Analysis of the mechanism underlying hypoxic response and application of vascular regenerative medicine in kidney disease

• Project/Area Number: 18590912
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Jikei University School of Medicine
• Principal Investigator: UTSUNOMIYA Yasunori Jikei University School of Medicine, 医学部, 准教授 (70231181)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,570,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥570,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 低酸素 / 血管新生 / 再生医療 / 血管内皮増殖因子 / 腎間質 / 慢性腎臓病 / IgA腎症 / 腎血管病変 / 腎予後 / 小葉間動脈病変 / 輸入細動脈病変 / 糖尿病性腎症 / 血管内皮細胞 / 形質転換 / メサンギウム / G-CSF / 骨髄血管内皮前駆細胞 / 糖尿病性網膜症

Research Abstract

慢性糸球体腎炎、高血圧、および糖尿病の腎障害の進展には血管病変に基づく尿細管間質内の低酸素が重要と考えられている。今回の検討結果で、腎臓内では腎障害が進行する過程で、さまざまな血管障害を促進する因子と防御する因子が産生され、そのバランスが重要であることが示された。また、血管内皮細胞は障害早期から形質の変換を起こし、その発症には加齢や高血圧が重要な役割を果たしていることが明らかになった。現在、慢性腎臓病における血管再生をターゲットとした新たな治療法の開発について基礎研究を継続している。

Research Products

• [Journal Article] Changes in the glomerular density and size in serial renal biopsies during the progression of IgA nephropathy. (2009)
  • Author(s): Tsuboi N, Kawamura T, Utsunomiya Y, et al.
  • Journal Title: Nephrol Dial Transplant 24 Pages: 892-99
  • Peer Reviewed
• [Journal Article] A case of glomerulopathy showing podocytic infolding in association with Sjoren's syndrome and primary biliary cirrhosis (2008)
  • Author(s): Koike K, Utsunomiya Y, Ito Y, et.al.
  • Journal Title: Clin Exp Nephrol 12 Pages: 489-93
  • Peer Reviewed
• [Journal Article] Bmp in podocytes is essential for normal glomerular capillary formation (2008)
  • Author(s): Ueda H, Miyazaki Y, Utsunomiya Y, et.al.(4)
  • Journal Title: J Am Soc Nephrol 19 Pages: 685-94
  • Peer Reviewed
• [Journal Article] Malakoplakia of the kidney (2008)
  • Author(s): Kobayashi A, Utsunomiya Y, Kono M, et.al.
  • Journal Title: Am J Kidney Dis 51 Pages: 326-30
  • Peer Reviewed
• [Journal Article] T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy (2008)
  • Author(s): Sugano N, Wakino S, Utsunomiya Y, et.al. (13)
  • Journal Title: Kidney Int 73 Pages: 826-34
  • Peer Reviewed
• [Journal Article] Proposal of podocytic infolding glomerulopathy as a new disease entity : a review of 25 cases from nationwide reseach in Japan. (2008)
  • Author(s): Joh K, Taguchi T, Utsunomiya Y, et al.
  • Journal Title: Clin Exp Nephrol 12 Pages: 421-31
  • Peer Reviewed
• [Journal Article] Bmp in podocytes is essential for normal glomerular capillary formation. (2008)
  • Author(s): Ueda H, Miyazaki Y, Utsunomiya Y, et. al.
  • Journal Title: J Am Soc Nephrol 19 Pages: 685-94
  • Peer Reviewed
• [Journal Article] T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy. (2008)
  • Author(s): Sugano N, Utsunonliya Y, Hayashi K, et. al.
  • Journal Title: Kidney Int 73 Pages: 826-34
  • Peer Reviewed
• [Journal Article] In vitro and pathological investigations of MODY5 with the R276X-HNF1beta(TCF2) mutation (2007)
  • Author(s): Fujimoto K, Sasaki T, Utsunomiya Y, et.al. (8)
  • Journal Title: Endocr J 54 Pages: 757-64
  • NAID: 130004443314
  • Peer Reviewed
• [Journal Article] Histological investigation of renal pathological changes in MPO-ANCA-related nephritis using repeated renal biopsies (2007)
  • Author(s): Komeda M, Yamaguchi Y, Utsunomiya Y, et.al.(4)
  • Journal Title: Nippon Jinzo Gakkai Shi 49 Pages: 438-45
  • NAID: 10019732058
  • Peer Reviewed
• [Journal Article] Prospective trial of combined therapy with heparin/warfarin and rennin-angiotensin system inhibitors in progressive of IgA nephropathy (2007)
  • Author(s): Ishii T, Kawamura T, Utsunomiya Y, et.al. (3)
  • Journal Title: Contrib Nephrol 157 Pages: 114-9
• [Journal Article] Xenobiotic kidney organogenesis from human mesenchymal stem cells using a growing rodent embryo (2006)
  • Author(s): Yokoo T, Fukui A, Utsunomiya Y, et.al.(6)
  • Journal Title: J Am Soc Nephrol 17 Pages: 1026-34
  • Peer Reviewed
• [Journal Article] Gene therapy for kidney disease : Inflamed site-specific transgenesis using a stem cell (2006)
  • Author(s): Koike K, Utsunomiya Y
  • Journal Title: Nippon Rinsho 64 Pages: 667-71
• [Journal Article] Inhibition of endogenous BMP in the glomerulus leads to mesangial matrix expansion (2006)
  • Author(s): Miyazaki Y, Ueda H, Utsunomiya Y, et.al.(5)
  • Journal Title: Biochem Biophys Res Commun 340 Pages: 681-8
  • Peer Reviewed
• [Journal Article] ANCA関連血管炎を合併した糖尿病性腎症の一例 (2006)
  • Author(s): 徳留さとり, 宇都宮保典, ほか。
  • Journal Title: 腎と透析 61・5 Pages: 725-35
• [Journal Article] Secondary focal segmental glomerulosclerosis following kidney transplantation in a patient with type I diabetes mellitus. (2006)
  • Author(s): Yamamoto I, Utsunomiya Y, et al.
  • Journal Title: Clin Transplant 20・15 Pages: 7-10
• [Journal Article] Xenobiotic kidney organogenesis from human mesenchymal stem cells using a growing rodent embryo. (2006)
  • Author(s): Tokoo T, Utsunomiya Y, et al.
  • Journal Title: J Am Soc Nephrol 17・4 Pages: 1026-34
• [Journal Article] Gene therapy for kidney disease : Inflamed site-specific transgenesis using a stem cell. (2006)
  • Author(s): Koike K, Utsunomiya Y.
  • Journal Title: Nippon Rinsho 64・2 Pages: 667-71
• [Presentation] メタボリック症候群による腎障害の機序と対策 (2008)
  • Author(s): 宇都宮保典ら.
  • Organizer: 第51回日本腎臓学会学術総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-06-01
• [Presentation] 糖尿病によるネフローゼ症候群の成因と治療 (2008)
  • Author(s): 宇都宮保典. オーバービュー
  • Organizer: 第38回日本腎臓学会東部学術大会
  • Place of Presentation: 東京
• [Presentation] シンポジウム : メタボリックシンドロームによる腎障害の機序と対策 (2008)
  • Author(s): 宇都宮保典, ら
  • Organizer: 第51回日本腎臓学会学術総会
  • Place of Presentation: 福岡
• [Presentation] Clinical impact of endogenous G-CSF in the progression of diabetic nephropathy. (2007)
  • Author(s): Utsunomiya Y, et. al.
  • Organizer: 2007年米国腎臓学会
  • Place of Presentation: 米国サンフランシスコ
  • Year and Date: 2007-11-03
• [Presentation] Clinical impact of endogenous granulocyte colony-stimulating factor (G-CSF) in the progression of diabetic nephropathy (2007)
  • Author(s): Utsunomiya Y, Tokudome S, Ito H, et.al.
  • Organizer: 40^<th> Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] ワークショップ : IgA腎症の基礎的・臨床的問題点の整理 ; 腎組織所見と予後との関連-予後分類の改訂に向けて (2007)
  • Author(s): 宇都宮保典, ら
  • Organizer: 第37回日本腎臓学会東部学術大会
  • Place of Presentation: 大宮