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The role of Galectin-3 in pathogensesis of pulmonary fibrosis

Research Project

Project/Area Number 18591132
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionClinical research Center, Chiba-East National Hospital, National Hospital Organization

Principal Investigator

RYUTARO Matsumura  Clinical research Center, Chiba-East National Hospital, National Hospital Organization, Division of clinical immunology, Clinical Research Center of Chiba east, 部長 (70246742)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsgalectin-3 / pulmonary fibrosis / lectin / 肺線維症
Research Abstract

Galectin-3 was specifically increased in BALF from patients with pulmonary fibrosis (IPF) and interstitial pneumonia associated with collagen vascular disease (CVD-IP). Galectin-3 levels in BALF seemed to be lower in IPF and CVD-IP patients receiving corticosteroid therapy. Alveolar macrophages from IPF patients expressed more galectin-3 compared with those from control. Galectin -3 expression was induced by tumor necrosis factor-alpha (TNF-a) and interferon (IFN)-r in a macrophage cell line U937. Galectin -3 also induced mRNA expression and protein production of TNF-a and interleukin (IL) -8 in a macrophage cell line THP-1. This lectin stimulated NIH-3T3 fibroblast to induce migration and collagen synthesis in vitro. These results suggest that Galectin-3 is involved in the pathogenesis fo human IPF and CVD-IP by activating macrophages and fibroblasts.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report

Research Products

(5 results)

All 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] 皮膚筋炎を伴う間質性肺炎に対する白血球除去療法の長期効果2008

    • Author(s)
      西出敏雄、松村竜太郎, ら
    • Journal Title

      日本アフェレーシス学会雑誌 27

      Pages: 78-84

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 皮膚筋炎を伴う間質性肺炎に対する白血球除去療法の長期効果2008

    • Author(s)
      西出 敏雄、松村 竜太郎, ら
    • Journal Title

      日本アフェレーシス学会雑誌 27

      Pages: 78-84

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Galectine-3 in human pulmonary fibrosis2007

    • Author(s)
      Yumiko Nishi, Ryutaro Matsumura, et. al.
    • Journal Title

      Allergology International 46

      Pages: 321-27

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of Galectine-3 in human pulmonary fibrosis2007

    • Author(s)
      Yumiko Nishi, Ryutaro Matsumura, et. al.
    • Journal Title

      Allergology lnternational 46

      Pages: 321-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of Galectin-3 in Human Pulmonary Fibrosis2007

    • Author(s)
      Yumiko Nishi, Hideki Sano, et al.
    • Journal Title

      Allergology International Vol.56・No.1

      Pages: 57-65

    • Related Report
      2006 Annual Research Report

URL: 

Published: 2006-03-31   Modified: 2016-04-21  

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