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The role of midkine family in inflammatory demyelination

Research Project

Project/Area Number 18590933
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionNagoya University

Principal Investigator

MIZUNO Tetsuya  Nagoya University, 環境医学研究所, 准教授 (70335008)

Co-Investigator(Kenkyū-buntansha) 錫村 明生  名古屋大学, 環境医学研究所, 教授 (50196896)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsミッドカイン / 炎症性脱髄 / 調節性T細胞 / 脳神経疾患 / 神経免疫
Research Abstract

多発性硬化症、自己免疫性脳脊髄炎などの炎症性脱髄において、ミッドカインが、自己免疫を調節している調節性T細胞や調節性樹状細胞の機能を抑制することによりその発症に関与していることを明らかにした.さらに、抗体よりも優れた結合力と特異性をもつRNAアプタマーを用いたミッドカイン機能の制御によって、自己免疫性脳脊髄炎の発症を効果的に抑制することができた.本研究は、ミッドカイン抑制を標的とした炎症性脱髄疾患の新規治療法の可能性を示すものである.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (22 results)

All 2008 2007 2006

All Journal Article (17 results) (of which Peer Reviewed: 14 results) Presentation (5 results)

  • [Journal Article] Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity2008

    • Author(s)
      Liang J, Mizuno T, Suzumura A 他(11人10番目)
    • Journal Title

      Brain Research 1210

      Pages: 11-19

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microglia express a functional receptor for interleukin-232008

    • Author(s)
      Sonobe Y, Mizuno T, Suzumura A 他(7人6番目)
    • Journal Title

      Biochemical and Biophysical Research Communications 370

      Pages: 129-133

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interferon-. directly induces neurotoxicity through a neuron specific, calcium- permeable complex of IFN- receptor and AMPA GluR1 receptor2008

    • Author(s)
      Mizuno T, Suzumura A 他(10人1番目)
    • Journal Title

      FASEB Journal 22

      Pages: 1797-1806

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Production and functions of IL-17 in microglia2008

    • Author(s)
      Kawanokuchi J, Mizuno T, Suzumura A 他(7人5番目)
    • Journal Title

      Journal of Neuroimmunology 194

      Pages: 54-61

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of midkine alleviates experimental autoimmune encephalo- myelitis through the expansion of regulatory T cell population2008

    • Author(s)
      Wang J, Takeuchi H, Sonobe Y, Mizuno T 他(12人5番目)
    • Journal Title

      Proc Natl Acad Sci U S A 105

      Pages: 3915-3920

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interferon-γ directly induces neurotoxicity through a neuron specific, calciumpermeable complex of IFN-γ receptor and AMPA GluR1 receptor.2008

    • Author(s)
      MIZUNO Tetsuya, SUZUMURA Akio
    • Journal Title

      FASEB Journal 22

      Pages: 1797-1806

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microglia express a functional receptor for interleukin-23.2008

    • Author(s)
      SONOBE Yoshifumi, MIZUNO Tetsuya, SUZUMURA Akio
    • Journal Title

      Biochemical and Biophysical Research Communic ations. 370

      Pages: 129-133

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity.2008

    • Author(s)
      LIANG Jianfeng, MIZUNO Tetsuya, SUZUMURA Akio
    • Journal Title

      Brain Research 1210

      Pages: 11-19

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell2008

    • Author(s)
      Wang J, Takeuchi H. Sonobe Y. Mizuno T.
    • Journal Title

      Proceedings of the National Academy of Sciences USA 105

      Pages: 3915-3920

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production and functions of IL-17 in microglia.2008

    • Author(s)
      Kawanokuchi J, Mizuno T, Suzumura A,
    • Journal Title

      Journal of Neuroimmunology 194

      Pages: 54-61

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronological changes of CD4+ and CD8+ T cell subsets in the experimental autoimmune encephalo- myelitis, a mouse model of multiple sclerosis2007

    • Author(s)
      Sonobe Y, Jin S, Takeuchi H, Mizuno T 他(7人6番目)
    • Journal Title

      Tohoku Journal of Experimental Medicine 213

      Pages: 329-339

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronological changes of CD8-T cell subsets in the cxperimental auloimmune eneephalomvelilis, a mouse model of multiple2007

    • Author(s)
      Sonobe Y, Jin S, Takeuchi H, Mizuno T,
    • Journal Title

      Tohoku Journal of Experimental Medicine 213

      Pages: 329-339

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of glia-derived cytokines on neuronal degeneration and regeneration2006

    • Author(s)
      Suzumura A, Takeuchi H, Zhang G, Kuno R, Mizuno T
    • Journal Title

      Annals of New York Academy of Science 1088

      Pages: 219-229

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Production of interferon-2006

    • Author(s)
      Kawanokuchi J, Mizuno T, Takeuchi H, Kato H, Wang J, Mitsuma N, Suzumura A
    • Journal Title

      by microglia Multiple Sclerosis 12

      Pages: 558-564

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of glia-derived cytokines on neuronal degeneration and regeneration.2006

    • Author(s)
      Suzumura A, Takeuchi H, Zhang G, Kuno R, Mizuno T
    • Journal Title

      Annals of New York Academy of Science 1088

      Pages: 219-229

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Midkine deficiency protects against Experimental Autoimmnue Encephalomyelitis by expansion of CD4^+CD25^+Foxp3^+ regulatory T cells.2006

    • Author(s)
      Wwng J, Takeuchi H, Jin S, Sonobe Y, Mizuno T, Muramatsu H, Muramatsu T, Suzumura A
    • Journal Title

      Journal of Neuroimmunology 178

      Pages: 169-169

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Production of interferon-γby microglia.2006

    • Author(s)
      Kawanokuchi J, Mizuno T, Takeuchi H, Kato H, Wang J, Mitsuma N, Suzumura A
    • Journal Title

      Multiple Sclerosis 12

      Pages: 558-564

    • Related Report
      2006 Annual Research Report
  • [Presentation] 中枢神経系におけるインターロイキン-25の発現とその機能2008

    • Author(s)
      片岡邦夫、水野哲也、錫村明生
    • Organizer
      第20回神経免疫学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2008-04-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 中枢神経系におけるインクーロイキン-25の発現とその機能2008

    • Author(s)
      片岡邦夫, 水野哲也, 錫村明生
    • Organizer
      第20回神経免疫学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗体及びaptamerを用いたMidkine阻害に基ずく多発性硬化症の新規治療法開発2007

    • Author(s)
      薗部佳史
    • Organizer
      第19回日本神経免疫学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2007-04-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗体及びaptamerを用いたMidkine阻害に基ずく多発性硬化症の新規治療法開発.2007

    • Author(s)
      薗部佳史
    • Organizer
      第19回日本神経免疫学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2007-04-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Midkine欠損マウスでは制御性T細胞の増加によりEAEの発症が抑制される2006

    • Author(s)
      竹内英之、王金岩、水野哲也、錫村明生
    • Organizer
      第47回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-11
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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