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Expressional regulation and pathophyisiiological role of a novel iron-binding protein, Ngal, in the kidney

Research Project

Project/Area Number 18590888
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKyoto University

Principal Investigator

MORI Kiyoshi  Kyoto University, Graduate School of Medicine, Department of Medicine and Clinical Science, Associate Professor (60343232)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,860,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsNephrology / Acute Kidney Injury / Chronic Kidney Disease / Lipocalin / Biomarker / Iron / Ischemia-reperfusion Injury / Nephron / 急性賢不全
Research Abstract

We have found that Ngal expression is induced in thick ascending limbs of Henle and livers during murine renal ischemia-reperfusion injury and unilateral ligation, and that newly synthesized Ngal protein circulates in the blood stream, filtered in glomeruli, reabsorbed by proximal tubules and accumulates in the endocytic vesicles (Kuwabata, Mori, et. al. submitted: Schmidt-Ott, Mori, et. al. J Am Soc Nephrol 2007). We also showed that urinary Ngal levels do decrease in nephrotic syndrome and diabetic nephropathy by treatments with steroids and angiotensin receptor blockers, suggesting that urinary Ngal is useful for the monitoring of disease activity and treatment efficacy in chronic kidney diseases (Kuwabara, Mori, et. Al. submitted).
We reported in earlier works that Ngal : siderophore ; Fe complex has activities of kidney differentiation, kidney protection and mesenchymal-epithelial transition of cancer (Schmidt-Ott, Mori, et. al. Curr Opin Nephrol Hypertens 2006). Recently we have elucidated that Ngal : siderophore complex (without Fe) acts as an iron chelator and induces morphological changes and apoptosis of activated microglia (Lee, Mori, et. al. J Immunol 2007).

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (57 results)

All 2008 2007 2006

All Journal Article (35 results) (of which Peer Reviewed: 15 results) Presentation (22 results)

  • [Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis.2008

    • Author(s)
      T. Nagae, et. al.
    • Journal Title

      Kidney Int (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice.2008

    • Author(s)
      H. Yokoi, et. al.
    • Journal Title

      Kidney Int 73

      Pages: 446-455

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 多彩な生命現象に関わる鉄結合性小化合物siderophoreの意義2008

    • Author(s)
      森 潔, ほか
    • Journal Title

      細胞工学 27

      Pages: 226-230

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis2008

    • Author(s)
      T., Nagae, et. al.
    • Journal Title

      Kidney Int (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice2008

    • Author(s)
      H., Yokoi, et. al.
    • Journal Title

      Kidney Int 73

      Pages: 446-455

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage.2007

    • Author(s)
      K. Mori, et. al.
    • Journal Title

      Kidney Int 71

      Pages: 967-970

    • NAID

      120004225591

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dual action of neutrophil gelatinase-associated lipocalin.2007

    • Author(s)
      K. M. Schmidt-Ott, et. al.
    • Journal Title

      J Am Soc Nephrol 18

      Pages: 407-413

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia.2007

    • Author(s)
      S. Lee, et. al.
    • Journal Title

      J Immunol 179

      Pages: 3231-3241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of CCN1(CYR61)in developing, normal, and diseased humankidney.2007

    • Author(s)
      K. Sawai, et. al.
    • Journal Title

      Am J Physiol Renal Physiol 293

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 腎臓におけるNeutrophil gelatinase-associated lipocalinの役割2007

    • Author(s)
      森 潔, ほか
    • Journal Title

      医学のあゆみ 221

      Pages: 247-248

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 多彩な生命現象の背後に潜む共通の分子基盤としてのNgalを介する鉄代謝2007

    • Author(s)
      森 潔, ほか
    • Journal Title

      感染、炎症、免疫 37

      Pages: 158-161

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage2007

    • Author(s)
      K., Mori, et. al.
    • Journal Title

      Kidney Int 71

      Pages: 967-970

    • NAID

      120004225591

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dual action of neutrophil gelatinase -associated lipocalin2007

    • Author(s)
      K.M., Schmidt-Ott, et. al.
    • Journal Title

      J Am Soc Nephrol 18

      Pages: 407-413

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia2007

    • Author(s)
      S., Lee, et. al.
    • Journal Title

      J Immunol179

      Pages: 3231-3241

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression of CCNI (CYR61) in developing, normal, and diseased human kidney2007

    • Author(s)
      K., Sawai, et. al.
    • Journal Title

      Am J Physiol Renal Physiol 293

      Pages: 1363-1372

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia.2007

    • Author(s)
      Lee S, Lee J, et. al.
    • Journal Title

      J Immunol 179

      Pages: 3231-3241

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage.2007

    • Author(s)
      Mori K and Nakao K
    • Journal Title

      Kidney Int 71

      Pages: 967-970

    • NAID

      120004225591

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual action of neutrophil gelatinase-associated lipocalin.2007

    • Author(s)
      Schmidt-Ott KM, Mori K, et. al.
    • Journal Title

      J Am Soc Nephrol 18

      Pages: 407-413

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage.2007

    • Author(s)
      Mori K, Nakao K
    • Journal Title

      Kidney Int (published online)

    • NAID

      120004225591

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dual action of neutrophil gelatinase-associated lipocalin.2007

    • Author(s)
      Schmidt-Ott KM, Mori K et al.
    • Journal Title

      J Am Soc Nephrol 18・2

      Pages: 407-413

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery.2006

    • Author(s)
      G. Wagener, et. al.
    • Journal Title

      Anesthesiology 105

      Pages: 485-491

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Neutrophil gelatinase-associated lipocalin-mediated iron traffic inkidney epithelia.2006

    • Author(s)
      K. M. Schmidt-Ott, et. al.
    • Journal Title

      Curr Opin Nephrol Hypertens 15

      Pages: 442-449

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Kidney NGAL is a novel early marker of acute injury following transplantation.2006

    • Author(s)
      J. Mishra, et. al.
    • Journal Title

      Pediatr Nephrol 21

      Pages: 856-863

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone.2006

    • Author(s)
      H. Makino, et. al.
    • Journal Title

      Diabetes 55

      Pages: 2747-2756

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Transgenic overexpression of brain natriuretic peptide prevents the progression of diabetic nephropathy in mice.2006

    • Author(s)
      H. Makino, et. al.
    • Journal Title

      Diabetologia 49

      Pages: 2514-2524

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Redistribution of connexin43 expression in glomerular podocytes predicts poorrenal prognosis in patients with type 2 diabetes and overt nephropathy.2006

    • Author(s)
      K. Sawai, et. al.
    • Journal Title

      Nephrol Dial Transplant 21

      Pages: 2472-2477

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Association between increases in urinary neutrophil gelatinase -associated lipocalin and acute renal dysfunction after adult cardiac surgery2006

    • Author(s)
      G., Wagener, et. al.
    • Journal Title

      Anesthesiology 105

      Pages: 485-491

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia2006

    • Author(s)
      K.M., Schmidt-Ott, et. al.
    • Journal Title

      Curr Opin Nephrol Hypertens 15

      Pages: 442-449

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Kidney NGAL is a novel early marker of acute injury following transplantation2006

    • Author(s)
      J., Mishra, et. al.
    • Journal Title

      Pediatr Nephrol 21

      Pages: 856-863

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone2006

    • Author(s)
      H., Makino, et. al.
    • Journal Title

      Diabetes 55

      Pages: 2747-2756

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tranagenic overexpression of brain natriuretic Peptide prevents the progression of diabetic nephropathy in mice2006

    • Author(s)
      H., Makino, et. al.
    • Journal Title

      Diabetologia 49

      Pages: 2514-2524

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Redistribution of connexin43 expression in glomerular podocytes predicts poor renal prognosis in patients with type 2 diabetes and overt nephropathy2006

    • Author(s)
      K., Sawai, et. al.
    • Journal Title

      Nephrol Dial Transplant 21

      Pages: 2472-2477

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal2006

    • Author(s)
      Wagener G, Mori K et al.
    • Journal Title

      Anesthesiology 105・3

      Pages: 485-491

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia.2006

    • Author(s)
      Schmidt-Ott KM, Mori K et al.
    • Journal Title

      Curr Opin Nephrol Hypertens 15・4

      Pages: 442-449

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Kidney NGAL is a novel early marker of acute injury following transplantation.2006

    • Author(s)
      Mishra J, Mori K et al.
    • Journal Title

      Pediatr Nephrol 21・6

      Pages: 856-863

    • Related Report
      2006 Annual Research Report
  • [Presentation] Urinary Ngal as an early biomarker for diabetic nephropathy in mice.2008

    • Author(s)
      K. Mori, et. al.
    • Organizer
      The Shiga International Symposium on Diabetic Nephropathy
    • Place of Presentation
      Otsu, Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Lipocalin, mammalian siderophoreと鉄代謝2008

    • Author(s)
      森 潔, ほか
    • Organizer
      BioIron2007 Kyoto フォローアップシンポジウム
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Urinary Ngal as an early biomarker for diabetic nephropathy in mice2008

    • Author(s)
      K., Mori, et. al.
    • Organizer
      The Shiga International Symposium on Diabetic Nephropathy
    • Place of Presentation
      Otsu, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Urinary neutrophil gelatinase-associated lipocalin(NGAL)as a novelmarker for acute progression of renal diseases.2007

    • Author(s)
      K. Mori, et. al.
    • Organizer
      International Symposium of Nephrology at Montecatini
    • Place of Presentation
      Montecatini Terme, Italy
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characterization of mammalian and bacterial siderophores.2007

    • Author(s)
      K. Mori, et. al.
    • Organizer
      BioIron
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Forest fire theory for renal failure and clinical impact of neutrophil gelatinase-associated lipocalin.2007

    • Author(s)
      K. Mori, et. al.
    • Organizer
      World Congress of Nephrology(ISN)
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Blood and urinary neutrophil gelatinase-associated lipocalin(Ngal)levels in the treatment courses of proteinuric glomerular diseases.2007

    • Author(s)
      K. Mori, et. al.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Francisco, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 急性腎不全におけるNga1及び鉄の役割2007

    • Author(s)
      森 潔, ほか
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 腎不全の「山火事」理論とNeutrophil gelatinase-associated lipocalin2007

    • Author(s)
      森 潔, ほか
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 腎不全におけるNgal: siderophore: Fe複合体の意義2007

    • Author(s)
      森 潔, ほか
    • Organizer
      日本透析医学会学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Neutrophil gelatinase-associated lipocalinの臨床的意義及び腎不全の「山火事」理論2007

    • Author(s)
      森 潔, ほか
    • Organizer
      日本透析医学会学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 糖尿病性腎症モデルマウスにおける低・中分子量蛋白の尿中排泄の多様性2007

    • Author(s)
      森 潔, ほか
    • Organizer
      日本心血管内分泌学会学術総会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characterization of mammalian and bacterial siderophores2007

    • Author(s)
      K., Mori, et. al.
    • Organizer
      BioIron
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Forest fire theory for renal failure and clinical impact of neutrophil gelatinase-associated lipocalin2007

    • Author(s)
      K., Mori, et. al.
    • Organizer
      World Congress of Nepbrology (ISN)
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Blood and urinary neutrophil gelatinase-associated lipocalin (Ngal) levels in the treatment courses of proteinuric glomerular diseases2007

    • Author(s)
      K., Mori, et. al.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Francisco, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Forest Fire Theory for Renal Failure and Clinical Impact of Neutrophil Gelatinase-Associated Lipocalin2007

    • Author(s)
      Mori K, Mukoyama M, et. al.
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規腎不全診断薬、治療薬としてのNeutrophil gelatinase-associated lipocalinの意義2006

    • Author(s)
      森 潔, ほか
    • Organizer
      日本内科学会総会講演会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] mammalian siderophoreの測定法の開発及びsiderophore-binding proteinの病態生理的意義の解明2006

    • Author(s)
      森 潔, ほか
    • Organizer
      日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 哺乳類における鉄結合性小化合物mammalian siderophoreの分析2006

    • Author(s)
      森 潔, ほか
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 急性腎不全における尿中neutrophil gelatinase-associated lipocalin(Nga1)測定の意義2006

    • Author(s)
      森 潔, ほか
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mammalian及びBacterial Siderophoreの性状2006

    • Author(s)
      森 潔, ほか
    • Organizer
      日本鉄バイオサイエンス学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ngalについて2006

    • Author(s)
      森 潔, ほか
    • Organizer
      日本腎臓学会西部学術大会
    • Place of Presentation
      熊本
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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