Mechanism of carcinogenesis from pulmonary atypical adenomatous hyperplasia to adenocarcinoma

• Project/Area Number: 18590851
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Okayama University
• Principal Investigator: TAKIGAWA Nagio Okayama University, 医学部・歯学部附属病院, 助教 (60325107)
• Co-Investigator(Kenkyū-buntansha): KIURA Katuyuki 岡山大学, 医歯薬学総合研究科, 准教授 (10243502) ; TABATA Masahiro 岡山大学, 医学部・歯学部附属病院, 准教授 (30243504)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,980,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 肺癌 / 発癌 / 遺伝子変異 / 肺腺癌 / 重複癌

Research Abstract

上皮成長因子受容体(EGFR)遺伝子変異は肺腺癌の前癌病変である異型腺腫様過形成(AAH)においても肺腺癌においても同程度に認められた。AAHおよび腺癌の多発病変を有する症例の解析により、同一患者においても病変ごとにEGFR遺伝子変異のパターンが異なっていることが多く、変異はランダムに生じていると考えられた。また、EGFR遺伝子変異の有無にかかわらず、STAT3の発現が癌進展の分子マーカーになりうる可能性が示唆された。

Research Products

• [Journal Article] GGOを呈する病変の分子生物学的検討 (2009)
  • Author(s): 瀧川奈義夫, 木浦勝行
  • Journal Title: 日本胸部臨床 68 Pages: 131-138
• [Journal Article] Impact of HER2 gene and protein status on the treatment outcome of cisplatin-based chemoradiotherapy for locally advanced non-small cell lung cancer (2008)
  • Author(s): Kuyama s, Hotta K, Tabata M, Segawa Y, Fujiwara Y. Takigawa N. Kiura K, Deoka H, Eguchi K. Taniioto M.
  • Journal Title: J Thorac Oncol 3 Pages: 477-482
  • Peer Reviewed
• [Journal Article] Mutation of the epidermal growth factor receptor gene in the development of adenocarcinoma of the lung (2007)
  • Author(s): Kozuki T, Hisamoto A, Tabata M, Takigawa N, Kiura K, Segawa Y, Nakata M, Mandai K, Eguchi K, Ueoka H, Tanimoto M.
  • Journal Title: Lung Cancer 58 Pages: 30-35
• [Journal Article] Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line (2007)
  • Author(s): Ogino A, Kitao H, Hirano S, Uchida A, Ishiai M, Kozuki T, Takigawa N, Takata M, Kiura K, Tanimoto M
  • Journal Title: Cancer Res 67 Pages: 7807-7814
• [Journal Article] Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice (2007)
  • Author(s): Hisamoto A, Kondo E, Kiura K, Okada T, Hosokawa S, Mimoto J, Takigawa N, Tanimoto M
  • Journal Title: Lung Cancer 58 Pages: 15-20
• [Journal Article] Activation of downstream epidermal growth factor receptor(EGFR)signaling provides gefitinib-resistance in cells carrying EGFR mutation (2007)
  • Author(s): Uchida A, Hirano S, Kitao H, Ogino A, Rai K, Toyooka S, Takigawa N, Tabata M, Takata M, Kiura K, Tanimoto M
  • Journal Title: Cancer Sci 98 Pages: 357-363
  • NAID: 10019481589
• [Journal Article] Mutation of the epidermal growth factor receptor gene in the development of adenocarcinoma of the lung. (2007)
  • Author(s): Kozuki T, Hisamoto A, Tabata M, Takigawa N, et. al.
  • Journal Title: Lung Cancer 58 Pages: 30-35
  • Peer Reviewed
• [Journal Article] Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice. (2007)
  • Author(s): Hisamoto A, Kondo E, Kiura K, Okada T, Hosokawa S, Mimoto J, Takigawa N, et. al.
  • Journal Title: Lung Cancer 58 Pages: 15-20
  • Peer Reviewed
• [Journal Article] Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line. (2007)
  • Author(s): Ogino A, Kitao H, Hirano S, Uchida A, Ishiai M, Kozuki T, Takigawa N, et. al.
  • Journal Title: Cancer Research 67 Pages: 7807-7814
  • Peer Reviewed
• [Journal Article] Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation. (2007)
  • Author(s): Uchida A, Hirano S, Kitao H, Ogino A, Rai K, Toyooka S, Takigawa N, et al.
  • Journal Title: Cancer Science 98巻・3号 Pages: 357-363
• [Journal Article] Second primary cancer in survivors following concurrent chemoradiation for locally advanced non-small-cell lung cancer. (2006)
  • Author(s): Takigawa N et al.
  • Journal Title: British Journal of Cancer 95巻・9号 Pages: 1142-1144
• [Presentation] すりガラス陰影を伴う肺腺癌の進展におけるEGFRシグナルの関与発表者 (2008)
  • Author(s): 高田三郎、瀧川奈義夫、大橋圭明、畝川芳彦、山下素弘、寺本典弘、新海哲、上月稔幸、堀田勝幸、田端雅弘、木浦勝行、谷本光音
  • Organizer: 第49回日本肺癌学会総会
  • Year and Date: 2008-11-13
• [Presentation] すりガラス陰影を伴う肺腺癌の進展におけるEGFRシグナルの関与 (2008)
  • Author(s): 高田三郎, 瀧川奈義夫, 大橋圭明, 畝川芳彦, 山下素弘, 寺本典弘, 新海哲, 上月稔幸, 堀田勝幸, 田端雅弘, 木浦勝行, 谷本光音
  • Organizer: 第49回日本肺癌学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2008-11-13
• [Presentation] Emergence of EGFR T790M mutation during chronic exposure to gefitinib in a NSCLC cell line (2007)
  • Author(s): Ogino A, Kitao H, Hirano S, Uchida A, Takigawa N, Kiura K, Tanimoto M
  • Organizer: 98^<th> Annual Meeting of American Association for Cancer Research
  • Place of Presentation: LA, USA
  • Year and Date: 2007-04-16
• [Presentation] Emergence of EGFR T790M mutation during chronic exposure to gefitinib in a NSCLC cell line. (2007)
  • Author(s): 34. Ogino A, Kitao H, Hirano S, Uchida A, Takigawa N, et. al.
  • Organizer: 97rd Annual Meeting of American Association for Cancer Research
  • Place of Presentation: LA, USA
  • Year and Date: 2007-04-16
• [Presentation] Early occurrence of epidermal growth factor receptor Mutation in lung adenocarcinoma: Comparison between pulmonary atypical adenomatous hyperplasia and adenocarcinoma (2006)
  • Author(s): Kozuki T, Hisamoto A, Takigawa N, Tabata M, Segawa Y, Nakata M, Umemura S, Ohashi K, Kiura K, Eguchi K, Ueoka H, Tanimoto M
  • Organizer: 97^<th> Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2006-04-17
• [Book] Therapy and Prognosis (2009)
  • Author(s): Kiura K, Takigawa N, Segawa Y
  • Total Pages: 609
  • Publisher: Springer, Methods of Cancer Diagnosis
• [Book] Methods of Cancer Diagnosis, Therapy and Prognosis (2009)
  • Author(s): Katsuyuki Kiura, Nagio Takigawa, Yoshihiko Segawa
  • Total Pages: 609
  • Publisher: Springer