| Project/Area Number |
18590942
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
ISHIHARA Takeshi Okayama University, Hospital, Neuropsychiatry, Lecturer (60335594)
|
|---|
| Project Period (FY) |
2006 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,760,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
|---|
| Keywords | tau / tauopathies / neurodegeneration / calpain-calpastatin pathway / mouse models / Alzheimer's disease / タウ蛋白 / 神経変性疾患 / 動物モデル / カルパイン / カルパスタチン |
|---|
| Research Abstract |
Tau transgenic mice (PrP T44) were crossbred with calpastatin knock-out mice (CS-KO) to investigate the influence of calpain-calpastatin pathway on neurodegeneration related to tau overexpression. Deletion of calpastatin in PrP T44 mice resulted in acceleration of behavioral symptoms and pathological and biochemical changes, indicating that calpain-calpastatin pathway is involved in the neurodegeneration induced by tau overexpression in the central nervous system in mice. The underlying mechanisms of the findings in this study remain to be elucidated by further investigations.
|
