Development of a bone marrow stem cell transplantation treatment for childhood acute encephalomyelitis using animal experimental models

• Project/Area Number: 18591147
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Shinshu University
• Principal Investigator: ICHIKAWA Motoki Shinshu University, 医学部, 教授 (60223088)
• Co-Investigator(Kenkyū-buntansha): SHIOHARA Masaaki 信州大学, 医学部, 准教授 (00293514)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,970,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥570,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 実験的自己免疫性脳脊髄炎 / 骨髄造血幹細胞移植 / 骨髄幹細胞移植 / 実験的自己免疫性脳脊髓炎 / 骨髓造血幹細胞移植

Research Abstract

ラットの骨髄造血幹細胞を採取し、実験的自己免疫性脳脊髄炎の発症時の中枢神経組織に移植したが、脳脊髄炎の臨床症状は移植群と非移植群の間に差はみられなかった。移植した骨髄造血幹細胞は脳脊髄炎を起こしていた腰部脊髄組織には確認できなかった。さらにNODマウスに髄鞘オリゴデンドロサイト糖蛋白を感作して発症させた再発寛解型脳脊髄炎に骨髄造血幹細胞を移植した。このNODマウスでは脳脊髄炎とともに視神経炎を起こしており、少量ではあるが移植した骨髄造血幹細胞が寛解期の視神経に確認され, 今後骨髄造血幹細胞移植の生着の促進と臨床症状の改善に関する研究を行う必要がある。

Research Products

• [Journal Article] Antibodies to myelin oligodendrocyte glycoprotein are not involved in the severity of chronic non-remitting experimental autoimmune encephalomyelitis (2009)
  • Author(s): Sekiguchi Y, Ichikawa M, 他6名
  • Journal Title: Immunology Letters 122 Pages: 145-149
  • Peer Reviewed
• [Journal Article] A novel nonsense mutation of the mineralcorticoid receptor gene in the renal form of pseudohypoaldosteronism type 1 (2009)
  • Author(s): Uchida N, Shiohara M, 他3名
  • Journal Title: J Pediatr Endocrinol Metab 22 Pages: 91-95
  • Peer Reviewed
• [Journal Article] Antibodies to myelin oligodendrocyte glycoprotein are not involved in the severity of chronic non-remitting experiraental auto immune encephalomyelitis (2009)
  • Author(s): Sekiguchi Y, Ichikawa M, Takamoto M, Ota H, Koh C-S, Muramatsu M, Honjo T, Ageraatsu K
  • Journal Title: Immunology Letters 122 Pages: 145-149
  • Peer Reviewed
• [Journal Article] Acquisition of loss of the wild-type NRAS locus with aggressive disease progression on a patient with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation (2007)
  • Author(s): Matsuda K, Nakazawa Y, Sakashita K, Shiohara M, 他2名
  • Journal Title: Haematologica 92 Pages: 1576-1578
  • Peer Reviewed
• [Journal Article] A complex karyotype, including a three-way translocation generating a NUP98-HOXD13 transcript, in an infant with acute myeloid leukemia (2007)
  • Author(s): Hidaka E, Tanaka M, Matsuda K, Ishikawa-Matsumura M, Yamauchi K, Sano K, Honda T, Wakui K, Yanagisawa R, Nakazawa Y, Sakashita K, Shiohara M, 他2名
  • Journal Title: Cancer Genet Cytogenet 176 Pages: 137-143
  • Peer Reviewed
• [Journal Article] 尿失禁を有する一般女性のQOLと関連する要因について (2007)
  • Author(s): 坂口けさみ, 大平雅美, 湯本敦子, 上條陽子, 芳賀亜紀子, 徳武千足, 本郷実, 市川元基, 他2名
  • Journal Title: 母性衛生 48 Pages: 323-330
  • Peer Reviewed
• [Journal Article] Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations (2007)
  • Author(s): Matsuda K, Shimada A, Yoshida N, Ogawa A, Watanabe A, Yajima S, Iizuka S, Koike K, Yanai F, Kawasaki K, Yanagimachi M, Kikuchi A, Ohtsuka Y, Hidaka E, Yamauchi K, Tanaka M, Yanagisawa R, Nakazawa Y, Shiohara M, 他3名
  • Journal Title: Blood 109 Pages: 5477-5480
  • Peer Reviewed
• [Journal Article] Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon (2007)
  • Author(s): Tanaka M, Gombart AF, Koeffler HP, Shiohara M
  • Journal Title: Int J Hematol 85 Pages: 304-311
  • Peer Reviewed
• [Journal Article] Effect of parathyroid hormone administration in a patient with severe hypoparathyroidism caused by gain-of-function mutation of calcium-sensing receptor (2006)
  • Author(s): Shiohara M, 他6名
  • Journal Title: Endocr J 53 Pages: 797-802
  • NAID: 10020612616
  • Peer Reviewed
• [Journal Article] Novel compound heterozygous mutation of the MC2R gene in a patient with familial glucocorticoid deficiency (2006)
  • Author(s): Matsuura H, Shiohara M, 他4名
  • Journal Title: J Pediatr Endocrinol Metab 19 Pages: 1167-1170
  • Peer Reviewed
• [Book] ナースとコメディカルのための小児科学 (2006)
  • Author(s): 市川元基, 他47名
  • Publisher: 日本小児医事出版社
• [Book] ナースとコメディカルのための小児科学 第2版 担当 : 第4章(148頁〜157頁). 「免疫, アレルギー性疾患」 (2005)
  • Author(s): 市川元基 他47名
  • Total Pages: 403
  • Publisher: 日本小児医事出版社