Microcirculation in pancreatic islets and adipose tissue

• Project/Area Number: 18590993
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kyushu University
• Principal Investigator: IWASE Masanori Kyushu University, 大学院・医学研究院, 准教授 (00203381)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥630,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 膵臓 / 膵ランゲルハンス氏島 / インスリン / 糖尿病 / 血行動態 / マイクロスフェア / ラット / グルコース / 糖尿病学 / エタノール / 血流量 / 胎児環境 / 妊娠 / アンジオテンシンII受容体拮抗薬 / 糖尿病細小血管障害 / 高血圧 / 経口糖尿病薬 / OLETFラット / 局所血流量 / モデル動物

Research Abstract

Islet of Langerhans is a small organ scattered through the pancreas. Islet has a unique microvascular system and its blood flow is meticulously regulated by some mechanisms. Glucose causes an increase in islet blood flow. In a repetitive administration of glucose, the increase in islet blood flow was smaller in the second administration than the first one. In addition, anti-diabetic and hypertensive medications affected islet blood flow, respectively. Finally, ethanol intakes during pregnancy induced impaired growth of pancreas without affecting islet blood flow in rats.

Research Products

• [Journal Article] Angiotensin II type 1 receptor antagonists prevent glucose-induced increases in islet blood flow in rats. (2009)
  • Author(s): Iwase M, Uchizono Y, Nohara S, Sasaki N, Sonoki K, Iida M
  • Journal Title: Scandinavian Journal of Clinical and Laboratory Investigation 69巻 Pages: 145-150
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor antagonists prevent glucose-induced increases in islet blood flow in rats (2009)
  • Author(s): 岩瀬正典
  • Journal Title: Scandinavian Journal of Clinical & Laboratory Investigation 69 Pages: 145-150
  • Peer Reviewed
• [Journal Article] Angi otensin II type 1 receptor antagoni sts prevent glucose-induced increases i n i sl et blood f low I n rats (2009)
  • Author(s): Iwase M., Uchi zono Y., Nohara S., Sasaki N., Sonoki K., Iida M
  • Journal Title: Scandi navi an Journal of Cl i ni cal & Laboratory Investi gati on 69(1) Pages: 145-50
  • Peer Reviewed
• [Journal Article] Acarbose feeding increases pancreatic islet blood flow in obese glucose-intolerant Otsuka Long-Evans Tokushima fatty rats. (2008)
  • Author(s): Iwase M, Imoto H, Oku M, Shibata S, Sonoki K, Iida M
  • Journal Title: Pancreas 37巻 Pages: 228-230
  • Peer Reviewed
• [Journal Article] 新時代の糖尿病学(1)膵島の血流 (2008)
  • Author(s): 岩瀬正典
  • Journal Title: 日本臨床増刊号 66巻 Pages: 115-118
• [Journal Article] Acarbose feeding increases pancreatic islet blood flow in obese glucose-I ntol erant Otsuka Long-Evans Tokushima fatty rats (2008)
  • Author(s): Iwase M, Imoto H, Oku M, Shi bata S, Sonoki K, Iida M
  • Journal Title: Pancreas 37 Pages: 228-230
  • Peer Reviewed
• [Journal Article] 膵島の血流 (2008)
  • Author(s): 岩瀬正典、飯田三雄
  • Journal Title: 新時代の糖尿病学(1)日本臨床66 増刊号3 Pages: 115-118
  • Peer Reviewed
• [Journal Article] Acarbose feeding increases pancreatic islet blood flow in obese glucose-intolerant Otsuka Long-Evans Tokushima fatty rats. (2008)
  • Author(s): Iwase M. Imoto H. Oku M. Shibata S. Sonoki K. Iida M.
  • Journal Title: Pancreas 37 Pages: 228-230
  • Peer Reviewed
• [Journal Article] インスリン分泌促進薬と膵ラ氏微小循環系 (2006)
  • Author(s): 岩瀬正典
  • Journal Title: 臨床薬理の進歩2006 Pages: 1-9
  • Peer Reviewed
• [Presentation] Acarbose feeding increases pancreatic islet blood flow in obese glucose-intolerant OLETF rats. (2008)
  • Author(s): Iwase M, Iida M
  • Organizer: American Diabetes Association, 68th Scientific Sessions
  • Place of Presentation: San Francisco, USA
• [Presentation] Effects of acarbose on pancreatic islet blood flow in rats. (2007)
  • Author(s): 岩瀬正典
  • Organizer: 4th International Glucobay Workshop
  • Place of Presentation: 大阪
• [Presentation] アルカボースは糖尿病ラットの膵ランゲルハンス氏島血流量を増加させる (2006)
  • Author(s): 岩瀬正典
  • Organizer: 第49回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
• [Remarks]
  • URL: http://www.c-shop.net/tounyou/