Important Role of Angiotensin Receptor Subtype in Adipocyte Differentiation and Insulin Resistance
Project/Area Number |
18590992
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Ehime University |
Principal Investigator |
IWAI Masaru Ehime University, 大学院・医学系研究科, 准教授 (00184854)
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Co-Investigator(Kenkyū-buntansha) |
HORIGUCHI Masatsugu 愛媛大学, 大学院・医学系研究科, 教授 (40150338)
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Project Period (FY) |
2006 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥3,880,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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Keywords | 血管病態学 / アンジオテンシン受容体 / 脂肪細胞 / 細胞分化 / AT1受容体ブロッカー / 動脈硬化 / インスリン感受性 / アディポサイトカイン / 転写調節因子 / 分化 / アンジオテンシン / AT1受容体 / AT2受容体 / インスリン抵抗性 / 糖尿病 / 炎症反応 / 脂肪組織 / 脂質代謝 / レニン-アンジオテンシン系 / 受容体 / メタボリックシンドローム |
Research Abstract |
本研究において、脂肪組織に対するアンジオテンシンII受容体サブタイプの役割について、我々の用いた動脈硬化モデルマウスにおいて、AT1受容体刺激が、糖取り込み低下をはじめ、脂肪重量増加、脂肪細胞大型化、脂肪細胞分化抑制、血中脂質上昇などの変化を引き起こすのに対し、もう一つの主要サブタイプであるAT2受容体刺激は、糖取り込み増加、脂肪細胞分化促進、脂肪細胞小型化、脂肪細胞重量低下、血中脂質低下などAT1受容体に拮抗的に働くことが示された。これらの結果から、将来AT2受容体アゴニストがメタボリック症候群の治療に新たな一面を切り開く可能性がある。
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Prevention of Vascular Injury by Combination of an AT1 Receptor Prevention of Vascular Injury by Combination of an AT1 Receptor Blocker, Olmesartan, with Various Calcium Antagonists2009
Author(s)
Inaba S, Iwai M, Tomono Y, Senba I, Furuno M, Kanno H, Okayama H, Mogi M, Higaki J, Horiuchi M
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Journal Title
Am J Hypertens 22(2)
Pages: 145-150
Related Report
Peer Reviewed
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[Journal Article] Temporary pretreatment with the angiotensin II type 1 receptor blocker, valsartan, prevents ischemic brain damage through an increase in capillary density2008
Author(s)
Li JM, Mogi M, Iwanami J, Min LJ, Tsukuda K, Sakata A, Fujita T, Iwai M, Horiuchi M
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Journal Title
Stroke 39
Pages: 2029-2036
Related Report
Peer Reviewed
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[Journal Article] Calcium channel blocker, azelnidipine, reduces glucose intolerance in diabetic mice via different mechanism to angiotensin receptor blocker, olmesartan.2006
Author(s)
Iwai, M., Li, H-S., Chen, R., Shiuchi, T., Wu, L., Min, L-J., Li, J-M., et al.
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Journal Title
J Pharmacol Exp Ther 319
Pages: 1081-1087
Related Report
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[Journal Article] Attenuation of inflammatory vascular remodeling by angiotensin II type 1 receptor-associated protein.2006
Author(s)
Oshita, A., Iwai, M., Chen, R., Ide, A., Okumura, M., Fukunaga, S., et al.
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Journal Title
Hypertension 48
Pages: 671-676
Related Report
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[Journal Article] Comparison of inhibitory action of candesartan and enalapril on brain ischemia through inhibition of oxidative stress.2006
Author(s)
Hamai, M., Iwai, M., Ide, A., Tomochika, H., Tomono, Y., et al.
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Journal Title
Neuropharmacology 51
Pages: 822-828
Related Report
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[Journal Article] The calcium-channel blocker, azelnidipine, enhanced the inhibitory action of AT1 receptor blockade on ischemic brain damage.2006
Author(s)
Iwai, M., Chen, R., Ide, A., Iwanami, J., Tomochika, H., et al.
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Journal Title
Journal of Hypertension 24
Pages: 2023-2031
Related Report
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[Journal Article] Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation.2006
Author(s)
Suzuki, J., Iwai, M., Mogi, M., Oshita, A., Yoshii, T., Higaki, J., et al.
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Journal Title
Arterioscler Thromb Vasc Biol 26
Pages: 917-921
Related Report
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[Journal Article] Regression of atherosclerosis by amlodipine via anti-inflammatory and anti-oxidative stress actions.2006
Author(s)
Yoshii, T., Iwai, M., Li, Z., Chen, R., Ide, A., Fukunaga, S., et al.
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Journal Title
Hypertension Res 29
Pages: 457-466
NAID
Related Report
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[Journal Article] Nifedipine inhibited angiotensin II-induced MCP-1 expression : involvement of IkB kinase and NF-kB-inducing kinase.2006
Author(s)
Wu, L., Iwai, M., Li, Z., Li, J-M., Mogi, M., Horiuchi, M
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Journal Title
Journal of Hypertension 24
Pages: 123-130
Related Report
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[Presentation] Comparison of the protective effects of combination of various calcium channel blockers and an AT1 receptor blocker, olmesartan, on inflammatory vascular injury in mice2008
Author(s)
Inaba S, Iwai M, Tomono Y, Kannno H, Senba I, Furuno M, Okayama H, Mogi M., Higaki J, Horiuchi M.
Organizer
18th Scientific meeting International Society of Hypertension
Place of Presentation
Berlin, Germany
Year and Date
2008-06-19
Related Report
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[Presentation] Renin angiotensin system in cerebrospinal fluid of patients with neurodegenerative diseases2008
Author(s)
Mogi M, Kawajiri M, Tsukuda K, Iwanami J, J-M Min, Sakata A, Fujita T, Iwai M, Miki T, Kira J-I, Horiuchi M
Organizer
18th Scientific meeting International Society of Hypertension
Place of Presentation
Berlin, Germany
Year and Date
2008-06-19
Related Report
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[Presentation] Enlargement of ischemic brain damage associated with oxidative stress after middle cerebral artery occlution in human renin/angiotensinogen transgenic mice2008
Author(s)
Inaba S, Iwai M, Furuno M, Tomono Y,Kanno,H, Senba I, Okayama H , Mogi M, Higaki J, Horiuchi M
Organizer
18th Scientific meeting International Society of Hypertension
Place of Presentation
Berlin, Germany
Year and Date
2008-06-19
Related Report
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[Presentation] Sex defferent effect of AT2 recepor signaling on bra brain ischemic injury and cognitive function2008
Author(s)
Sakata A, Mogi M, Iwanami J, Tsukuda K, Li J-M, Min L-J, Fujita T, Iwai M, Ito M, Horiuchi M
Organizer
18th Scientific meeting International Society of Hypertension
Place of Presentation
Berlin, Germany
Year and Date
2008-06-14
Related Report
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[Presentation] Diabetes-associated cognitive impairment Is improved by a calcium channel blocker, nifedipine2007
Author(s)
Tsukuda K, Mogi M, Li J-M, Iwanami J, Min L-J, Fujita T, Sakata A, Iwai M., Horiuchi M
Organizer
61st Annual High Blood Pressure Research
Place of Presentation
Tucson AZ, USA
Year and Date
2007-09-27
Related Report
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[Presentation] Effectiveness of candesartan based combination therapy in essential hypertension. Ehime candesartan assessment trail (E-CAT)2006
Author(s)
Okura T, Kurata M, Manabe S, Irita J, Enomoto D, Miyoshi K, Fukuoka T, Higaki J, Iwai M, Horiuchi M
Organizer
The 21st Scientific Meeting of the International Society of Hypertension
Place of Presentation
Fukuoka, Japan
Year and Date
2006-10-18
Related Report
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