Research Project
Grant-in-Aid for Scientific Research (C)
We have clarified the following issues about bisphosphonates triangle from 1st April 2006 to 31st March 2008.1) BPs demonstrated the that in vitro antitumor effects against not only leukemia but also osteosarcoma(Brit J Cancer 2006, Cancer Left 2006) and bladder cancer (Bin Cancer 2006). Osteosarcoma cells showed higher sensitivity for BPs than other cancer cells Intravesical administration of BPs to bladder was extremely effective for orthotopic bladder cancer mice model. We also clarified that the concentration of BPs in bone marrow was enough to show the direct antitumor effects while that in peripheral blood was not enough. In addition, we reported that an ABL tyrosine kinase inhibitor, INNO-406 which was a good candidate for the combination therapy with BPs also augmented the effects of BCL-2 inhibitor (Cell Death Diff 2007), was effective against most mutated ABL (Leuk Res 2006) and central nervous leukemia (Blood 2007).2) γδ T cells killed myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface (BBRC 2007).3) Inoculated leukemic cells via tail vein were engrafted from the edge of bone where osteoclasts mainly existed. Reveromycin A which specifically inhibited the growth of osteoclasts reduced the engraftment of inoculated leukemic cells, suggesting BPs which also had anti-osteoclast activity also may had indirect antitumor effects via osteoclast destruction.
All 2008 2007 2006 Other
All Journal Article (66 results) (of which Peer Reviewed: 25 results) Presentation (103 results) Book (6 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results)
Leuk Res 32
Pages: 980-983
Br. J. Haematol 140
Pages: 181-190
Mol Cancer Ther (In press)
Leuk Res (In press)
Biol Blood Marrow Tr (In press)
Int J Hemato (In press)
Bone Marrow Transplant (In press)
Int J Clin Oncol (In press)
Analytical Chemistry Insights (In press)
ファルマシア 44
Pages: 213-217
Clinical Calcium (印刷中)
分子細胞治療 (印刷中)
Blood 109
Pages: 306-314
Brit J Cancer 96
Pages: 255-261
Transplantation 83
Pages: 506-509
Transfusion Med 7
Pages: 97-106
Biochem Biophys Res Commun 354
Pages: 613-618
Biochem Biophys Res Commun 357
Pages: 353-359
The Analyst 132
Pages: 512-514
Cell Death Diff 14
Pages: 1667-1677
Int Med 46
Pages: 1919-1922
Current Medicinal Chemistry 14
Pages: 2126-2135
癌と化学療法 34
Pages: 1623-1627
血液フロンティア、17:19-29, 2007. 17
Pages: 19-29
Cancer Frontier 9
Pages: 137-145
Front Wave in Hematology 21
Pages: 8-9
Front Wave in Hematology 22
Biotherapy 4
Pages: 256-263
血液・腫瘍科 54
Pages: 710-718
臨床血液 48
Pages: 46-55
日本臨床 65
Pages: 46-51
医学のあゆみ 220
Pages: 783-788
医学のあゆみ 224
Pages: 109-114
Current Medical Chemistry 14
Biochemical and Biophysical Research Communications 354
British Journal of Cancer 95
Pages: 1354-1361
British Journal of Cancer 96
Proc Natl Acad Sci USA 103
Pages: 1443-1446
Leuk Res 30
Acta Haematol 117
Pages: 132-144
Recent Patent Review on Anti-Cancer Drug Discovery 1
Pages: 347-355
Curr Pharm Bio 7
Pages: 371-379
Cancer Chemoth Pharm 58
Pages: 55-61
がん分子標的治療 4
Pages: 67-71
血液・腫瘍科 52
Pages: 555-562
遺伝子医学MOOK 4
Pages: 100-105
血液Frontier 16
Pages: 1357-1370
京都府立医大雑誌. 115
Pages: 749-760
感染・炎症・免疫 36
Pages: 152-155
最新医学 61
Pages: 1102-1109
臨床研修プラクティス 3
Pages: 53-65
Brit J Cancer 95
Cancer Lett 238
Pages: 111-118
Proc Natl Aced Sci USA 103
Pages: 14907-14912
Proceedings of National Academy of Science, USA 103
Leukemia Research 30
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