The predictive or monitoring marker for Alzheimer's disease
| Project/Area Number |
18590968
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | National Institute for Longevity Sciences,NCGG |
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Principal Investigator |
MATSUBARA Etsuo National Institute for Longevity Sciences,NCGG, National Center for Geriatrics and Gerontology, 室長 (70219468)
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| Co-Investigator(Kenkyū-buntansha) |
SHOJI Mikio Hirosaki University, Graduate School of Medicine, Professor (60171021)
ITO Nobuo Mie University, Graduate School of Medicine, Instructor (10362344)
KAWARABAYASHI Takeshi Hirosaki University, Graduate School of Medicine, Assistant Professor (90186156)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Alzheimer's disease / ELISA / Aβ oligomers / marker |
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| Research Abstract |
In the present research, we have developed a sandwich ELISA specific to Aβ oligomers. The combination of this methodology with size exclusion chromatography allowed us to identify the presence of Aβ oligomers in human cerebrospinal fluid(CSF). It is well known that the levels of Aβ monomers was decreased in the CSF obtained from Alzheimer's disease(AD) compared to age-matched normal subjects. Interestingly, the levels of Aβ oligomers were increased in AD patients with a comcomitant reduction of Aβ monomers. Therefore, it is relevant to note that the measurement of the ratio, Aβ oligomers to monomers, was a potential tool to monitor the Alzheimer's disease. We also found that the administration of melatonin caused the elevation of Aβ in plasma obtained from the model mice of Alzheimer's disease, whch allowed us to see if which mice have an accumulation of Aβ in the brain. Our results may indicate that both could be a potential "surrogate marker" for AD.
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Report
(3 results)
Research Products
(38 results)
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[Journal Article] Plasma antibodies to Abeta40 and Abeta42 in patients with Alzheimer's disease and normal controls.2008
Author(s)
Xu W, Kawarabayashi T, Matsubara E, Deguchi K, Murakami T, Harigaya Y, Ikeda M, Amari M, Kuwano R, Abe K, Shoji M.
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Journal Title
Brain Res (Epub ahead of print)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The Japanese Genetic Study Consortium for Alzheimer's Disease, Consortium Information : Members are listed in the acknowledgements. Genetic association of CTNNA3 with late-onset Alzheimer's disease in females.2007
Author(s)
Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R
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Journal Title
Hum Mol Genet 16
Pages: 2854-2869
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Enhanced accumulation of phosphorylated alpha-synuclein double transgenic mice expressing mutant beta-amyloid precursor protein and presenilin-1.2007
Author(s)
Kurata T, Kawarabayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Ikeda M, Matsubara E, Westaway D, Hyslop PS, Harigaya Y, Kamiya T, Shoji M, Abe K.
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Journal Title
J Neurosci Res. 85(10)
Pages: 2246-52
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] PINK1, a gene product of PARK6, accumulates in {alpha}-synucleinopathy brains.2007
Author(s)
Murakami T, Moriwaki Y, Kawarabayashi T, Nagai M, Ohta Y, Deguchi K, Kurata T, Takehisa Y, Matsubara E, Ikeda M, Harigaya Y, Shoji M, Takahashi R, Abe K.
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Journal Title
J Neurol Neurosurg Psychiatry. 78(6)
Pages: 653-4
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cortical neuronal and glial pathology in TgTauP301L transgenic mice : neuronal degeneration, memory disturbance, and phenotypic variation.2006
Author(s)
Murakami T, Paitel E, Kawarabayashi T, Ikeda M, Chishti MA, Janus C, Matsubara E, Sasaki A, Kawarai T, Phinney AL, Harigaya Y, Home P, Egashira N, Mishima K, Hanna A, Yang J, Iwasaki K, Takahashi M, Fujiwara M, Ishiguro K, Bergeron C, Carlson GA, Abe K, Westaway D, St George-Hyslop P, Shoji M
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Journal Title
Am J Pathol 169(4)
Pages: 1365-1375
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Enhanced accumulation of tau in double transgenic mice expressing mutant beta APP and presenilin-1.2006
Author(s)
Samura E, Shoji M, Kawarabayashi T, Sasaki A, Matsubara E, Murakami T, Wuhua X, Tamura S, Ikeda M, Ishiguro K, Saido TC, Westaway D, St George Hyslop P, Harigaya Y, Abe K
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Journal Title
Brain Res 1094(1)
Pages: 192-199
Description
「研究成果報告書概要(欧文)」より
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