Characterization of ER stress induced gene, stanniocalcin 2 in apoptosis and neurological diseases.
| Project/Area Number |
18590955
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
ITOH Daisuke Keio University, 医学部, 講師 (80286450)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Shigeaki 慶應義塾大学, 医学部, 講師 (50276242)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,450,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 小胞体ストレス / スタニオカルチン2 / アポトーシス / ノックアウトマウス / 老化 / アポトーシスソ |
|---|
| Research Abstract |
The role of a novel ER stress related gene, Stanicalcin2 (STC2) remain clear. To clarify the function of STC2 in vivo, we generated STC2 knock out mice. Deletion of STC2 rescuers osteomalasia in Klotho insufficiency, suggesting STC2 associated with bone metabolism.
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Report
(6 results)
Research Products
(42 results)
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[Journal Article] Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir.2010
Author(s)
Yagi T, Hattori H, Ohira M, Nakamichi K, Takayama-Ito M, Saijo M, Shimizu T, Ito D, Takahashi K, Suzuki N
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Journal Title
Clin Neurol Neurosurg 112(2)
Pages: 153-156
Related Report
Peer Reviewed
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[Presentation] TDP-43プロテイノパチーの病態解明へのアプローチ-孤発性筋萎縮性側索硬化症患者からのiPS細胞樹立-2009
Author(s)
二瓶義廣, 八木拓也, 伊東大介, 小堺有史, 吉崎崇仁, 赤松和土, 岡田洋平, 川村雅文, 高橋愼一, 岡野栄之, 鈴木則宏
Organizer
第28回日本認知症学会
Place of Presentation
仙台
Year and Date
2009-10-21
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