Novel Regeneration System based on Fat Producing Adipokine

• Project/Area Number: 18591023
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Osaka University
• Principal Investigator: MAEDA Kazuhisa Osaka University, Graduate School of Medicine, Assistant Professor (60397750)
• Co-Investigator(Kenkyū-buntansha): NISHIDA Kouji Tohoku University, Graduate School of Medicine, Professor (40244610) ; NAKAGAMI Hironori Osaka Univetsty, Graduate School of Medicine, Assistant Professor (20325369)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: adipokine / transplantation / feeder cell / 移植・再生医療 / 循環器・高血圧 / アディポサイエンス / アディポサイトカイン / 血管新生 / 角膜移植

Research Abstract

1. Adipose tissue-derived cells (ADSC) demonstrated potential as angiogenic cell therapy for ischemic disease in mice, which appears to be mainly achieved by their ability to secrete angiogenic growth factors.
2. A novel human feeder cell layer of mesenchymal stem cells harvested from human adipose tissues was established. Transplantation of completely autologous tissue-engineered corneal epithelial cell sheets with healthy donor adipose derived stromal beds were done under the approval by the institutional review board of Osaka University Medical School.
3. Effects of cultured adipose tissue-derived stromal cells on proliferation and differentiation of hematopoietic stem cell was examined. URB (Up-Regulated Bombesin receptor subtype3 knock out mouse) was shown to be abundantly expressed in ADSC and act as a novel adipokine.

Research Products

• [Journal Article] URB is abundantly expressed in adipose tissue and dysregulated in obesity (2008)
  • Author(s): Okada T, et. al.
  • Journal Title: Biochemical and Biophysical Research Communications 367 Pages: 370-376
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] URB is abundantly expressed in adipose tissue and dysregulated in obesity (2008)
  • Author(s): Okada, T, Nishizawa, H, Kurata, A, Tamba, S, Sonoda, M, Yasui, A, Kuroda, Y, Hibuse, T, Maeda, N, Kihara, S, Hadama, T, Tobita, K, Akamatsu, S, Maeda, K, Shimomura, I, Funahashi, T
  • Journal Title: Biochem Biophys Res Commun 367(2) Pages: 370-376
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] URB is abundantly expressed in adipose tissue and dysregulated in obesity. (2008)
  • Author(s): Okada T, et. al.
  • Journal Title: Biochemical and Biophysical Research Communications 367 Pages: 370-376
  • Peer Reviewed
• [Journal Article] 脂肪組織由来細胞(ADSC)を用いた再生医療 (2007)
  • Author(s): 前田和久
  • Journal Title: ACROSS 15 Pages: 8-13
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Novel Regeneration System based on Fat Producing Adipokine (2007)
  • Author(s): Maeda, K
  • Journal Title: ACROSS 15 Pages: 8-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy. (2006)
  • Author(s): Nakagami H, Maeda K., et. al.
  • Journal Title: J Atheroscler Thromb. 13(2) Pages: 77-81
  • NAID: 10020627442
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy (2006)
  • Author(s): Nakagami, H, Morishita, R, Maeda, K, Kikuchi, Y, Ogihara, T, Kaneda, Y
  • Journal Title: J Atheroscler Thromb 13(2) Pages: 77-81
  • NAID: 10020627442
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy. (2006)
  • Author(s): Nakagami H, et al.
  • Journal Title: J Atheroscler Thromb. 13 Pages: 77-81
  • NAID: 10020627442
• [Journal Article] 肥満症の新たな治療戦略 (2006)
  • Author(s): 前田和久 他
  • Journal Title: 糖尿病学の進歩(日本糖尿病学会編) 第40集 Pages: 229-234
• [Presentation] 肥満と発ガン (2007)
  • Author(s): 前田和久
  • Organizer: 第33回日本泌尿器疾患予防医学研究会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Obesity and Cancer (2007)
  • Author(s): Kazuhisa, Maeda
  • Organizer: The 33rd Japanese Society for Preventive Nephrology and Urology
  • Place of Presentation: Osaka
  • Year and Date: 2007-07-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] アディポサイトカインの臨床展開 (2007)
  • Author(s): 前田和久
  • Organizer: 第8回Pharmaco Hematologyシンポジウム
  • Place of Presentation: 富山
  • Year and Date: 2007-06-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Launching Adipokine into the Clinical Practice (2007)
  • Author(s): Kazuhisa, Maeda
  • Organizer: The 8th Pharmaco-Hematology Symposium, Pharmaceutical Society of Japan
  • Place of Presentation: Toyama
  • Year and Date: 2007-06-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] メタボリックシンドロームとアディポネクチン (2006)
  • Author(s): 前田和久
  • Organizer: 第16回日本小児栄養消化器肝臓学会
  • Place of Presentation: 大阪
  • Year and Date: 2006-10-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Metabolic syndrome and Adiponectin (2006)
  • Author(s): Kazuhisa, Maeda
  • Organizer: The 16th Annual Meeting of The Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition
  • Place of Presentation: Osaka
  • Year and Date: 2006-10-06
  • Description: 「研究成果報告書概要(欧文)」より