Microcirculation in pancreatic islets and adipose tissue
Project/Area Number |
18590993
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | Kyushu University |
Principal Investigator |
IWASE Masanori Kyushu University, 大学院・医学研究院, 准教授 (00203381)
|
Project Period (FY) |
2006 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
|
Keywords | 膵臓 / 膵ランゲルハンス氏島 / インスリン / 糖尿病 / 血行動態 / マイクロスフェア / ラット / グルコース / 糖尿病学 / エタノール / 血流量 / 胎児環境 / 妊娠 / アンジオテンシンII受容体拮抗薬 / 糖尿病細小血管障害 / 高血圧 / 経口糖尿病薬 / OLETFラット / 局所血流量 / モデル動物 |
Research Abstract |
Islet of Langerhans is a small organ scattered through the pancreas. Islet has a unique microvascular system and its blood flow is meticulously regulated by some mechanisms. Glucose causes an increase in islet blood flow. In a repetitive administration of glucose, the increase in islet blood flow was smaller in the second administration than the first one. In addition, anti-diabetic and hypertensive medications affected islet blood flow, respectively. Finally, ethanol intakes during pregnancy induced impaired growth of pancreas without affecting islet blood flow in rats.
|
Report
(6 results)
Research Products
(13 results)