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A multidisciplinary study of autosomal dominant lateral temporal lobe epilepsy (ADLTE)

Research Project

Project/Area Number 18590935
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKyoto University

Principal Investigator

IKEDA Akio  Kyoto University, 医学研究科, 准教授 (90212761)

Co-Investigator(Kenkyū-buntansha) KAWAMATA Jun  京都大学, 医学研究科, 助教 (60360814)
ISHIZU Kouichi  京都大学, 医学研究科, 准教授 (50314224)
MATSUMOTO Riki  京都大学, 医学研究科, 助教 (00378754)
長峯 隆  京都大学, 医学研究科, 准教授 (10231490)
臼井 桂子  静岡てんかん・医療センター, 臨床研究部, 医師 (60402872)
木下 真幸子  独立行政法人国立病院機構宇多野病院, 臨床研究部, 研究員 (90402883)
Co-Investigator(Renkei-kenkyūsha) NAGAMINE Takashi  札幌医科大学, 医学部, 教授 (10231490)
USUI Keiko  静岡てんかん, 神経医療センター, 医師 (60402872)
KINOSHITA Masako  国立病院機構宇多野病院, 医長 (90402883)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords常染色体優性外側側頭葉てんかん / 部分てんかん / LGI1 遺伝子 / genotype / phenotype / 脳神経疾患 / 生理学 / 遺伝子 / 臨床 / てんかん / LGI1遺伝子 / 聴覚誘発磁場
Research Abstract

側頭葉てんかんは成人てんかんで最も多く、常染色体優性外側側頭葉てんかん(ADLTE)はイオンチャンネル以外の遺伝子(LGI1)異常が発見され、その病態を検討した.3家系でのLGI1 のアミノ酸置換を伴う点変異は、exon8 の1645G>A と1642C>T、exon7 の677T>G で、家系間と家系内で症状差を認め、外側・内側側頭葉症状、パニック発作などが混在した.FDG-PET、MRI で外側側頭葉の糖代謝低下と容量低下を示した.音刺激での誘発発作を有する患者では、全頭型脳磁場計測装置で聴覚誘発磁場振幅の異常増強を認めた.本疾患では、genotype とphenotype の相違を決定する修飾因子の存在が示唆され、今後は全国規模の多数例の解析と動物モデルでの病態研究を予定する.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (109 results)

All 2009 2008 2007 2006

All Journal Article (63 results) (of which Peer Reviewed: 15 results) Presentation (19 results) Book (27 results)

  • [Journal Article] Improved cerebral function in mesial temporal lobe epilepsy after subtemporal amydgalohoppocampectomy2009

    • Author(s)
      Takaya S, Mikuni N, Mitsueda T, Satow T, Taki J, Kinoshita M, Miyamoto S, Hashimoto N, Ikeda A, Fukuyama H
    • Journal Title

      Brain 132

      Pages: 185-94

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Journal Article] Negative motor seizure arising from negative motor area : is it ictal apraxia?2009

    • Author(s)
      Ikeda A, Hirasawa K, Kinoshita M, Hitomi T, Matsumoto R, Mitsueda T, Ta ki J, Mikuni N, Hori T, Fukuyama H, Hashimoto N, Shibasaki H, Takahashi R
    • Journal Title

      Epilepsia (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy : the first report from Asian families2009

    • Author(s)
      Kawamata J, Ikeda A, Fujita Y, Usui K, Shimohama S, Takahas hi R
    • Journal Title

      Epilepsia (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Temporal dynamics of Japanese morphogram and syllabogram processing in the left basal temporal area studied by event-related potentials2009

    • Author(s)
      Usui K, Ikeda A, Nagamine T, Matsuhashi M, Kinoshita M, Mikuni N, Mi yamoto S, Hashimoto N, Fukuyama H, Shibasaki H
    • Journal Title

      J Clin Neurophysiol (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] 稀発大発作と振戦様ミオクローヌスを認めたUnverricht-Lundborg 病の成人例2009

    • Author(s)
      近藤孝之、山中崇弘、山門穂高、川又純、冨本秀和、人見健文、池田昭夫、高橋良輔
    • Journal Title

      臨床神経 49

      Pages: 43-47

    • Related Report
      2008 Final Research Report
  • [Journal Article] Leucine-rich glioma-inactivated 1(LGI1)変異を伴う常染色体優性外側側頭葉てんかんの1 例2009

    • Author(s)
      藤田祐之、池田昭夫、門野賢太郎、川又純、冨本秀和、福山秀直、高橋良輔
    • Journal Title

      臨床神経学 (印刷中)

    • Related Report
      2008 Final Research Report
  • [Journal Article] 閃光刺激誘発スパイクの自動検出2009

    • Author(s)
      西田茂人、杉剛直、池田昭夫、長峯隆、柴崎浩、中村政俊
    • Journal Title

      臨床神経生理学 (印刷中)

    • NAID

      10027056206

    • Related Report
      2008 Final Research Report
  • [Journal Article] Negative motor seizure arising from negative motor area : is it ictal apraxia?2009

    • Author(s)
      Ikeda A, Hirasawa K, Kinoshita M, Hitomi T, Matsumoto R, Mitsueda T, Taki J, Mikuni N, Hori T, Fukuyama H, Hashimoto N, Shibasaki H, Takahashi R
    • Journal Title

      Epilepsia (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy : the first report from Asian families2009

    • Author(s)
      Kawamata J, Ikeda A, Fujita Y, Usui K, Shimohama S, Takahashi R
    • Journal Title

      Epilepsia (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal dynamics of Japanese morphogram and syllabogram processing in the left basal temporal area studied by event-related potentials2009

    • Author(s)
      Usui K, Ikeda A, Nagamine T, Matsuhashi M, Kinoshita M, Mikuni N, Miyamoto S, Hashimoto N, Fukuyama H, Shibasaki H
    • Journal Title

      J Clin Neurophysiolol (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leucine-rich glioma-inactivated 1 (LGI1)変異を伴う常染色体優性外側側頭葉てんかんの1例2009

    • Author(s)
      藤田祐之, 池田昭夫, 門野賢太郎, 川又純, 冨本秀和, 福山秀直, 高橋良輔
    • Journal Title

      臨床神経学 49

      Pages: 186-190

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 閃光刺激誘発スパイクの自動検出2009

    • Author(s)
      西田茂人, 杉剛直, 池田昭夫, 長峯隆, 柴崎浩, 中村政俊
    • Journal Title

      臨床神経生理学 (印刷中)

    • NAID

      10027056206

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of the 2001 diagnostic scheme and the 2006 ILAE report of seizure and epilepsy : a feedback from the clinical practice of adult epilepsy2008

    • Author(s)
      Kinoshita M, Takahashi R, Ikeda A
    • Journal Title

      Epileptic Disord 10

      Pages: 206-12

    • NAID

      110006827310

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Journal Article] Usefulness of MEG magnetometer for spike detection iinpatients with mesial temporal lobe epileptic focus2008

    • Author(s)
      Enatsu R, Mikuni N, Usui K, Matsubayashi J, Taki J, Begum T, Matsumoto R, Ikeda A, Nagamine T, Fukuyama H, Hashimoto N
    • Journal Title

      Neuroimage 41

      Pages: 1206-1219

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Journal Article] Hemispheric asymmetry of the arcuate fasciculus in patients with unilateral language dominance defined by Wada test : A diffusion tensor tractography study2008

    • Author(s)
      Matsumoto R, Okada T, Mikuni N, Mitsueda T, Taki J, Sawamoto N, Hanakawa T, Miki Y Hashimoto N, Fukuyama H, Takahashi R, Ikeda A
    • Journal Title

      J Neurol 255

      Pages: 1703-11

    • Related Report
      2008 Final Research Report
  • [Journal Article] 発作時にGerstmann 症候群を呈した症候性頭頂葉てんかんの1例2008

    • Author(s)
      下竹昭寛、藤田祐之、池田昭夫、冨本秀和、高橋潤、高橋良輔
    • Journal Title

      臨床神経 48

      Pages: 208-210

    • NAID

      10021187360

    • Related Report
      2008 Final Research Report
  • [Journal Article] 成人難治性てんかん患者におけるクロバザムおよび活性代謝物の体内動態に関する解析2008

    • Author(s)
      安田幸代、矢野育子、橋田亨、木下真幸子、池田昭夫、高橋良輔、乾賢一
    • Journal Title

      TDM 研究 25

      Pages: 165-169

    • Related Report
      2008 Final Research Report
  • [Journal Article] Hemispheric asymmetry of the arcuate fasciculus in patients with unilateral language dominance defined by Wada test : A diffusion tensor tractography study2008

    • Author(s)
      Matsumoto R, Okada T, Mikuni N, Mitsueda T, Taki J, Sawamoto N, Hanakawa T, Miki Y Hashimoto N, Fukuyama H, Takahashi R, Ikeda A
    • Journal Title

      J Neuol 255

      Pages: 1703-1711

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 発作時にGerstmann症候群を呈した症候性頭頂葉てんかんの1例2008

    • Author(s)
      下竹昭寛, 藤田祐之, 池田昭夫, 冨本秀和, 高橋潤, 高橋良輔
    • Journal Title

      臨床神経 48

      Pages: 208-210

    • NAID

      10021187360

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 稀発大発作と振戦様ミオクローヌスを認めたUnverricht-Lundborg病の成人例2008

    • Author(s)
      近藤孝之, 山中崇弘, 山門穂高, 川又純, 冨本秀和, 人見健文, 池田昭夫, 高橋良輔
    • Journal Title

      臨床神経 49

      Pages: 43-47

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 成人難治性てんかん患者におけるクロバザムおよび活性代謝物の体内動態に関する解析2008

    • Author(s)
      安田幸代, 矢野育子, 橋田亨, 木下真幸子, 池田昭夫, 高橋良輔, 乾賢一
    • Journal Title

      TDM研究 25

      Pages: 165-169

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 発作時にGerstmann症候群を呈した症候性頭頂葉てんかんの1例2008

    • Author(s)
      下竹昭寛、藤田祐之、池田昭夫、冨本秀和、高橋潤、高橋良輔
    • Journal Title

      臨床神経学 48

      Pages: 208-210

    • NAID

      10021187360

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 稀発大発作と振戦様ミオクローヌスを認めたUnverricht-Lundborg病の成人例2008

    • Author(s)
      近藤孝之, 山中崇弘, 山門穂高, 川又純, 冨本秀和, 人見健文, 池田昭夫, 高橋良輔
    • Journal Title

      臨床神経学 (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison between motor evoked potential recording and fiber tracking for estimating pyramidal tracts near brain tumors2007

    • Author(s)
      Mikuni N, Okada T, Nishida N, Taki J, Enatsu R, Ikeda A, Miki Y, Hanakawa T, Fukuyama H, Hashimoto N
    • Journal Title

      J Neurosurg 106

      Pages: 128-133

    • Related Report
      2008 Final Research Report
  • [Journal Article] Fibers from the dorsal premotor cortex elicit motor-evoked potential in a cortical dysplasia2007

    • Author(s)
      Mikuni N, Okada T, Taki J, Matsumoto R, Nishida N, Enatsu R, Hanakawa T, Ikeda A, Miki Y, Urayama S, Fukuyama H, Hashimoto N
    • Journal Title

      Neuroimage 34

      Pages: 12-18

    • Related Report
      2008 Final Research Report
  • [Journal Article] Dynamic change of proximal conduction in demyelinating neuropathies : a cervical magnetic stimulation combined with maximum voluntary contraction2007

    • Author(s)
      Hitomi T, Kaji R, Murase N, Kohara N, Mezaki T, Nodera H, Ikeda A, Shibasaki H
    • Journal Title

      Clin Neurophysiol 118

      Pages: 741-750

    • Related Report
      2008 Final Research Report
  • [Journal Article] Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB2007

    • Author(s)
      Kinoshita M, Ikeda A, Begum T, Terada K, Shibasaki H
    • Journal Title

      J Neurol Sci 263

      Pages: 44-8

    • Related Report
      2008 Final Research Report
  • [Journal Article] Comparison between motor evoked potential recording and fiber tracking for estimating pyramidal tracts near brain tumors.2007

    • Author(s)
      Mikuni N, Okada T, Nishida N, Taki J, Enatsu R, Ikeda A, Miki Y, Hanakawa T, Fukuyama H, Hashimoto N
    • Journal Title

      J Neurosurg 106

      Pages: 128-133

    • Related Report
      2007 Annual Research Report 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibers from the dorsal premotor cortex elicit motor-evoked potential in a cortical dysplasia.2007

    • Author(s)
      Mikuni N, Okada T, Taki J, Matsumoto R, Nishida N, Enatsu R, Hanakawa T, Ikeda A, Miki Y, Urayama S, Fukuyama H, Hashimoto N
    • Journal Title

      Neuroimage 34

      Pages: 12-18

    • Related Report
      2007 Annual Research Report 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic change of proximal conduction in demyelinating neuropathies: a cervical magnetic stimulation combined with maximum voluntary contraction.2007

    • Author(s)
      Hitomi T, Kaji R, Murase N, Kohara N, Mezaki T, Nodera H, Ikeda A, Shibasaki H
    • Journal Title

      Clin Neurophysiol 118

      Pages: 741-750

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB.2007

    • Author(s)
      Kinoshita M, Ikeda A, Begum T, Terada K, Shibasaki H
    • Journal Title

      J Neuroll Sci 263

      Pages: 44-48

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered plasticity of the human motor cortex in pakinson's disease2006

    • Author(s)
      Ueki Y, Mima T, Kotb MA, Sawada H, SaikiH, Ikeda A, Begum T, Reza F, Nagamine T, Fukuyama H
    • Journal Title

      Ann Neurol 59

      Pages: 60-71

    • Related Report
      2008 Final Research Report
  • [Journal Article] Evidence of a wide distribution of negative motor areas in the perirolandic cortex2006

    • Author(s)
      Mikuni N, Ohara S, Ikeda A, Hayashi N, Nishida N, Taki J, Enatsu R, Matsumoto R, Shibasaki H, Hashimoto N
    • Journal Title

      Clin Neurophysiol 117

      Pages: 33-40

    • Related Report
      2008 Final Research Report
  • [Journal Article] "Burst and slow complexes " in nonconvulsive2006

    • Author(s)
      Ikeda A, Matsui M, Hase Y, Hitomi T, Takahashi Y, Shibasaki H, Shimohama S
    • Journal Title

      epileptic status. Epileptic Disord 8

      Pages: 61-64

    • Related Report
      2008 Final Research Report
  • [Journal Article] "Burst and slow complexes " in nonconvulsive2006

    • Author(s)
      Ikeda A, Matsui M, Hase Y, Hitomi T, Takahashi Y, Shibasaki H, Shimoh ama S
    • Journal Title

      epileptic status. Epileptic Disord 8

      Pages: 61-64

    • Related Report
      2008 Final Research Report
  • [Journal Article] Widdess-Walshl P : Are epilepsy classifications based on epileptic syndromes and seizure types outdated2006

    • Author(s)
      Luders HO, Acharya J, Alexopoulosl A, Baumgartner, Bautista J, R. Burgess R, Carreno M, Diehl B, Dinner D1, Ebner A, Foldvary N, Godoy J, Hamer H, Ikeda A, Kallen K, Kellinghaus C, Kotagal P, Lachhwanil D, Loddenkemper T , ManI J, Matsumoto R, Moddel G, Nair D, Noachtar S, 0' Donovan CA, Rona S, Rosenow F, Schuelel S, Szabo CA, Tandon N, Tanner A
    • Journal Title

      Epileptic Disord 8

      Pages: 81-85

    • Related Report
      2008 Final Research Report
  • [Journal Article] Generators and temporal succession of giant somatsensory evoked potentials epicortical recording from sensorimotor cortex2006

    • Author(s)
      Hitomi T, Ikeda A, Matsumoto R, Kinoshita M, Taki J, Usui K, Mikuni N, Nagamine T, Hashimoto N, Shibasaki H, Takahashi R
    • Journal Title

      Clin Neurophysiol 117

      Pages: 1481-1486

    • Related Report
      2008 Final Research Report
  • [Journal Article] Bereitschaftspotentials recorded from the lateral part of the superior frontal gyrus in humans2006

    • Author(s)
      Ohara S, Ikeda A, Matsuhashi M, Satow T, Kunieda T, Mikuni N, Baba K, Mihara T, Miyamoto S, Shibasaki H
    • Journal Title

      Neurosci Lett 399

      Pages: 1-5

    • Related Report
      2008 Final Research Report
  • [Journal Article] Low-frequency electric cortical stimulation decreases interictal and ictal activity in human epilepsy2006

    • Author(s)
      Yamamoto J, Ikeda A, Kinoshita M, Matsumoto R, Satow T, Takeshita K, Matsuhashi M, Mikuni N, Miyamoto S, Hashimoto N, Shibasaki H
    • Journal Title

      Seizure 15

      Pages: 520-527

    • Related Report
      2008 Final Research Report
  • [Journal Article] Narcolepsy without cataplexy : two subtypes based on CSF hypoicretin-1/ orexin-A findings2006

    • Author(s)
      Oka Y, Inoue Y, Kanbayashi T, Kuroda K, Miyamoto M, Miyamoto T, Horiuchi F, Ikeda A, Shimizu T, Shibasaki H
    • Journal Title

      Sleep 29

      Pages: 1439-1443

    • Related Report
      2008 Final Research Report
  • [Journal Article] Subtemporal hippocampectomy preserving the basal temporal language area for intractable mesial temporal lobe epilepsy- preliminary results2006

    • Author(s)
      Mikuni N, Miyamoto S, Ikeda A, Satow T, Taki J, Takahashi J, Ohigashi Y, Hashimoto N
    • Journal Title

      Epilepsia 47

      Pages: 1347-53

    • NAID

      10019307665

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy2006

    • Author(s)
      Takaya S, Hanakawa T, Hashikawa K, Ikeda A, Sawamoto N, Nagamine T, Ishizu K, Fukuyama H
    • Journal Title

      Neurology 67

      Pages: 1674-1676

    • Related Report
      2008 Final Research Report 2006 Annual Research Report
  • [Journal Article] Proposed diagnostic schema for the classification of epileptic seizures and eipilepsies (ILAE, 2001) : proposal from Japan Epilepsy Society2006

    • Author(s)
      Iinuma K, Morimoto K, Akiyama T, Ikeda A, Kurimoto M
    • Journal Title

      Epilepsia 47

      Pages: 1588-1591

    • Related Report
      2008 Final Research Report
  • [Journal Article] Ipsilateral facial sensory and motor response to basal fronoto-temporal cortical stimulation : evidence suggesting direct activation of cranial nerves2006

    • Author(s)
      Begum T, Ikeda A, Matsuhashi M, Mikuni N, Miyamoto S, Hashimoto N, Nagamine T, Fukuyama H, Shibasaki H
    • Journal Title

      Epilepsy Res 71

      Pages: 216-222

    • Related Report
      2008 Final Research Report
  • [Journal Article] A step-by-step resection guided by electrocorticography for nonmalignant brain tumors associated with long-term intractable epilepsy2006

    • Author(s)
      Mikuni N, Ikeda A, Takahashi JA Nozaki K, Miyamoto S, Taki W, Hashimoto N
    • Journal Title

      Epilepsy and Behavior 8

      Pages: 560-564

    • Related Report
      2008 Final Research Report
  • [Journal Article] Rapid recovery from coma with multifocal PLEDs in a patient with severe dementia2006

    • Author(s)
      Begum T, Ikeda A, Yoshioka A, Sawada H, Fukuyama H, Shibasaki H
    • Journal Title

      Int Med 45

      Pages: 141-144

    • Related Report
      2008 Final Research Report
  • [Journal Article] Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI : a case report2006

    • Author(s)
      Mitsueda-Ono T, Ikeda A, Noguchi E, Takaya S, Fukuyama H, Shimohama S, Takahashi R
    • Journal Title

      J Neurol Sci 247

      Pages: 109-111

    • Related Report
      2008 Final Research Report 2006 Annual Research Report
  • [Journal Article] Heterogenous epileptogenicity and cortic function within malformation of cortical development : a case report2006

    • Author(s)
      Kinoshita M Ikeda A, Taki J, Usui K, Matsumoto R, Mikuni N, Takahashi JB, Fukuyama H, Hashimoto N, Takahashi R
    • Journal Title

      J Neurol Sci 251

      Pages: 129-133

    • Related Report
      2008 Final Research Report
  • [Journal Article] 一次体性感覚野の皮質異形成にともない難治部分発作と皮質反射性ミオクローヌスを示した1例2006

    • Author(s)
      中川寧子、松本理器、池田昭夫、三国信啓、松橋眞生、花川隆、福山秀直、下濱俊
    • Journal Title

      臨床神経 46

      Pages: 335-338

    • NAID

      10017612672

    • Related Report
      2008 Final Research Report
  • [Journal Article] 副甲状腺機能低下症による低カルシウム血症を合併した側頭葉てんかんの1例2006

    • Author(s)
      竹内幸喜、池田昭夫、大塚快信、斎木英資、下濱俊、高橋良輔
    • Journal Title

      臨床神経 46

      Pages: 510-512

    • NAID

      10020347981

    • Related Report
      2008 Final Research Report
  • [Journal Article] 食後に離人症体験、おかしみの情動、失語から始まるeating epilepsyの1例2006

    • Author(s)
      斉木英資、池田昭夫、石倉大輔、下濱俊、高橋良輔
    • Journal Title

      てんかん研究 24

      Pages: 63-67

    • NAID

      110006152520

    • Related Report
      2008 Final Research Report
  • [Journal Article] Evidence of a wide distribution of negative motor areas in the perirolandic cortex.2006

    • Author(s)
      Mikuni N, Ohara S, Ikeda A, Hayashi N, Nishida N, Taki J, Enatsu R, Matsumot R, Shibasaki H, Hashimoto N
    • Journal Title

      Clin Neurophysiol 117

      Pages: 33-40

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clinical outcome of patients with SREDA (Subclinical Rhythmic EEG Discharge of Adults).2006

    • Author(s)
      Begum T, Ikeda A, Takahashi J, Tomimoto H, Shimohama S, Satow T, Nagamine T, Fukuyama H, Shibasaki H
    • Journal Title

      Int Med 45

      Pages: 141-144

    • NAID

      130000076582

    • Related Report
      2006 Annual Research Report
  • [Journal Article] "Burst and slow complexes" in nonconvulsive, epileptic status.2006

    • Author(s)
      Ikeda A, Matsui M, Hase Y, Hitomi T, Takahashi Y, Shibasaki H, Shimohama S
    • Journal Title

      Epileptic Disord 8

      Pages: 61-64

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Generators and temporal succession giant somatsensory evoked potentials : epicortical recording from sensorimotor cortex.2006

    • Author(s)
      Hitomi T, Ikeda A, Matsumoto R, Kinoshita M, Taki J, Usui K, Mikuni N, Nagamine T, Hashimoto N, Shibasaki H, Takahashi R
    • Journal Title

      Clin Neurophysiol 117

      Pages: 1481-1486

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bereitschaftspotentials recorded from the lateral part of the superior frontal gyrus in humans.2006

    • Author(s)
      Ohara S, Ikeda A, Matsuhashi M, Satow T, Kunieda T, Mikuni N, Baba K, Mihara T, Miyamoto S, Shibasaki H
    • Journal Title

      Neurosci Lett 399

      Pages: 1-5

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Rapid recovery from coma with multifocal PLEDs in a patient with severe dementia.2006

    • Author(s)
      Begum T, Ikeda A, Yoshioka A, Sawada H, Fukuyama H, Shibasaki H
    • Journal Title

      Int Med 45

      Pages: 141-144

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Low-frequency electric cortical stimulation decreases interictal and ictal activity in human epilepsy.2006

    • Author(s)
      Yamamoto J, Ikeda A, Kinoshita M, Matsumoto R, Satow T, Takeshita K, Matsuhashi M, Mikuni N, Miyamoto S, Hashimoto N, Shibasaki H
    • Journal Title

      Seizure 15

      Pages: 520-527

    • Related Report
      2006 Annual Research Report
  • [Journal Article] heterogenicity and cortic function within malformation of cortical development : a case rport.2006

    • Author(s)
      Kinoshita M, Ikeda A, Taki J, Usui K, Matsumoto R, Mikuni N, Takahashi JB, Fukuyama H, Hashimoto N, Takahashi R
    • Journal Title

      J Neurol Sci 251

      Pages: 129-133

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Subtemporal hippocampectomy preserving the basal temporal language area for intractable mesial temporal lobe epilepsy-preliminary results.2006

    • Author(s)
      Mikuni N, Miyamoto S, Ikeda A, Satow T, Taki J, Takahashi J, Ohigashi Y, Hashimoto N
    • Journal Title

      Epilepsia 47

      Pages: 1347-1353

    • NAID

      10019307665

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Proposed diagnostic schema for the classification of epileptic seizures and eipilepsies (ILAE, 2001) : proposal from Japan Epilepsy Society.2006

    • Author(s)
      Iinuma K, Morimoto K, Akiyama T, Ikeda A, Kurimoto M
    • Journal Title

      Epilepsia 47

      Pages: 1588-1591

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ipsilateral facial sensory and motor response to basal fronoto-temporal cortical stimulation : evidence suggesting direct activation of cranial nerves.2006

    • Author(s)
      Begum T, Ikeda A, Matsuhashi M, Mikuni N, Miyamoto S, Hashimoto N, Nagamine T, Fukuyama H, Shibasaki H
    • Journal Title

      Epilepsy Res 71

      Pages: 216-222

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A step-by-step resection guided by electrocorticography for nonmalignant brain tumors associated with long-term intractable epilepsy.2006

    • Author(s)
      Mikuni N, Ikeda A, Takahashi JA, Nozaki K, Miyamoto S, taki W, Hashimoto N
    • Journal Title

      Brain and Behavor 8

      Pages: 560-564

    • Related Report
      2006 Annual Research Report
  • [Presentation] 特別シンポジウム、てんかん外科と地域医療「神経内科からの観点」2009

    • Author(s)
      池田昭夫
    • Organizer
      第32回日本てんかん外科学会
    • Place of Presentation
      東京
    • Year and Date
      2009-01-22
    • Related Report
      2008 Final Research Report
  • [Presentation] てんかん外科と地域医療「神経内科からの観点」2009

    • Author(s)
      池田昭夫
    • Organizer
      第32回日本てんかん外科学会, 特別シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-01-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] てんかんの外科手術のための神経生理診断、教育講演2008

    • Author(s)
      池田昭夫
    • Organizer
      第42回日本臨床神経生理学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-14
    • Related Report
      2008 Final Research Report
  • [Presentation] てんかんの外科手術のための神経生理診断2008

    • Author(s)
      池田昭夫
    • Organizer
      第38回日本臨床神経生理学会, 教育講演
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Maturation of EEG : Development of the awake and & sleep pattern2008

    • Author(s)
      Ikeda A
    • Organizer
      EEG workshop on 12th AOCN, 16th IANCON, 2008
    • Place of Presentation
      New Delhi, India
    • Year and Date
      2008-10-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Normal EEG : from adlescent to elderly2008

    • Author(s)
      Ikeda A
    • Organizer
      EEG workshop on 12th AOCN, 16th IANCON, 2008
    • Place of Presentation
      New Delhi, India
    • Year and Date
      2008-10-22
    • Related Report
      2008 Final Research Report
  • [Presentation] てんかんの症候学Update2008

    • Author(s)
      池田昭夫
    • Organizer
      第42回日本てんかん学会教育講演
    • Place of Presentation
      東京
    • Year and Date
      2008-10-18
    • Related Report
      2008 Final Research Report
  • [Presentation] てんかんの症候学Update2008

    • Author(s)
      池田昭夫
    • Organizer
      第42回日本てんかん学会, 教育講演
    • Place of Presentation
      東京
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] てんかん治療の新たなる展開2008

    • Author(s)
      池田昭夫
    • Organizer
      第50回日本小児神経学会セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-29
    • Related Report
      2008 Final Research Report
  • [Presentation] てんかん治療の新たなる展開2008

    • Author(s)
      池田昭夫
    • Organizer
      第50回日本小児神経学会, セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Spectrum of epileptic disorders in Japan, JNS-KNA- 1st Joint Symposium, International Comparison of Neurological Disorders2008

    • Author(s)
      Ikeda A
    • Organizer
      focusing on spinocerebellar atrophies and epilepsies
    • Place of Presentation
      Yokohama, Japan (Symposium)
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] てんかん診療Update、難治てんかんの最近の治療2008

    • Author(s)
      池田昭夫
    • Organizer
      第49回日本神経学会総会セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-15
    • Related Report
      2008 Final Research Report
  • [Presentation] てんかん診療Update、難治てんかんの最近の治療2008

    • Author(s)
      池田昭夫
    • Organizer
      第49回日本神経学会総会, セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 難治性てんかんの治療戦略2008

    • Author(s)
      池田昭夫
    • Organizer
      第28回日本脳神経外科コングレスセミナー
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 難治性てんかんの治療戦略2008

    • Author(s)
      池田昭夫
    • Organizer
      第28回日本脳神経外科コングレス, セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 特別セッション : てんかん外科における関連診療科との協力体制 「てんかん外科への紹介のタイミング」大学病院の神経内科の立場から2008

    • Author(s)
      池田昭夫
    • Organizer
      第31回日本てんかん外科学会
    • Place of Presentation
      浜松
    • Year and Date
      2008-01-24
    • Related Report
      2008 Final Research Report
  • [Presentation] てんかん外科における関連診療科との協力体制「てんかん外科への紹介のタイミング」大学病院の神経内科の立場から2008

    • Author(s)
      池田昭夫
    • Organizer
      第31回日本てんかん外科学会, 特別セッション
    • Place of Presentation
      浜松
    • Year and Date
      2008-01-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Movement-related changes in human cortical activity : an input from direct cortical recording, Workshop 42008

    • Author(s)
      Ikeda A, Nagamine T, Matsuhashi M, Taki J
    • Organizer
      MEG based analysis of spontaneous cortical oscillations
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Magnetoencephalography(MEG)and Epileptiform Pattern2008

    • Author(s)
      Ikeda A
    • Organizer
      1st CAAE EEG and Clinicl Neurophysiological Conference, Tianjin
    • Place of Presentation
      Tianjin, China
    • Related Report
      2008 Final Research Report
  • [Book] 失神、痙攣、症候編、内科実践マニュアル (日本臨床内科医会編)2009

    • Author(s)
      池田昭夫(分担執筆)
    • Publisher
      日本医学出版
    • Related Report
      2008 Final Research Report
  • [Book] てんかん、神経疾患、内科実践マニュアル (日本臨床内科医会編)2009

    • Author(s)
      池田昭夫(分担執筆)
    • Publisher
      日本医学出版
    • Related Report
      2008 Final Research Report
  • [Book] Event-related potentials (ERPs) in patients with epilepsy : from current state to future prospect, Progress in Epileptic Disorders2008

    • Author(s)
      Ikeda A, Inoue Y(eds)(分担執筆)
    • Publisher
      John Libbey, Paris
    • Related Report
      2008 Final Research Report
  • [Book] Event-related potentials in epilepsy surgery2008

    • Author(s)
      Usui K, Ikeda A(分担執筆)
    • Publisher
      In : Luders HO (eds), Textbook of epilepsy surgery, Taylor and Francis Book Ltd
    • Related Report
      2008 Final Research Report
  • [Book] Cortical mapping using evoked potentials and Bereitschafts- potentials2008

    • Author(s)
      Ikeda A, Shibasaki H(分担執筆)
    • Publisher
      In : Luders HO (eds), Textbook of epilepsy surgery, Informa UK Ltd
    • Related Report
      2008 Final Research Report
  • [Book] DC recordings to localize the ictal onset zone2008

    • Author(s)
      Ikeda A(分担執筆)
    • Publisher
      In : Luders HO (eds), Textbook of epilepsy surgery, Informa UK Ltd
    • Related Report
      2008 Final Research Report
  • [Book] Epilepsy surgery and ERPs : invasive study in epilepsy for motor function2008

    • Author(s)
      Ikeda A(分担執筆)
    • Publisher
      In : Ikeda A, Inoue Y(eds), Event-related potentials (ERPs) in patients with epilepsy : from current state to future prospect, Progress in Epileptic Disorders
    • Related Report
      2008 Final Research Report
  • [Book] ERP study in Epilepsy : introductory remarks2008

    • Author(s)
      Luders HO, Ikeda A(分担執筆)
    • Publisher
      In : Ikeda A, Inoue Y(eds), Event-related potentials (ERPs) in patients with epilepsy : from current state to future prospect, Progress in Epileptic Disorders
    • Related Report
      2008 Final Research Report
  • [Book] 機能性疾患、神経・運動器疾患、わかりやすい内科学(井村裕夫編)第3版2008

    • Author(s)
      池田昭夫(分担執筆)
    • Publisher
      文光堂、東京
    • Related Report
      2008 Final Research Report
  • [Book] けいれん・不随意運動、 症候・検査編、わかりやすい内科学(井村裕夫編)第3版2008

    • Author(s)
      池田昭夫(分担執筆)
    • Publisher
      文光堂、東京
    • Related Report
      2008 Final Research Report
  • [Book] Event-related potentials (ERPs) in patients with epilepsy : from current state to future prospect, Progress in Epileptic Disorders, vol. 62008

    • Author(s)
      Ikeda A, Inoue Y (eds)
    • Total Pages
      291
    • Publisher
      John Libbey, Paris
    • Related Report
      2008 Annual Research Report
  • [Book] Event-related potentials in epilepsy surgery. In : Luders HO (eds), Textbook of epilepsy surgery2008

    • Author(s)
      Usui K, Ikeda A
    • Total Pages
      10
    • Publisher
      Taylor and Francis Book Ltd ; London
    • Related Report
      2008 Annual Research Report
  • [Book] Cortical mapping using evoked potentials and Bereitschafts-potentials. In : Luders HO (eds), Textbook of epilepsy surgery2008

    • Author(s)
      Ikeda A, Shibasaki H
    • Total Pages
      13
    • Publisher
      Informa UK Ltd ; London
    • Related Report
      2008 Annual Research Report
  • [Book] DC recordings to localize the ictal onset zone. In : Luders HO (eds), Textbook of epilepsy surgery2008

    • Author(s)
      Ikeda A
    • Total Pages
      8
    • Publisher
      Informa UK Ltd ; London
    • Related Report
      2008 Annual Research Report
  • [Book] Epilepsy surgery and ERPs : invasive study in epilepsy for motor function. In : Ikeda A, Inoue Y (eds), Event-related potentials (ERPs) in patients with epilepsy : from current state to future prospect, Progress in Epileptic Disorders, vol. 62008

    • Author(s)
      Ikeda A
    • Total Pages
      13
    • Publisher
      John Libbey, Paris
    • Related Report
      2008 Annual Research Report
  • [Book] ERP study in Epilepsy : introductory remarks, In : Ikeda A, Inoue Y (eds), Event-related potentials (ERPs) in patients with epilepsy : from current state to future prospect, Progress in Epileptic Disorders, vol. 62008

    • Author(s)
      Luders HO, Ikeda A
    • Total Pages
      8
    • Publisher
      Progress in Epileptic Disorders, vol. 6, John Libbey, Paris
    • Related Report
      2008 Annual Research Report
  • [Book] 機能性疾患、神経・運動器疾患、わかりやすい内科学(井村裕夫編)第3版2008

    • Author(s)
      池田昭夫
    • Total Pages
      12
    • Publisher
      文光堂
    • Related Report
      2008 Annual Research Report
  • [Book] けいれん・不随意運動、症候・検査編、わかりやすい内科学(井村裕夫編)第3版2008

    • Author(s)
      池田昭夫
    • Total Pages
      6
    • Publisher
      文光堂
    • Related Report
      2008 Annual Research Report
  • [Book] 失神、痙幸、症候編、内科実践マニュアル(日本臨床内科医会編)2008

    • Author(s)
      池田昭夫
    • Total Pages
      4
    • Publisher
      日本医学出版
    • Related Report
      2008 Annual Research Report
  • [Book] てんかん、神経疾患、内科実践マニュアル(日本臨床内科医会編)2008

    • Author(s)
      池田昭夫
    • Total Pages
      9
    • Publisher
      日本医学出版
    • Related Report
      2008 Annual Research Report
  • [Book] Event-related potentials in epilepsy surgery. In:Luders HO (eds), Textbook of epilepsy surgery2008

    • Author(s)
      Usui K, Ikeda A
    • Total Pages
      10
    • Publisher
      Taylor and Francis Book Ltd; London, (in press)
    • Related Report
      2007 Annual Research Report
  • [Book] Cortical mapping using evoked potentials and Bereitschaftspotentials. In:Luders HO (eds), Textbook of epilepsy surgery2008

    • Author(s)
      Ikeda A, Shibasaki H
    • Total Pages
      12
    • Publisher
      Taylor and Francis Book Ltd; London, (in press)
    • Related Report
      2007 Annual Research Report
  • [Book] DC recordings to localize the ictal onset zone. In:Luders HO (eds), Textbook of epilepsy surgery2008

    • Author(s)
      Ikeda A
    • Total Pages
      10
    • Publisher
      Taylor and Francis Book Ltd; London, (in press)
    • Related Report
      2007 Annual Research Report
  • [Book] Epilepsy surgery and ERPs: invasive study in epilepsy for motor function. In: Ikeda A, Inoue Y (eds), Event-related potentials (ERPs) in patients with epilepsy: from current state to future prospect2008

    • Author(s)
      Ikeda A
    • Total Pages
      15
    • Publisher
      Progress in Epileptic Disorders, vol. 6, John Libbey, Paris, (in press)
    • Related Report
      2007 Annual Research Report
  • [Book] Event-related potentials in epilepsy surgery.2006

    • Author(s)
      Usui K, Ikeda A
    • Publisher
      In : Luders HO (eds), Textbook of epilepsy surgery, Taylor and Francis Book Ltd; London, (in press)
    • Related Report
      2006 Annual Research Report
  • [Book] Cortical mapping using evoked potentials and Bereitschaftspotentials.2006

    • Author(s)
      Ikeda A, Shibasaki H
    • Publisher
      In : Luders HO (eds), Textbook of epilepsy surgery, Taylor and Francis Book Ltd; London, (in press)
    • Related Report
      2006 Annual Research Report
  • [Book] DC recordings to localize the ictal onset zone.2006

    • Author(s)
      Ikeda A
    • Publisher
      In : Luders HO (eds), Textbook of epilepsy surgery, Taylor and Francis Book Ltd; London, (in press)
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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