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The role and therapeutic application of blood stem/progenitor cells in lung injury

Research Project

Project/Area Number 18590870
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNippon Medical School

Principal Investigator

ABE Sinji (ABE Shinji)  Nippon Medical School, 医学部, 講師 (20386163)

Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,430,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Keywords再生医学 / 造血幹細胞 / 肺障害 / 顆粒球コロニー刺激因子(G-CSF) / エリスロポエチン / 顆粒球コロニー刺激因子
Research Abstract

Regeneration of various tissues by hematopoietic stem/progenitor cells has been reported and expected to be therapeutic application in future. This study was aimed to clarify the effect of mobilized bone marrow stem/progenitor cells on experimental lung injuries using granurocyte colony stimulating factor (G-CSF) and erythropoietin. In mice, mobilization of marrow stem cells by G-CSF is amplified by splenectomy. C57/Bl mice were splenectomized and then injected bleomycin intravenously. In splenectomized mice, lung injuries were induced as well as control mice. We gave G-CSF and erythropoietin subcutaneously day 0-5 after bleomycin injection and attempted to mobilize marrow stem/progenitor cells into lung. On day 21 and 28, bronchial alveolar lavage fluid (BALF) and lung tissues were evaluated. In BALF, the proportion of neutrophils in experimental groups was significantly reduced compared to control ones. However there was not significant difference in the degree of lung injuries. In acute lung injury model using intra-trachial injection of bleomycin, there was not significant improvement of lung injury in experimental groups.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (7 results)

All 2010 2008 2007 2006

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Neutrophil Adsorption by Polymyxin B-Immobilized Fiber Column for Acute Exacerbation in Patients with Interstitial Pneumonia: A Pilot Study.2010

    • Author(s)
      Abe S, Seo Y, Hayashi H, Matsuda K, Usuki J, Azuma A, Kudoh S, Gemma A
    • Journal Title

      Blood Purif 29

      Pages: 321-326

    • Related Report
      2009 Final Research Report
  • [Journal Article] Neutrophil adsorption by polymyxin B-immobilized fiber column (PMX) for acute exacerbation in patients with interstitial pneumonia : a pilot study.2010

    • Author(s)
      Shinji Abe, 他
    • Journal Title

      Blood Purification 29

      Pages: 1-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of gefitinib on radiation-induced lung injury in mice.2008

    • Author(s)
      Wang C, Abe S, Matsuda K, Yu C, Usuki J, Azuma A, Kudoh S
    • Journal Title

      J Nippon Med Sch 75

      Pages: 96-105

    • NAID

      130004146947

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of gefitinib on radiation-induced lung injury in mice2008

    • Author(s)
      Wang C, Abe S, Matsuda K, Yu C, Usuki J, Azuma A, Kudoh S.
    • Journal Title

      J Nippon Med Sch. 75

      Pages: 96-105

    • NAID

      130004146947

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Presentation] Stem cellを用いた呼吸器細胞への分化と機能 : 肺傷害修復とstem/progenitor細胞2006

    • Author(s)
      阿部信二
    • Organizer
      第46回日本呼吸器学会学術講演会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2006-06-02
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 肺傷害修復とstem/progenitor細胞2006

    • Author(s)
      阿部信二
    • Organizer
      第46回日本呼吸器学会学術講演会シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Book] 医学のあゆみ別冊呼吸器疾患-state of arts「肺の再生と幹細胞」2007

    • Author(s)
      阿部信二、工藤翔二
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2008 Self-evaluation Report

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Published: 2006-04-01   Modified: 2016-04-21  

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