| Project/Area Number |
18590862
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
TOMODA Koichi Nara Medical University, Faculty of Medicine, Associate (90364059)
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| Co-Investigator(Kenkyū-buntansha) |
OSAKI Shigeyoshi Nara Medical University, Faculty of Medicine, Professor (90273911)
YOSHIKIAWA Masanori Nara Medical University, Faculty of Medicine, Assistant Professor (80271203)
KIMURA Hiroshi Nara Medical University, Faculty of Medicine, Professor (20195374)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,840,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Human Lung / Centrilobular Emphysema / Mechanical Anisotropy / Collagen Fiber |
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| Research Abstract |
It has not been elucidated why centrilobular emphysema, associated with cigarette smoke, occurs predominantly at upper lung. Respiratory movement in the upper lobe is smaller than that in the lower lung. We hypothesize that reconstruction of extra cellular matrix varies according to range of mechanical load by respiratory movement. Based on this hypothesis the threshold against mechanical stress in the upper lung may be lower than that in the lower lung. In this context we tried to evaluate mechanical anisotropy in human lung to make clear the role of mechanical property in development of centrilobular emphysema.
We prepared sheet samples from coronal plate of human lung. Slit samples for mechanical measurements were prepared by cutting the sheet samples. The threshold against mechanical stress was evaluated by stretching the samples until their breakdown.
As a result, the mechanical stretching strength in the upper lung was lower than in the lower lung. This result suggests that the distribution of mechanical property may contribute to the development of centrilobular emphysema.
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