Mechanism of developing severe Legionella pneumonia

• Project/Area Number: 18590832
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: KIKUCHI Toshiaki Tohoku University, 病院, 講師 (10280926)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,100,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 重症肺炎 / レジオネラ肺炎 / 無作為遺伝子変異法

Research Abstract

レジオネラ菌(Legionella pneumophila)は重症肺炎の起炎菌として、しばしば臨床的問題となっている。当該研究ではレジオネラ菌の無作為遺伝子変異株を作製し、その原因遺伝子の探索を行った。その結果、レジオネラ菌ゲノム上に計7個の責任遺伝子が同定された。これらはレジオネラ菌において分泌機構に関わっていることが知られている遺伝子だったため、なんらかの分泌因子がレジオネラ菌より分泌され、これによってレジオネラ肺炎が重症化するものと考えられた。

Research Products

• [Journal Article] Combined efficacy of clarithromycin plus cefazolin or vancomycin against Staphylococcus aureus biofilms formed on titanium medical devices (2008)
  • Author(s): Fujimura S, Sato T, Mikami T, Kikuchi T, Gomi K, Watanabe A
  • Journal Title: Int J Antimicrob Agents 32 Pages: 481-484
  • Peer Reviewed
• [Journal Article] Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells (2008)
  • Author(s): Chen S, Ndhlovu LC, Takahashi T, Takeda K, Ikarashi Y, Kikuchi T, Murata K, Pandolfi PP, Riccardi C, Ono M, Sugamura K, Ishii N
  • Journal Title: Eur J Immunol 38 Pages: 2229-2240
  • Peer Reviewed
• [Journal Article] Suppression of surfactant protein A by an epidermal growth factor receptor tyrosine kinase inhibitor exacerbates lung (2008)
  • Author(s): Inoue A, Xin H, Suzuki T, Kanehira M, Kuroki Y, Fukuhara T, Kikuchi T, Maemondo M, Nukiwa T, Saijo Y
  • Journal Title: inflammation. Cancer Sci 99 Pages: 1679-1684
  • Peer Reviewed
• [Journal Article] Secretory leukocyte peptidase inhibitor and lung cancer (2008)
  • Author(s): Nukiwa T, Suzuki T, Fukuhara T, Kikuchi T
  • Journal Title: Cancer Sci 99 Pages: 849-855
  • NAID: 10024005504
  • Peer Reviewed
• [Journal Article] In vitro susceptibility of clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) to manufactured generic drugs compared with the brand (2008)
  • Author(s): Fujimura S, Watanabe A, Fuse K, Kikuchi T, Gomi K, Tokue Y
  • Journal Title: vancomycin. Int J Antimicrob Agents 31 Pages: 391-392
  • Peer Reviewed
• [Journal Article] Suppression of surfactant protein A by an epidermal growth factor receptor tyrosine kinase inhibitor exacerbates lung inflammation (2008)
  • Author(s): Inoue A, et.al.
  • Journal Title: Cancer Sci 99 Pages: 1679-1684
  • Peer Reviewed
• [Journal Article] Secretory leukocyte peptidase inhibitor and lung cancer (2008)
  • Author(s): Nukiwa T, et.al.
  • Journal Title: Cancer Sci 99 Pages: 849-855
  • Peer Reviewed
• [Journal Article] Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-denendent natural killer T cells (2008)
  • Author(s): Chen S, et.al.
  • Journal Title: Eur J Immunol 38 Pages: 2229-2240
  • Peer Reviewed
• [Journal Article] Evaluation of dosing designs of carbapenems for severe respiratory infection using Monte Carlo simulation (2007)
  • Author(s): Watanabe A, Fujimura S, Kikuchi T, Gomi K, Fuse K, Nukiwa T
  • Journal Title: J Infect Chemother 13 Pages: 332-340
  • NAID: 10019774239
  • Peer Reviewed
• [Journal Article] OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice (2007)
  • Author(s): Zaini J, Andarini S, Tahara M, Saijo Y, Ishii N, Kawakami K, Taniguchi M, Sugamura K, Nukiwa T, Kikuchi T
  • Journal Title: J Clin Invest 117 Pages: 3330-3338
  • Peer Reviewed
• [Journal Article] Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells (2007)
  • Author(s): Xin H, Kanehira M, Mizuguchi H, Hayakawa T, Kikuchi T, Nukiwa T, Saijo Y
  • Journal Title: Stem Cells 25 Pages: 1618-1626
  • Peer Reviewed
• [Journal Article] Antibacterial activity of carbapenems against clinically isolated respiratory bacterial pathogens in Japan between 2005 and 2006 (2007)
  • Author(s): Gomi K, Watanabe A, Aoki S, Kikuchi T, Fuse K, Nukiwa T, Kurokawa I, Fujimura S
  • Journal Title: Int J Antimicrob Agents 29 Pages: 586-592
  • Peer Reviewed
• [Journal Article] Lipid-mediated transbronchial human interleukin-10 gene transfer decreases acute inflammation associated with allograft rejection in a rat model of lung transplantation (2007)
  • Author(s): Oishi H, Okada Y, Kikuchi T, Sado T, Oyaizu T, Hoshikawa Y, Suzuki S, Matsumura Y, Kondo T
  • Journal Title: Transplant Proc 39 Pages: 283-285
  • Peer Reviewed
• [Journal Article] OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. (2007)
  • Author(s): Zaini J, et. al.
  • Journal Title: J Clin lnvest 117 Pages: 3330-8
  • Peer Reviewed
• [Journal Article] Evaluation of dosing designs of carbapenems for severe respiratory infection using Monte Carlo simulation. (2007)
  • Author(s): Watanabe A, et. al.
  • Journal Title: J Infect Chemother 13 Pages: 332-40
  • Peer Reviewed
• [Journal Article] Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymalstem cells. (2007)
  • Author(s): Xin H, et. al.
  • Journal Title: Stem Cells 25 Pages: 1618-26
  • Peer Reviewed
• [Journal Article] Antibacterial activity of carbapenems against clinically isolated respiratory bacterial pathogens in Japan between 2005 and 2006. (2007)
  • Author(s): Gomi K, et al.
  • Journal Title: Int J Antimicrob Agents. (印刷中)
• [Journal Article] Targeted-delivery of CX3CL1 to Multiple Lung Tumors by Mesenchymal Stem Cells. (2007)
  • Author(s): Xin H, et al.
  • Journal Title: Stem Cells. (印刷中)
• [Journal Article] Mouse and human cell activation by N-dodecanoyl-DL-homoserine lactone, a Chromobacterium violaceum autoinducer (2006)
  • Author(s): Gomi K, Kikuchi T, Tokue Y, Fujimura S, Uehara A, Takada H, Watanabe A, Nukiwa T
  • Journal Title: Infect Immun 74 Pages: 7029-7031
  • Peer Reviewed
• [Journal Article] Acute-onset sarcoidosis with erythema nodosum and polyarthralgia (Lofgren's syndrome) (2006)
  • Author(s): Ohta H, Tazawa R, Nakamura A, Kimura Y, Maemondo M, Kikuchi T, Ebina M, Nukiwa T
  • Journal Title: in Japan : a case report and a review of the literature. Intern Med 45 Pages: 659-662
  • Peer Reviewed
• [Journal Article] Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors (2006)
  • Author(s): Nukiwa M, Andarini S, Zaini J, Xin H, Kanehira M, Suzuki T, Fukuhara T, Mizuguchi H, Hayakawa T, Saijo Y, Nukiwa T, Kikuchi T
  • Journal Title: Eur J Immunol 36 Pages: 1019-1027
  • Peer Reviewed
• [Journal Article] Genetically modified dendritic cells for therapeutic immunity (2006)
  • Author(s): Kikuchi T
  • Journal Title: Tohoku J Exp Med 208 Pages: 1-8
  • NAID: 10017087851
  • Peer Reviewed
• [Journal Article] A case of pulmonary Langerhans cell histiocytosis discovered by CT mass screening and followed by bronchoalveolar lavage][Article in Japanese (2006)
  • Author(s): Watanabe H, Maemondo M, Okouchi S, Suzuki T, Kikuchi T, Tazawa R, Ebina M, Saijo Y, Hoshikawa Y, Nukiwa T
  • Journal Title: Nihon Kokyuki Gakkai Zasshi 44 Pages: 869-873
  • Peer Reviewed
• [Journal Article] Genetically modified dendritic cels for therapeutic immunity. (2006)
  • Author(s): Kikuchi T.
  • Journal Title: Tohoku J Exp Med. 208・1 Pages: 1-8
• [Journal Article] Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors. (2006)
  • Author(s): Nukiwa M, et al.
  • Journal Title: Eur J Immunol. 36・4 Pages: 1019-27
• [Journal Article] Mouse and human cell activation by N-dodecanoyl-DL-homoserine lactone, a Chromobacterium violaceum autoinducer. (2006)
  • Author(s): Gomi k, et al.
  • Journal Title: Infect Immun. 74・12 Pages: 7029-31
• [Journal Article] Acute-onset sarcoidosis with erythema nodosum ad polyarthralgia (Lofgren's syndrome) in Japan : a case report and a review of the literature. (2006)
  • Author(s): Ohta H, et al.
  • Journal Title: Intern Med. 45・9 Pages: 659-62
• [Presentation] Combined efficacy of clarithromycin plus vancomycin in mice with device-related infection by biofilms-forming S. aureus. International Symposium on (2008)
  • Author(s): Fujimura S, Sato T, Kikuchi T, Zaini J, Watanabe A
  • Organizer: Staphylococci and Staphylococcal Infections
  • Place of Presentation: ケインズ、オ-ストラリア
  • Year and Date: 2008-09-07
• [Presentation] Pseudomonas aeruginosaの産生色素と薬剤耐性に関する検討 (2008)
  • Author(s): 布施克浩、藤村茂、五味和紀、菊地利明、渡辺彰
  • Organizer: 第56回日本化学療法学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-06
• [Presentation] 2007年分離の呼吸器病原細菌に対するカルバペネム系5薬剤の抗菌力 (2008)
  • Author(s): 五味和紀、藤村茂、菊地利明、布施克浩、黒川いく、渡辺彰
  • Organizer: 第56回日本化学療法学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-06
• [Presentation] 抗緑膿菌性注射用抗菌薬における先発品の薬剤感受性比較 (2008)
  • Author(s): 藤村茂、布施克浩、五味和紀、菊地利明、渡辺彰
  • Organizer: 第56回日本化学療法学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-06
• [Presentation] 抗緑膿菌性注射用抗菌薬における先発品とジェネリック品の薬剤感受性比較 (2008)
  • Author(s): 藤村茂、布施克浩、五味和紀、菊地利明、渡辺彰
  • Organizer: 第56回日本化学療法学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-06
• [Presentation] Induction of antitumor immunity by intratumoral administration of genetically modified dendritic cells (DCs) to overexpress OX40 Ligand (2008)
  • Author(s): Andarini S, Zaini J, Kikuchi T, Tahara M, Saijo Y, Ishi N, Sugamura K, Nukiwa T
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: トロント、カナダ
  • Year and Date: 2008-05-16
• [Presentation] OX40L-OX40 Interactions Contribute to NKT Activation in a Mouse Model of Allergic Airway Disease (2008)
  • Author(s): Zaini J, Andarini S, Kikuchi T, Nukiwa T
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: トロント、カナダ
  • Year and Date: 2008-05-16
• [Presentation] OX4040L-OX40 interactions contribute to NKT activation in a mouse model of allergic airway disease (2008)
  • Author(s): Zaini J, et.al.
  • Organizer: 米国胸部学会
  • Place of Presentation: カナダトロント
  • Year and Date: 2008-05-16
• [Presentation] 2006~2007年度に東北地区で分離された緑膿菌の薬剤感受性疫学調査成績 (2008)
  • Author(s): 五味和紀、菊地利明、布施克浩、藤村茂、渡辺 彰
  • Organizer: 第82回日本感染症学会総会
  • Place of Presentation: 松江
  • Year and Date: 2008-04-18
• [Presentation] 上皮成長因子受容体(EGFR)遺伝子変異を認めた肺癌の一家系 (2008)
  • Author(s): 榊原智博、井上彰、福原達朗、五味和紀、菊地利明、石本修、菅原俊一、西條康夫、貫和敏博
  • Organizer: 第105回日本内科学会総会講演会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-11
• [Presentation] VNTR型別によるM.avium菌の系統樹解析で、同一系統株と考えられたM. aviumによる過敏性肺臓炎の2例 (2008)
  • Author(s): 榊原智博、菊地利明、井上彰、五味和紀、渡辺彰、貫和敏博
  • Organizer: 日本呼吸器学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2008-03-01
• [Presentation] 上皮成長因子受容体(EGFR)遺伝子変異を認めた肺癌の一家系 (2007)
  • Author(s): 榊原智博、井上彰、福原達朗、五味和紀、菊地利明、石本修、西條康夫、貫和敏博
  • Organizer: 第48回日本肺癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-11-09
• [Presentation] The role of Secretory Leukoprotease Inhibitor (SLPI) in lung tumor formation (2007)
  • Author(s): Fukuhara T, Suzuki T, Sakakibara T, Tahara M, Inoue A, Kikuchi T, Saijo Y, Nukiwa T
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] 無加療で縮小した多発肺結節・多発骨腫瘤・脳腫瘤の一例 (2007)
  • Author(s): 久田修、福原達朗、菊地利明、井上彰、海老名雅仁、西條康夫、貫和敏博、渡辺みか、石田和之
  • Organizer: 東北胸部疾患ワークショップ
  • Place of Presentation: 仙台
  • Year and Date: 2007-09-08
• [Presentation] NKT Cell Activation through OX40. (2007)
  • Author(s): Kikuchi T
  • Organizer: シンガポール大学/東北大学合同シンポジウム
  • Place of Presentation: ビンタン(インドネシア)
  • Year and Date: 2007-09-06
• [Presentation] NKT cells activation through OX40 (2007)
  • Author(s): Kikuchi T
  • Organizer: OLS/NUS-Tohoku/ COE Joint Symposium
  • Place of Presentation: シンガポール
  • Year and Date: 2007-09-05
• [Presentation] Secretory Leukoprotease inhibitor(SLPI)and cancer development (2007)
  • Author(s): Hisata S, Fukuhara T, Suzuki T, Kikuchi T, Saijo Y
  • Organizer: OLS/NUS-Tohoku/ COE Joint Symposium
  • Place of Presentation: シンガポール
  • Year and Date: 2007-09-05
• [Presentation] 1年の経過で悪性胸膜中皮腫と確定診断した1症例 (2007)
  • Author(s): 佐藤輝幸、久田修、福原達朗、菊地利明、西條康夫、貫和敏博
  • Organizer: 第183回日本内科学会東北地方会
  • Place of Presentation: 青森
  • Year and Date: 2007-09-01
• [Presentation] 背部痛を主訴に胸水を指摘され悪性リンパ腫と診断された一例 (2007)
  • Author(s): 榊原智博、菊地利明、西條康夫、貫和敏博、佐渡哲、星川康、近藤丘、佐藤秀隆
  • Organizer: 内科学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-16
• [Presentation] Mycobacterium avium complexが原因抗原と考えられた過敏性肺臓炎の一例 (2007)
  • Author(s): 榊原智博、菊地利明、田澤立之、貫和敏博
  • Organizer: 第289回しんぱい会
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-06
• [Presentation] In vitro耐性獲得実験によるP.aeruginosaの多剤耐性化の検討 (2007)
  • Author(s): 藤村茂、菊地利明、五味和紀、布施克浩、渡辺彰
  • Organizer: 第55回日本化学療法学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-01
• [Presentation] ディスク拡散法による薬剤感受性試験の迅速定量分析システムの開発(2)-迅速性評価- (2007)
  • Author(s): 山内崇弘、竹茂求、那須潜思、小川廣幸、渡辺彰、菊地利明
  • Organizer: 第55回日本化学療法学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-01
• [Presentation] 2005~2006年度に東北地区で分離された緑膿菌の薬剤感受性疫学調査成績 (2007)
  • Author(s): 五味和紀、渡辺彰、菊地利明、藤村茂、貫和敏博
  • Organizer: 第81回日本感染症学会総会
  • Place of Presentation: 京都
  • Year and Date: 2007-04-10
• [Presentation] 労作時呼吸困難を主訴に,胸部CTでスリガラス状陰影を認めた一例 (2007)
  • Author(s): 榊原智博、菊地利明、田澤立之、貫和敏博
  • Organizer: 第14回東北胸部疾患ワ-クショップ
  • Place of Presentation: 仙台
  • Year and Date: 2007-03-03
• [Presentation] Mycobacterium avium complexが原因抗原と考えられた過敏性肺臓炎の一例 (2007)
  • Author(s): 榊原智博、菊地利明、田澤立之、貫和敏博
  • Organizer: 第181回日本内科学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2007-02-17
• [Presentation] Role of SLPI expression on tumor growth (2007)
  • Author(s): Zaini J, Kikuchi T, Saijo Y, Nukiwa T
  • Organizer: 第127回東北大学加齢医学研究所集談会
  • Place of Presentation: 仙台
  • Year and Date: 2007-01-26
• [Presentation] Involvement of Fractalkine/CX3CL1 expression by dendritic cells in host immunity against Legionella pneumophila (2006)
  • Author(s): Kikuchi T, Nukiwa T
  • Organizer: 11th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: 京都
  • Year and Date: 2006-11-19
• [Presentation] 遺伝子改変樹状細胞を用いた感染免疫応答の誘導 (2006)
  • Author(s): 菊地利明
  • Organizer: 沖縄感染免疫シンポジウム
  • Place of Presentation: 沖縄
  • Year and Date: 2006-11-10
• [Presentation] Antitumor immunity induced by intratumoral administration dendritic cells expressing OX40 ligand (2006)
  • Author(s): Zaini J, Kikuchi T, Andarini S, Nukiwa T
  • Organizer: The 21st century COE program The 3rd international symposium on novel perspectives in cancer research and translation to the clinic
  • Place of Presentation: 仙台
  • Year and Date: 2006-11-09
• [Presentation] 2005年度に東北地方で分離された緑膿菌の薬剤感受性疫学調査成績 (2006)
  • Author(s): 五味和紀、渡辺彰、菊地利明、藤村茂、布施克浩、貫和敏博
  • Organizer: 第55回日本感染症学会東日本地方会総会・第53回日本化学療法学会東日本支部総会・合同学会
  • Place of Presentation: 東京
  • Year and Date: 2006-10-26
• [Presentation] 2005~2006年分離の呼吸器病原細菌に対するカルバペネム4薬剤(MEPM, IPM, PAPM, BIPM)の抗菌力 (2006)
  • Author(s): 五味和紀、渡辺彰、菊地利明、藤村茂、布施克浩、黒川いく、貫和敏博
  • Organizer: 第55回日本感染症学会東日本地方会総会・第53回日本化学療法学会東日本支部総会・合同学会
  • Place of Presentation: 東京
  • Year and Date: 2006-10-26
• [Presentation] 樹状細胞の抗腫瘍免疫誘導におけるOX40リガンドの働き (2006)
  • Author(s): ザイニジャマル、菊地利明、貫和敏博
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2006-09-28
• [Presentation] 肺癌細胞と蛋白分解酵素阻害物質Secretory Leukoprotease inhibitor(SLPI) (2006)
  • Author(s): 福原達朗、鈴木拓児、榊原智博、田原稔、菊地利明、西條康夫、貫和敏博
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2006-09-28
• [Presentation] fibrotic NSIPの急性増悪にて急速に呼吸不全が進行し死亡した1例 (2006)
  • Author(s): 佐々木ときわ、木村雄一郎、佐藤大希、菊地利明、海老名雅仁、貫和敏博
  • Organizer: 第83回日本呼吸器学会東北地方会・第113回日本結核病学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2006-09-16
• [Presentation] 両側末梢優位の陰影を呈し診断に苦渋した肺胞蛋白症の1例 (2006)
  • Author(s): 佐藤大希、田澤立之、木村雄一郎、菊地利明、海老名雅仁、貫和敏博、三木誠
  • Organizer: 第179回日本内科学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2006-06-17
• [Presentation] 中枢性尿崩症発4年後にPulumonary Langerhans Cell Histocytosis (LCH)が発見された1例 (2006)
  • Author(s): 佐々木ときわ、五味和紀、菊地利明、貫和敏博、森建文、星史彦、野田雅史、渡辺みか、遠藤希之
  • Organizer: 第179回日本内科学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2006-06-17
• [Presentation] Antitumor immunity induced by intratumoral administration of dendritic cells transduced with adenovirus vector expressing OX40 ligand (2006)
  • Author(s): Zaini J, Andarini S, Kikuchi T, Nukiwa T
  • Organizer: 第46回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2006-06-01
• [Presentation] 時間外受診・救急搬入を契機に発見された結核症例に関する臨床的検討 (2006)
  • Author(s): 高橋洋、佐藤忍、五味和紀、菊地利明、渡辺彰
  • Organizer: 第81回日本結核病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2006-04-27
• [Presentation] 肺ランゲルハンス組織球症(LCH)5症例の臨床的検討 (2006)
  • Author(s): 小山正平、木村雄一郎、菊地利明、田澤立之、海老名雅仁、渡辺彰、貫和敏博
  • Organizer: 第103回日本内科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2006-04-14
• [Book] 非結核性抗酸菌症 (2009)
  • Author(s): 菊地利明、南江堂
  • Publisher: 呼吸器疾患最新の治療2010-2012 VI-16(印刷中)
• [Book] 『呼吸器疾患最新の治療2010-2012』VI-16. 非結核性抗酸菌症 (2009)
  • Author(s): 菊地利明
  • Publisher: 南江堂(印刷中)
• [Book] メデイカルサイエンス・インターナショナル、『疾患からまとめた病態生理FIRST AID吸器疾患最新の治療2007-2009』 (2007)
  • Author(s): 菊地利明
  • Publisher: サルコイドーシス
• [Book] レジオネラ感染症ハンドブック (2007)
  • Author(s): 菊地 利明, 他
  • Total Pages: 303
  • Publisher: 日本醫事新報社
• [Remarks]
  • URL: http://www.kokyuu.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://www.kokyuu.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://romm.idac.tohoku.ac.jp/index.html
• [Patent(Industrial Property Rights)] VNTR型別による非結核性抗酸菌症の病勢の予測方法 (2008)
  • Inventor(s): 貫和敏博, 渡辺彰, 五味和紀, 榊原智博, 菊地利明
  • Industrial Property Rights Holder: 同上
  • Filing Date: 2008-12-18
• [Patent(Industrial Property Rights)] VNTR型別による非結核性抗酸菌症の病勢の予測方法 (2008)
  • Inventor(s): 貫和敏博, 他4名
  • Industrial Property Rights Holder: 貫和敏博, 他4名
  • Filing Date: 2008-12-18