Role of fibrocytes, a newly identified tone marrow-derived cells, in the pathogenesis of renal fibrosis
Project/Area Number |
18590887
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
|
Research Institution | Kanazawa University |
Principal Investigator |
WADA Takashi Kanazawa University, Graduath Schcol of Medical Science, Professor (40334784)
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Project Period (FY) |
2006 – 2007
|
Project Status |
Completed (Fiscal Year 2007)
|
Budget Amount *help |
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
Keywords | fibre cote / chemokine / kidney / fibrosis / renin / angiotensin / angiotensin recentor / collagen / 慢性腎臓病 / CCL21 / SLC / CCR7 |
Research Abstract |
Fibrocytes are supposed to be a circulating connective tissue cell progenitor that consists of a novel population of peripheral blood cells. This distinct population of blood-borne cells shares markers of leukocytes as well as mesenchymal cells. Accumulating evidence indicates that fibrosis is characteristic of progressive chronic kidney diseases of any etiologies, resulting in kidney failure. We have uncovered that CCR7-positive fibrocytes migrate into the kidney in response to secondary lymphoid tissue chemokine (SLC/CCL21) and contribute to kidney fibrosis induced by unilateral ureteral obstruction in mice. In addition, the blockade of CCL21/CCR7 signaling by anti-CCL21 antibodies reduced kidney fibrosis, which was confirmed by a decrease in fibrosis in CCR7-null mice with concomitant reduction in macrophage recruitment along with reduced renal transcripts of monocyte chemoattractant protein-1 (MCP-1/CCL2). In addition, angiotensin receptor type 1 /type 2 signaling may contribute to the pathogenesis of renal fibrosis by at least two mechanisms: (1) by regulating the number of fibrocytes in bone marrow, and (2) by direct activation of fibrocytes via these two receptors. These findings suggest that fibrocytes dependent on CCL21/CCR7 signaling pathways and renin-angiotensin system contribute to the pathogenesis of kidney fibrosis, thereby providing that regulating fibrocytes may provide a novel therapeutic benefit for kidney fibrosis.
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Report
(3 results)
Research Products
(36 results)
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[Presentation] 慢性腎臓病とケモカイン2007
Author(s)
和田隆志, 他
Organizer
第28回日本炎症・再生医学会シンポジウム
Place of Presentation
東京
Year and Date
2007-08-03
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] Chronic kidney disease and chemokines2007
Author(s)
Wada, T., Kaneko, S., Matsushima, K
Organizer
28th Annual Meeting of the Japanese Society of Inflammation and regeneration
Place of Presentation
Tokyo
Year and Date
2007-08-03
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Chemokines in renal injury2007
Author(s)
Wada, T., Kaneko, S., Matsushima, K
Organizer
8th World Congress on Inflammation
Place of Presentation
Copenhagen
Year and Date
2007-06-17
Description
「研究成果報告書概要(欧文)」より
Related Report
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