Clarification of the pathogenic mechanism of proteinuria

• Project/Area Number: 18590886
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Niigata University
• Principal Investigator: KAWACHI Hiroshi Niigata University, Institute of Medcine and Dentistry, Associate Professor (60242400)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: proteinuria / podocyte / slit diaphragm / SV2B / ephrin B1 / subtraction / siRNA

Research Abstract

We have been studying the nature of slit diaphragm (SD) of podocyte that is accepted to play a critical role for maintaining the barrier function of glomerular capillary wall. However, the molecular composition of the SD was not fully understood yet. In this project, we intended to identify the functional molecule of the SD. In the first year of this project (2006), to identify the molecules which are involved in the development of proteinuria, the subtraction assay was performed using normal and proteinuric glomerular materials. Synaptic vesicle-protein 2B (SV2B) is detected to be clearly downregulated in the proteinuric glomeruli. In the second year (2007), the expression and the function of SV2B in podocyte were analyzed. The analyses with siRNA techniques showed that SV2B play a role for maintaining the proper localization of CD2AP, a critical molecule of the SD. We also observed that the expression of ephrin B1 is clearly decreased at the very early stage of disease before the onset of proteinuria. The findings suggest that ephrin B1 play a critical role for maintaining the barrier function of the glomerular capillary wall. We published these findings as manuscripts in the top journals of Nephrology field, Kidney International and Journal of American Society of Nephrology. We reported some important results at the annual meeting of the American Society of Nephrology held in San Francisco (2007). We are convinced that the results obtained in this project contributed to the better understanding the pathogenic mechanism of proteinuria and to establishment for the novel therapy.

Research Products

• [Journal Article] The mTOR inhibitor everolimus attenuates the time course of chronic anti-Thy1 nephritis in the rat (2008)
  • Author(s): Wittmann S
  • Journal Title: Nephron Exp Nephrol 108 Pages: 45-56
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis (2008)
  • Author(s): Uchida K
  • Journal Title: Kidney Int 73 Pages: 926-932
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rosuvastatin is additive to high-dose candesartan in slowing progression of experimental mesangioproliferative glomerulosclerosis (2008)
  • Author(s): Kramer S
  • Journal Title: Am J Physiol Renal Physiol. 294
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Eplerenone potentiates the antiproteinuric effects of enalapril in experimental nephrotic syndrome. (2008)
  • Author(s): Nakhoul F
  • Journal Title: Am J Physiol Renal Physiol 294
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes (2008)
  • Author(s): Zhu J
  • Journal Title: Kidney Int 73 Pages: 556-566
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Use of mizoribine as a rescue drug for steroid-resistant pediatric IgA nephropathy (2008)
  • Author(s): Ikezumi Y
  • Journal Title: Pediatr Nephrol 23 Pages: 645-650
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The mTOR inhibitor everolimus attenuates the time course of chronic anti-Thyl nephritis in the rat (2008)
  • Author(s): Wittmann, S, Daniel, C, Braun, A, Vogelbacher, R, Shimizu, F, Kawachi, H, Hugo, C
  • Journal Title: Nephron Exp Nephrol 108 Pages: 45-56
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis (2008)
  • Author(s): Uchida, K, Suzuki, K, Iwamoto, M, Kawachi, H, Ohno, M, Horita, S, Nitta, K
  • Journal Title: Kidney Int 73 Pages: 926-932
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rosuvastatin is additive to high-dose candesartan in slowing progression of experimental mesangioproliferative glomerulosclerosis (2008)
  • Author(s): Kramer, S, Kron, S, Wang-Rosenke, Y, Loof, T, Khadzhynov, D, Morgera, S, Kawachi, H, Shimizu, F, Martini, S, Neumayer, HH, Peters, H
  • Journal Title: Am J Physiol Renal Physiol 294 Pages: 801-811
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Eplerenone potentiates the antiproteinuric effects of enalapril in experimental nephrotic syndrome (2008)
  • Author(s): Nakhoul, F, nankin, E, Yaccob, A, Kawachi, H, Karram, T, Awaad, H, Nakhoul, N, Hoffman, A, Abassi, Z
  • Journal Title: Am J Physiol Renal Physiol 294 Pages: 628-637
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes (2008)
  • Author(s): Zhu, J, Sun, N, Aoudjit, L, Li, H, Kawachi, H, Lemay, S, Takano, T
  • Journal Title: Kidney Int 73 Pages: 556-66
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nikolic-Paterson DJ, Uchiyama M., Use of mizoribine as a rescue drug for steroid-resistant pediatric IgA nephropathy (2008)
  • Author(s): Ikezumi, Y, Suzuki, T, Karasawa, T, Kawachi, H
  • Journal Title: Pediatr Nephrol 23 Pages: 645-50
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Decreased tyrosine phosphorylation of nephrin in rat and human nephreosis (2008)
  • Author(s): Uchida K
  • Journal Title: Kidney Int 73 Pages: 926-932
  • Peer Reviewed
• [Journal Article] Neutralization of CXCL10 accelerates liver regeneration in carbon tetrachloride-induced acute liver injury. (2007)
  • Author(s): Yoneyama H
  • Journal Title: Med Mol Morphol 40 Pages: 191-197
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Prevention of hypertension with or without renin-angiotensin system inhibition precludes nephrin loss in the early stage of experimental diabetes mellitus. (2007)
  • Author(s): Amazonas RB
  • Journal Title: Nephron Physiol 107 Pages: 57-64
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Podocyte protection by darbepoetin: preservation of the cytoskeleton and nephrin expression. (2007)
  • Author(s): Eto N
  • Journal Title: Kidney Int 72 Pages: 455-463
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Ephrin-B1 localizes at the slit diaphragm of the glomerular podocyte (2007)
  • Author(s): Hashimoto T
  • Journal Title: Kidney Int 72 Pages: 954-964
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] SM22alpha: the novel phenotype marker of injured glomerular epithelial cells in anti-glomerular basement membrane nephritis (2007)
  • Author(s): Ogawa A
  • Journal Title: Nephron Exp Nephrol 106 Pages: 77-87
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Blockade of interferon-gamma-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells. (2007)
  • Author(s): Suzuki K
  • Journal Title: Pathol Int 57 Pages: 413-420
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 pote-ntates the anchorage-independent growth of human hepatoma HepG2 cells (2007)
  • Author(s): Hokari M
  • Journal Title: Life Science 81 Pages: 336-345
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Blockade of IP-10/CXCR3 promotes progressive renal fibrosis (2007)
  • Author(s): Nakaya I
  • Journal Title: Nephron Exp Nephrol 107 Pages: 12-21
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Chemically modified siRNA prolonged RNA interference in renal disease (2007)
  • Author(s): Takabatake Y
  • Journal Title: Biochem Biophys Res Commun 363 Pages: 432-437
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Angiotensin II Type 1 and Type 2 Receptors Play Opposite Roles in Regulating the Barrier Function of Kidney Glomerular Capillary wall. (2007)
  • Author(s): Suzuki K
  • Journal Title: The American Journal of Pathology 170 Pages: 1841-1853
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Podocyte as the target for aldosterone (2007)
  • Author(s): Shibata S
  • Journal Title: Hypertension 49 Pages: 355-364
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Expression of allograft inflammatory factor-1 in kidneys: A novel molecular component of podocyte. (2007)
  • Author(s): Tsubata Y
  • Journal Title: Kidney International 70 Pages: 1948-54
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Neutralization of CXCL10 accelerates liver regeneration, in carbon tetrachloride-induced acute liver injury (2007)
  • Author(s): Yoneyama, H, Kai, Y, Koyama, J, Suzuki, K, Kawachi, H, Narumi, S, Ichida, T
  • Journal Title: Med Mol Morphol 40 Pages: 191-197
  • NAID: 10024380332
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prevention of hypertension with or without renin-angiotensin system inhibition precludes nephrin loss in the early stage of experimental diabetes mellitus (2007)
  • Author(s): Amazonas, RB, Sanita, Rde A, Kawachi H, de Faria, JB
  • Journal Title: Nephron Physiol 107 Pages: 57-64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Podocyte protection by darbepoetin: preservation of the cytoskeleton and nephrin expression (2007)
  • Author(s): Eto ,N, Wada, T, Inagi, R, Takano, H, Shimizu A, Kato, H, Kurihara, H, Kawachi, H, Shankland, SJ, Fujita, T, Nangaku, M
  • Journal Title: Kidney Int 72 Pages: 455-63
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ephrin-B1 localizes at the slit diaphragm of the glomeiular podocyte (2007)
  • Author(s): Hashimoto, T, Karasawa, T, Saito, A, Miyauchi, N, Han, GD, Hayasaka, K, Shimizu, F, Kawachi, H
  • Journal Title: Kidney Int 72 Pages: 954-64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] SM22alpha: the novel phenotype marker of injured glomerular epithelial cells in anti-glomerular basement membrane nephritis (2007)
  • Author(s): Ogawa, A, Sakatsume, M, Wang, X, Sakamaki, Y, Tsubata, Y, Alchi, B, Kuroda, T, Kawachi, H, Narita, I, Shimizu, F, Gejyo, F
  • Journal Title: Nephron Exp Nephrol 106 Pages: 77-87
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blockade of interferon-gamma-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells. (2007)
  • Author(s): Suzuki, K, Kawauchi, Y, Palaniyandi, SS, Veeraveedu, PT, Fujii, M, Yamagiwa, S, Yoneyama, H, Han, GD, Kawachi, H, Okada, Y, Ajioka, Y, Watanabe, K, Hosono, M, Asakura, H, Aoyagi, Y, Narumi, S
  • Journal Title: Pathol Int 57 Pages: 413-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 pote-ntates the anchorage-independent growth o human hepatoma HepG2 cells (2007)
  • Author(s): Hokari, M, Matsuda, Y, Wakai, T, Shirai, Y, Sato, M, Tsuchiya, A, Takamura, M, Yamagiwa, S, Suzuki, K, Ohkoshi, S, Ichida, T, Kawachi, H Aoyagi, Y
  • Journal Title: Life Sci 81 Pages: 336-345
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blockade of IP-10/ CXCR3 promotes progressive renal fibrosis (2007)
  • Author(s): Nakaya, I, Wada, T, Furuichi, K, Sakai, N, Kitagawa, K, Yokoyama, H, Ishida, Y, Kondo, T, Sugaya, T, Kawachi, H, Shimizu, F, Narumi, S, Haino, M, Gerard, C, Matsushima, K, Kaneko, S
  • Journal Title: Nephron Exp Nephrol 107 Pages: 12-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Chemically modified siRNA prolonged RNA interference in renal disease (2007)
  • Author(s): Takabatake, Y, Isaka, Y, Mizui, M, Kawachi, H, Imai, E
  • Journal Title: Biochem Biophys Res Commun 363 Pages: 432-437
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Angiotensin II Type 1 and Type 2 Receptors Play Opposite Roles in Regulating the Barrier Function of Kidney Glomerular Capillary Wall (2007)
  • Author(s): Suzuki, K, Han, GD, Miyauchi, N, Hashimoto, T, Nakatsue, T, Fujioka, Y Koike, H, Shimizu, F, Kawachi, H
  • Journal Title: Am J Pathol 170 Pages: 1841-1853
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Podocyte as the target for aldosterone (2007)
  • Author(s): Shibata, S, Nagase, M, Yoshida, S, Kawachi, H, Fujita, T
  • Journal Title: Hypertension 49 Pages: 355-64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of allograft inflammatory factor-1 in kidneys: A novel molecular component of podocyte (2007)
  • Author(s): Tsubata, Y, Sakatsume, M, Ogawa, A, Alchi, B, Kaneko, Y, Kuroda, T, Kawachi, H, Narita, I, Yamamoto, T, Gejyo, F
  • Journal Title: Kidney Intemational 70 Pages: 1948-54
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 pote-ntates the anchorage-independent growth of human hepatoma HepG2 cells (2007)
  • Author(s): Hokari M
  • Journal Title: Life Science 72 Pages: 954-964
  • Peer Reviewed
• [Journal Article] Angiotensin IIType 1 and Type 2 Receptors Play Opposite Roles in Regulating the Barrier Function of Kidney Glomerular Capillary Wall. (2007)
  • Author(s): Suzuki K
  • Journal Title: The American Journal of Pathology 170(印刷中)
• [Journal Article] Podocyte as the target for aldosterone : roles of oxidative stress and Sgk1. (2007)
  • Author(s): Shibata S
  • Journal Title: Hypertension 49 Pages: 355-64
• [Journal Article] Synaptic Vesicle Protein 2B Is Expressed in Podocyte, and Its Expression Is Altered in Proteinuric Glomeruli. (2006)
  • Author(s): Miyauchi N
  • Journal Title: Journal of the American Society of Nephrology 17 Pages: 2748-59
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Histological differences in newly onset IgA nephropathy between children and adults. (2006)
  • Author(s): Ikezumi Y
  • Journal Title: Nephrology Dialysis Transplantation. 21 Pages: 3466-3474
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rat nephrin modulates cell morphology via the adaptor protein Nck. (2006)
  • Author(s): Li H
  • Journal Title: Biochem Biophys Res Commun 349 Pages: 310-316
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of podocyte slit diaphragm as a filtration barrier. (2006)
  • Author(s): Kawachi H
  • Journal Title: Nephrology(Calton) 11 Pages: 274-81
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage. (2006)
  • Author(s): Ichihara A
  • Journal Title: Journal of the American Society of Nephrology. 17 Pages: 2495-503
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of IP-10/CXCL 10 in the progression of pancreatitis-like injury in mice after murine retroviral infection. (2006)
  • Author(s): Kawauchi Y
  • Journal Title: Am J Physiol Gastrointest Liver Physiol 291 Pages: 345-54
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Transcription factor Ets-1 is essential for mesangial matrix remodeling. (2006)
  • Author(s): Mizui M
  • Journal Title: Kidney lnternational 70 Pages: 298-305
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Blockade of VEGF accelerates proteinuria, via decrease in nephrin expression in rat crescentic glomerulonephritis. (2006)
  • Author(s): Hara A
  • Journal Title: Kidney lnternational 69 Pages: 1986-95
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Microarray analysis of a reversible model and an irreversible model of anti-Thy-1 nephritis. (2006)
  • Author(s): Tsuji M
  • Journal Title: Kidney International 69 Pages: 996-1004
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis. (2006)
  • Author(s): Ostendorf T
  • Journal Title: Journal of the American Society of Nephrology 17 Pages: 1054-1062
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver. (2006)
  • Author(s): Hanawa T
  • Journal Title: The Journal of Gene Medicine 8 Pages: 623-635
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Exogenous 5'-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats. (2006)
  • Author(s): Takenaka T
  • Journal Title: American Journal Physiology Renal Physiology. 290 Pages: 844-853
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Synaptic Vesicle Protein 2B Is Expressed in-Podocyte, and Its Expression Is Altered in Proteinuric Glomeruli (2006)
  • Author(s): Miyauchi, N, Saito, A, Karasawa, T, Harita, Y, Suzuki, K, Koike, H, Han, GD, Shimizu, F, Kawachi, H
  • Journal Title: I Am Soci Nephrol 17 Pages: 2748-59
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nikolic-Paterson DJ, Uchiyama M., Histological differences in newly onset IgA nephropathy between children and adults. (2006)
  • Author(s): Ikezumi, Y, Suzuki, T, Imai, N, Ueno, M, Narita, I, Kawachi, H, Shimizu, F
  • Journal Title: Nephrol Dial Transplant 21 Pages: 3466-74
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rat nephrin modulates cell morphology via the adaptor protein Nck (2006)
  • Author(s): Li, H, Zhu, J, Aoudjit, L, Latreille, M, Kawachi, H, Larose, L, Takano, T
  • Journal Title: Biochem Biophys Res Commun 349 Pages: 310-6
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of podocyte slit diaphragm as a filtration barrier (2006)
  • Author(s): Kawachi, H, Miyauchi, N, Suzuki, K, Han, GD, Orikasa, M, Shimizu, F
  • Journal Title: Nephrology 11 Pages: 274-81
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage (2006)
  • Author(s): Ichihara, A, Kaneshiro, Y, Takemitsu, T, Sakoda, M, Nakagawa, T, Nishiyama, A, Kawachi, H, Shimizu, F, Inagami, T
  • Journal Title: J Am Soci Nephrol 17 Pages: 2495-503
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of IP-10/CXCL10 in the progression of pancreatitis-like injury in mice after murine retroviral infection (2006)
  • Author(s): Kawauchi, Y, Suzuki, K, Watanabe, S, Yamagiwa, S, Yoneyama, S, Han, GD, Palaniyandi, SS, Veeraveedu, PT, Watanabe, K, Kawachi, H, Okada, Y, Shimizu, F, Asakura, H, Aoyagi, Y, Narumi, S
  • Journal Title: Am J Physiol 291
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transcription factor Ets-1 is essential for mesangial matrix remodeling (2006)
  • Author(s): Mizui, M, Isaka, Y, Takabatake, Y, Sato, Y, Kawachi, H, Shimizu, F, Takahara, S, Ito, T, Imai, E
  • Journal Title: Kidney International 70 Pages: 298-305
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blockade of VEGF accelerates proteinuria, via decrease in nephrin expression in rat crescentic glomerulonephritis (2006)
  • Author(s): Hara, A, Wada, T, Furuichi, K, Sakai, N, Kawachi, H, Shimizu, F, Shibuya, M, Matsushima, K, Yokoyama, H
  • Journal Title: Kidney International 69 Pages: 1986-95
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Microarray analysis of a reversible model and an irreversible model of and-Thy-1 nephritis (2006)
  • Author(s): Tsuji, M, Monkawa, T, Yoshino, J, Asai, M, Fukuda, S, Kawachi, H, Shimizu, F, Hayashi, M, Saruta, T
  • Journal Title: Kidney International 69 Pages: 996-1004
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis (2006)
  • Author(s): Ostendorf, T, Rong, S, Boor, P, Wiedemann, S, Kunter, U, Haubold, U, van Roeyen, CR, Eitner, F, Kawachi, H, Starling, G, Alvarez, E, Smithson, G Floege, J
  • Journal Title: J Am Soci Nephrol 17 Pages: 1054-62
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver (2006)
  • Author(s): Hanawa, T, Suzuki, K, Kawauchi, Y, Takamura, M, Yoneyama, H, Han, GD, Kawachi, H, Shimizu, F, Asakura, H, Miyazaki, J, Maruyama, H Aoyagi, Y
  • Journal Title: The Journal of Gene Medicine 8 Pages: 623-35
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Exogenous 5'-nucleotidase improves gloinerular autoregulation in Thy-1 nephritic rats (2006)
  • Author(s): Takenaka, T, Okada, H, Kanno, Y, Inoue, T, Ryuzaki, M, Nakamoto, H, Kawachi, H, Shimizu, F, Suzuki, H
  • Journal Title: Am J Physiol 290 Pages: 844-53
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of allograft inflammatory factor-1 in kidneys : A novel molecular component of podocyte. (2006)
  • Author(s): Tsubata Y
  • Journal Title: Kidney International 70 Pages: 1948-54
• [Journal Article] Histological differences in newly onset IgA nephropathy between children and adults. (2006)
  • Author(s): Ikezumi Y
  • Journal Title: Nephrology Dialysis Transplantation 21 Pages: 3466-74
• [Journal Article] Role of IP-10/CXCL10 in the progression of pancreatitis-like injury in mice after murine retroviral infection. (2006)
  • Author(s): Kawauchi Y
  • Journal Title: Am J Physiol Gastrointest Liver Physiol 291 Pages: 345-54
• [Journal Article] Transcription factor Ets-1 is essential for mesangial matrix remodeling. (2006)
  • Author(s): Mizui M
  • Journal Title: Kidney International 70 Pages: 298-305
• [Journal Article] Blockade of VEGF accelerates proteinuria, via decrease in nephrinexpression in rat crescentic glomerulonephritis. (2006)
  • Author(s): Hara A
  • Journal Title: Kidney International 69 Pages: 1986-95
• [Journal Article] Attenuation of mouse acute colitis by naked hepatocyte factor gene transfer into the liver. (2006)
  • Author(s): Hanawa T
  • Journal Title: The Journal of Gene Medicine 8 Pages: 623-35
• [Journal Article] Exogenous 5'-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats. (2006)
  • Author(s): Takenaka T
  • Journal Title: erican Journal Physiology Renal Physiology. 290 Pages: 844-53
• [Presentation] Glomerular Podocyte Possesses Syntaxin-2/Epimorphin, and Injured Podocyte Secretes It into Urine (2007)
  • Author(s): Miyauchi N
  • Organizer: 米国腎臓学会
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2007-11-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Glomerular Podocyte Possesses Syntaxin-2/Epimorphin, and Injured Podocyte Secretes It into Urine (2007)
  • Author(s): Miyauchi, N, Otaki, Y, Kawachi, H
  • Organizer: 40 th Annual Meeting of Am Soc of Nephrol
  • Place of Presentation: San Francisco
  • Year and Date: 2007-11-04
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] An Actin-Binding Protein I-Plastin Located at the Basal Area of Podocyte and Its Expression Is Altered in the Slit Diaphragm Injury (2007)
  • Author(s): Han GD
  • Organizer: 米国腎臓学会
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2007-11-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] An Actin-Binding Protein I-Plastin Located at the Basal Area of Podocyte and Its Expression Is Altered in the Slit Diaphragm Injury (2007)
  • Author(s): Han, GD, Miyauchi, N, Shimizu, F, Kawachi, H
  • Organizer: 40th Annual Meeting of Am Soc of Nephrol
  • Place of Presentation: San Francisco
  • Year and Date: 2007-11-02
  • Description: 「研究成果報告書概要(欧文)」より