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Effects of adiponectin for diabetic nephropathy

Research Project

Project/Area Number 18590896
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionFukushima Medical University

Principal Investigator

SATOH Hiroaki  Fukushima Medical University, School of Medicine, Assistant Professor (20323595)

Co-Investigator(Kenkyū-buntansha) WATANABE Tsuyoshi  Fukushima Medical University, School of Medicine, Professor (80158641)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,810,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsDiabetic Nephropathy / Adiponectin / Resistin / アディポカイン
Research Abstract

In this study, we investigated whether adiponectin would inhibit the progression of diabetic nephropathy in vitro and in vivo. The mesangial cell proliferation appears to play an early and pivotal role in the pathogenesis of progressive glomerular injury. Therefore, we first demonstrated the adiponectin inhibited resistin-induced DNA synthesis as measured by [3H]-thymidine incorporation on rat cultured mesangial cells. Consistent with the thymidine incorporation data, adiponectin diminished the resistin induced phosphorylation of MAPK.
Next, we investigated the effect of adiponectin on diabetic nephropathy in experimental diabetic rats by overexpression the adipinectin protein using intravenous administration of an adenovirus (Ad-Adipo). Male Wistar rats,. 6-week-old, were used. Diabetic rat was induced by intraperitoneal injection of streptozotocin (STZ) (80 mg/kg) in citrate buffer (pH 4.5). At 10 weeks after the STZ injection, Ad-lacZ or Ad-Adipo was injected intravenous. The effects of adiponectin on urinary protein excretion were observed after 3 weeks post Ad injection. Body weight, plasma fasting glucose levels, plasma fasting insulin levels, total cholesterol levels, HDL-cholesterol levels, and plasma creatinine levels are no difference between two groups, whereas and urinary protein/creatinine exertion ratio levels were significantly determined by 25%.
In kidney, TGF-a mRNA expression was significantly decreased in the Ad-Adipo rats compared with Ad-lacZ rats, whereas collagen type I and IV mRNA expression were no difference between two groups. In addition, nehrin mRNA expression in kidney was significantly increased in the Ad-Adipo rats. Interestingly, iNOS, ET-1, and PAI-1 mRNA expression were significantly increased, whereas eNOS mRNA expression was in kidney with the ad-Adipo rats compared with Ad-lacZ rats.
These results suggest a role of adiponectin in the prevention of diabetic nephropathy and show that adiponectin is a potential therapeutic strategy.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (13 results)

All 2008 2007 2006

All Journal Article (3 results) Presentation (10 results)

  • [Journal Article] レジスチンの培養メサンギウム細胞における影響についての検討2007

    • Author(s)
      平井 裕之, 佐藤 博亮, 中牧 慎太郎, 工藤 明宏, 長谷川 浩司, 藤原 淳, 中嶋 真一, 渡辺 毅
    • Journal Title

      Therapeutic Research 28

      Pages: 1896-1896

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of resistin in rat mesangial cells2007

    • Author(s)
      Hiroyuki, Hirai, Hiroaki, Satoh, Shintaro, Nakamaki, Akihiro, Kudoh, Koji, Hasegawa, Makoto, Fujiwara, Shinichi, Nakajima, Tsuyoshi, Watanabe
    • Journal Title

      Therapeutic Research 28

      Pages: 1896-1896

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] レジスチンの培養メサンギウム細胞における影響についての検討2007

    • Author(s)
      平井裕之, 佐藤博亮, 中牧慎太郎, 工藤明宏, 長谷川浩司, 藤原淳, 中嶋真一, 渡辺毅
    • Journal Title

      Therapeutic Research 28巻10号

      Pages: 1896-1896

    • Related Report
      2007 Annual Research Report
  • [Presentation] Pioglitazone Increases Insulin Sensitivity via the Upregulation of AdipoR2 in 3T3-L1 Adipocytes.(1278-P)2008

    • Author(s)
      Akihiro Kudo, Hiroaki Sato, Hiroyuki Hirai, Shintaroh Nakamaki, Koji Hasegawa, Makoto Fujiwara, Ryo Muraoka, Miyuki Honma, Shinichi Nakjima, Shigeatsu Hashimoto, Sanae Midorikawa, Tsuyoshi Watanabe
    • Organizer
      68th American Diabetes Association Scientific Sessions
    • Place of Presentation
      San Francisco,CA.,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The Interaction between Resistin and Adiponectin on Rat Vascular Smooth Muscle Cells Proliferation.(703-P)2008

    • Author(s)
      Hiroyuki Hirai, Hiroaki Satoh, Akihiro Kudoh, Shintaroh Nakamaki, Koji Hasegawa, Makoto Fujiwara, Ryo Muraoka, Miyuki Honma, Shinichi Nakajima, Shigeatsu Hashimoto, Sanae Midorikawa, Tsuyoshi Watanabe
    • Organizer
      68th American Diabetes Association Scientific Sessions
    • Place of Presentation
      San Francisco,CA.,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pioglitazone Increases Insulin Sensitivity via the Upregulation of AdipoR2 in 3T3-L1 Adipocytes. (1278-P)2008

    • Author(s)
      Akihiro, Kudo, Hiroaki, Sato, Hiroyuki, Hirai, Shintaroh, Nakamaki, Koji, Hasegawa, Makoto, Fujiwara, Ryo, Muraoka, Miyuki, Honma, Shinichi, Nakajima, Shigeatsu, Hashimoto, Sanae, Midorikawa, Tsuyoshi, Watanabe
    • Organizer
      68th American Diabetes Association Scientific Sessions.
    • Place of Presentation
      San Francisco, CA., USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The Interaction between Resistin and Adiponectin on Rat Vascular Smooth Muscle Cells Proliferation. (703-P)2008

    • Author(s)
      Hiroyuki, Hirai, Hiroaki, Satoh, Akihiro, Kudoh, Shintaroh, Nakamaki, Koji, Hasegawa, Makoto, Fujiwara, Ryo, Muraoka, Miyuki, Honma, Shinichi, Nakajima, Shigeatsu, Hashimoto, Sanae, Midorikawa, Tsuyoshi, Watanabe
    • Organizer
      68th American Diabetes Association Scientific Sessions.
    • Place of Presentation
      San Francisco, CA., USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Yacon Diet Improves Hepatic Insulin Sensitivity via Reduction of TRB3 Expression in Zucker fa/fa Rats.(1528-P)2007

    • Author(s)
      Hiroahi Satoh, Akihiro Kudoh, Hiroyuki Hirai, Makoto Fujiwara, Koji Hasegawa, Shinichi Nakajima, Shintaro Nakamaki, Tsuyoshi Watanabe
    • Organizer
      67th American Diabetes Association Scientific Sessions
    • Place of Presentation
      Chicago,IL,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Yacon Diet Improves Hepatic Insulin Sensitivity via Reduction of TRB3 Expression in Zucker fa/fa Rats. (1528-P)2007

    • Author(s)
      Hiroaki, Satoh, Akihiro, Kudoh, Hiroyuki, Hirai, Makoto, Fujiwara, Koji, Hasegawa, Shinichi, Nakajima, Shintaro, Nakamaki, Tsuyoshi, Watanabe
    • Organizer
      67th American Diabetes Association Scientific Sessions
    • Place of Presentation
      in Chicago, IL., USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adiponectin Improves Free-Fatty Acid-Induced Insulin Resistance in Estrogen-Deficient, Insulin Resistant Female Wistar Rats.(1466-P)2006

    • Author(s)
      Himaki Satoh, MT Audrey Nguyen, Tsuyosbi Watanabe, Jerrold M Olefsky
    • Organizer
      66th Alnehcan Diabetes Association Scientific Sessions
    • Place of Presentation
      Washington,D.C,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The Interaction among Resistin, TNF-alpha, and Adiponectin on Glucose Transport in 3T3-L1 Adipocytes.(31-LB)2006

    • Author(s)
      Akihiro Kudoh, Hiroaki Satoh, Hiroyuki Hirai, Koji Hasegawa, Makoto Fujiwara, Shinichi Nakajima, Tsuyoshi Watanabe
    • Organizer
      66th American Diabetes Association Scientific Sessions
    • Place of Presentation
      Washington D.C,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adiponectin Improves Free-Fatty Acid-Induced Insulin Resistance in Estrogen-Deficient, Insulin Resistant Female Wistar Rats. (1466-P)2006

    • Author(s)
      Hiroaki, Satoh, MT, Audrey, Nguyen, Tsuyoshi, Watanabe, Jerrold, M., Olefsky
    • Organizer
      66th American Diabetes Association Scientific Sessions.
    • Place of Presentation
      in Washington, D.C., USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The Interaction among Resistin, TNF-alpha, and Adiponectin on Glucose Transport in 3T3-L1 Adipocytes. (31-LB)2006

    • Author(s)
      Akihiro, Kudoh, Hiroaki, Satoh, Hiroyuki, Hirai, Koji, Hasegawa, Makoto, Fujiwara, Shinichi, Nakajima, Tsuyoshi, Watanabe
    • Organizer
      66th American Diabetes Association Scientific Sessions.
    • Place of Presentation
      in Washington, D.C., USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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