• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pathway analysis in bronchial asthma

Research Project

Project/Area Number 18591097
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionUniversity of Tsukuba

Principal Investigator

NOGUCHI Emiko  University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant Professor (40344882)

Co-Investigator(Kenkyū-buntansha) UCHIDA Kazuhiko  University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant Professor (90211078)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsasthma / microarray / proteome
Research Abstract

Asthma is the most common chronic disorder in childhood, and asthma exacerbation is an important cause of childhood morbidity and hospitalization. Allergic responses are known to be biased toward T-helper type 2 in asthmatics; however, the pathogenesis of asthma is not simple, and our understanding of the disease mechanism remains incomplete. The aim of the present study was to identify gene/protein expression signatures that reflect acute exacerbation of asthma.
Blood was taken twice from pediatric asthmatic patients, once during asthma exacerbation and once during a stable period. Blood was also taken from healthy children as a control. Total RNA was extracted from peripheral blood mononuclear cells and subjected to microarray analysis with a Takara IntelliGene HS Human Expression CHIP and an Illumina Sentrix Human-6 Expression BeadChip. Paired t-test was performed to identify genes showing altered expression during asthma exacerbation. Quantitative real-time reverse transcription-pol … More ymerase chain reaction was performed with 48 asthmatic children to verify the microarray results. Pathway analysis was performed with IPA version 5.0 software. Expression of 26/3 genes was significantly up/down-regulated during asthma exacerbation by microarray analysis. Many of the differentially expressed genes were involved in defense responses against pathogens and interferon induction. In pathway analysis, tumor necrosis factor and interferon gamma were centered with the highest connections in the network. Tumor necrosis factor is associated with asthma exacerbation as a potent pro-inflammatory cytokine. Interferon gamma is involved in numerous immune interactions during viral infection and contributes to antiviral mechanisms. Expression levels of IFN-related genes were higher in rhinovirus viremia positive-group than in negative-group (P<0.05).
Protein expression profiles of plasma during asthma exacerbation were analyzed by 2-DE, and 49 spots were differentially expressed during asthma exacerbation. Thirty-eight of the spots were successfully identified by MALD-TOF MS. Proteins up-or down-regulated during asthma exacerbation were involved in responses to stress and pathogens, in the complement and coagulation cascades, and in acute phase responses. Among the differentially expressed proteins, up-regulation of alpha-1-antitrypsin and complement component C7 was confirmed by nephelometry and ELISA. Our present results suggest that IFN-related genes/protease inhibitors and complement components may be involved in asthma exacerbation. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (71 results)

All 2008 2007 2006

All Journal Article (40 results) (of which Peer Reviewed: 16 results) Presentation (31 results)

  • [Journal Article] Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population,family and case-control study2008

    • Author(s)
      Enomoto H, Hirata K, Otsuka K, Kawai T, Takahashi T, Hirota T, Suzuki Y, Tamari M, Otsuka F.
    • Journal Title

      J Hum Genet (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Alpha-1-antitrypsin and complement component C7 are involved in asthm a exacerbation2008

    • Author(s)
      Nishiioka T, Uchida K, Meno K, Ishii T, Aoki T, Imada Y. Makino Y, Hirata K, Matsumoto Y, Arinami T, Noguchi E
    • Journal Title

      Proteomics Clin Appl 2

      Pages: 46-54

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Eenetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae)expression is associated with childhood atopic asthma in a Japanese population2008

    • Author(s)
      Hirota T, Harada M, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Noguchi E, Satio H, Nakamura Y, Tamari M
    • Journal Title

      J Allergy Clin Immunol 121

      Pages: 769-770

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population, family and case-control study2008

    • Author(s)
      Enomoto H, Hirata K, Otsuka K, Kawai T, Takahashi T, Hirota T, Suzuki Y, Tamari M, Otsuka F, Fujieda S, Arinami T, Noguchi E
    • Journal Title

      J Hum Genet (in press)

    • NAID

      10021249695

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Noguchi E Alpha-1-antitrypsin and complement component C7 are involved in asthma exacerbation2008

    • Author(s)
      Nishioka T, Uchida K, Meno K, Ishii T, Aoki T, Imada Y, Makino Y, Hirata K, Matsumoto Y, Arinami T
    • Journal Title

      Proteomics Clin Appl 2

      Pages: 46-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Genetic polymorphism regulating ORM1-like 3(Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population2008

    • Author(s)
      Hirota T, Harada M, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Ebisawa M, Yoshiaa S, Noguchi E, Saito H, Nakamura Y, Tamari M
    • Journal Title

      J Allergy Clin Immunol 121

      Pages: 769-770

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Genetic polymorphism regulating ORM1-like 3(Saccharomyces cerevisiae)expression is associated with childhood atopic asthma in a Japanese population2008

    • Author(s)
      Hirota T, Harada M, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Noguchi E, et. al.
    • Journal Title

      J Allergy Clin Immunol 121

      Pages: 769-770

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alpha-1-antitrypsin and complement component C7 are involved in asthma exacerbation.2008

    • Author(s)
      Nishioka T, Uchida K, Meno K, Ishii T, Aoki T, Imada Y, Makino Y, Hirata K, Matsumoto Y, Arinami T, Noguchi E
    • Journal Title

      Proteomics Clin Appl 2

      Pages: 46-54

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー疾患の遺伝要因2007

    • Author(s)
      野口恵美子
    • Journal Title

      日本小児アレルギー学会雑誌 21

      Pages: 69-74

    • NAID

      10024133293

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] 喘息治療におけるpharmacogenetics2007

    • Author(s)
      野口恵美子
    • Journal Title

      臨床免疫・アレルギー科 47

      Pages: 664-669

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 喘息の薬理遺伝学2007

    • Author(s)
      野口恵美子
    • Journal Title

      International Review of Asthma 9

      Pages: 56-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Growth suppression of thyroid cancer cells by adenylcyclase activator2007

    • Author(s)
      Yano Y, Kamma H, Matsumoto H, Fujiwara M, Bando H, Hara H, Yashiro T, Ueno E, Ito K, Uchida K
    • Journal Title

      Oncol Rep 18

      Pages: 441-445

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Predicition of in vitro response to interferon-alpha in renal cell carcinoma celllines2007

    • Author(s)
      Shimazui T, Ami Y, Yoshikawa K, uchida K, Kojima T, Oikawa T, Nakamura K, Honda N, Hinotsu S, Miyazaki J, Kunita N, Akaza H
    • Journal Title

      Cancer Sci 98

      Pages: 529-534

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis Families.2007

    • Author(s)
      Enomoto H, Noguchi E, Iijima S, Takahashi T, Hayakawa K, Ito M, Kano T, Aoki T, Suzuki Y, Koga M, Tamari M, Shiohara T, Otsuka F, Arinami T
    • Journal Title

      BMC Dermatol 7

      Pages: 5-5

    • NAID

      120007138747

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genetics of allergic diseases2007

    • Author(s)
      Emiko Noguchi
    • Journal Title

      Japan pediatric allergology journal 21

      Pages: 69-74

    • NAID

      40016863337

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pharmacogenetics in asthma treatment2007

    • Author(s)
      Emiko Noguchi
    • Journal Title

      Clinical immunology・Allergology 47

      Pages: 664-669

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pharmacogenetics of asthma2007

    • Author(s)
      Emiko Noguchi
    • Journal Title

      International Review of Asthma 9

      Pages: 56-65

    • NAID

      40015567033

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prediction of in vitro response to interferon-alpha in renal cell carcinoma cell lines2007

    • Author(s)
      Shimazui T, Ami Y, Yoshikawa K, Uchida K, Kojima T, Oikawa T, Nakamura K, Honda N, Hinotsu S, Miyazaki J, Kunita N, Akaza H
    • Journal Title

      Cancer Sci 98

      Pages: 529-534

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families2007

    • Author(s)
      Enomoto H, Noguchi E, Iijima S, Takahashi T, Hayakawa K, Ito M, Kano T, Aoki T, Suzuki Y, Koga M, Tamari M, Shiohara T, Otsuka F, Arinami T
    • Journal Title

      BMC Dermatol 7

      Pages: 5-5

    • NAID

      120007138747

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families2007

    • Author(s)
      Enomoto H, Noguchi E, Iijima S, Takahashi T, Hayakawa K, Ito M, Kano T, Aoki T, Suzuki Y, Koga M, Noguchi E
    • Journal Title

      BMC Dermatology 7

    • NAID

      120007138747

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 花粉症は遺伝するのか? 花粉症と周辺アレルギー疾患.2006

    • Author(s)
      野口恵美子
    • Journal Title

      診断と治療社

      Pages: 151-153

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 花粉症の遺伝的背景2006

    • Author(s)
      野口恵美子
    • Journal Title

      臨床検査 50

      Pages: 139-144

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Determination of structrue and transcriptional regulation of of CYSLTR1and an association study with asthma and rhinitis2006

    • Author(s)
      Zhang J, Migita O, Koga M, Shibasaki M, Arinami T, Noguchi E
    • Journal Title

      Pediatr Allergy Immunol 17

      Pages: 242-249

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gene expression profiling defined pathways correlated with fibroblast celproliferation induced by Opisthorchis vierrini excretory/secretory product2006

    • Author(s)
      Thuwajit C, Thuwajit P, Uchida K, Daorueang D, Kaewkes S, Wongkham S, Miwa M
    • Journal Title

      World Gastroenterol 12

      Pages: 3585-3592

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] ADAM33 polymorphisms are associated with astima susceptibility in a Japanese population.2006

    • Author(s)
      Noguchi E, Ohtsuki Y, Tokunaga K, Yamaoka-Sageshima M, lchikawa K, Aoki T, Shibasaki M, Arinami T
    • Journal Title

      Clin Exp Allergy 36

      Pages: 602-608

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Failure to find an asso.ci ation between CD14-159C/T polymorphism and asthma: a family-based as sociation test and meta-analysis.2006

    • Author(s)
      Nishimura F, Shibasaki M, Ichikawa K, Arinami T, Noguchi E
    • Journal Title

      Allergol lnt 55

      Pages: 55-58

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Quantitation of thyroid peroxidase mRNA peripheral blood for early detection of thyroid papillary carcinoma2006

    • Author(s)
      Ishikawa T, Miwa M, Uchida K
    • Journal Title

      Thyroid 16

      Pages: 435-442

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Monoallelic and unequal allelic expression of the HTR2A gene in human brain and peripheral lymphocytes2006

    • Author(s)
      Fukuda Y, Koga M, Arai M, Noguchi E, Ohtsuki T, Horiuchi Y, Ishigtiro H, Niizato K, lritani S, Itokawa M. Arinami T
    • Journal Title

      Biol Psychiatry 60

      Pages: 1331-1335

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] An association between asthma and TNF-308G/A polymorphism:meta-analysis2006

    • Author(s)
      Aoki T, Hirota T, Tamari M, Ichikawa .K, Takeda K, Arinami T, Shibasaki M, Noguchi E
    • Journal Title

      J Hum Genet 51

      Pages: 677-685

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Is hay fever heritable? Hay fever and other allergic diseases2006

    • Author(s)
      Emiko Noguchi
    • Journal Title

      Diagnosis and therapeutics

      Pages: 151-153

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Genetic background of hay fever2006

    • Author(s)
      Emiko Noguchi
    • Journal Title

      Clinical Test 50

      Pages: 139-144

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis2006

    • Author(s)
      Zhang J, Migita O, Koga M, Shibasaki M, Arinami T, Noguchi E
    • Journal Title

      Pediatr Allergy Immunol 17

      Pages: 242-249

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] Gene expression profiling defined pathways correlated with fibroblast cell proliferation induced by Opisthorchis viverrini excretory/secretory product2006

    • Author(s)
      Thuwajit C, Thuwajit P, Uchida K, Daorueang D, Kaewkes S, Wongkham S, Miwa M
    • Journal Title

      World J Gastroenterol 12

      Pages: 3585-3592

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population2006

    • Author(s)
      Noguchi E, Ohtsuki Y, Tokunaga K, Yamaoka-Sageshima M, Ichikawa K, Aoki T, Shibasaki M, Arinami T
    • Journal Title

      Clin Exp Allergy 36

      Pages: 602-608

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Failure to find an association between CD14-159C/T polymorphism and asthma : a family-based association test and meta-analysis2006

    • Author(s)
      Nishimura F, Shibasaki M, Ichikawa K, Arinami T, Noguchi E
    • Journal Title

      Allergol Int 55

      Pages: 55-58

    • NAID

      10020557549

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] Quantitation of thyroid peroxidase mRNA in peripheral blood for early detection of thyroid papillary carcinoma2006

    • Author(s)
      Ishikawa T, Miwa M, Uchida K
    • Journal Title

      Thyroid 16

      Pages: 435-442

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Monoallelic and unequal allelic expression of the HTR2A gene in human brain and peripheral lymphocytes2006

    • Author(s)
      Fukuda Y, Koga M, Arai M, Noguchi E, Ohtsuki T, Horiuchi Y, Ishiguro H, Niizato K, Iritani S, Itokawa M, Arinami T
    • Journal Title

      Biol Psychiatry 60

      Pages: 1331-1335

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] An association between asthma and TNF-308G/A polymorphism : meta-analysis2006

    • Author(s)
      Aoki T, Hirota T, Tamari M, Ichikawa K, Takeda K, Arinami T, Shibasaki M, Noguchi E
    • Journal Title

      J Hum Genet 51

      Pages: 677-685

    • NAID

      10019285915

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population.2006

    • Author(s)
      Noguchi E, Ohtsuki Y, Tokunaga K, Yamaoka-Sageshima M, Ichikawa K, Aoki T, Shibasaki M, Arinami T
    • Journal Title

      Clin Exp Allergy 36

      Pages: 602-608

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Monoallelic and unequal allelic expression of the HTR2A gene in human brain and peripheral lymphocytes.2006

    • Author(s)
      Fukuda Y, Koga M, Arai M, Noguchi E, Ohtsuki T, Horiuchi Y, Ishiguro H, Niizato K, Iritani S, Itokawa M, Arinami T
    • Journal Title

      Biol Psychiatry 60

      Pages: 1331-1335

    • Related Report
      2006 Annual Research Report
  • [Presentation] アレルギー疾患の遺伝子配列解析研究の進歩と現状2007

    • Author(s)
      野口恵美子
    • Organizer
      第44回目本小児アレルギー学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-12-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Progress in genetic research for allergic diseases2007

    • Author(s)
      Emiko Noguchi
    • Organizer
      The 44th Japan Pediatric Allergology Congress
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-12-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アレルギー疾患の遺伝子配列解析研究の進歩と現状2007

    • Author(s)
      野口恵美子
    • Organizer
      第44回日本小児アレルギー学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 小児気管支喘息の発症機序 遺伝学的アプローチを中心に2007

    • Author(s)
      野口恵美子
    • Organizer
      つくば地区小児喘息学術講演会
    • Place of Presentation
      茨城
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of Pediatric Asthma, Focused on the genetic analysis2007

    • Author(s)
      Emiko Noguchi
    • Organizer
      Pediatric asthma conference in Tsukuba
    • Place of Presentation
      Ibaraki
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 全ゲノム関連解析による気管支喘息疾患感受性遺伝子の同定2007

    • Author(s)
      藤本正弥、野口恵美子, ら
    • Organizer
      第57回日本アレルギー学会秋季学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロテ耳門ム解析による花粉症関連タンパク質の同定2007

    • Author(s)
      牧野友香, 内田和彦, 有波忠雄, 野口恵美子, 藤枝重治, ら
    • Organizer
      第57回日本アレルギー学会秋季学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-11-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 全ゲノム関連解析による気管支喘息疾患感受性遺伝子の同定2007

    • Author(s)
      藤本政弥, 野口恵美子, ら
    • Organizer
      第57回日本アレルギー学会秋季学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-11-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 網羅的遺伝子発現解析による喘息および花粉症関連璋伝子の同定2007

    • Author(s)
      青木健, 牧野友香, 内田和彦, 有波忠雄, 野口恵美子, 藤枝重治, ら
    • Organizer
      第57回日本アレルギー学会秋季学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-11-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 日本人アトピー性皮膚炎家系を用いた全ゲノム連鎖解析2007

    • Author(s)
      榎本久子, 有波忠雄, 野口恵美子, ら
    • Organizer
      第57回日本アレルギー学会秋季学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-11-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of protein related to hay fever by proteomic research2007

    • Author(s)
      Yuka Makino, Kazuhiko Uchida, Tadao Arinami, Emiko Noguchi
    • Organizer
      The 57th Japan Allergology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-11-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of asthma susceptibility genes by whole-genome-wide association study2007

    • Author(s)
      Masaya Fujimoto, Emiko Noguchi, et. al.
    • Organizer
      The 57th Japan Allergology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-11-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of asthma and hay fever related genes by microarray analysis2007

    • Author(s)
      Takeshi Aoki, Yuka Makino, Kazuhiko Uchida, Tadao Arinami, Emiko Noguchi, et. al.
    • Organizer
      The 57th Japan Allergology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-11-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genome-wide linkage study using Japanese atopic dermatitis families2007

    • Author(s)
      Hisako Enomoto, Tadao Arinami, Emiko Noguchi, et. al.
    • Organizer
      The 57th Japan Allergology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-11-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 網羅的遺伝子発現解析による喘息関連遺伝子の同定2007

    • Author(s)
      青木健、野口恵美子, ら
    • Organizer
      第57回日本アレルギー学会秋季学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-11-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 非標識定量2D-LC MALDI-TOF MSによる低分子量プロテオミクス解析2007

    • Author(s)
      内田和彦
    • Organizer
      第4回千葉疾患プロテオミクス研究会
    • Place of Presentation
      千葉
    • Year and Date
      2007-10-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] small molecule proteomic analysis with Unlabeled 2D-LC MALDI-TOF MS2007

    • Author(s)
      Kazuhiko Uchida
    • Organizer
      The 4th Chiba disease proteomics conference
    • Place of Presentation
      Chiba
    • Year and Date
      2007-10-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アレルギー性疾患の遺伝研究:全ゲノム解析から2007

    • Author(s)
      野口恵美子
    • Organizer
      第17回小児気道アレルギー研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetic analysis of allergic diseases, genome-wide analysis2007

    • Author(s)
      Emiko Noguchi
    • Organizer
      The 17th Pediatric Airway Allergy conferenc
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-10-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] オミックス医療を支える基盤構築に向けて一臨床プロテオミクスを支える基盤構築に向けて2007

    • Author(s)
      内田和彦
    • Organizer
      第4回ゲノム・オミックス医療情報シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-07-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Establishing fundamental systems to support Omics Medicine2007

    • Author(s)
      Kazuhiko Uchida
    • Organizer
      The 4th Omics medical informatics symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-07-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アレルギー疾患と遺伝2006

    • Author(s)
      野口恵美子
    • Organizer
      第43回日本小児アレルギー学会
    • Place of Presentation
      千葉
    • Year and Date
      2006-11-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetics of Allergic diseases2006

    • Author(s)
      Emiko Noguchi
    • Organizer
      The 43th Japan Pediatric Allergology Congress
    • Place of Presentation
      Chiba
    • Year and Date
      2006-11-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 喘息治療とPharmacogenetics2006

    • Author(s)
      野口恵美子
    • Organizer
      第56回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2006-11-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気管支喘息発症における候補遺伝子多型のメタアナリシス2006

    • Author(s)
      野口恵美子, 柴崎正修, 有波忠雄, ら
    • Organizer
      第56回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2006-11-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 網羅的遺伝子発現解析による喘息関連遺伝子の同定2006

    • Author(s)
      青木健, 有波忠雄, 野口恵美子, ら .
    • Organizer
      第56回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2006-11-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Metaanalysis in candidate genes for the development of asthma2006

    • Author(s)
      Emiko Noguchi, Masanao Shibasaki, Tadao Arinami, et. al.
    • Organizer
      The 56th Japan Allergology Congress
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-11-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacogenetics of asthma treatment2006

    • Author(s)
      Emiko Noguchi
    • Organizer
      The 56th Japan Allergology Congress
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-11-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of asthma-related genes by microarray analysis2006

    • Author(s)
      Takeshi Aoki, Tadao Arinami, Emiko Noguchi, et. al.
    • Organizer
      The 56th Japan Allergology Congress
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-11-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 花粉症と遺伝.2006

    • Author(s)
      野口恵美子
    • Organizer
      臨床研セミナー
    • Place of Presentation
      東京
    • Year and Date
      2006-04-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetics of hay fever2006

    • Author(s)
      Emiko Noguchi
    • Organizer
      Rinshyo-ken Seminar
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-04-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi