Thyroid Hormone Acton in Nervous System : Screening for Novel Thyroid Hormone Responsive Gene in Hippocampus
| Project/Area Number |
18591019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Nagoya University |
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Principal Investigator |
HAYASHI Yoshitaka Nagoya University, Research Institute of Environmental Medicine, Associate Professor (80420363)
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Yoshiharu Nagoya University, Res. Inst. of Emvonmental Medicine, Professor (80174308)
TAKAGISHI Yoshiko Nagoya University, Res. Inst. of Emvonmental Medicine, Assistant Professor (50024659)
KANOU Yasuhiko Nagoya University, Res. Inst. of Emvonmental Medicine, Assistant Professor (50252292)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Endocrinology / Thyroid Hormone Action / Hippocampus / Thyroid Hormone Receptor |
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| Research Abstract |
Thyroid hormone plays crucial role in normal development of nervous system. Insufficiency of thyroid hormone during embryonal, neonatal, or infant periods leads to irreversible deficit in development of nervous systems. It is well known that insufficiency or excess of thyroid hormone also affects brain function in adolescents. Depression and/or Alzheimer's disease-like symptoms have been documented in patients with hypothyroidism. Although several genes regulated by thyroid hormone in nervous systems have been identified, most of these genes are not responsive to thyroid hormone in adult nervous system as in immature nervous system. The present study was, thereby, aimed to identify novel thyroid hormone responsive genes expressed in adult nervous system. For this purpose, mice were rendered hypothyroid by we performed cDNA subtraction using RNA extracted from hippocampus, in which neurogenesis has been documented in mature animals.
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Report
(3 results)
Research Products
(51 results)
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[Journal Article] Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile2008
Author(s)
R.Q. Shi, J. K., Lee, Y. Hayashi, Y., Takeuchi, F., Kambe, S., Futaki, H., Seo, Y., Murata, I., Kodama
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Journal Title
Eur. J. Pharmacol 578-(2-3)
Pages: 270-278
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Insertion of an intracistemal A particle retrotransposon element in plasma membrane calcium ATPase 2 gene attenuates its expression and produces an ataxic phenotype in joggle mutant mice2008
Author(s)
X.Y. Sun, Z. Y., Chen, Y., Hayashi, Y., Kanou, Y., Takagishi, S., Oda, Y., Murata
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Journal Title
Gene 411-(1-2)
Pages: 94-102
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] 「研究成果報告書概要(欧文)」より2007
Author(s)
Y. Takagishi, K. Hashimoto, T. Kayahara, M. Watanabe, H. Otsuka, A. Mizoguchi, M. Kato, Y. Murata
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Journal Title
Dev. Neurobiol 67-7
Pages: 909-923
Related Report
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[Journal Article] Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity2007
Author(s)
Y. Kanou, A. Hishinuma, K. Tsunekawa, K. Seki, Y. Mizuno, H. Fujisawa, T. Imai, Y. Murata, T. Nagasaka, C. Yamada, T. Ieiri, M. Murakami, Y. Murata
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Journal Title
J. Clin. Endocrinol. Metab 92-4
Pages: 1451-1457
NAID
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Expression of estrogen receptor and its effect on cell proliferation in papillary thyroid cancer. Japanese2007
Author(s)
R. Watanabe, T. Imai, T. Kikumori, M. Sawaki, A. Shibata, H. Kobayashi, H. Takada, T. Kagawa, Y. Hayashi, Y. Murata
Organizer
The 107th Annual Meeting of Japan Surgery Association
Place of Presentation
Osaka, Japan
Year and Date
2007-04-13
Description
「研究成果報告書概要(欧文)」より
Related Report
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