Advanced medical technology on cardiovascular disease- Elucidation of the molecular mechanism and the application on various pathological conditions for the establishment of HDL therapy

• Project/Area Number: 18590826
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukuoka University
• Principal Investigator: SAKU Keijiro Fukuoka University, 医学部, 教授 (40183371)
• Co-Investigator(Kenkyū-buntansha): OTA Takao 琉球大学, 医学部, 教授 (70185271) ; IWAMOTO Takahiro 福岡大学, 医学部, 教授 (20300973) ; MIURA Shinichiro 福岡大学, 医学部, 准教授 (20343709) ; 岩田 敦 福岡大学, 医学部, 助手 (00412586)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,000,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 合成HDL / コレステロール引き抜き能 / 血流改善作用 / 抗不整脈作用 / 心リモデリング抑制 / ペプチド型HDL / 遺伝性高脂血症ウサギ / コレステロール引き抜き作用 / プラーク / 不整脈 / 心リモデリング / nitric oxide / 再生医療 / シグナル伝達 / 脂質

Research Abstract

合成(r)HDLは、強力なコレステロール引き抜き能を有し、 native HDLの作用を増強することが示唆された。また、rHDLの抗動脈硬化作用以外の多面的効果では、マウス下肢虚血モデルにおける血流改善作用、ラット心筋虚血再潅流不整脈モデルおける抗不整脈作用、ラット心筋梗塞モデルにおける心リモデリング抑制作用が認められた。rHDLは、その主作用のみならず多面的効果により、今後、心血管疾患の新たな治療手段として期待される。

Research Products

• [Journal Article] Reconstituted high-density lipoprotein attenuates postinfarction left ventricular remodeling in rats (2009)
  • Author(s): Kiya Y, Miura S, Imaizumi S, UeharaY, Matsuo Y, Abe S, Jimi S, Urata H, Rye KA, Saku K.
  • Journal Title: Atherosclerosis 203 Pages: 137-144
  • Peer Reviewed
• [Journal Article] Reconstituted high-density lipoprotein attenuates postinfarction left ventricular remodeling in rats. (2009)
  • Author(s): Kiya Y, Miura S, Imaizumi S, Uehara Y, Matsuo Y, Abe S, Jimi S, Urata H, Rye KA, Saku K.
  • Journal Title: Atherosclerosis 203 Pages: 137-144
  • Peer Reviewed
• [Journal Article] Anti-arrhythmogenic effect of reconstituted high-density lipoprotein against ischemia/reperfusion in rats (2008)
  • Author(s): Imaizumi S, Miura S, Nakamura K, Kiya Y, Uehara Y, Zhang B, Matsuo Y, Urata H, Ideishi M, Rye KA, Sata M, Saku K.
  • Journal Title: J Am Coll Cardiol. 51 Pages: 1604-1612
  • Peer Reviewed
• [Journal Article] POPC/apoA-I discs as a potent lipoprotein modulator in Tangier disease (2008)
  • Author(s): Uehara Y, Tsuboi Y, Zhang B, Miura S, Baba Y, Higuchi MA, Yamada T, Rye KA, Saku K.
  • Journal Title: Atherosclerosis 197 Pages: 283-289
  • Peer Reviewed
• [Journal Article] Anti-arrhythmogenic effect of reconstituted high-density lipoprotein against ischemia/reperfusion in rats. (2008)
  • Author(s): Imaizumi S, Miura S, Nakamura K, Kiya Y, Uehara Y, Zhang B, Matsuo Y, Urata H, Ideishi M, Rye KA, Sata M, Saku K.
  • Journal Title: J Am Coll Cardiol 51 Pages: 1604-1612
  • Peer Reviewed
• [Journal Article] Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formation (2007)
  • Author(s): Matsuo Y, Miura S, Kawamura A, Uehara Y, Rye KA, Saku K.
  • Journal Title: Atherosclerosis 194 Pages: 159-168
  • Peer Reviewed
• [Journal Article] High-density lipoprotein stimulates differentiation of endothelial progenitor cells and enhances ischemia-induced angiogenesis (2007)
  • Author(s): Sumi M, Sata M, Miura S, Rye KA, Toya N, Kanaoka Y, YanagaK, Ohki T, Saku K, Nagai R.
  • Journal Title: Arteriosder Thromb Vasc Biol. 27 Pages: 813-818
  • Peer Reviewed
• [Journal Article] Effects of apoA-I/phosphatidylcholine discs on charge-based LDL sub fractions as characterized by capillary isotachophoresis (2007)
  • Author(s): Zhang B, Uehara Y Hida S, Miura S, Rainwater DL, Segawa M, Kumagai K, Rye KA, Saku K.
  • Journal Title: J Lipid Res. 48 Pages: 1175-1189
  • Peer Reviewed
• [Journal Article] Effects of apoA-I/phosphatidylcholine discs on charge-based LDL subfractions as characterized by capillary isotachophoresis (2007)
  • Author(s): Zhang B, Uehara Y Hida S, Miura S, Rainwater DL, Segawa M, Kumagai K, Rye KA, Saku K.
  • Journal Title: Lipid Res 48 Pages: 1175-1189
  • Peer Reviewed
• [Journal Article] Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formation (2007)
  • Author(s): Matsuo Y, Miura S, Kawamura A, Uehara Y, Rye KA, Saku K
  • Journal Title: Atherosclerosis 194 Pages: 159-168
  • Peer Reviewed
• [Journal Article] 動脈硬化性心血管疾患に対する合成HDL治療 (2007)
  • Author(s): 三浦 伸一郎、朔啓 二郎
  • Journal Title: 脈管学 47 Pages: 313-318
  • NAID: 10019739309
• [Journal Article] Reconstituted high-density lipoprotein stimulates differentiation of endothelial progenitor cells and enhances ischemia-induced angiogenesis. (2007)
  • Author(s): Sumi M, Sata M, Miura S, Rye KA, Toya N, Kanaoka Y, Yanaga K, Ohki T, Saku K, Nagai R
  • Journal Title: Arterioscler Thromb Vasc Biol 27 Pages: 813-818
• [Journal Article] ApoA-I/Phosphatidylchol ine discs remodel fast-migrating HDL into slow-migrating HDL as characterized by capillary isotachophoresis atherosclerosis (2006)
  • Author(s): Zhang B, Miura S, Fan P, Kumagai K, Takeuchi K, Uehara Y, Rye KA, Saku K.
  • Journal Title: Atherosclerosis 188 Pages: 95-101
  • Peer Reviewed
• [Journal Article] ApoA-I/phosphatidylcholine discs remodels fast-migrating HDL into slow-migrating HDL as characterized by capillary isotachophoresis. (2006)
  • Author(s): Zang B, miura S, Fan P, Kumagai K, Takeuchi K, Uehara Y, McMahon M, Rye KA, Saku K
  • Journal Title: Atherosclerosis 188 Pages: 95-101
• [Journal Article] Effects of atorvastatin and apoA-I/phosphatidylcholine discs on triglyceride-rich lipoprotein subfractions as characterized by capillary (2006)
  • Author(s): Zhang B, Kanafuch R, Arishima H, Matsunaga A, Rye KA, Saku K
  • Journal Title: Clin Chim Acta 273 Pages: 55-61
• [Presentation] Intravenous ApoA-I mimetic peptide (ETO642) discs inhibit the progression of atherosclerosis in myocardial infarction-prone Waranabe-heritable hyperl ipidemic (WHHL-MI) rabbits (2009)
  • Author(s): Iwata A, Zhang B, Imaizumi S, Miura S, Saku K.
  • Organizer: The 73th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Osaka, Japan
• [Presentation] Intravenous ApoA-I mimetic peptide (ETC-642) discs inhibit the progression od atherosclerosis in myocardial infarction-prone Waranabe-heritable hyperlipidemic (WHHL-MI)rabbits. (2009)
  • Author(s): Iwata A, Zhang B, Imaizumi S, Miura S, Saku K.
  • Organizer: The 73^<th> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Osaka, Japan.
• [Presentation] 合成HDLはラットにおける心筋梗塞後左室リモデリングを抑制する (2008)
  • Author(s): 木谷嘉博、三浦伸一郎、朔啓二郎
  • Organizer: 第12回日本心血管内分泌代謝学会
  • Place of Presentation: 熊本
• [Presentation] Low HDL-C: Role of lipid transporter and apoA-I mimetic peptide (2008)
  • Author(s): Uehara Y, Iwata A, Zhang B, Miura S, Saku K.
  • Organizer: シンポジウム、第40回日本動脈硬化学会総会
  • Place of Presentation: 大阪
• [Presentation] RECONSTITUTED HDL THERAPY FOR CARDIOVASCULAR DISEASE (2008)
  • Author(s): Miura S, Imaizumi S, KiyaY, Sata M, Rye KA, Saku K, Uehara Y.
  • Organizer: he 77th Congres s of the European Atherosclerosis Society
  • Place of Presentation: Istanbul, Turkey
• [Book] 最新狭心性診療の実際(分担)、28.脂質異常症を合併する狭心症患者の治療 (2009)
  • Author(s): 杉原充、三浦伸一郎、朔啓二郎
  • Publisher: 文光堂
• [Book] 急性冠症候群のエキスパートをめざして(分担)、4章:急性冠症候群の再発をいかに防ぐか。F.スタチン製剤の重要性 (2009)
  • Author(s): 三浦伸一郎、朔啓二郎
  • Publisher: 中山書店(印刷中)