Characterization of ER stress induced gene, stanniocalcin 2 in apoptosis and neurological diseases.

• Project/Area Number: 18590955
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Keio University
• Principal Investigator: ITOH Daisuke Keio University, 医学部, 講師 (80286450)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Shigeaki 慶應義塾大学, 医学部, 講師 (50276242)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,450,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 小胞体ストレス / スタニオカルチン2 / アポトーシス / ノックアウトマウス / 老化 / アポトーシスソ

Research Abstract

The role of a novel ER stress related gene, Stanicalcin2 (STC2) remain clear. To clarify the function of STC2 in vivo, we generated STC2 knock out mice. Deletion of STC2 rescuers osteomalasia in Klotho insufficiency, suggesting STC2 associated with bone metabolism.

Research Products

• [Journal Article] Characterization of alternative isoforms and inclusion body of the TAR DNA binding protein-43. (2010)
  • Author(s): Nishimoto Y, Ito D, Yagi T, Nihei Y, Tsunoda Y, Suzuki N
  • Journal Title: J Biol Chem 285(1) Pages: 608-619
  • Peer Reviewed
• [Journal Article] Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir. (2010)
  • Author(s): Yagi T, Hattori H, Ohira M, Nakamichi K, Takayama-Ito M, Saijo M, Shimizu T, Ito D, Takahashi K, Suzuki N
  • Journal Title: Clin Neurol Neurosurg 112(2) Pages: 153-156
  • Peer Reviewed
• [Journal Article] Characterization of alternative isoforms and inclusion body of the TAR DNA binding protein-43. (2010)
  • Author(s): Nishimoto Y, Ito D, Yagi T, Nihei Y, Tsunoda Y, Suzuki N.
  • Journal Title: J Biol Chem. 285(1) Pages: 608-619
  • Peer Reviewed
• [Journal Article] Retinopathy: an overlooked adverse effect of interferon-beta treatment of multiple sclerosis. (2009)
  • Author(s): Ohira M, Ito D, Shimizu T, Shibata M, Ohde H, Suzuki N
  • Journal Title: Keio J Med 58(1) Pages: 54-56
  • NAID: 10026202740
  • Peer Reviewed
• [Journal Article] Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17. (2008)
  • Author(s): Ito D, Fujisawa T, Iida H, Suzuki N
  • Journal Title: Neurobiol Dis 31(2) Pages: 266-277
  • Peer Reviewed
• [Journal Article] Seipinopathy : a novel endoplasmic reticulum stress-associated disease (2008)
  • Author(s): Ito D, Suzuki N
  • Journal Title: Brain 132(1) Pages: 8-15
  • Peer Reviewed
• [Journal Article] Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17 (2008)
  • Author(s): Ito D, Fujisawa T, Iida H, Suzuki N
  • Journal Title: Neurobiol Dis 31(2) Pages: 266-277
  • Peer Reviewed
• [Journal Article] 神経変性と小胞体ストレス -新規小胞体ストレス関連疾患、Seipinopathy の神経変性分子機構- (2008)
  • Author(s): 伊東大介
  • Journal Title: 慶應医学 85(1) Pages: 25-30
  • NAID: 10024168671
• [Journal Article] Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17. (2008)
  • Author(s): Ito D, Fujisawa T, Iida H, Suzuki N
  • Journal Title: Neurobioi Dis. 31(2) Pages: 266-277
  • Peer Reviewed
• [Journal Article] Seipinopathy : a novel endoplasmic reticulum stress-associated disease. (2008)
  • Author(s): Ito D, Suzuki N
  • Journal Title: Brain 132(1) Pages: 8-15
  • Peer Reviewed
• [Journal Article] A novel compound heterozygous dysferlin mutation in Miyoshi myopathy siblings responding to dantrolene. (2007)
  • Author(s): Hattori H, Nagata E, Oya Y, Takahashi T, Aoki M, Ito D, Suzuki N
  • Journal Title: Eur J Neurol 14(11) Pages: 1288-1291
  • Peer Reviewed
• [Journal Article] Molecular pathogenesis of seipin/BSCL2-related motor neuron diseases. (2007)
  • Author(s): Ito D, Suzuki N
  • Journal Title: Ann Neurol 61(3) Pages: 237-250
  • Peer Reviewed
• [Journal Article] 新規コンフォメーション病、Seipin/BSCL2 関連運動ニューロン疾患と小胞体ストレス (2007)
  • Author(s): 伊東大介、鈴木則宏
  • Journal Title: 臨床神経 47(6) Pages: 329-335
  • NAID: 10019729851
• [Journal Article] A novel compound heterozygous dysferlin mutation in Miyoshi myopathy siblings responding to dantrolene (2007)
  • Author(s): Hattori H, Nagata E, Oya Y, Takahashi T, Aoki M, Ito D, Suzuki N
  • Journal Title: EurJ Neurol 14(11) Pages: 1288-1291
  • Peer Reviewed
• [Journal Article] Molecular pathogenesis of seipin/BSCL2-related motor neuron diseases (2007)
  • Author(s): Ito D, Suzuki N
  • Journal Title: Ann Neurol 61(3) Pages: 237-250
  • Peer Reviewed
• [Journal Article] 新規コンフォメーション病、Seipin/BSCL2関連運動ニューロン疾患と小胞体ストレス (2007)
  • Author(s): 伊東 大介、鈴木 則宏
  • Journal Title: 臨床神経 47・6 Pages: 329-335
  • NAID: 10019729851
• [Journal Article] Molecular pathogenesis of seipin/BSCL2-related motor neuron diseases. (2007)
  • Author(s): Ito D, Suzuki N
  • Journal Title: Annals of Neurology 61・3 Pages: 237-250
• [Journal Article] G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke. (2006)
  • Author(s): Hattori H, Sonoda A, Sato H, Ito D, Tanahashi N, Murata M, Saito I, Watanabe K, Suzuki N
  • Journal Title: Brain Res 1121(1) Pages: 246-249
  • Peer Reviewed
• [Journal Article] A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia. (2006)
  • Author(s): Hattori H, Sato H, Ito D, Tanahashi N, Murata M, Saito I, Watanabe K, Suzuki N
  • Journal Title: Brain Res 1108(1) Pages: 221-223
  • Peer Reviewed
• [Journal Article] 脳虚血と小胞体ストレス (2006)
  • Author(s): 伊東 大介
  • Journal Title: 日本臨床 64巻・S17 Pages: 127-131
• [Presentation] TDP-43プロテイノパチーの病態解明へのアプローチ-孤発性筋萎縮性側索硬化症患者からのiPS細胞樹立- (2009)
  • Author(s): 二瓶義廣, 八木拓也, 伊東大介, 小堺有史, 吉崎崇仁, 赤松和土, 岡田洋平, 川村雅文, 高橋愼一, 岡野栄之, 鈴木則宏
  • Organizer: 第28回日本認知症学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-10-21
• [Presentation] Klothoマウスにおける線条体黒質ドパミン系の解析. (2009)
  • Author(s): 小堺有史, 伊東大介, 山下修二, 高橋一司, 岡田保典, 鈴木則宏
  • Organizer: 第28回日本認知症学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-10-20
• [Presentation] Characterization of proteolytic cleavage and inclusions of the TDP-43 protein (2009)
  • Author(s): Y. Nishimoto, D. Ito, T. Yagi, Y. Nihei, Y. Tsunoda, N. Suzuki
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-19
• [Presentation] Characterization of proteolytic cleavage and inclusions of the TDP-43 protein. (2009)
  • Author(s): 西本祥仁, 伊東大介, 八木拓也, 二瓶義廣, 角田佳子, 鈴木則宏
  • Organizer: Neuroscience
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-19
• [Presentation] Characterization of alternative isoform and inclusion body of the TDP-43. (2009)
  • Author(s): 西本祥仁、伊東大介、八木拓也、二瓶義廣、角田佳子、鈴木則宏
  • Organizer: 神経変性疾患コンソーシアム
  • Place of Presentation: 東京
  • Year and Date: 2009-09-23
• [Presentation] TDP-43プロテイノパチー:分子病態解明へのアプローチ (2009)
  • Author(s): 伊東大介
  • Organizer: 第23回老年期認知症研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-13
• [Presentation] 孤発性パーキンソン病患者からのiPS細胞の樹立. (2009)
  • Author(s): 八木拓也、伊東大介、二瓶義廣、吉崎崇仁、高橋一司、赤松和土、岡田洋平、大山学、天谷雅行、岡野栄之、鈴木則宏
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-22
• [Presentation] セイピン封入体は新規の小胞体蛋白品質管理機構である (2009)
  • Author(s): 伊東大介、角田桂子、鈴木則宏
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-21
• [Presentation] セイピン封入体は新規の小胞体蛋白品質管理機構である. (2009)
  • Author(s): 伊東大介、角田桂子、鈴木則宏
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-21
• [Presentation] Evaluation of the dopaminergic system in the substantia nigra in aging-accelerated klotho mice. (2008)
  • Author(s): Kosakai A, Ito D, Takahashi K, Yamashita S, Okada Y, Suzuki N
  • Organizer: 第26回日本認知症学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-18
• [Presentation] Klothoマウスにおける線条体黒質ドパミン系の解析. (2008)
  • Author(s): 小堺有史, 伊東大介, 山下修二, 高橋一司, 岡田保典, 鈴木則宏
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-14
• [Presentation] ヒト脳組織におけるTDP-43の選択的スプライシングバリアントの同定と生化学的解析. (2008)
  • Author(s): 西本祥仁, 伊東大介, 鈴木則宏
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-11
• [Presentation] ヒト脳組織におけるTDP-43の選択的スプライシングバリアントの同定と生化学的解析 (2008)
  • Author(s): 西本祥仁, 伊東大介, 鈴木則宏
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-11
• [Presentation] SPG17、dHMN-V原因遺伝子Seipinの細胞内封入体と機能ドメインの解析 (2008)
  • Author(s): 伊東大介、藤澤大志、鈴木則宏
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] Stanniocalcin 2 Modulates Calcium Homeostasis and Cellular Viability. (2008)
  • Author(s): Zeiger W, Ito D, Keat M, Pei S, Villereal M, Thinakaran G
  • Organizer: Keystone Symposia on Molecular and Cellular Biology, Keystone
  • Place of Presentation: Co, U.S. A
  • Year and Date: 2008-03-05
• [Presentation] Klotho マウスにおける線条体黒質ドパミン系の解析 (2008)
  • Author(s): 小堺有史, 伊東大介, 山下修二, 高橋一司, 岡田保典, 鈴木則宏
  • Organizer: 第27 回日本認知症学会
  • Place of Presentation: 前橋
• [Presentation] ヒト脳組織におけるTDP-43 の選択的スプライシングバリアントの同定と生化学的解析 (2008)
  • Author(s): 西本祥仁, 伊東大介, 鈴木則宏
  • Organizer: 第27 回日本認知症学会
  • Place of Presentation: 前橋
• [Presentation] SPG17、dHMN-V 原因遺伝子Seipin の細胞内封入体と機能ドメインの解析 (2008)
  • Author(s): 伊東大介、藤澤大志、鈴木則宏
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
• [Presentation] Stanniocalcin 2 Modulates Calcium Homeostasis and Cellular Viability (2008)
  • Author(s): Zeiger W, Ito D, Keat M, Pei S, Villereal M,and Thinakaran G
  • Organizer: Keystone Symposia on Molecular and Cellular Biology
  • Place of Presentation: Keystone, Co, U.S.A
• [Presentation] SPG17、dHMN-V原因遺伝子Seipinの発現部位と細胞内局在の検討 (2007)
  • Author(s): 伊東大介, 鈴木則宏
  • Organizer: 第48回日本神経学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-17
• [Presentation] SPG17、dHMN-V原因遺伝子Seipin変異による神経変性分子機構 (2006)
  • Author(s): 伊東大介, 鈴木則宏
  • Organizer: 第47回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2006-05-12
• [Book] 失語 失行 失語、痴呆、Alzheimer病.内科研修マニュアル改訂第2版(慶應義塾大学医学部内科学教室) (2006)
  • Author(s): 伊東大介
  • Publisher: 南江堂