-361
Related Report
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