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Identification of epitopes of autoantibodies in multiple sclerosis

Research Project

Project/Area Number 18590949
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionSaga University

Principal Investigator

KURODA Yasuo  Saga University, Faculty of Medicine, Professor (30117105)

Co-Investigator(Kenkyū-buntansha) SUEOKA Eizaburou  Saga University, Faculty of Medicine, Associate Professor (00270603)
SUEOKA Naoko  Saga University, Faculty of Medicine, Assistant Professor (20321846)
YUKITAKE Motohiro  Saga University, Faculty of Medicine, Assistant Professor (10304891)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordsmultiple sclerosis / hnRNP A2 / B1 / cerebrospinal fluid / HAM / epitope / autoantibody / demyelinating encephalitis / disease marker / hnRNP B1 / 抗hnRNP-B1抗体 / 自己免疫疾患 / 脱髄疾患 / hnRNP A1 / 診断
Research Abstract

We performed a blind study on the association between anti-hnRNP A2/B1 antibody and multiple sclerosis. We assayed anti-hnRNP A2/B1 protein antibody in 105 cerebrospinal fluid samples from patients affected neurological disorders. Both anti-hnRNP A Al proteinantibdy and anti-hnRNP A2/B1 protein antibody were significantly frequently found in cerebrospinal fluid of multiple sclerosis patients than those with other neurological diseases. We next made a study on the epitope of hnRNP B1 protein. We made fragments of hnRNP B1 protein, and then analyzed reactivity of cerebrospinal fluid of multiple sclerosis against those peptides by use of Western immunoblots. We identified anti-hnRNP B1 protein antibody reacted with the amino acid sequence between 234 and 305 of hnRNP B1 protein.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (7 results)

All 2006 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] 髄液内抗hnRNP B1抗体と多発性硬化症2006

    • Author(s)
      雪竹 基弘
    • Journal Title

      神経治療学 23

      Pages: 99-105

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Significantly increased antibody response ton heterogeneous nuclear ribo nucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lymphotropic virus type-I-associated myelopathy/tropical spastic paraparesis2006

    • Author(s)
      Yukitake M, Sueoka E, Sueoka N, Sato A, Ohashi H, Yakushiji Y, Saito M, Osame M, Izumo S, Kuroda Y
    • Journal Title

      Journal of Neurovirology 14

      Pages: 130-135

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid anti-hnRNP B1 antibody and multiple Sclerosis2006

    • Author(s)
      Yukitake, M.
    • Journal Title

      Shinkeichiryougaku 23

      Pages: 99-105

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Significantly increased antibody Response to heterogeneous nuclear ribonucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lmyphotropic virus type-I-associated myelopathy/tropica ; spastic Paraparesis2006

    • Author(s)
      Yukitake, M., Sueoka, E., Sueoka, N., Sato, A., Ohashi, H., Yakushiji, Y., Saito, M., Osame, M., Izumo, S., Kuroda, Y
    • Journal Title

      Journal of Neurovirology 14

      Pages: 130-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Autoantibodies against heterogeneous nuclear ribonucleoproteins:analysis of 168 CSF samples from neurological disorders

    • Author(s)
      Yukitake M, Sueoka M, Sueoka N, Kuroda Y
    • Journal Title

      Journal of Neurovirology (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Daignostic value of CSF autoantibodies against heterogeneous nuclear ribonucleoprotein A1 and A2B1 in multiple sclerosis patients2006

    • Author(s)
      Yukitake M, Sueoka E, Sueoka N, Kuroda Y
    • Organizer
      8th International Congress of Neuroimmunolgy
    • Place of Presentation
      Nagoya,Japan
    • Year and Date
      2006-10-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diagnostic value of CSF autoantibodies against heterogeneous nuclear ribonucleoprotein Al and in multiple sclerosis patients2006

    • Author(s)
      Yukitake M., Sueoka E., Sueoka, N., Kuroda, Y
    • Organizer
      8th International Congress of Neuroimmunology
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2006-10-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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