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Analysis of the mechanism underlying hypoxic response and application of vascular regenerative medicine in kidney disease

Research Project

Project/Area Number 18590912
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionJikei University School of Medicine

Principal Investigator

UTSUNOMIYA Yasunori  Jikei University School of Medicine, 医学部, 准教授 (70231181)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,570,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords低酸素 / 血管新生 / 再生医療 / 血管内皮増殖因子 / 腎間質 / 慢性腎臓病 / IgA腎症 / 腎血管病変 / 腎予後 / 小葉間動脈病変 / 輸入細動脈病変 / 糖尿病性腎症 / 血管内皮細胞 / 形質転換 / メサンギウム / G-CSF / 骨髄血管内皮前駆細胞 / 糖尿病性網膜症
Research Abstract

慢性糸球体腎炎、高血圧、および糖尿病の腎障害の進展には血管病変に基づく尿細管間質内の低酸素が重要と考えられている。今回の検討結果で、腎臓内では腎障害が進行する過程で、さまざまな血管障害を促進する因子と防御する因子が産生され、そのバランスが重要であることが示された。また、血管内皮細胞は障害早期から形質の変換を起こし、その発症には加齢や高血圧が重要な役割を果たしていることが明らかになった。現在、慢性腎臓病における血管再生をターゲットとした新たな治療法の開発について基礎研究を継続している。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (24 results)

All 2009 2008 2007 2006

All Journal Article (18 results) (of which Peer Reviewed: 12 results) Presentation (6 results)

  • [Journal Article] Changes in the glomerular density and size in serial renal biopsies during the progression of IgA nephropathy.2009

    • Author(s)
      Tsuboi N, Kawamura T, Utsunomiya Y, et al.
    • Journal Title

      Nephrol Dial Transplant 24

      Pages: 892-99

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of glomerulopathy showing podocytic infolding in association with Sjoren's syndrome and primary biliary cirrhosis2008

    • Author(s)
      Koike K, Utsunomiya Y, Ito Y, et.al.
    • Journal Title

      Clin Exp Nephrol 12

      Pages: 489-93

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bmp in podocytes is essential for normal glomerular capillary formation2008

    • Author(s)
      Ueda H, Miyazaki Y, Utsunomiya Y, et.al.(4)
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 685-94

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Malakoplakia of the kidney2008

    • Author(s)
      Kobayashi A, Utsunomiya Y, Kono M, et.al.
    • Journal Title

      Am J Kidney Dis 51

      Pages: 326-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy2008

    • Author(s)
      Sugano N, Wakino S, Utsunomiya Y, et.al. (13)
    • Journal Title

      Kidney Int 73

      Pages: 826-34

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proposal of podocytic infolding glomerulopathy as a new disease entity : a review of 25 cases from nationwide reseach in Japan.2008

    • Author(s)
      Joh K, Taguchi T, Utsunomiya Y, et al.
    • Journal Title

      Clin Exp Nephrol 12

      Pages: 421-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bmp in podocytes is essential for normal glomerular capillary formation.2008

    • Author(s)
      Ueda H, Miyazaki Y, Utsunomiya Y, et. al.
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 685-94

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy.2008

    • Author(s)
      Sugano N, Utsunonliya Y, Hayashi K, et. al.
    • Journal Title

      Kidney Int 73

      Pages: 826-34

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro and pathological investigations of MODY5 with the R276X-HNF1beta(TCF2) mutation2007

    • Author(s)
      Fujimoto K, Sasaki T, Utsunomiya Y, et.al. (8)
    • Journal Title

      Endocr J 54

      Pages: 757-64

    • NAID

      130004443314

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histological investigation of renal pathological changes in MPO-ANCA-related nephritis using repeated renal biopsies2007

    • Author(s)
      Komeda M, Yamaguchi Y, Utsunomiya Y, et.al.(4)
    • Journal Title

      Nippon Jinzo Gakkai Shi 49

      Pages: 438-45

    • NAID

      10019732058

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prospective trial of combined therapy with heparin/warfarin and rennin-angiotensin system inhibitors in progressive of IgA nephropathy2007

    • Author(s)
      Ishii T, Kawamura T, Utsunomiya Y, et.al. (3)
    • Journal Title

      Contrib Nephrol 157

      Pages: 114-9

    • Related Report
      2008 Final Research Report
  • [Journal Article] Xenobiotic kidney organogenesis from human mesenchymal stem cells using a growing rodent embryo2006

    • Author(s)
      Yokoo T, Fukui A, Utsunomiya Y, et.al.(6)
    • Journal Title

      J Am Soc Nephrol 17

      Pages: 1026-34

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene therapy for kidney disease : Inflamed site-specific transgenesis using a stem cell2006

    • Author(s)
      Koike K, Utsunomiya Y
    • Journal Title

      Nippon Rinsho 64

      Pages: 667-71

    • Related Report
      2008 Final Research Report
  • [Journal Article] Inhibition of endogenous BMP in the glomerulus leads to mesangial matrix expansion2006

    • Author(s)
      Miyazaki Y, Ueda H, Utsunomiya Y, et.al.(5)
    • Journal Title

      Biochem Biophys Res Commun 340

      Pages: 681-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ANCA関連血管炎を合併した糖尿病性腎症の一例2006

    • Author(s)
      徳留さとり, 宇都宮保典, ほか。
    • Journal Title

      腎と透析 61・5

      Pages: 725-35

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Secondary focal segmental glomerulosclerosis following kidney transplantation in a patient with type I diabetes mellitus.2006

    • Author(s)
      Yamamoto I, Utsunomiya Y, et al.
    • Journal Title

      Clin Transplant 20・15

      Pages: 7-10

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Xenobiotic kidney organogenesis from human mesenchymal stem cells using a growing rodent embryo.2006

    • Author(s)
      Tokoo T, Utsunomiya Y, et al.
    • Journal Title

      J Am Soc Nephrol 17・4

      Pages: 1026-34

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gene therapy for kidney disease : Inflamed site-specific transgenesis using a stem cell.2006

    • Author(s)
      Koike K, Utsunomiya Y.
    • Journal Title

      Nippon Rinsho 64・2

      Pages: 667-71

    • Related Report
      2006 Annual Research Report
  • [Presentation] メタボリック症候群による腎障害の機序と対策2008

    • Author(s)
      宇都宮保典ら.
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-06-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 糖尿病によるネフローゼ症候群の成因と治療2008

    • Author(s)
      宇都宮保典. オーバービュー
    • Organizer
      第38回日本腎臓学会東部学術大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] シンポジウム : メタボリックシンドロームによる腎障害の機序と対策2008

    • Author(s)
      宇都宮保典, ら
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Clinical impact of endogenous G-CSF in the progression of diabetic nephropathy.2007

    • Author(s)
      Utsunomiya Y, et. al.
    • Organizer
      2007年米国腎臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Clinical impact of endogenous granulocyte colony-stimulating factor (G-CSF) in the progression of diabetic nephropathy2007

    • Author(s)
      Utsunomiya Y, Tokudome S, Ito H, et.al.
    • Organizer
      40^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] ワークショップ : IgA腎症の基礎的・臨床的問題点の整理 ; 腎組織所見と予後との関連-予後分類の改訂に向けて2007

    • Author(s)
      宇都宮保典, ら
    • Organizer
      第37回日本腎臓学会東部学術大会
    • Place of Presentation
      大宮
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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