Identification of glucocorticoid target genes involved in visceral obesity

• Project/Area Number: 18590997
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: University of Hyogo
• Principal Investigator: KAJI Hidesuke University of Hyogo, College of Nursing Art & Science, Professor (90224401)
• Co-Investigator(Kenkyū-buntansha): FUKANO Chika University of Hyogo, College of Nursing Art & Science, Assistant Professor (00405367) ; TANIDA Keiko University of Hyogo, College of Nursing Art & Science, Senior Assistant Professor (60405371) ; KIMURA Yukari University of Hyogo, College of Nursing Art & Science, Associate (80438259)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,850,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: adipocyte / glucocorticoid / RNA interference (RNAi) / metabolic syndrome (MetS) / single nuculeotide polymorphism (SNP) / CCAAT / enhancer binding protein 8 (C / EBPδ) / neuropeptide Y (NPY) / NPY type 2 receptor (NPY2R) / ニューロペプチドY2受容体 / メタボリックシンドローム / 内臓肥満 / 1塩基多型 / 遺伝子転写調節 / 脂肪細胞分化 / RNA干渉 / C / EBPδ / SNP / 血圧高値 / 脂質代謝異常 / 空腹時高血糖

Research Abstract

We investigated to clarify whether connective tissue growth factor, emerin, and calpain 1 are essential for the initial step of adipocyte differentiation, since glucocorticoid is very important for adipocyte differentiation, and mRNA expressions of these 3 molecules are induced by cocktail with dexamethasone during the initial adipocyte differentiation from 3T3-L1 cells, and they have their human ortholog as well as glucocorticoid responsive element on their 5'-flanking region of the gene. The RNA interference in each mRNA expression failed to change the adipocyte differentiation, suggesting that these molecules, at least by each single molecule, are not essential for the initial step of the adipocyte differentiation.
Next, the association between metabolic syndrome (MetS) and CCAAT/enhancer binding protein δ (C/EBPδ) was investigated after informed consent in 172 persons for health checkup. It has been reported in the study using C/EBPδ knockout mouse that C/EBPδ mRNA induction by gluc ocorticoid during the initial adipocyte differentiation from 3T3-L1 cells is essential for visceral obesity. Our result indicated for the first time that genotype C/T in SNP rs15955 was more prevalent in dyslipidemia as well as impaired glucose tolerance (IGT) among phenotypes of MetS.
Furthermore, neuropeptide Y (NPY)/NPY type 2 receptor (NPY2R) pathway is recently reported to be involved in high fat and sucrose diet-induced visceral obesity under certain stresses with stimulated glucocorticoid secretion. Therefore, we tested the association between MetS (IDF Asia criteria) and the 5'-flanking region of NPY2R gene SNPs with high minor allele frequency in Asian population. In 317 persons for health checkup participated in this study after informed consent, genotype '17 in SNP rs6857715 was more prevalent in MetS and IGT. Genotype AA in SNP rs6857530 was more prevalent in IGT. Further functional studies of the transcriptional control of these SNP regions will be required for the development of prevention strategy and drug discovery for MetS.

Research Products

• [Journal Article] Genetic variations at the CCAAT/Enhancer-binding protein δ are associated with metabolic phenotypes in the Japanese population (2008)
  • Author(s): Kaji H, Fukano C, imura Y Takiguchi E, anida K
  • Journal Title: Metabolic Syndrome and Related Disorders 6 Pages: 24-31
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes (2008)
  • Author(s): Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, IidaK Okimura Y, Kaji H, Kitazawa S, Kasuga M, Chihara K.
  • Journal Title: FEBS Lett 582(5) Pages: 573-578
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Low serum IGF-I/GH ratio is associated with abnormal glucose tolerance in acromegaly (2008)
  • Author(s): Fukuoka H, Takahashi Y, Iida K, Kaji H(8/9), et. al.
  • Journal Title: Hormone Research 69 Pages: 165-171
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexsamethasone-induced expressions of muscle-snecific ubiauitin lieases. Atrogin-1 and MuRF1 (2008)
  • Author(s): Yamamoto D, Ikeshita N, Matsubara T, Tasaki H, Kaji H(9/11), et. al.
  • Journal Title: Life Sciences 82 Pages: 460-466
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of mPOU(Brn-5),a class VI POU protein,in the gene expression of Pit-1 as well as PRL (2008)
  • Author(s): Toda K, Yamamoto D, Fumoto M, Ikeshita N, Kali H(9/11), et. al.
  • Journal Title: Molecular and Cellular Endocrinology 280 Pages: 20-29
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Genetic variations at the CCAAT/Enhancer-binding protein 6 areassociated with metabolic phenotypes in the Japanese population (2008)
  • Author(s): Kaji H, Fukano C, Kimura Y, Takiguchi E, Tanida, K
  • Journal Title: Metabolic Syndrome and Related Disorders 6 Pages: 24-31
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes (2008)
  • Author(s): Takahashi M, Takahashi Y, Takahashi K, Zolotaryov, FN, Hong, KS, Kitazawa R, IidaK, Okimura Y, Kaji H, Kitazawa S, Kasuga M, Chihara, K
  • Journal Title: FEBS Lett 582(5)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Low serum IGF-I/GH ratio is associated with abnormal glucose tolerance in acromegaly (2008)
  • Author(s): Fukuoka H, Takahashi Y, Iida K, Kaji, H(8/9), et. al.
  • Journal Title: Hormone Research 69 Pages: 165-171
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexsamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1 (2008)
  • Author(s): Yamamoto D, Ikeshita N, Matsubara T, Tasaki H, Kaji, H(9/11), et. al.
  • Journal Title: Life Sciences 82 Pages: 460-466
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of mPOU(Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL (2008)
  • Author(s): Toda K, Yamamoto D, Fumoto M, Ikeshita N, Kaji, H(9/11), Okimura Y, et. al.
  • Journal Title: Molecular and Cellular Endocri nology 280 Pages: 20-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of mPOU(Brn-5),a class VI POU protein,in the gene expression of Pit-1 as well as PRL (2008)
  • Author(s): Toda K, Yamamoto D, Fumoto M, Ikeshita N, Kaji H(9/11), et. al.
  • Journal Title: Molecular and Cellular Endocrinology 280 Pages: 20-29
  • Peer Reviewed
• [Journal Article] GHRP-2,a GHS-R agonist,directly acts on myocytes to attenuate the dexsamethasone-induced expressions of muscle-specific ubiquitin ligases,Atrogin-1 and MuRF1 (2008)
  • Author(s): Yamamoto D, Ikeshita N, Matsubara T, Tasaki H, Kaji H(9/11), et. al.
  • Journal Title: Life Sciences 82 Pages: 460-466
  • Peer Reviewed
• [Journal Article] Genetic variations at the CCAAT/Enhancer-binding protein δ are associated with metabolic phenotypes in the Japanese population (2008)
  • Author(s): Kaji H, Fukano C, Kimura Y, Takiguchi E, Tanida K
  • Journal Title: Metabolic Syndrome and Related Disorders 6 Pages: 24-31
  • Peer Reviewed
• [Journal Article] CXCL14 enhances insulin-dependent glucose uptake in adipocytes and is related to high-fat diet-induced obesity (2007)
  • Author(s): Takahashi M, Takahashi Y, Takahashi K, Kaji H(8/9), et. al.
  • Journal Title: Biochem Biophys ResCommun 364 Pages: 1037-1042
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamnine. method (2007)
  • Author(s): Imanaka M, Iida K, Nishizawa H, Fukuoka H, Takeno R, Kaii H(10/11), et. al.
  • Journal Title: Internal Medicine 46 Pages: 1577-1583
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hormone replacement therapy and vascular risk disorders in adult hypopituitarism (2007)
  • Author(s): Kaji H, Iida K, Takahashi Okimura Y, Chihara K
  • Journal Title: Endocrine Journal 54 Pages: 239-245
  • NAID: 10019478618
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] プレクリニカルクッシング症候群を伴った副腎皮質癌の1例 (2007)
  • Author(s): 竹野 亮子、飯田 啓二、井上 喜文, 加治 秀介(10/12)千原 和夫, 他
  • Journal Title: 日本内分泌学会雑誌 83 Pages: 158-160
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 2A型VHL病の1家系におけるVHL遺伝子解析 (2007)
  • Author(s): 今中 真理、飯田 啓二、高橋 健太郎、置村 康彦、加治 秀介(11/12), 他
  • Journal Title: 日本内分泌学会雑誌 83 Pages: 174-177
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Health needs of patients with chronic diseases who lived through the Great Hanshin Earthquake (2007)
  • Author(s): Mori K, Ugai K, Nonami Y, Kirimura T, Kondo C, Nakamura T, Motoki E, Kaii H
  • Journal Title: Disaster Management & Response 5・1 Pages: 8-13
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats (2007)
  • Author(s): Yamamoto D, Ikehashi N, Daito R, Herningtyas EH, Toda K, Kaji H(9/11), Okimura Y, et. al.
  • Journal Title: Regulatory Peptides 138 Pages: 141-144
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency (2007)
  • Author(s): Takahashi Y, Iida K, Takahashi K, Yoshioka S, Kaji H(14/16), et. al.
  • Journal Title: Gastroenterology 132-3 Pages: 938-943
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] CXCL14 enhances insulin-dependent glucose uptake in adipocytes and is related to high-fat diet-induced obesity (2007)
  • Author(s): Takahashi M, Takahashi Y, Takahashi K, Kaji, H(8/9), et. al.
  • Journal Title: Biochem Biophys Res Commun 364 Pages: 1037-1042
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method (2007)
  • Author(s): Imanaka M, Iida K, Nishizawa H, Fukuoka H, Takeno R, Kaji, H(10/11), et. al.
  • Journal Title: Internal Medicine 46 Pages: 1577-1583
  • NAID: 130000076004
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hormone replacement therapy and vascular risk disorders in adult hypopituitarism (2007)
  • Author(s): Kaji H, Iida K, Takahashi Y, Okimura Y, Chihara, K
  • Journal Title: Endocrine Journal 54 Pages: 239-245
  • NAID: 10019478618
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Health needs of patients with chronic diseases who lived through the Great Hanshin Earthquake (2007)
  • Author(s): Mori K, Ugai K, Nonami Y, Kirimura T, Kondo C, Nakamura T, Motoki E, Kaji, H
  • Journal Title: Disaster Management & Response 5(1) Pages: 8-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neither intravenous nor intracerebroventricular Administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats (2007)
  • Author(s): Yamamoto D, Ikehashi N, Daito R, Herningtyas, EH, Toda K, Kaji, H(9/11), Okimura Y, et. al.
  • Journal Title: Regulatory Peptides 138 Pages: 141-144
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency (2007)
  • Author(s): Takahashi Y, Iida K, Takahashi K, Yoshioka S, Kaji, H(14/16), et. al.
  • Journal Title: Gastroenterology 132-3 Pages: 938-943
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hormone replacement therapy and vascular risk disorders in adult hypopituitarism. (2007)
  • Author(s): Kaji H, Iida K, Takahashi Y, Okimura Y, Chihara K
  • Journal Title: Endocrine Journal 54 Pages: 239-245
  • NAID: 10019478618
  • Peer Reviewed
• [Journal Article] McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method (2007)
  • Author(s): Imanaka M, Iida K, Nishizawa H, Fukuoka, H, Takeno R, Kaji H(10/11), et. al.
  • Journal Title: Internal Medicine 46 Pages: 1577-1583
  • NAID: 130000076004
  • Peer Reviewed
• [Journal Article] CXCL14 enhances insulin-dependent glucose uptake in adipocytes and is related to high-fat diet-induced obesity (2007)
  • Author(s): Takahashi M, Takahashi Y, Takahashi K, Kaji H(8/9), et. al.
  • Journal Title: Biochemical and Biophysical Research Communications 364 Pages: 1037-1042
  • Peer Reviewed
• [Journal Article] 2A型VHL病の1家系におけるVHL遺伝子解析 (2007)
  • Author(s): 今中 真理、飯田 啓二、高橋 健太郎 置村 康彦、加治 秀介(11/12), 他
  • Journal Title: 日本内分泌学会雑誌 83 Pages: 174-177
  • Peer Reviewed
• [Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency (2007)
  • Author(s): Takahashi Y, Iida K, Takahashi K, Yoshioka S, Fukuoka H, Takeno R, Imanaka M, Nishikawa H, Takahashi M, Seo Y, Hayashi Y, Kondo T, Okimura Y, Kaji H, Kitazawa R, Chihara K
  • Journal Title: Gastroenterology 132・3 Pages: 938-943
• [Journal Article] Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH,PRL,TSH and ACTH in rats. (2007)
  • Author(s): Yamamoto D, Ikehashi N, Daito R, Herningtyas EH, Toda K, Takahashi K, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y
  • Journal Title: Regulatory Peptides 138 Pages: 141-144
• [Journal Article] Health needs patients with chronic diseases who lived through the Great Hanshin Earthquake (2007)
  • Author(s): Mori K, Ugai K, Nonami Y, Kirimura T, Kondo C, Nakamura T, Motoki E, Kaji H
  • Journal Title: Disaster Management ＆ Response 5・1 Pages: 8-13
• [Journal Article] The N131S mutation in the von Hippel-Lindau gene in a Japanese family with pheochromocytoma and hemangioblastomas (2006)
  • Author(s): Imanaka M, Iida K, Takahashi K, Tsuji K, Nishizawa H., Fukaoka H, Takeno R, Takahashi Y, Okimura Y, Kaii H, Chihara K
  • Journal Title: Endocrine Journal 53 Pages: 819-827
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A novel mutation in the von Hippel-Lindau tumor suppressor gene identified in a Japanese family with pheochromocytoma and hepatic hemaneioma (2006)
  • Author(s): Takahashi K, Iida K, Kaji H(9/10), Chihara K, et. al.
  • Journal Title: Internal Medicine 45 Pages: 265-269
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The N131S mutation in the von Hippel-Lindau gene in a Japanese family with pheochromocytoma and hemangioblastomas (2006)
  • Author(s): Imanaka M, Iida K, Takahashi K, Tsuji K, Nishizawa, H., Fukaoka H, Takeno R, Takahashi Y, Okimura Y, Kaji H, Chihara, K
  • Journal Title: Endocrine Journal 53 Pages: 819-827
  • NAID: 10020612693
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel mutation in the von Hippel-Lindau tumor suppressor gene identified in a Japanese family with pheochromocytoma and hepatic hemangioma (2006)
  • Author(s): Takahashi K, Iida K, Kaji, H(9/10), Chihara K, et. al.
  • Journal Title: Internal Medicine 45 Pages: 265-269
  • NAID: 130000076543
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel mutation in the von Hippel-Lindau tumor suppressor gene identified in a Japanese family with pheochromocytoma and hepatic hemangioma (2006)
  • Author(s): Takahashi K, Iida K, Okimura Y, Takahashi Y, Naito J, Nishikawa S, Kadowaki S, Iguchi G, Kaji H, Chihara K
  • Journal Title: Internal Medicine 45 Pages: 265-269
  • NAID: 130000076543
• [Journal Article] The N131S mutation in von Hippel-Lindau gene in a Japanese family with pheochromocytoma and hemangioblastomas. (2006)
  • Author(s): Imanaka M, Iida K, Takahashi K, Tsuji K, Nishikawa, Fukaoka H, Takeno R, Takahashi Y, Okimura Y, Kaji H, Chihara K
  • Journal Title: Endocrine Journal 53 Pages: 819-827
  • NAID: 10020612693
• [Presentation] スプライシング異常が確認できたGitelman症候群の1例 (2008)
  • Author(s): 飯田 啓二、野津 寛大、高橋 裕、加治 秀介(5/8)千原 和夫, 他
  • Organizer: 日本内分泌学会(第18回臨床内分泌代謝Update)
  • Place of Presentation: 高知
  • Year and Date: 2008-03-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 妊娠中毒症、糖尿病を契機に診断されたクッシング症候群の1例 (2008)
  • Author(s): 今中 真理、飯田 啓二、内藤 純子、加治 秀介(10/12)千原 和夫, 他
  • Organizer: 日本内分泌学会(第18回臨床内分泌代謝Update)
  • Place of Presentation: 高知
  • Year and Date: 2008-03-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 成長ホルモン受容体拮抗剤により著明に耐糖能が改善した先端巨大症の1例 (2007)
  • Author(s): 高橋 裕、飯田 啓二、福岡 秀規、加治 秀介(8/10)春日 雅人, 他
  • Organizer: 第44回日本糖尿病学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 変異Propl S156insTはDNA結合性を保持するが、転写活性を欠く (2007)
  • Author(s): 池下 伸子、川岸 万佑子、芝原 優美, 加治 秀介(9/11)置村 康彦, 他
  • Organizer: 第34回日本神経内分泌学会
  • Place of Presentation: 前橋
  • Year and Date: 2007-08-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 変異Prop1 S156insTはDNA結合性を保持するが、転写活性を欠く (2007)
  • Author(s): 池下 伸子、川岸 万佑子、芝原 優美 加治 秀介(9/11)置村 康彦, 他
  • Organizer: 第34回日本神経内分泌学会
  • Place of Presentation: 前橋
  • Year and Date: 2007-08-04
• [Presentation] 日本人下垂体機能低下症患者のQOL評価質問紙(JAHQ)の完成と臨床知見 (2007)
  • Author(s): 石井 均、山城 小百合、島津 章、加治 秀介(7/9)沖 隆, 他
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 新規ケモカイン、メタボカイン1はインスリン感受性と脂質代謝を改善する (2007)
  • Author(s): 高橋 路子、高橋 裕、高橋 健一、加治 秀介(12/19)、千原 和夫, 他
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Graves病寛快に伴い糖尿病の著明な改善がみられた1例 (2007)
  • Author(s): 今中 真理、高橋 健太郎、飯田 啓二、加治 秀介(10/12)千原 和夫, 他
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 低身長児で報告された変異Prop1 S156insTの機能解析 (2007)
  • Author(s): 池下 伸子、川岸 万佑子、芝原 優美、加治 秀介(10/12)置村 康彦, 他
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] IGF-I stimulates reactive oxygen species (ROS) production,thereby affecting insulin sensitivity in adipocytes (2007)
  • Author(s): Fukuoka H, TakahashiY, Iida K, Kaji H(11/12), et. al.
  • Organizer: The Endocrine Society's 89th Annual Meeting
  • Place of Presentation: Toronto,Canada
  • Year and Date: 2007-06-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] IGF-I stimulates reactive oxygen species(ROS) production, thereby affecting insulin sensitivity in adipocytes (2007)
  • Author(s): Fukuoka, H., Takahashi, Y., Iida, K., Kaji, H.(11/12), et. al.
  • Organizer: The Endocrine Society's 89th Annual Meeting
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2007-06-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] IGF-I stimulates reactive oxyen species (ROS)production, thereby affecting insulin sensitivity in adipocytes (2007)
  • Author(s): Fukuoka H, Takahashi Y, Iida K, Kaji H(11/12), et. al.
  • Organizer: The Endocrine Society's 89^<th> Annual Meeting,
  • Place of Presentation: Toronto,Canada
  • Year and Date: 2007-06-05
• [Presentation] A metabolic syndrome model for adult growth hormone deficiency in GH-deficient spontaneous dwarf rat (2006)
  • Author(s): Takahashi, Y., Yoshioka, S., Kaji, H(17/18), Chihara, K., et. al.
  • Organizer: The Third International Congress of GRS and IGF Society
  • Place of Presentation: Kobe
  • Year and Date: 2006-11-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Growth hormone increase FoxOl protein levels and the expression of its target genes in adipose tissue (2006)
  • Author(s): Fukuoka, H., Takahashi, Y., Okimura, Y., Kaji, H(10/11)., Chihara, K., et. al.
  • Organizer: The Third International Congress of GRS and IGF Society
  • Place of Presentation: Kobe
  • Year and Date: 2006-11-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Growth hormone increase FoxO1 protein levels and the expression of its target genes in adipose tissue (2006)
  • Author(s): Fukuoka, H., Takahashi, Y., Okimura, Y., Kaji, H.(10/11), Chihara, K., et. al.
  • Organizer: The Third International Congress of GRS and IGF Society
  • Place of Presentation: Kobe
  • Year and Date: 2006-11-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Difference in the frequency of polymorphism in the growth hormone receptor gene between Japanese and Caucasian populations (2006)
  • Author(s): Iida, K., Takahashi, Y., Kaji, H., Okimura, Y., Nose, O., Chihara, K.
  • Organizer: The Endocrine Society's88th Annual Meeting
  • Place of Presentation: Boston,USA
  • Year and Date: 2006-06-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Difference in the frequency of polymorphism in the growth hormone receptor gene between Japanese and Caucasian populations (2006)
  • Author(s): Iida, K., Takahashi, Y., Kaji, H., Okimura, Y., Nose, O., Chihara, K
  • Organizer: The Endocrine Society's88th Annual Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2006-06-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] cDNAマイクロアレイを用いた骨格筋、骨における成長ホルモン標的遺伝子の解析 (2006)
  • Author(s): 吉岡 嗣朗、高橋 裕、福岡 秀規、工藤 工、高橋 健太郎、飯田 啓二、加治 秀介、置村 康彦、千原 和夫
  • Organizer: 第79回日本内分泌学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2006-05-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] GH,PRL.TSH欠乏を特徴とする後天性複合下垂体機能低下症PIT1自己抗体の検出 (2006)
  • Author(s): 竹野 亮子、高橋 裕、加治 秀介(11/12)、千原 和夫, 他
  • Organizer: 第79回日本内分泌学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2006-05-19
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 臨床検査データブックコンパクト版第4版 (2007)
  • Author(s): 加治 秀介
  • Total Pages: 16
  • Publisher: 医学書院
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 臨床検査データブック2007-2008 (2007)
  • Author(s): 加治 秀介
  • Total Pages: 29
  • Publisher: 医学書院
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 成人生長ホルモン分泌不全症の臨床Chapter3-C, 5-B-3) (2006)
  • Author(s): 加治 秀介
  • Total Pages: 13
  • Publisher: メディカルビュー社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] インフォームドコンセントのための図説シリーズ先端巨大症5.治療 (3)薬物療法 (2006)
  • Author(s): 加治 秀介
  • Total Pages: 6
  • Publisher: 医薬ジャーナル社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 臨床病態学2 2下垂体の異常 1下垂体腫瘍 (2006)
  • Author(s): 加治 秀介
  • Total Pages: 5
  • Publisher: NOUVELL HIROKAWA
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 災害看護学習テキスト慢性疾患患者 (2006)
  • Author(s): 森 菊子、鵜飼 和浩、加治 秀介、野並 葉子
  • Total Pages: 8
  • Publisher: 日本看護協会出版社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 成人成長ホルモン分泌不全症の臨床(Chapter 3-C,5-B-3) (2006)
  • Author(s): 加治 秀介
  • Total Pages: 13
  • Publisher: メディカルビュー社
• [Book] インフォームドコンセントのための図説シリーズ 先端巨大症 5.治療 (3)薬物療法 (2006)
  • Author(s): 加治 秀介
  • Total Pages: 6
  • Publisher: 医薬ジャーナル社
• [Book] 災害看護 学習テキスト 慢性疾患患者 (2006)
  • Author(s): 森菊子, 鵜飼和浩, 加治 秀介, 野並葉子
  • Total Pages: 8
  • Publisher: 日本看護協会出版