Biological response to oxidative stress as initial formation of atherosclerotic lesion and development of its treatment

• Project/Area Number: 18591005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Nippon Medical School
• Principal Investigator: OIKAWA Shinichi Nippon Medical School, 医学部, 教授 (30142946)
• Co-Investigator(Kenkyū-buntansha): MIYAZAWA Teruo 東北大学, 大学院・農学研究科, 教授 (20157639)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥630,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: PCOOH / ヒドロペルオキシド / 接着分子 / 細胞接着 / 単球 / LFA-1 / 活性酸素

Research Abstract

酸化ストレスに対する反応として生成する過酸化脂質が動脈硬化初期病変形成に及ぼす影響として、本研究では過酸化リン脂質であるフォスファチジルコリンヒドロペルオキシド(PCOOH)が単球の接着能に及ぼす影響を中心に検討した。培養細胞を用いた解析の結果、PCOOHが単球細胞のICAM-1への接着を誘導する生理活性分子として作用する可能性を見出し、その作用機序を検討した。

Research Products

• [Journal Article] OiPhosphatidylcholine hydroperoxide-induced THP-1 cell adhesion to intracellular adhesion molecule-1 (2009)
  • Author(s): Asai, A., F. Okajima, K. Nakagawa, D. Ibusuki, K. Tanimura, Y. Nakajima, M. Nagao, M. Sudo, T. Harada, T. Miyazawa, and S. Oikawa
  • Journal Title: J. Lipid Res 50 Pages: 957-965
  • Peer Reviewed
• [Journal Article] Phosphatidylcholine hydroperoxide-induced THP-1 cell adhesion to intracellular adhesion molecule-1. 50 : 957-965, 2009 (2009)
  • Author(s): Asai A, Okajima F, Nakagawa K, Ibusuki D, Tanimura K, Nakajima Y, NagaoM, Sudo M, Harada T, Miyazawa T, Oikawa S
  • Journal Title: J Lipid Res 50 Pages: 957-965
  • Peer Reviewed
• [Journal Article] Waist circumference as a cardiovascular and metabolic risk in Japanese patients with type 2diabetes (2009)
  • Author(s): Sone, H, Tanaka S, Iimuro S, Oida K, Yamasaki Y, Ishibashi S, Oikawa S, Katayama S, Ito H, Y Ohashi Y, Akanuma Y, Yamada N
  • Journal Title: Obesity (Silver Spring) 17 Pages: 585-592
  • Peer Reviewed
• [Journal Article] Preparation of pure lipid hydroperoxides (2008)
  • Author(s): Ibusuki, D., K. Nakagawa, A. Asai, S. Oikawa, Y. Masuda, T. Suzuki, and T. Miyazawa
  • Journal Title: J. Lipid Res 49 Pages: 2668-2677
  • Peer Reviewed
• [Journal Article] Association of serum apolipoprotein B48 level with the presence of carotid plaque in type2 diabetes mellitus (2008)
  • Author(s): Tanimura K, Nakajima Y, Nagao M, Ishizaki A, Kano T, Harada T, Okajima F, Sudo M, Tamura H, Ishii S, Sugihara H, Yamashita S, Asai A, Oikawa S
  • Journal Title: Diab Res Clin Pract 81 Pages: 338-344
  • Peer Reviewed
• [Journal Article] Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients : subanalysis of the JELIS trial (2008)
  • Author(s): Tanaka K, Ishikawa Y, Yokoyama M, Origasa H, Matsuzaki M, Saito Y, Matsuzawa Y, Sasaki J, Oikawa S, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, ShimadaK, Shirato K
  • Journal Title: Stroke 39 Pages: 2052-2058
  • Peer Reviewed
• [Journal Article] Proposed guidelines for hypertriglyceridemia in Japan with non-HDL cholesterol as the second target (2008)
  • Author(s): Shimano, H, Arai H, Harad-Shiba M, Ueshima H, Ohta T, Yamashita S, Gotoda T, Kiyohara Y, Hayashi T, KobayashiJ, Shimamoto K, Bujo H, Ishibashi S, Shirai K, Oikawa S, Saito Y, YamadaN
  • Journal Title: J Atheroscler Thromb. 15 Pages: 116-121
  • NAID: 10022608184
  • Peer Reviewed
• [Journal Article] Tumor anti-angiogenic effect and mechanism of action of delta-tocotrienol (2008)
  • Author(s): Shibata A, Nakagawa K, Scokwong P, Tsuzuki T, Oikawa S, Miyazawa T
  • Journal Title: Biochem Pharmacol 76 Pages: 330-339
  • Peer Reviewed
• [Journal Article] Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors : sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS) (2008)
  • Author(s): Saito Y, Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, BCitabatake A, Nakaya N, Sakata T, Shimada K, Shiralo K
  • Journal Title: Atherosclerosis 200 Pages: 135-140
  • Peer Reviewed
• [Journal Article] Validation of an ion trap tandem mass spectrometnic analysis of mulberry 1-deoxynojirimycin in human plasma : application to pharmacokinetic studies (2008)
  • Author(s): Nakagawa K, Kubcta H, TsuzuM T, Kariya J, Kimura T, Oikawa S, Miyazawa T
  • Journal Title: Biosci Biotechnol Biochem 72
  • Peer Reviewed
• [Journal Article] Relationship between coronary events and serum cholesterol during 10 years of low-dose simvastatin therapy : long-term eiScacy and safety in Japanese patients with hypercholesterole mia in the Japan Lipid Intervention Trial (J-LIT) Extension 10 Study, a prospective large-scale observational cohort study (2008)
  • Author(s): Itakura H, Kita T, Mabuchi H, Matsuzaki M, Matsuzawa Y, Nakaya N, Oikawa S, Saito Y, Sasaki J, Shimamoto K
  • Journal Title: Cric J 72 Pages: 1218-1224
  • Peer Reviewed
• [Journal Article] Preparation of pure lipid hydroperoxides (2008)
  • Author(s): Ibusuki D, Nakagawa K, Asai A, Oikawa S, Masuda Y, Suzuki T, Miyazawa T
  • Journal Title: J Lipid Res 9 Pages: 2668-2677
  • Peer Reviewed
• [Journal Article] Stratified analyses for selecting appropriate target patients with diabetic peripheral neuropathy for long-term treatment with an aldose reductase inhibitor, epalrestat (2008)
  • Author(s): Hotta N, Kawamori R, Atsumi Y, Baba M, Kishikawa H, Nakamura J, Oikawa S, Yamada N, Yasuda H, Shigeta Y
  • Journal Title: Diabet Med 25 Pages: 818-825
  • Peer Reviewed
• [Journal Article] Variations in the FTO gene are associated with severe obesity in the Japanese (2008)
  • Author(s): Hotta K, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimalsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y
  • Journal Title: J Hum Genet 53 Pages: 546-553
  • NAID: 10021249391
  • Peer Reviewed
• [Journal Article] INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese (2008)
  • Author(s): Hotta K, Nakamura M, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazald S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanaiusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y
  • Journal Title: J Hum Genet 53 Pages: 857-862
  • NAID: 10021929575
  • Peer Reviewed
• [Journal Article] Association of single-nucleotide polymorphisms in MTMR9 gene with obesity (2007)
  • Author(s): Yanagiya T, Tanabe A, Iida A, Saito S, Sekine A, Takahashi A, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K
  • Journal Title: Hum Mol Genet 16 Pages: 3017-3026
  • Peer Reviewed
• [Journal Article] Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans (2007)
  • Author(s): Kimura T, Nakagawa K, Kubota H, Kojima Y, Goto Y, Yamagishi K, Oita S, Oikawa S, Miyazawa T
  • Journal Title: J Agric Food Chem 55 Pages: 5869-5874
  • Peer Reviewed
• [Journal Article] Ion-trap tandem mass spectrometric analysis of squalene monohydroperoxide isomers in sunlight-exposed human skin (2007)
  • Author(s): Nakagawa K, Ibusuki D, Suzuki Y, Yamashita S, Higuchi O, Oikawa S, Miyazawa T
  • Journal Title: J Lipid Res 48 Pages: 2779-2787
  • Peer Reviewed
• [Journal Article] Occurrence of orally administered mulberry 1-Deoxynojirimycin in rat plasma (2007)
  • Author(s): Nakagawa K, Kubota H, Kimura T, Yamashita S, Tsuzuki T, Oikawa S, Miyazawa T
  • Journal Title: J Agric. Food Cehm 55 Pages: 8928-8933
  • Peer Reviewed
• [Journal Article] Polymorphisms of apolipoprotein E and methylenetetrahydrofolate reductase in the Japanese population (2007)
  • Author(s): Arai H, Yamamoto A, Matsuzawa Y, Saito Y, Yamada N, Oikawa S, Mabuchi H, Teramoto T, Sasaki J, Nakaya N, Itakura H, Ishikawa Y, Ouchil Y, Horibe H, Egashira T, Hattori H, Kita T
  • Journal Title: J Atheroscler Thromb 14 Pages: 167-171
  • NAID: 10022606786
  • Peer Reviewed
• [Journal Article] In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotorienol (2007)
  • Author(s): Nakagawa K, Shibata A, Yamashita S, Tsuzuki T, Kariya J, Oikawa S, Miyazawa T
  • Journal Title: J Nutr 137 Pages: 1938-1943
  • Peer Reviewed
• [Journal Article] Effect of hypertension and type2 diabetes meliitus on the risk of total cardiovascular events in Japanese patients with hypercholesterolemia: Implications from the Japan Lipid Intervention Trial(J-LIT) (2007)
  • Author(s): Shimamoto K, Kita T, Mabuchi H, Matsuzaki M, Matsuzawa Y, Nakaya N, Oikawa S, Saito Y, Sasaki J, Itakura H, and the J-LIT Study group
  • Journal Title: Hypertens Res 30 Pages: 119-123
  • Peer Reviewed
• [Journal Article] Long-term Outcome after Living Donor Liver Transplantation for Two Cases of Homozygous Familial Hypercholesterolemia from a Heterozygous Donor (2007)
  • Author(s): Kawagishi N, Satoh K, Akamatsu Y, Sekiguchi S, Ishigaki Y, Oikawa S, and Satomi S
  • Journal Title: J Atheroscl Thromb 14 Pages: 94-97
  • NAID: 10022606445
  • Peer Reviewed
• [Journal Article] Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS) : a randomized open-label, blinded endpoint analysis (2007)
  • Author(s): Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, Shirato K, for the Japan EPA lipid intervention study (JELIS) Investigators
  • Journal Title: The Lancet 369 Pages: 1090-1098
• [Journal Article] Functional Single-Nucleotide Polymorphisms in the Secretogranin III (SCG3) Gene that Form Secretory Granules with Appetite-Related Neuropeptides Are Associated with Obesity (2007)
  • Author(s): Tanabe A, Yanagiya T, Iida A, Saito S, Sekine A, Takahashi A, Nakamura T, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Shimada T, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K
  • Journal Title: J Clin Endocrinol Metab 92・3 Pages: 1145-1154
• [Journal Article] Prevalence of Metabolic Syndrome in the General Japanese Population in 2000 (2006)
  • Author(s): Arai H, Yamamoto A, Matsuzawa Y, Saito Y, Yamada N, Oikawa S, Mabuchi H, Teramoto T, Sasaki J, Nakaya N, Itakura H, Ishikawa Y, Ouchil Y, Horibe H, Shirahashi N, Kita T
  • Journal Title: J Atheroscler Thromb 13・4 Pages: 202-208
  • NAID: 10020627207
• [Journal Article] Gender difference in coronary events in relation to risk factors in Japanese hypercholesterolemic patients treated with low-dose simvastatin (2006)
  • Author(s): Sasaki J, Kita T, Mabuchi H, Matsuzaki M, Matsuzawa Y, Nakaya N, Oikawa S, Saito Y, Shimamoto K, Kono S, Itakura H
  • Journal Title: Circ J 70・7 Pages: 810-814
  • NAID: 110004741042
• [Journal Article] Aminophospholipid glycation and its inhibitor screening system : A new role of pyridoxal 5'-phosphate and pyridoxal as lipid glycation inhibitor (2006)
  • Author(s): Higuchi O, Nakagawa K, Tsuzuki T, Suzuki T, Oikawa S, Miyazawa T.
  • Journal Title: J Lipid Res 47・5 Pages: 964-974
• [Journal Article] The new worldwide definition of metabolic syndrome is not a better diagnostic predictor of cardiovascular disease in Japanese diabetic patients than the existing definitions : additional analysis from the Japan Diabetes Complications Study (2006)
  • Author(s): Sone H, Tanaka S, Ishibashi S, Yamasaki Y, Oikawa S, Ito H, Saito Y, Ohashi Y, Akanuma Y, Yamada N
  • Journal Title: Diabetes Care 29・1 Pages: 145-147
• [Presentation] 過酸化リン脂質PCOOHによって誘導されるTHP-1細胞のICAM-1への接着と、スタチン、トコトリエノールによるその抑制作用 (2008)
  • Author(s): 浅井明、岡島史宜、仲川清隆、指宿大悟、谷村恭子、中島泰、長尾元嗣、宮澤陽夫、及川眞一
  • Organizer: 第16回生体パーオキサイド研究会
  • Place of Presentation: 仙台
  • Year and Date: 2008-08-30
• [Presentation] 糖尿病と動脈硬化-OverView (2008)
  • Author(s): 及川眞一
  • Organizer: 第14回日本心臓病リハビリテーション学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-07-18
• [Presentation] Serum apolipoproteinB48 profiles after an oral loading of whole fat milk, low fat milk, calcium-adjusted milk, or soybean milk. (2008)
  • Author(s): 岡島史宜, 谷村恭子, 中島泰, 長尾元嗣, 原田太郎, 首藤真理子, 浅井明, 及川眞一
  • Organizer: 第40回日本動脈硬化学会総会
  • Place of Presentation: 筑波
  • Year and Date: 2008-07-10
• [Presentation] Sequential changes of serum apolipoproteinB48 levels in hypertriglyceridemia after intravenous heparin treatment. (2008)
  • Author(s): 谷村恭子, 岡島史宜, 長尾元嗣, 中島泰, 原田太郎, 首藤真理子, 浅井明, 及川眞一
  • Organizer: 第40回日本動脈硬化学会総会
  • Place of Presentation: 筑波
  • Year and Date: 2008-07-10
• [Presentation] The presence of carotid plaque is associated with fasting apoB48 and AUC-apoB48, but not with iAUC-apoB48 (2008)
  • Author(s): 松田崇, 谷村恭子, 中島泰, 首藤真理子, 長尾元嗣, 原田太郎, 岡島史宜, 浅井明, 及川眞一
  • Organizer: 第40回日本動脈硬化学会総会
  • Place of Presentation: 筑波
  • Year and Date: 2008-07-10
• [Presentation] 2型糖尿病患者における血清シスタチンC値と頚動脈硬化の検討 (2008)
  • Author(s): 長尾元嗣, 首藤真理子, 原田太郎, 中島泰, 谷村恭子, 岡島史宜, 及川眞一
  • Organizer: 第40回日本動脈硬化学会総会
  • Place of Presentation: 筑波
  • Year and Date: 2008-07-10
• [Presentation] 2型糖尿病患者におけるIGF-1の検討 (2008)
  • Author(s): 長尾元嗣, 及川眞一
  • Organizer: 第50回日本老年医学会
  • Place of Presentation: 千葉県幕張
  • Year and Date: 2008-06-19
• [Presentation] 演題 : 高齢者糖尿病患者におけるエネルギー消費量の検討 (2008)
  • Author(s): 中島 泰, 近藤秀士, 首藤真理子, 長尾元嗣, 谷村恭子, 岡島史宜, 杉原 仁, 幣 憲一郎, 津田謹輔, 及川眞一
  • Organizer: 第50回日本老年医学会
  • Place of Presentation: 千葉県幕張
  • Year and Date: 2008-06-19
• [Presentation] 酸化変注リン脂質は膵β細胞のインスリン分泌能を低下させる (2008)
  • Author(s): 原田太郎, 岡島史宜, 栗原美樹子, 首藤真理子, 長尾元嗣, 中島泰, 谷村恭子, 杉原仁, 及川眞一
  • Organizer: 第51回日本糖尿病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Presentation] 2型糖尿病患者におけるアポB48と頚動脈プラークの有無との関係 (2008)
  • Author(s): 谷村恭子, 長尾元嗣, 首藤真理子, 加納稔子, 石崎晃, 中島泰, 岡島史宜, 田村秀樹, 石井新哉, 杉原仁, 及川眞一
  • Organizer: 第51回日本糖尿病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Presentation] インスリン抵抗性症例のトリグリセライド代謝に対する塩酸ピオグリタゾンの影響 (2008)
  • Author(s): 中島 泰, 首藤真理子, 長尾元嗣, 原田太郎, 谷村恭子, 岡島史宜, 田村秀樹, 石井新哉, 杉原 仁, 小竹英俊, 及川眞一
  • Organizer: 第51回日本糖尿病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Presentation] 血糖コントロール前後での血清シスタチンC値の変化と細小血管合併症の関係 (2008)
  • Author(s): 長尾元嗣, 岡島史宜, 首藤真理子, 加納稔子, 石崎晃, 原田太郎, 中島泰, 谷村恭子, 田村秀樹, 石井新哉, 杉原仁, 及川眞一
  • Organizer: 第51回日本糖尿病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Presentation] Serum insulin-like growth factor-1 levels are associated with carotid atherosclerosis in type 2 diabetes (2008)
  • Author(s): Nagao M, Nakajima Y, Sudo M, Kano T, Ishizaki A, Harada T, Tanimura K, OkajimaF, TamuraH, IshiiS, Sugihara H, Oikawa S
  • Organizer: 第77回欧州動脈硬化学会(EAS)
  • Place of Presentation: イスタンブール
  • Year and Date: 2008-04-26
• [Presentation] Fasting level and diurnal change of serum apoprotein B48 correlated to carotid artery plaque in type 2 diabetes (2008)
  • Author(s): Tanimura K, Nagao M, Nakajima Y, Su do M, Kano T, Ishizaki A, Harada T, O kajima F, Tamura H, Ishii S, Sugihara H, Oikawa S
  • Organizer: 第77回欧州動脈硬化学会(EAS)
  • Place of Presentation: イスタンブール
  • Year and Date: 2008-04-26
• [Presentation] PHOSPHATIDYLCHOLINE HYDROPEROXIDE, A PRIMARY OXTDATION PRODUCT OF PHOSPHATIDYLCHOLINE, INDUCES THP-1 CELL ADHESION TO ICAM-1 (2008)
  • Author(s): Asai A, Okajima F, Tanimura K, Nakajima Y, Nagao M, Nakagawa K, Miyazawa T, Oikawa S
  • Organizer: 第77回欧州動脈硬化学会(EAS)
  • Place of Presentation: イスタンブール
  • Year and Date: 2008-04-26
• [Presentation] Effects ofEPA on coronary artery disease in patients with gluco-metabolism derangement : JELIS subgroup analysis (2008)
  • Author(s): Oikawa S, Yokoyama M, Origasa H, Matsuzaki M, Saito Y, Matsuzawa Y, Ishikawa Y, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, Shirato K, for the JELIS Investigators
  • Organizer: 第72回日本循環器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-29
• [Presentation] Effects of EPA on Coronary Artery Disease in Patients with Gluco-Metabolism Derangement: JELIS Subgroup Analysis (2008)
  • Author(s): Oikawa S, Yokoyama M, Origasa H, Matsuzaki M, Saito Y, Matsuzawa Y, for the JELIS Investigators
  • Organizer: 第72回日本循環器病学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-29
• [Presentation] 過酸化脂質phosphatidylcholine hydroperoxide(PCOOH)による単球細胞の接着誘導 (2008)
  • Author(s): 浅井明、岡島史宜、谷村恭子、中島泰、長尾元嗣、仲川清隆、指宿大悟、宮澤陽夫、及川眞一
  • Organizer: 第9回糖尿病合併症とVascular Biology研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-01
• [Presentation] Phosphatidylcholine hydroperoxide, a primary oxidation product of phosphatidylcholine, induces THP-1 cell adhesion to ICAM-1 (2008)
  • Author(s): Asai, A., F. Okajima, K. Tanimura, Y. Nakajima, M. Nagao, K. Nakagawa, D. Ibusuki, T. Miyazawa, S. Oikawa
  • Organizer: 77th European Atherosclerosis Society Congress
  • Place of Presentation: Istanbul, Turkey
• [Presentation] リン脂質酸化一次生成物phosphatidylcholine hydroperoxide(PCOOH)によるTHP-1細胞のICAM-1への接着誘導 (2008)
  • Author(s): 浅井明、岡島史宜、谷村恭子、中島泰、長尾元嗣、仲川清隆、指宿大悟、宮澤陽夫、及川眞一
  • Organizer: 第41回日本動脈硬化学会総会・学術集会
  • Place of Presentation: つくば
• [Presentation] Effects of EPA on coronary artery disease in patients with gluco-metabolism derangement: JELIS subgroup analysis (2007)
  • Author(s): Oikawa S, Yokoyama H, Origasa M, Matsuzaki M, Saito Y, Matsuzawa Y
  • Organizer: 第43回欧州糖尿病学会年次集会
  • Place of Presentation: アムステルダム
  • Year and Date: 2007-09-20
• [Presentation] 過酸化リン脂質PCOOHによる単球細胞株THP-1の血管内皮接着分ICAM-1への接着誘導とそのメカニズム (2007)
  • Author(s): 浅井明、岡島史宜、仲川清隆、指宿大悟、谷村恭子、中島泰、長尾元嗣、宮澤陽夫、及川眞一
  • Organizer: 第15回生体パーオキサイド研究会
  • Place of Presentation: 仙台
  • Year and Date: 2007-08-25
• [Presentation] 糖尿病の大血管症を進めないために (2007)
  • Author(s): 及川眞一
  • Organizer: 第50回日本糖尿病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-26
• [Presentation] 糖尿病または高血糖を伴う高脂血症患者における冠動脈イベント発症率と EPA の発症抑制効果:JELISサブグループ解析 (2007)
  • Author(s): 及川眞一, 横山光宏, 折笠秀樹, 松崎益徳、松澤佑次, 齋藤 康, 石川雄一, 佐々木 淳、菱田仁士, 板倉弘重, 北 徹北畠 顯, 中谷矩章, 坂田利家, 島田和幸、白土邦男, JELIS研究会
  • Organizer: 第50回日本糖尿病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-26
• [Presentation] 過酸化リン脂質PCOOHは単球の接着分子ICAM-1への結合を亢進する (2006)
  • Author(s): 浅井明、岡島史宜、谷村恭子、中島泰、仲川清隆、宮澤陽夫、及川眞一
  • Organizer: 第14回生体パーオキサイド研究会
  • Place of Presentation: 仙台
  • Year and Date: 2006-08-12
• [Book] 健康診断で血糖値が高めの人が読む本 (2007)
  • Author(s): 及川眞一
  • Total Pages: 126
  • Publisher: 幻冬舎