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Clarification of the involvement of angiogenesis-associated factors in chronic kidney disease and the development of novel therapeutic approaches

Research Project

Project/Area Number 18590889
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionOkayama University

Principal Investigator

MAESHIMA Yohei  Okayama University, University Hospital of Medicine and Dentistry, Senior Assistant Professor (10343287)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,950,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsChronic Kidney Disease / Diabetic nephropathy / angmeenesis / peritoneal sclerosis / Peritoneal Dialysis / endostatin / NM-3 / Vasohibin-1 / 糖尿病腎症 / VEGF / アデノウィルスベクター / endostatin peptide / angiopoietin-2 / vasohibin
Research Abstract

In Japan, the population of Chronic Kidney Disease is estimated as 19. million, facilitating the recognition of CKD as a common disorder. Chronic kidney disease is a risk factor for developing end-stage renal failure and cardiovascular disorders, requiring appropriate preventive management from the early stage. The number of patients requiring dialysis therapies such as hemodialysis or peritoneal dialysis due to end-stage renal failure is increasing, and the main cause of renal failure is diabetic nephropathy. On the other hand, continuous peritoneal dialysis for long-term leads to peritoneal dysfunction, and peritoneal sclerosis. Angiogenesis and vascular dysregulation are considered as potential mechanisms for the development of-peritoneal sclerosis.
We recently reported the therapeutic efficacies of anti-angiogenic tumstatin peptide and endostatin peptide in ameliorating the progression of diabetic nephropathy. Vasohibin is an endothelium-derived negative feedback regulator of angiogenesis, synthesized upon stimulation by VEGF. NM-3 is an orally available compound with the anti-angiogenic as well as anti-tumor effects.
In the present study, we observed the suppressive effects of NM-3 on early diabetic nephropathy in the db/db type 2 diabetse mouse model. NM-3 suppressed high glucose-induced production of VEGF and TGF-beta in mesangial cells, and of VEGF in podocytes.
In chlorhexidine gluconate-induced peritoneal sclerosis mouse model, treatment by endostatin peptide via subcutaneous infusion through osmotic minipumps lead to the inhibition of peritoneal fibrosis.
Treatment with adenoviral vector encoding vasohibin-1 resulted in the amelioration of early diabetic nephropathy in type 1 and 2 diabetes mouse model. Intraperitoneal overexpression of vasohibin-1 lead to the suppression of peritoneal sclerosis.
These results suggested the potential usefulness of anti-angiogenic therapies in patients with chronic kidney disease.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (79 results)

All 2008 2007 2006

All Journal Article (22 results) (of which Peer Reviewed: 8 results) Presentation (50 results) Book (5 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Amelioration of cisplatin-induced acute renal injury by renal progenitor-like cells derived from the adult rat kidney2008

    • Author(s)
      Kinomura M
    • Journal Title

      Cell Transplantation 17(In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Type IV collagen alpha6 chain-derived non-collagenous domain 1(alpha6(IV)NC1) inhibits angiogenesis and tumor growth2008

    • Author(s)
      Mundel TM
    • Journal Title

      Int J Cancer 122

      Pages: 1738-1744

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Amelioration of cisplatin-induced acute renal injury, by renal progenitor-like cells derived from the adult rat kidney2008

    • Author(s)
      Kinomura, M
    • Journal Title

      Cell Transplant (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] type IV collagen alpha6 chain-derived non-collagenous domain linhibits angiogenesis and tumor growth2008

    • Author(s)
      Mundel, TM
    • Journal Title

      Int J Cancer 122

      Pages: 1738-1744

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Endostatin peptide, an inhibitor of angiogenesis, prevents the progression of peritoneal sclerosis in a mouse experimental model2008

    • Author(s)
      Tanabe, K
    • Journal Title

      Kidney Int 71

      Pages: 227-238

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Amelioration of cisplatin-induced acute renal injury by renal progenitor-like cells derived from the adult rat kidney2008

    • Author(s)
      Kinomura M
    • Journal Title

      Cell Transplantation 17(in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type IV collagen alpha6 chain-derived non-collagenous domain 1 (alpha6 (IV) NC1) inhibits angiogenesis and tumor growth2008

    • Author(s)
      Mundel TM
    • Journal Title

      Int J Cancer 122

      Pages: 1738-1744

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated serum sFlt-1/Ang-2 ratio in women with preeclampsia2007

    • Author(s)
      Hirokoshi K
    • Journal Title

      Nephron Clin Pract 106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Endostatin peptide, an inhibitor of angiogenesis, prevents the progression of peritoneal sclerosis in a mouse experimental model2007

    • Author(s)
      Tanabe K
    • Journal Title

      Kidney Int 71

      Pages: 227-238

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Elevated serum sFlt-1/Ang-2 ratio in women with preeclampsia2007

    • Author(s)
      Hirokoshi, K
    • Journal Title

      Nephron Clin Pract 106

      Pages: 43-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 2-(8-Hydroxy-6-Methoxy-1-Oxo-1H-2-Benzopyran-3-yl) Propionic Acid, an Inhibitor of Angiogenesis, Ameliorates Renal Alterations Renal Alterations in Obese Type 2 Diabetic Mice2006

    • Author(s)
      Ichinose K
    • Journal Title

      Diabetes 55

      Pages: 1232-1242

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regulation of angiogenic factors in Angiotensin-II infusion model in association with tubulointerstitial injuries2006

    • Author(s)
      Kitayama H
    • Journal Title

      AmJ Hypertens 19

      Pages: 718-727

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Good response of membranous lupus nephritis to tacrolimus.2006

    • Author(s)
      Maruyama M
    • Journal Title

      Clinical Nephrology 65(4)

      Pages: 276-279

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] Altered levels of adipocytokines in association with insulin resistance in patients with systemic lupus erythematosus.2006

    • Author(s)
      Sada KE
    • Journal Title

      Journal of Rheumatology 33(8)

      Pages: 1545-1552

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] Steroid pulse therapy impaired endothelial function while increasing plasma high molecule adiponectin concentration in patients with IgA nephropathy.2006

    • Author(s)
      Uchida HA
    • Journal Title

      Nephrology Dialysis Transplantation 21(12)

      Pages: 3475-3480

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] 2(8-Hydroxy-6-Methoxy-1-Oxo-1H-2- Benzopyran-3-yl) Propionic Acid, an Inhibitor of Angiogenesis, Ameliorates Renal Alterations in Obese Type 2 Diabetic Mice2006

    • Author(s)
      Ichinose, K
    • Journal Title

      Diabetes 55

      Pages: 1232-1242

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Regulation of angiogenic factors in Angiotensin-II infusion model in association with tubulointerstitial injuries2006

    • Author(s)
      Kitayama, H
    • Journal Title

      Am J Hypertens 19

      Pages: 718-727

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Good response of membranous lupus nephritis totacrolimus2006

    • Author(s)
      Maruyama, M
    • Journal Title

      Clin Nephrol 65

      Pages: 276-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Altered levels of adipocytokines in association with insulin resistance in patients with systemic lupus erythematosus2006

    • Author(s)
      Sada, KE
    • Journal Title

      J Rheumatol 33

      Pages: 1545-1552

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Steroid pulse therapy impaired endothelial function while increasing plasma high molecule adiponectin concentration in patients with IgA nephropathy2006

    • Author(s)
      Uchida, HA
    • Journal Title

      Nephrol Dial Transplant 21

      Pages: 3475-3480

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 2-(8-Hydroxy-6-Methoxy-1-Oxo-1H-2-Benzopyran-3-yl) Propionic Acid, an Inhibitor of Angiogenesis, Ameliorates Renal Alterations in Obese Type 2 Diabetic Mice.2006

    • Author(s)
      Ichinose K
    • Journal Title

      Diabetes 55

      Pages: 1232-1242

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of angiogenic factors in Angiotensin-II infusion model in association with tubulointerstitial injuries.2006

    • Author(s)
      Kitayama H
    • Journal Title

      American Journal of Hypertension 19

      Pages: 718-727

    • Related Report
      2006 Annual Research Report
  • [Presentation] 血管新生抑制因子vasohibinによる腹膜硬化症抑制効果の検討2007

    • Author(s)
      田邊 克幸
    • Organizer
      第13回日本腹膜透析研究会大会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2007-11-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel therapeutic approach to inhibit the progression of experimental peritoneal sclerosis by an endothelium-derived angiogenesis inhibitor vasohibin2007

    • Author(s)
      Tanabe, K
    • Organizer
      The 13th Japanese Society of peritoneal dialysis research
    • Place of Presentation
      Hiroshima
    • Year and Date
      2007-11-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 血管新生抑制因子vasohibinによる腹膜硬化症抑制効果の検討2007

    • Author(s)
      田邊 克幸
    • Organizer
      第13回日本腹膜透析研究会大会
    • Place of Presentation
      広島市
    • Year and Date
      2007-11-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] A novel therapeutic approach to inhibit the progression of experimental peritoneal sclerosis by an endothelium-derived angiogenesis inhibitor vasohibin.2007

    • Author(s)
      田邊 克幸
    • Organizer
      2007年米国腎臓学会年次総会
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2007-11-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel immunosuppressant FTY720 ameliorates tubulointerstitial injuries in the mouse unilateral ureteral obstruction model.2007

    • Author(s)
      広越 久美子
    • Organizer
      2007年米国腎臓学会年次総会
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2007-11-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel therapeutic approach to inhibit the progression of early diabetic nephropathy by an endothelium-derived angiogenesis inhibitor vasohibin.2007

    • Author(s)
      那須 達世
    • Organizer
      2007年米国腎臓学会年次総会
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2007-11-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel therapeutic approach to inhibit the progression of experimental peritoneal sclerosis by an endothelium-derived angiogenesis inhibitor vasohibin2007

    • Author(s)
      Tanabe, K
    • Organizer
      Renal Week 2007, Annual meeting of the American Society of Nephrology
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-11-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel immunosuppressant FTY720 ameliorates tubulointerstitial injuries in the mouse unilateral ureteral obstruction model2007

    • Author(s)
      Hirokoshi, K
    • Organizer
      Renal Week 2007, Annual meeting of the American Society of Nephrology
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-11-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel therapeutic approach to inhibit the progression of early diabetic nephropathy by an endothelium-derived angiogenesis inhibitor vasohibin2007

    • Author(s)
      Nasu, T
    • Organizer
      Renal Week 2007, Annual meeting of the American Society of Nephrology
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-11-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel therapeutic approach to inhibit the progression of experimental peritoneal sclerosis by an endothelium-derived angiogenesis inhibitor vasohibin2007

    • Author(s)
      田邊 克幸
    • Organizer
      2007年米国腎臓学会年次総会
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] A novel immunosuppressant FTY720 ameliorates tubulointerstitial injuries in the mouse unilateral ureteral obstruction model2007

    • Author(s)
      広越 久美子
    • Organizer
      2007年米国腎臓学会年次総会
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] A novel therapeutic approach to inhibit the progression of early diabetic nephropathy by an endothelium-derived angiogenesis inhibitor vasohibin2007

    • Author(s)
      那須 達世
    • Organizer
      2007年米国腎臓学会年次総会
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血管新生抑制因子vasohibinによる腹膜硬化症抑制効果の検討2007

    • Author(s)
      田邊 克幸
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新規免疫抑制剤FTY720による腎尿細管間質障害モデルにおけ治療効果の検討2007

    • Author(s)
      広越 久美子
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] IgA腎症患者の扁桃における糖転移酵素遺伝子発現の解析2007

    • Author(s)
      井上 達之
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 血管新生抑制因子vasohibinによる糖尿病腎症進展抑制効果の検討2007

    • Author(s)
      那須 達世
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] IgA腎症に対する扁桃摘出術・ステロイドパルス療法の尿所見寛解への影響を及ぼす因子の検討2007

    • Author(s)
      井上 達之
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 慢性腎臓病における血清シスタチンC濃度と従来からの腎機能評価法との比較2007

    • Author(s)
      小林 みずほ
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel therapeutic approach to inhibit the progression of experimental peritoneal sclerosis by an endothelium-derived angiogenesis inhibitor vasohibin2007

    • Author(s)
      Tanabe, K
    • Organizer
      The 50th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel immunosuppressant FTY720 ameliorates tubulointerstitial injuries in the mouse unilateral ureteral obstruction model2007

    • Author(s)
      Hirokoshi, K
    • Organizer
      The 50th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of galactosyl-transferase genes in tonsils of patients with IgA nephropathy2007

    • Author(s)
      Inoue, T
    • Organizer
      The 50th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel therapeutic approach to inhibit the progression of early diabetic nephropathy by an endothelium-derived angiogenesis inhibitor vasohibin2007

    • Author(s)
      Nasu, T
    • Organizer
      The 50th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of factors involved in remission by tonsillectomy and steroid-pulse therapy in IgA nephropathy2007

    • Author(s)
      Inoue, T
    • Organizer
      The 50th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Comparison between cystatin C and conventional parameters of renal function in CKD2007

    • Author(s)
      Kobayashi, M
    • Organizer
      The 50th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 血管新生抑制因子vasohibinによる腹膜硬化症抑制効果の検討2007

    • Author(s)
      田邊 克幸
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      浜松市
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規免疫抑制剤FTY720による腎尿細管間質障害モデルにおけ治療効果の検討2007

    • Author(s)
      広越 久美子
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      浜松市
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] lgA腎症患者の扁桃における糖転移酵素遺伝子発現の解析2007

    • Author(s)
      井上 達之
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      浜松市
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血管新生抑制因子vasohibinによる糖尿病腎症進展抑制効果の検討2007

    • Author(s)
      那須 達世
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      浜松市
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] lgA腎症に対する扁桃摘出術・ステロイドパルス療法の尿所見寛解への影響を及ぼす因子の検討2007

    • Author(s)
      井上 達之
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      浜松市
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 慢性腎臓病における血清シスタチンC濃度と従来からの腎機能評価法との比較2007

    • Author(s)
      小林 みずほ
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      浜松市
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Antiangiogenic endostatin peptide prevents the progression of experimental peritoneal sclerosis.2006

    • Author(s)
      田邊 克幸
    • Organizer
      2006年米国腎臓学会年次総会
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Amelioration of cisplatin-induced acute renal tubular injury by intrarenal injection of rat renal progenitor-like cells.2006

    • Author(s)
      木野村 賢
    • Organizer
      2006年米国腎臓学会年次総会
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adenoviral delivery of angiopoietin-1 ameliorates tubulointerstitial injuries in the mouse unilateral ureteral obstruction model.2006

    • Author(s)
      高沢 有紀
    • Organizer
      2006年米国腎臓学会年次総会
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Down-regulation of beta1,3-galactosyltransferase gene in tonsillar Bcells and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy.2006

    • Author(s)
      井上 達之
    • Organizer
      2006年米国腎臓学会年次総会
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adenoviral delivery of angiopoietin-1 ameliorates tubulointerstitial injuries in the mouse unilateral urethral obstruction model2006

    • Author(s)
      Takazawa, Y
    • Organizer
      Renal Week 2006, Annual meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Down-regulation of betal,3-galactosyl - transferase gene in tonsillar B cells and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy2006

    • Author(s)
      Inoue, T
    • Organizer
      Renal Week 2006, Annual meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Amelioration of cisplatin-induced acute renal tubular injury by intrarenal injection of rat renal progenitor-like cells2006

    • Author(s)
      Kinomura, M
    • Organizer
      Renal Week 2006, Annual meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Antiangiogenic endostatin peptide prevents the progression of experimental peritoneal sclerosis2006

    • Author(s)
      Tanabe, K
    • Organizer
      Renal Week 2006, Annual meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] シンポジウム:糖尿病性腎症の基礎的知見の進歩:血管新生抑制因子による糖尿病性腎症進展制御2006

    • Author(s)
      前島 洋平
    • Organizer
      第49回日本腎臓学会学術総会
    • Place of Presentation
      東京都(京王プラザホテル)
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 血管新生抑制因子endostatin peptideによる腹膜硬化症抑制効果の検討2006

    • Author(s)
      田邊 克幸
    • Organizer
      第49回日本腎臓学会学術総会
    • Place of Presentation
      東京都(京王プラザホテル)
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 妊娠高血圧症候群における血清sFlt-1/アンジオポエチン-2比の検討2006

    • Author(s)
      広越 久美子
    • Organizer
      第49回日本腎臓学会学術総会
    • Place of Presentation
      東京都(京王プラザホテル)
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アデノウィルスを用いたangiopoietin-1遺伝子治療による尿細管間質病変制御効果の検討2006

    • Author(s)
      高沢 有紀
    • Organizer
      第49回日本腎臓学会学術総会
    • Place of Presentation
      東京都(京王プラザホテル)
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] NM-3による糖尿病腎症進展抑制機序の検討2006

    • Author(s)
      一瀬 邦弘
    • Organizer
      第49回日本腎臓学会学術総会
    • Place of Presentation
      東京都(京王プラザホテル)
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] シスプラチン誘導急性腎不全モデルにおけるラット腎幹/前駆細胞(rKS56)治療効果の検討2006

    • Author(s)
      木野村 賢
    • Organizer
      第49回日本腎臓学会学術総会
    • Place of Presentation
      東京都(京王プラザホテル)
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of diabetic nephropathy by anti-angiogenic factors (Symposium)2006

    • Author(s)
      Maeshima, Y
    • Organizer
      The 49th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Antiangiogenic endostatin peptide prevents the progression of experimental peritoneal sclerosis2006

    • Author(s)
      Tanabe, K
    • Organizer
      The 49th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of serum levels of sFlt-1/Angiopoietin-2 ratio in pregnancy induced hypertension2006

    • Author(s)
      Hirokoshi, K
    • Organizer
      The 49th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adenoviral delivery of angiopoietin-I ameliorates tubulointerstitial injuries in the mouse unilateral ureteral obstruction model2006

    • Author(s)
      Takazawa, Y
    • Organizer
      The 49th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of the mechanisms of suppression of diabetic nephropathy by NM-32006

    • Author(s)
      Ichinose, K
    • Organizer
      The 49th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Amelioration of cisplatin-induced acute renal tubular injury by intrarenal injection of rat renal progenitor-like cells2006

    • Author(s)
      Kinomura, M
    • Organizer
      The 49th Annual meeting of the Japanese Society of Nephrology
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 糖尿病性腎症 基礎と臨床の最前線.血管新生抑制による治療2007

    • Author(s)
      前島洋平
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 糖尿病性腎症 基礎と臨床の最前線.血管新生抑制による治療2007

    • Author(s)
      前島 洋平
    • Publisher
      中外医学社
    • Related Report
      2007 Annual Research Report
  • [Book] 分子糖尿病学の進歩2006 基礎から臨床まで.腎症進展における糸球体上皮細胞障害の意義2006

    • Author(s)
      前島洋平
    • Publisher
      金原出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Book] In "Apoptpsis, Cell Signaling, and Human Diseases" . Angiogenesis and Cancer.2006

    • Author(s)
      Maeshima Y
    • Publisher
      Humana Press
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] In "Apoptpsis,Cell Signaling, and Human Diseases". Angiogenesis and Cancer.2006

    • Author(s)
      Maeshima Y
    • Publisher
      Humana Press
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] バゾヒビンからなる糖尿病性腎症治療剤2007

    • Inventor(s)
      前島洋平
    • Industrial Property Rights Holder
      前島洋平
    • Industrial Property Number
      2007-089122
    • Filing Date
      2007-03-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] バゾヒビンからなる腹膜硬化症治療剤2007

    • Inventor(s)
      前島洋平
    • Industrial Property Rights Holder
      前島洋平
    • Industrial Property Number
      2007-089123
    • Filing Date
      2007-03-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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