Identification of epitopes of autoantibodies in multiple sclerosis
| Project/Area Number |
18590949
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Saga University |
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Principal Investigator |
KURODA Yasuo Saga University, Faculty of Medicine, Professor (30117105)
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| Co-Investigator(Kenkyū-buntansha) |
SUEOKA Eizaburou Saga University, Faculty of Medicine, Associate Professor (00270603)
SUEOKA Naoko Saga University, Faculty of Medicine, Assistant Professor (20321846)
YUKITAKE Motohiro Saga University, Faculty of Medicine, Assistant Professor (10304891)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | multiple sclerosis / hnRNP A2 / B1 / cerebrospinal fluid / HAM / epitope / autoantibody / demyelinating encephalitis / disease marker / hnRNP B1 / 抗hnRNP-B1抗体 / 自己免疫疾患 / 脱髄疾患 / hnRNP A1 / 診断 |
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| Research Abstract |
We performed a blind study on the association between anti-hnRNP A2/B1 antibody and multiple sclerosis. We assayed anti-hnRNP A2/B1 protein antibody in 105 cerebrospinal fluid samples from patients affected neurological disorders. Both anti-hnRNP A Al proteinantibdy and anti-hnRNP A2/B1 protein antibody were significantly frequently found in cerebrospinal fluid of multiple sclerosis patients than those with other neurological diseases. We next made a study on the epitope of hnRNP B1 protein. We made fragments of hnRNP B1 protein, and then analyzed reactivity of cerebrospinal fluid of multiple sclerosis against those peptides by use of Western immunoblots. We identified anti-hnRNP B1 protein antibody reacted with the amino acid sequence between 234 and 305 of hnRNP B1 protein.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Significantly increased antibody Response to heterogeneous nuclear ribonucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lmyphotropic virus type-I-associated myelopathy/tropica ; spastic Paraparesis2006
Author(s)
Yukitake, M., Sueoka, E., Sueoka, N., Sato, A., Ohashi, H., Yakushiji, Y., Saito, M., Osame, M., Izumo, S., Kuroda, Y
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Journal Title
Journal of Neurovirology 14
Pages: 130-135
Description
「研究成果報告書概要(欧文)」より
Related Report
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