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A Study of the Regulation of Dendritic Cells and Immunological Memory by Immunoglobulins in Multiple Sclerosis

Research Project

Project/Area Number 18590923
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionTohoku University

Principal Investigator

FUJIHARA Kazuo  Tohoku University, TOHOKU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR (70280873)

Co-Investigator(Kenkyū-buntansha) NAKASHIMA Ichiro  TOHOKU UNIVERSITY, HOSPITAL, ASSISTANT PROFESSOR (50333810)
ITOYAMA Yasuto  TOHOKU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR (30136428)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsMultiple Sclerosis / Demyelinating Disease / Immunoglobulin / Dendritic Cell
Research Abstract

Intravenous immunoglobulin preparations (IVIg) are reportedly effective in inhibiting the relapseof multiple sclerosis (MS), but few reports have investigated the effect of IVIg on dendritic cells (DCs), which are thought to be involved in such relapses. Using a system that uses monokines to differentiate DCs from peripheral blood monocytes (Mo-DCs), we investigated the effect of Immunoglobulin G (IgG) on these antigen-presenting cells. Treatment of monocytes derived from a healthy volunteer with IgG partially inhibited the expression of CD1a, a marker of immature DCs (imDCs), and CD40 and CD80, which are markers associated with T cell activation. In contrast, IgG treatment enhanced the expression of CD83, a marker of mature DCs (mDCs). IgG markedly inhibited the expression of CD49d [very late activation antigen (VLA)-4 〓4-integrin], the adhesion molecule required for mDCs to cross the blood brain barrier (BBB). As neutralizing antibodies against CD49d have a therapeutic effect on MS, we investigated the effect of IgG on Mo-DCs derived from the peripheral blood of relapsing-remitting MS patients. We obtained similar results in both MS patients and healthy controls. In addition, IgG treatment of cells from both healthy controls and MS patients inhibited the production of interleukin (IL)-12, a cytokine associated with mDC maturation, but did not inhibit the production of IL-10. These results suggested the possibility that IgG treatment, apart from its known ability to regulate inflammation, may help prevent relapses of MS by controlling DC maturation, consequently inhibiting invasion of the central nervous system and affecting the cytokine profile.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (156 results)

All 2008 2007 2006 Other

All Journal Article (116 results) (of which Peer Reviewed: 36 results) Presentation (31 results) Book (9 results)

  • [Journal Article] Mercury Chloride Decreases the water permeability of aquaporin-4-reconstituted proteoliposomes2008

    • Author(s)
      Yukutake Y
    • Journal Title

      Biol Cell (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A Prominent Elevation of the Cerebrospinal Fluid-Glial Fibrillary Acidic Protein (GFAP) Level during Relapse in Neuromyelitis Optica2008

    • Author(s)
      Takano R
    • Journal Title

      Tohoku Exp Med (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations2008

    • Author(s)
      Takahashi T
    • Journal Title

      J Neurol Neurosurg Psychiatry (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 視神経脊髄炎(Neuromyelitis Optica)におけるアクアポリン4抗体の意義:多発性硬化症との鑑別を中心に2008

    • Author(s)
      藤原一男
    • Journal Title

      医薬ジャーナル 44

      Pages: 690-693

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] 視神経脊髄炎(NMO)とアクアポリン4抗体2008

    • Author(s)
      三須建郎
    • Journal Title

      神経進歩 (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 視神経脊髄炎(Neuromyelitis Optica)とアクアポリン4抗体:多発性硬化症と異なる疾患概念の解明への鍵2008

    • Author(s)
      藤原一男
    • Journal Title

      Frontiers in Rheumatology & Clinical Immunology 2

      Pages: 92-94

    • NAID

      40016138858

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Preferential spinal central gray matter involvement in neuromyelitis optica: an MRI study2008

    • Author(s)
      Nakamura M, Miyazawa I, Fujihara K, Nakashima I, Misu T, Watanabe S, Takahashi T, Itoyama Y.
    • Journal Title

      J Neurol 255

      Pages: 163-170

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The implications of aquaporin-4 antibody in Neuromyelitis Optica2008

    • Author(s)
      Fujihara K.
    • Journal Title

      Iyaku Journal (Medicine and Drug Journal) 44

      Pages: 690-693

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neuromyelitis Optica and aquaporin-4 antibody2008

    • Author(s)
      Fujihara K.
    • Journal Title

      Frontiers in Rheumatology & Clinical Immunology 2

      Pages: 92-94

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Therapeutic efficacy of plasma exchange in NMO-IgG-positive patients with neuromyelitis optica2007

    • Author(s)
      Watanabe S
    • Journal Title

      Mult Scler 13

      Pages: 128-132

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] High CSF-neurofilament beavy chain levels in neuromyelitis optica2007

    • Author(s)
      Miyazawa I
    • Journal Title

      Neurology 68

      Pages: 865-867

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinical and laboratory features of neuromyelitis optica with oligoclonal IgG bands2007

    • Author(s)
      Nakamura M
    • Journal Title

      Mult Scler 13

      Pages: 332-335

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Loss of aquaporin-4 in lesions of neuromyelitis optica: distinction from multiple sclerosis2007

    • Author(s)
      Misu T
    • Journal Title

      Brain 130

      Pages: 1224-1234

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titer2007

    • Author(s)
      Takahashi T
    • Journal Title

      Brain 130

      Pages: 1235-1243

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Successful treatment of a hypothalamic lesion in neuromyelitis optica by plasma exchange2007

    • Author(s)
      Watanabe S
    • Journal Title

      J Neurol 254

      Pages: 670-671

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Two subtypes of optic-spinal form of multiple sclerosis in Japan: clinical and laboratory features2007

    • Author(s)
      Nakashima I
    • Journal Title

      J Neurol 254

      Pages: 488-492

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Candidate antigens specifically detected by celebrospinal fluid-immunoglobulin G in oligoclonal immunoglobulin G bands-positive multiple sclerosis patients2007

    • Author(s)
      Nakamura M
    • Journal Title

      Proteomics-Clinical Applications 1

      Pages: 681-687

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Alteratin of Cystatin C in the cerebrospinal fluid of multiple sclerosis2007

    • Author(s)
      Nakashima I
    • Journal Title

      Ann Neurol 62

      Pages: 197-200

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Low-dose corticosterods reduce relapses in neuromyelitis optica: a retrospective analysis2007

    • Author(s)
      Watanabe S
    • Journal Title

      Mult Scler 13

      Pages: 968-974

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Modulation of dendritic cell development by immunoglobulin G in control subjects and multiple sclerosis patients2007

    • Author(s)
      Ohkuma K
    • Journal Title

      Clin Exp Immunol 150

      Pages: 397-406

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Preferential spinal central gray matter involvement in neuromyelitis optica: an MRI study2007

    • Author(s)
      Nakaura M
    • Journal Title

      J Neurol 255

      Pages: 163-170

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally2007

    • Author(s)
      Shimizu Y
    • Journal Title

      J Neurol 255

      Pages: 305-307

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Painfu tonic seizure2007

    • Author(s)
      渡辺承平
    • Journal Title

      脊椎脊髄ジャーナル 20

      Pages: 715-718

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 視神経脊髄炎(Neuromyuelitis optica)-多発性硬化症と異なる疾患概念-2007

    • Author(s)
      藤原一男
    • Journal Title

      医学のあゆみ 223

      Pages: 851-852

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] 視神経脊髄炎(NMO)の疾患概念、病態と治療2007

    • Author(s)
      藤原一男
    • Journal Title

      臨床神経 47

      Pages: 883-885

    • NAID

      10020102812

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] 視神経脊髄炎(Neuromyelitis Optica)〜アクアポリン4抗体の発見とその疾患概念及び病態への意義〜2007

    • Author(s)
      藤原一男
    • Journal Title

      Laboratory and Clinical Practice 25

      Pages: 97-99

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] 二次進行型多発性硬化症2007

    • Author(s)
      藤原一男
    • Journal Title

      Current Insights in Neurological Science 16

      Pages: 6-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Therapeutic efficacy of plasma exchange in NMO-IgG-positive patients with neuromyelitis optica2007

    • Author(s)
      Watanabe S, Nakashima I, Misu T, Miyazawa I, Shiga Y, Fujihara K, Itoyama Y.
    • Journal Title

      Mult Scler 13

      Pages: 128-132

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] High CSF-neurofilament heavy chain levels in neuromyelitis optica2007

    • Author(s)
      Miyazawa I, Nakashima I, Petzold A, Fujihara K, Sato S, Itoyama Y.
    • Journal Title

      Neurology 68

      Pages: 865-867

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clinical and laboratory features of neuromyelitis optica with oligoclonal IgG bands2007

    • Author(s)
      Nakamura M, Nakashima I, Sato S, Fujihara K, Itoyama Y.
    • Journal Title

      Mult Scler 13

      Pages: 332-335

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Loss of aquaporin-4 in lesions of neuromyelitis optica: distinction from multiple sclerosis2007

    • Author(s)
      Misu T, Fujihara K, Kakita A, Konno H, Nakamura M, Watanabe S, Takahashi T, Nakashima I, Takahashi H, Itoyama Y.
    • Journal Title

      Brain 130

      Pages: 1224-1234

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titer2007

    • Author(s)
      Takahashi T, Fujihara K, Nakashima I, Misu T, Miyazawa I, Nakamura M, Watanabe S, Shiga Y, Kanaoka C, Fujimori J, Sato S, Itoyama Y.
    • Journal Title

      Brain 130

      Pages: 1235-1243

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Successful treatment of a hypothalamic lesion in neuromyelitis optica by plasma exchange2007

    • Author(s)
      Watanabe S, Nakashima I, Miyazawa I, Misu T, Shiga Y, Nakagawa Y, Fujihara K, Itoyama Y.
    • Journal Title

      J Neurol 254

      Pages: 670-671

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Two subtypes of optic-spinal form of multiple sclerosis in Japan; clinical and laboratory features2007

    • Author(s)
      Nakashima I, Fukazawa T, Ota K. Nohara C, Warabi Y. Ohashi T, Miyazawa I, Fujihara Y, Itoyama Y.
    • Journal Title

      J Neurol 254

      Pages: 488-492

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Candidate antigens specifically detected by celebrospinal fluid-immunoglobulin G in oligoclonal immunoglobulin G bands-positive multiple sclerosis patients2007

    • Author(s)
      Nakamura M, Kuramasu A, Nakashima I, Fujihara K, Itoyama Y.
    • Journal Title

      Proteomics-Clinical Applications 1

      Pages: 681-687

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Alteration of Cystatin C in the cerebrospinal fiuid of multiple sclerosis2007

    • Author(s)
      Nakashima I. Fuiinoki M. Fuiihara K. Kawamura T. Nishimura T. Nakamura M. Itovama Y.
    • Journal Title

      Ann Neurol 62

      Pages: 197-200

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Low-dose corticosteroids reduce relapses in neuromyelitis optica: a retrospective analysis2007

    • Author(s)
      Watanabe S, Misu T, Miyazawa I, Nakashima I, Shiga Y, Pujihara K, Itoyama Y.
    • Journal Title

      Mult Scler 13

      Pages: 968-974

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Modilation of dendritic cell development by immunoglobulin G in control subijects and multiple sclerosis patients2007

    • Author(s)
      Ohkuma K. Sasaki T.Kamei S. Nakano H. Oknda S. Hamamotn T. Fujihara K, Nakashima I, Misu T, Itoyama Y.
    • Journal Title

      Clin Exp Immunol 150

      Pages: 397-406

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis2007

    • Author(s)
      Shimizu Y, Yokoyama K, Misu T, Takahashi T, Fujihara K, Kikuchi S, Itoyama Y, Iwata M.
    • Journal Title

      J Neurol 255

      Pages: 305-307

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Painful tonic seizure2007

    • Author(s)
      Watanabe S, Fujihara K.
    • Journal Title

      J Spine Spin Cord 20

      Pages: 715-718

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neuromyuelitis optica) -A clinical entity distinct from multiple sclerosis-2007

    • Author(s)
      Fujihara K.
    • Journal Title

      Igaku No Ayumi (Journal of Clinical and Experimental Medicine) 223

      Pages: 851-852

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The clinical entity, pathogenesis and therapy of NMO2007

    • Author(s)
      Fujihara K.
    • Journal Title

      Rinshoshinkeigaku (Clinical Neurology) 47

      Pages: 883-885

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neuromyelitis Optica-The discovery of aquaporin-4 antibody and its implications to the clinical entity and pathogenesis2007

    • Author(s)
      Fujihara K.
    • Journal Title

      Laboratory and Clinical Practice 25

      Pages: 97-99

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Secondary progressive multiple sclerosis2007

    • Author(s)
      Fujihara K.
    • Journal Title

      Current Insights in Neurological Science 16

      Pages: 6-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] TheraPeutic efficacy of Plasma exchange in NMO-IgG-positive patients with neuromyelitis optics2007

    • Author(s)
      Watanabe S
    • Journal Title

      Mult Scler 13

      Pages: 128-132

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High CSF-neurofilamlent heavy chain levels in neuromyelitis optica2007

    • Author(s)
      Miyazawa I
    • Journal Title

      Neurology 68

      Pages: 865-867

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-aquaPorin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titer2007

    • Author(s)
      Takahashi T
    • Journal Title

      Brain 130

      Pages: 1235-1243

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two subtypes of optic-spinal form of multiple sclerosis in Japan: clipical and laboratory features2007

    • Author(s)
      Nakashima I
    • Journal Title

      J Neurol 254

      Pages: 488-492

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of Cystatin C in the cerebrospinal fluid of multiple sclerosis2007

    • Author(s)
      Nakashima I
    • Journal Title

      Ann Neurol 62

      Pages: 197-200

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-dose corticosteroids reduce relaPses in neuromyelitis optica: a retrospective analysis2007

    • Author(s)
      Watanabe S
    • Journal Title

      Mult Scler 13

      Pages: 968-974

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of dendritic cell development by immunoglobulin G in control subiects and multiple sclerosis patients2007

    • Author(s)
      Ohkuma K
    • Journal Title

      Clin Exp Immunol 150

      Pages: 397-406

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preferential spinal central gray matter involvement in neuromyelitis optica: an MRI study2007

    • Author(s)
      Nakamura M
    • Journal Title

      J Neurol 255

      Pages: 163-170

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DeveloPment of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis2007

    • Author(s)
      Shimizu Y
    • Journal Title

      J Neurol 255

      Pages: 305-307

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Painful tonic seizure2007

    • Author(s)
      渡辺承平
    • Journal Title

      脊椎脊髄ジャーナル 20

      Pages: 715-718

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Therapeutic efficacy of plasma exchange in NMO-IgG-positive patients with neuromyelitis optica2007

    • Author(s)
      Watanabe S
    • Journal Title

      Mult Sclr 13

      Pages: 128-132

    • Related Report
      2006 Annual Research Report
  • [Journal Article] High CSF-neurofilament heavy chain levels in neuromyelitis optica2007

    • Author(s)
      Miyazawa I
    • Journal Title

      Neurology 68

      Pages: 865-867

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Successful treatment of a hypothalamic lesion in neuromyelitis optica by plasma exchange2007

    • Author(s)
      Watanabe S
    • Journal Title

      J Neurol (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clinical and laboratory features of neuromyelitis optica with oligoclonal IgG bands2007

    • Author(s)
      Nakamura M
    • Journal Title

      Mult Sclr (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Alteration of Cystatin C in the cerebrospinal fluid of multiple sclerosis2007

    • Author(s)
      Nakashima I
    • Journal Title

      Ann Neurol (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Two subtypes of optic-spinal form of multiple sclerosis in Japan : clinical and laboratory features2007

    • Author(s)
      Nakashima I
    • Journal Title

      J Neurol (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Preferential spinal central gray matter involvement in neuromyelitis optica : an MRI study2007

    • Author(s)
      Nakamura M
    • Journal Title

      J Neurol (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Low-dose corticosteroids reduce erelapses in neuromyelitis optica : a retrospective analysis2007

    • Author(s)
      Watanabe S
    • Journal Title

      Mult Sclr (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Loss of aquaporin-4 in lesions of neuromyelitis optica : distinction from multiple sclerosis2007

    • Author(s)
      Misu T
    • Journal Title

      Brain (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO : a study on antibody titer2007

    • Author(s)
      Takahashi T
    • Journal Title

      Brain (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] NMO-IgG陽性多発性硬化症の臨床的・画像的特徴2007

    • Author(s)
      中島一郎
    • Journal Title

      神経内科 (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 視神経脊髄型多発性硬化症〜臨床検査のトピックス〜2007

    • Author(s)
      藤原一男
    • Journal Title

      臨床神経学 (印刷中)

    • NAID

      10020347385

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Painful tonic seizure2007

    • Author(s)
      渡辺承平
    • Journal Title

      脊椎脊髄ジャーナル (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relevance of callosal and periventricular lesions to oligoclonal bands in multiple sclerosis.2006

    • Author(s)
      Nakashima I
    • Journal Title

      Acta Neurol Scand 113

      Pages: 125-131

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] OSMS is NMO, but not MS: Proven clinically, pathologically and by NMO-IgG.2006

    • Author(s)
      Weinshenker BG
    • Journal Title

      Lancet Neurol 5

      Pages: 110-111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Soluble CD26 and CD30 levels in CSF and sera of patients with relapsing neuromyelitis optica2006

    • Author(s)
      Narikawa K
    • Journal Title

      J Neurol 253

      Pages: 111-113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Loss of Aquaporin-4 in Active Perivascular Lesions in Neuromyelitis Optica: a Case2006

    • Author(s)
      Misu T
    • Journal Title

      Tohoku J Exp Med 209

      Pages: 269-275

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Remarkable effect of anti-coagulation therapy in Churg-Strauss syndrome-associated neuropathy: a case report2006

    • Author(s)
      Takahashi T
    • Journal Title

      Eur J Neurol 13

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinical and MRI features of Japanese MS patients with NMO-IgG2006

    • Author(s)
      Nakashima I
    • Journal Title

      J Neurol Neurosurg Psychiatry 77

      Pages: 1073-1075

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of CCR7 and its ligands CCL19/CCL21 in muscles of polymyositis2006

    • Author(s)
      Tateyama M
    • Journal Title

      J Neurol Sci 249

      Pages: 158-165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Establishment of a new sensitive assay for anti-human aquaporin-4 antibody in neuromyelitis optica2006

    • Author(s)
      Takahashi T
    • Journal Title

      Tohoku J Exp Med 210

      Pages: 307-310

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADEM(急性散在性脳脊髄炎)2006

    • Author(s)
      西山修平
    • Journal Title

      Clinical Neuroscience 24

      Pages: 346-347

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] 内科疾患最新の治療 専門家からのアドバイス 多発性硬化症2006

    • Author(s)
      中村正史
    • Journal Title

      内科 97

      Pages: 1278-1279

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] 脳神経筋の自己免疫疾患 多発性硬化症2006

    • Author(s)
      佐藤 滋
    • Journal Title

      Brain Medical 18

      Pages: 178-182

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] 視神経脊髄型多発性硬化症2006

    • Author(s)
      藤原一男
    • Journal Title

      神経研究の進歩 50

      Pages: 549-557

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] 視神経脊髄型多発性硬化症の概念とNMO-IgG2006

    • Author(s)
      藤原一男
    • Journal Title

      Current Insights in-Neuroglogical Science 14

      Pages: 6-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 視神経脊髄型多発性硬化症〜多発性硬化症の病型分類における位置づけ〜2006

    • Author(s)
      藤原一男
    • Journal Title

      医学の歩み 219

      Pages: 121-124

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] NMO-IgG陽性多発性硬化症の臨床的・画像的特徴2006

    • Author(s)
      中島一郎
    • Journal Title

      神経内科 65

      Pages: 377-387

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 視神経脊髄型多発性硬化症〜臨床検査のトピックス〜2006

    • Author(s)
      藤原一男
    • Journal Title

      臨床神経学 46

      Pages: 866-868

    • NAID

      10020347385

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Current Topics in Neuroimmunology2006

    • Author(s)
      Fujihara K
    • Pages
      5-5
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Relevance of callosal and periventricular lesions to oligoclonal bands in multiple sclerosis2006

    • Author(s)
      Nakashima I, Fujihara K, Miyazawa H, Misu T, Fujimori, J, Sato S, Itoyama Y.
    • Journal Title

      Acta Neurol Scand 113

      Pages: 125-131

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Lennon VA. OSMS is NMO, but not MS: Proven clinically, pathologically and by NMO-IgG2006

    • Author(s)
      Weinshenker BG, Wingerchuk DM, Nakashima I, Fujihara K
    • Journal Title

      Lancet Neurol 5

      Pages: 110-111

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Soluble CD26 and CD30 levels in CSF and sera of patients with relapsing neuromyelitis optica2006

    • Author(s)
      Narikawa K, Misu T, Fuiihara K, Nakashima I, Sato S, Itoyama Y.
    • Journal Title

      J Neurol 253

      Pages: 111-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Loss of Aquaporin-4 in Active Pervascular Lesions in Neuromyelitis Optica; a Case Report2006

    • Author(s)
      Misu T, Fujihara K, Nakamura M, Murakami K, Endo M, Konno H, Itoyama Y.
    • Journal Title

      Tohoku J Exp Med 209

      Pages: 269-275

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Remarkable effect of anti-coagulation therapy in Churg-Strauss syndrome-associated neuropathy: a case report2006

    • Author(s)
      Takahashi T, Kikuchi A, Kuroda H, Fujihara K, Itoyama Y.
    • Journal Title

      Eur J Neurol 13

      Pages: 12-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clinical and MRI features of Japanese MS patients with NMO-IgG2006

    • Author(s)
      Nakashima I, Pujihara K, Miyazawa I, Misu T, Narikawa K, Nakamura M, Watanabe S, Takahashi T, Nishiyama S, Shiga Y, Sato S, Weinshenker BG, Itoyama Y.
    • Journal Title

      J Neurol Neurosurg Psychiatry 77

      Pages: 1073-1075

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression of CCR7 and its ligands CCL19/CCL21 in muscles of polymyositis2006

    • Author(s)
      Tateyama M, Fujihara K, Misu T, Feng J, Onodera Y, Itoyama Y.
    • Journal Title

      J Neurol Sci 249

      Pages: 158-165

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Establishment of a new sensitive assay for anti-human aquaporin-4 antibody in neuromyelitis optica2006

    • Author(s)
      Takahashi T, Fujihara K, Nakashima I, Misu T, Miyazawa I, Nakamura M, Watanabe S, Ishii N, Itoyama Y.
    • Journal Title

      Tohoku J Exp Med 210

      Pages: 307-310

    • NAID

      10018809832

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ADEM2006

    • Author(s)
      Nishiyama S, Fujihara K, Itoyama Y.
    • Journal Title

      Clinical Neuroscience 24

      Pages: 346-347

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multiple Sclerosis2006

    • Author(s)
      Nakamura M, Fujihara K.
    • Journal Title

      Naika (Internal Medicine) 97

      Pages: 1278-1279

    • NAID

      40020608851

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multiple Sclerosis2006

    • Author(s)
      Sato S, Fujihara K, Itoyama Y.
    • Journal Title

      Brain Medical 18

      Pages: 178-182

    • NAID

      40020608851

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Optic-spinal multiple sclerosis2006

    • Author(s)
      Fujihara K, Nakashima I, Misu T, Miyazawa I, Fujimori J, Narikawa K, Nakamura M, Takahashi T, Watanabe S, Sato S, Itoyama Y.
    • Journal Title

      Shinkei Kenkyu No Shinpo (Advances in Neurological Sciences) 50

      Pages: 549-557

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The concept of optic-spinal multiple sclerosis and NMO-IgG2006

    • Author(s)
      Fujihara K.
    • Journal Title

      Current Insights in Neurological Science 14(3)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Optic-spinal multiple sclerosis2006

    • Author(s)
      Fujihara K.
    • Journal Title

      Igaku No Ayumi (Journal of Clinical and Experimental Medicine) 219

      Pages: 121-124

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Fujihara K Clinicala and neuroimaging features of NMO-IgG-positive multiple sclerosis2006

    • Author(s)
      Nakashima I
    • Journal Title

      Shinkeinaika (Neurological Medicine) 65

      Pages: 377-387

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Optic-spianl multiple sclerosis-topics in laboratory findings-2006

    • Author(s)
      Fujihara K.
    • Journal Title

      Rinshoshinkeigaku (Clinical Neurology) 46

      Pages: 866-868

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] OSMS is NMO, but not MS : Proven clinically, pathologically and by NMO-IgG.2006

    • Author(s)
      Weinshenker BG
    • Journal Title

      Lancet Neurol 5

      Pages: 110-111

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Soluble CD26 and CD30 levels in CSF and sera of patients with relapsing nenromyelitis optica2006

    • Author(s)
      Narikawa K
    • Journal Title

      J Neurol 253

      Pages: 111-113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Loss of Aquaporin-4 in Active Perivascular Lesions in Neuromyelitis Optica : a Case Report2006

    • Author(s)
      Misu T
    • Journal Title

      Tohoku J Exp Med 209

      Pages: 269-275

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Remarkable effect of anti-coagulation therapy in Churg-Strauss syndrome-associated neuropathy : a case report2006

    • Author(s)
      Takahashi T
    • Journal Title

      Eur J Neurol 13

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clinical and MRI features of Japanese MS patients with NMO-IgG.2006

    • Author(s)
      Nakashima I
    • Journal Title

      J Neurol Neurosurg Psychiatry 77

      Pages: 1073-1075

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of CCR7 and its ligands CCL19/CCL21 in muscles of polymyositis2006

    • Author(s)
      Tateyama m
    • Journal Title

      J Neurol Sci 249

      Pages: 158-165

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 視神経脊髄型多発性硬化症の概念とNMO-IgG2006

    • Author(s)
      藤原一男
    • Journal Title

      Current Insights in Neurological Science 14

      Pages: 6-6

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mercury Chloride Decreases the water permeability of aquaporin-4-reconstituted proteoliposomes

    • Author(s)
      Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M.
    • Journal Title

      Biol Cell

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A Prominent Elevation of the Cerebrospinal Fluid- Glial Fibrillary Acidic Protein (GFAP) Level during Relapse in Neuromyelitis Optica: a Case Report

    • Author(s)
      Takano R, Misu T, Takahashi T, Izumiyama M, Fujihara K, Itoyama Y.
    • Journal Title

      Tohoku J Exp Med

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations

    • Author(s)
      Takahashi T, Miyazawa I, Misu T, Takano R, Nakashima I, Fujihara K, Tobita M, Itoyama Y.
    • Journal Title

      J Neurol Neurosurg Psychiatry

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neuromyelitis optica and aquaporin-4 antibody

    • Author(s)
      Misu T, Fujihara K, Itoyama Y.
    • Journal Title

      Shinkei Kenkyu no Shinpo (Advances in Neurological Sciences)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mercury Chloride Decreases the eater permeability of aquapor in-4-reconstituted proteoliposomes

    • Author(s)
      Yukutake Y
    • Journal Title

      Biol Cell (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Prominent Elevation of the Cerebrospinal Fluid-Glial Fibrillary Acidic Protein (GFAP) Level during Relapse in Neuromyelitis Optica

    • Author(s)
      Takano R
    • Journal Title

      Tohoku J Exp Med (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations

    • Author(s)
      Takahashi T
    • Journal Title

      J Neurol Neurosurg Psychiatry (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 視神経脊髄炎(NMO)とアクアポリン4抗体

    • Author(s)
      三須建郎
    • Journal Title

      神経進歩 (印刷中)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 視神経脊髄炎(Neuromyelitis Optica)とアクアポリン4抗体:多発性硬化症と異なる疾患概念の解明への鍵

    • Author(s)
      藤原一男
    • Journal Title

      rontiers in Rheumatology & Clinical Immunology (印刷中)

    • NAID

      40016138858

    • Related Report
      2007 Annual Research Report
  • [Presentation] Neuromyelitis Optica:その疾患概念、病態と治療抗aquaporin-4抗体の発見とその疾患概念及び病態への意義2007

    • Author(s)
      藤原一男
    • Organizer
      第45回日本神経眼科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-12-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Neuromyelitis Optica: the concept, pathogenesis and therapy2007

    • Author(s)
      Fujihara K.
    • Organizer
      Luncheon Seminar in the 45^<th> Annual Meeting of Japanese Neuro-Ophthalmology Society
    • Place of Presentation
      Osaka
    • Year and Date
      2007-12-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 視神経脊髄炎(Neuromyelitis Optica):抗aquaporir-4抗体の発見とその疾患概念及び病態への意義2007

    • Author(s)
      藤原一男
    • Organizer
      第28回日本アフェレシス学会学術大会
    • Place of Presentation
      久留米
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Neuromyelitis Optica: the discovery of aquaporin-4 antibody and its implications to the clinical entity and pathogenesis-.2007

    • Author(s)
      Fujihara K.
    • Organizer
      Special Symposium in the 28^<th> Annual Meeting of Japanese Society for Apheresis
    • Place of Presentation
      Kurume
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 視神経脊髄炎(Neuromyelltis Optica):抗aquaporin-4抗体の発見とその疾患概念及び病態への意義2007

    • Author(s)
      藤原一男
    • Organizer
      第28回日本アフェレシス学会学術大会
    • Place of Presentation
      久留米
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Neuromyelitis optica and OSMS: the Japanese Experience2007

    • Author(s)
      Fujihara K
    • Organizer
      Seminar Series on Neuroimmunological Diseases
    • Place of Presentation
      ウイーン
    • Year and Date
      2007-10-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Neuromyelitis optica and OSMS: the Japanese Experience2007

    • Author(s)
      Fujihara K.
    • Organizer
      Seminar Series on Neuroimmunological Diseases
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2007-10-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 多発性硬化症(MS)と視神経脊髄炎(NMO)-髄液抗体及びタンパクからみた病態の違い-2007

    • Author(s)
      藤原一男
    • Organizer
      第17回日本臨床検査専門医会春季大会
    • Place of Presentation
      旭川
    • Year and Date
      2007-06-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Multiple Sclerosis and Neuromyelitis Optica2007

    • Author(s)
      Fujihara K.
    • Organizer
      Symposium in the 17^<th> Annual Meeting of Japanese Association of Clinical Laboratory Physicians
    • Place of Presentation
      Asahikawa
    • Year and Date
      2007-06-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Is there a role for plasmapheresis and low-dose corticosteroids in NMO2007

    • Author(s)
      Fujihara K
    • Organizer
      MS Forum the 4th Consensus Group Meeting
    • Place of Presentation
      東京
    • Year and Date
      2007-05-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Is there a role for plasmapheresis and low-dose corticosteroids in NMO.2007

    • Author(s)
      Fujihara K.
    • Organizer
      MS Forum the 4th Consensus Group Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-05-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Recent advances in anti-AQP4 antibody research2007

    • Author(s)
      Fujihara K
    • Organizer
      MS Forum the 4th Consensus Group Meeting
    • Place of Presentation
      東京
    • Year and Date
      2007-05-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Recent advances in anti-AQP4 antibody research2007

    • Author(s)
      Fujihara K.
    • Organizer
      MS Forum the 4th Consensus Group Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-05-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 視神経脊髄炎(NMO)の疾患概念、病態と治療2007

    • Author(s)
      藤原一男
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] The concept, pathogenesis and therapy of neuromyelitis optica2007

    • Author(s)
      Fujihara K.
    • Organizer
      Symposium in the 48^<th> Annual Congress of Japanese Society of Neurology
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-05-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] NMO, MS and Plasmapheresis in Japan2007

    • Author(s)
      Fujihara K
    • Organizer
      World Apheresis Association 11th Congress/6th WorId Congress for the International Society for Apheresis
    • Place of Presentation
      横浜
    • Year and Date
      2007-03-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] MS and Plasmapheresis in Japan. Symposium 3 (Recent advance in therapeutic apheresis for multiple sclerosis)2007

    • Author(s)
      Fujihara K. NMO
    • Organizer
      World Apheresis Association 11^<th> Congress/6^<th> World Congress for the International Society for Apheresis
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-03-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Finalized MS Forum Consensus Statements2006

    • Author(s)
      Fujihara K
    • Organizer
      Fourth MS Forum. Pan Asian Conference
    • Place of Presentation
      ソウル
    • Year and Date
      2006-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Finalized MS Forum Consensus Statements. Fourth MS Forum2006

    • Author(s)
      Fujihara K.
    • Organizer
      Pan Asian Conference Multiple Sclerosis in Asia Pacific: Tackling Issues, Optimizing Management
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2006-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Aquaporin-4 and Neuromyelitis Optica2006

    • Author(s)
      Fujihara K
    • Organizer
      Keio Aquaporin Mini Symposium
    • Place of Presentation
      東京
    • Year and Date
      2006-10-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Aquaporin-4 and Neuromyelitis Optica2006

    • Author(s)
      Fujihara K.
    • Organizer
      Keio Aquaporin Mini Symposium
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-10-31
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Apheresis in MS and NMO-evidence and topics of research-2006

    • Author(s)
      Fujihara K
    • Organizer
      8th International Congress of Neuroimmunology
    • Place of Presentation
      名古屋
    • Year and Date
      2006-10-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Apheresis in MS and NMO-evidence and topics of research-. Luncheon Seminar (Apheresis Therapy in Multiple Sclerosis: A New Horizon)2006

    • Author(s)
      Fujihara K.
    • Organizer
      in the 8^<th> International Congress of Neuroimmunology
    • Place of Presentation
      Nagoya, Japan.
    • Year and Date
      2006-10-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] NMO-lgG testing in Asian patients: research update2006

    • Author(s)
      Fujihara K
    • Organizer
      MS Forum the 3rd Consensus Group Meeting
    • Place of Presentation
      ソウル
    • Year and Date
      2006-06-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] NMO-IgG testing in Asian patients: research update2006

    • Author(s)
      Fujihara K.
    • Organizer
      MS Forum the 3rd Consensus Group Meeting
    • Place of Presentation
      Seoul
    • Year and Date
      2006-06-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pan Asian Consensus Statements: summary of the consensus agreements and update on status of the publication2006

    • Author(s)
      Fujihara K
    • Organizer
      MS Forum the 3rd Consensus Group Meeting
    • Place of Presentation
      ソウル
    • Year and Date
      2006-06-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pan Asian Consensus Statements: summary of the consensus agreements and update on status of the publication2006

    • Author(s)
      Fujihara K.
    • Organizer
      MS Forum the 3rd Consensus Group Meeting
    • Place of Presentation
      Seoul
    • Year and Date
      2006-06-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 視神経脊髄型多発性硬化症 臨床検査のトピックス2006

    • Author(s)
      藤原一男
    • Organizer
      第47回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Optic-spinal multiple sclerosis-topics in laboratory findings-.2006

    • Author(s)
      Fujihara K.
    • Organizer
      Symposium (Optic-spinal multiple sclerosis in Japan) in the 47^<th> Annual Congress of Japnese Society of Neurology
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-05-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Multiple Sclerosis in Japan: recent perspectives on clinical subtypes and pathogenesis2006

    • Author(s)
      Fujihara K
    • Organizer
      The 24th Annual Congress of the Korean Neurological Association
    • Place of Presentation
      テグ(韓国)
    • Year and Date
      2006-04-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Multiple Sclerosis in Japan: recent perspectives on clinical subtypes and pathogenesis Symposium 1-3 (Multiple Sclerosis)2006

    • Author(s)
      Fujihara K.
    • Organizer
      The 24^<th> Annual Congress of the Korean Neurological Association
    • Place of Presentation
      Daegu, Republic of Korea.
    • Year and Date
      2006-04-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Current Topics in Neuroimmunology2007

    • Author(s)
      Fujihara K
    • Publisher
      Medimond(In press)
    • Related Report
      2006 Annual Research Report
  • [Book] Current Topics in Neuroimmunology2006

    • Author(s)
      Fujihara K
    • Total Pages
      5
    • Publisher
      Medimond
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 整形外科診療実践ガイド2006

    • Author(s)
      藤原一男
    • Total Pages
      5
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 神経救急・集中治療ハンドブック2006

    • Author(s)
      高橋利幸
    • Total Pages
      7
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Book] Japanese patients with NMO-IgG2006

    • Author(s)
      Fujihara K, Nakashima I, Misu T, Takahashi T, Watanabe S, Nakamura M, Miyazawa I, Fujimori J, Narikawa K, Sato S, Itoyama Y.
    • Total Pages
      5
    • Publisher
      ed by Tabira T, Yamamura T, Kira J. in Current Topics in Neuroimmunology (1^<st> edition), Medimond, Bologna
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Multiple sclerosis2006

    • Author(s)
      Fujihara K.
    • Total Pages
      3
    • Publisher
      ed by Moriya H et al in Practice Guideline of Orthopedic Surgery. Bunkodo, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Acute disseminated encephalomyelitis2006

    • Author(s)
      Fujihara K.
    • Total Pages
      2
    • Publisher
      ed by Moriya H et al in Practice Guideline of Orthopedic Surgery. Bunkodo, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Demyelinating Disease2006

    • Author(s)
      Takahashi T, Fujihara K, Itoyama Y.
    • Total Pages
      7
    • Publisher
      Ed by Shinohara Y et al in Handbook of Nueorlogical Emergency and Intensive Care. Igakushoin, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 整形外科診療実践ガイド2006

    • Author(s)
      藤原一男
    • Total Pages
      5
    • Publisher
      文光胴
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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