Therapeutic potency of platinum nanoparticle in metabolic syndrome
| Project/Area Number |
18591016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIMOSAWA Tatsuo The University of Tokyo, Faculty of Medicine, Lecturer (90231365)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Katsuyuki The University of Tokyo, Faculty of Medicine, Associate Professor (60184313)
MIYAMOTO Yusei The University of Tokyo, Dept of Integrated Biosciences, Professor (60157691)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Oxidative stress / platinum / Metabolic syndrome / renal injury / safety / vascular damage / insulin resistance / アドレノメデュリン / 催奇形性 |
|---|
| Research Abstract |
In the present study, we revealed the therapeutic potency of platinum nanoparticle in dB/dB mouse loaded with angiotensin II and salt loaded model, aged adrenomedullin knockout mouse, and cisplatinum-induced renal failure mouse model. These models are related with metabolic syndrome and vascular damage in dB/dB mouse was remarkably reversed by platinum. Also aged-adrenomedullin knockout mouse reversed its insulin resistance when platinum is administered for 3 month but not for 1 month. Platinum showed its safety by reversing cis-platinum-induced nephrotoxicity and its main role was inhibiting ROS production. To investigate platinum safety we examined its effects on immunity, teratogeniety and tissue accumulation. Neither examination revealed toxicity. To improve its bioavailability and further investigation in human will lead us to new therapeutic approach in metabolic syndromes and its related organ damages.
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Report
(3 results)
Research Products
(92 results)
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[Journal Article] ステロイド高血圧2007
Author(s)
王紅, 下澤達雄, 藤田敏郎
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Journal Title
循環器症候群(第2版).別冊日本臨床 新領域別症候群シリーズNo.4 4
Pages: 111-114
Description
「研究成果報告書概要(和文)」より
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[Presentation] 血管内皮細胞におけるNF-κBシグナルが全身代謝へ与える役割の検討.2007
Author(s)
長谷川豊, 片桐秀樹, 荻原健英, 下澤達雄, 齊藤徳郎, 石垣泰, 山田哲也, 今井淳太, 宇野健司, 高俊弘, 金子慶三, 桧尾好徳, 藤田敏郎, 岡芳知
Organizer
第44回日本臨床分子医学会学術総会
Place of Presentation
和歌山
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] メタボリックシンドロームにおける酸化ストレスと臓器障害の関連及び新しい抗酸化薬について.2006
Author(s)
金子知代, 下澤達雄, 宮本有正, 岡山峰延, 梶田昌志, 松井宏光, 王紅, 板倉香南, 小倉彩世子, 上竹勇三郎, 栗原裕基, 藤田敏郎
Organizer
第79回日本内分泌学会学術総会
Place of Presentation
神戸
Description
「研究成果報告書概要(和文)」より
Related Report
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