• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of Immunodeficiencies with defective DNA damage response

Research Project

Project/Area Number 18591184
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MORIO Tomohiro  Tokyo Medical and Dental University, Graduate School, 准教授 (30239628)

Co-Investigator(Kenkyū-buntansha) 森尾 友宏  東京医科歯科大学, 大学院・医歯学総合研究科 (30239628)
MINEGISHI Yoshiyuki  Tokyo Medical and Dental University, Graduate School, 准教授 (10343154)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsDNA damage response / Immunodeficiency / Malignancy / Ataxia telangiectasia / Artemis / KU70 / 80 / DNA ligase IV / Cernunnos / 原発性免疫不全症 / DNA損傷修復異常 / 毛細血管拡張性小脳失調症 / ATM / V(D)J再構成 / 免疫グロブリンクラススイッチ / 悪性腫瘍 / リン酸化
Research Abstract

We sought to analyze molecular mechanism of immunodeficiency caused by defective DNA damage response working on cells from disorders including ataxia-telangiectasia (AT), Artemis deficiency, and Nijmegen breakage syndrome (NBS1 deficiency).
We have so far revealed that S645 of Artemis is phosphorylated by ATM upon DNA damaging reagent. Through this study, we have shown 70-kDa molecule is associated with Artemis and controls stability of Artemis. The interaction requires phosphorylation of Artemis, but the site is not in the hitherto-known region. A new role of Artemis was also demonstrated. Endonuclease activity of Artemis was shown to be required for double strand DNA break when DNA replication is stalled in a ragging strand. This process was dependent on ATM. Further investigation is currently in progress.
DNA damage response (DDR) is absolutely required for diversification of immune receptors; and disrupted DDR during the process leads to chromosomal aberration. We analyzed involvement of the DDR molecules in tumorigenesis, and found that DDR is activated in pre-malignant stage. The loss of DDR led to malignant transformation of the cells with mutation in p53 in some cases (Leukemia 2006).
ATM and Ku70/80 were shown to be degraded upon oxidative stress leading to cellular apoptosis (Ann NY Acad Sci 2006, Int J Biochem Cell Biol. 2008)。 The cells escaped from apoptosis may lead to acquisition of chromosomal aberration.
We diagnosed 14 patients with AT, 2 DNA ligase IV deficiency, 2 Mre11deficiency (ATLD) and one Cernunnos deficiency. Finally, we carried out the first nation-wide survey for AT. We observed phenotypic variety between sibling cases with AT. Hyper-IgM was noted in 10% of the patients indicating involvement of ATM in class switch recombination.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (65 results)

All 2008 2007 2006

All Journal Article (43 results) (of which Peer Reviewed: 17 results) Presentation (21 results) Book (1 results)

  • [Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.2008

    • Author(s)
      Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H.
    • Journal Title

      Cell 132

      Pages: 794-806

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 分類不能型免疫不全症2008

    • Author(s)
      高橋尚美、森尾友宏
    • Journal Title

      日本臨床免疫学会雑誌 31

      Pages: 9-16

    • NAID

      10021242183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Vesical varices and telangiectasias in a patient with ataxia telangiectasia.2008

    • Author(s)
      Suzuki K, Tsugawa K, Oki E, Morio T. Ito E, Tanaka H.
    • Journal Title

      Ped. Nephrol. (Epub ahead of print)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ku, Artemis, and Ataxia-Telangiectasia-Mutated: Signaling Networks in DNA Damage.2008

    • Author(s)
      Morio T, Kim H.
    • Journal Title

      Int J Biochem Cell Biol. 40

      Pages: 598-603

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Successful treatment of chronic granulomatous disease with fludarabine-based reduced-intensity conditioning and unrelated bone marrow transplantation.2008

    • Author(s)
      Hasegawa D, Fukushima M, Hosokawa Y, Takeda H, Kawasaki K, Mizukami T, Nunoi H, Ochiai H, Morio T, Kosaka Y.
    • Journal Title

      Int J Hematol 87

      Pages: 88-90

    • NAID

      10021255278

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals2008

    • Author(s)
      Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H.
    • Journal Title

      Cell 132

      Pages: 794-806

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Common variable immunodeficiency2008

    • Author(s)
      Takahashi N, Morio T.
    • Journal Title

      Nihon Rinsho Meneki Gakkai Kaishi 31

      Pages: 9-16

    • NAID

      10021242183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Vesical varices and telangiectasias in a patient with ataxia telangiectasia2008

    • Author(s)
      Suzuki K, Tsugawa K, Oki E, Morio T, Ito E, Tanaka H.
    • Journal Title

      Ped. Nephrol

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Signaling Networks in DNA Damage2008

    • Author(s)
      Morio T, Kim H. Ku, Artemis, and Ataxia-Telangiectasia-Mutated
    • Journal Title

      Int J Biochem Cell Biol 40

      Pages: 598-603

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Successful treatment of chronic granulomatous disease with fludarabine-based reduced-intensity conditioning and unrelated bone marrow transplantation2008

    • Author(s)
      Hasegawa D, Fukushima M, Hosokawa Y, Takeda H, Kawasaki K, Mizukami T, Nunoi H, Ochiai H, Morio T, Kosaka Y.
    • Journal Title

      Int J Hematol 87

      Pages: 88-90

    • NAID

      10021255278

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Strategy to Combat Opportunistic Infections after Umbilical Cord Blood Transplantation (UCBT) - Monitoring of Multiple Pathogens with a Novel Multiplex PCR System and Infusion of Ex-vivo Expanded CD4 T-Cells (CD4-DLI).2007

    • Author(s)
      Morio T.
    • Journal Title

      Biol Blood Marrow Transplant. 13

      Pages: 1400-1

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] DNA damage check points prevent leukemic transformation in myelodysplastic syndrome.2007

    • Author(s)
      Horibe S, Takagi M, Unno J, Nagasawa M, Morio T, Arai A, Miura O, Ohta M, Kitagawa M, Mizutani S.
    • Journal Title

      Leukemia 10

      Pages: 2195-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Correction of immunodeficiency associated with NEMO mutation by umbilical cord blood transplantation using a reduced-intensity conditioning regimen.2007

    • Author(s)
      Tono C, Takahashi Y, Terui K, Sasaki S, Kamio T, Tandai S, Sato T, Kudo K, Toki T, Tachibana N, Yoshioka T, Nakahata T, Morio T, Nishikomori R, Ito E.
    • Journal Title

      Bone Marrow Transplant. 39

      Pages: 801-4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immune-deficiency.2007

    • Author(s)
      Okamoto H, Arii C, Shibata F, Toma T, Wada T, Inoue M, Tone Y, Kasahara Y, Koizumi S, Kamachi Y, Ishida Y, Inagaki J, Kato M, Morio T, Yachie A.
    • Journal Title

      Clin. Exp. Immunol 148

      Pages: 450-60

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2R null Mice Develop Human Lymphoid System and Induce Long-Lasting HIV-1 Infection with Specific Humoral Immune Responses.2007

    • Author(s)
      Watanabe S., Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y, Dewan Md Z, Yu Z, Ito M, Morio T, Shimizu N, Honda M, and Yamamoto N.
    • Journal Title

      Blood 109

      Pages: 212-28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Knockdown of XAB2 enhances All-Trans Retinoic Acid-Induced Cellular Differentiation in All-Trans Retinoic Acid-Sensitive and-Resistant Cancer Cells.2007

    • Author(s)
      Ohnuma-Ishikawa K, Morio T, Yamada T, Sugawara Y, Ono M, Nagasawa M, Yasuda A, Morimoto C, Ohnuma K, Dang NH, Hosoi H, Verdin E, and Mizutani S.
    • Journal Title

      Cancer Res. 67

      Pages: 1019-29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Omenn症候群の成因と病態2007

    • Author(s)
      森尾友宏
    • Journal Title

      臨床免疫・アレルギー科 47

      Pages: 484-488

    • NAID

      40015482720

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Strategy to Combat Opportunistic Infections after Umbilical Cord Blood Transplantation(UCBT) - Monitoring of Multiple Pathogens with a Novel Multiplex PCR System and Infusion of Ex-vivo Expanded CD4 T-Cells(CD4-DLI)2007

    • Author(s)
      Morio T.
    • Journal Title

      Biol Blood Marrow Transplant 13

      Pages: 1400-1

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] DNA damage check points prevent leukemic transformation in myelodysplastic syndrome2007

    • Author(s)
      Horibe S, Takagi M, Unno J, Nagasawa M, Morio T, Arai A, Miura O, Ohta M, Kitagawa M, Mizutani S.
    • Journal Title

      Leukemia 10

      Pages: 2195-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Correction of immunodeficiency associated with NEMO mutation by umbilical cord blood transplantation using a reduced-intensity conditioning regimen2007

    • Author(s)
      Tono C, Takahashi Y, Terui K, Sasaki S, Kamio T, Tandai S, Sato T, Kudo K, Toki T, Tachibana N, Yoshioka T, Nakahata T, Morio T, Nishikomori R, Ito E.
    • Journal Title

      Bone Marrow Transplant 39

      Pages: 801-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation(HSCT) in patients with severe combined immunodeficiency. Clin. Exp2007

    • Author(s)
      Okamoto H, Arii C, Shibata F, Toma T, Wada T, Inoue M, Tone Y, Kasahara Y, Koizumi S, Kamachi Y, Ishida Y, Inagaki J, Kato M, Morio T, Yachie A.
    • Journal Title

      Immunol 148

      Pages: 450-60

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2R□^<null> Mice Develop Human Lymphoid System and Induce Long-Lasting HIV-1 Infection with Specific Humoral Immune Responses2007

    • Author(s)
      Watanabe S., Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y, Dewan Md Z, Yu Z, Ito M, Morio T, Shimizu N, Honda M, and Yamamoto N.
    • Journal Title

      Blood 109

      Pages: 212-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Knockdown of XAB2 enhances All-Trans Retinoic Acid-Induced Cellular Differentiation in All-Trans Retinoic Acid-Sensitive and -Resistant Cancer2007

    • Author(s)
      Ohnuma-Ishikawa K, Morio T, Yamada T, Sugawara Y, Ono M, Nagasawa M, Yasuda A, Morimoto C, Ohnuma K, Dang NH, Hosoi H, Verdin E, and Mizutani S.
    • Journal Title

      Cells. Cancer Res 67

      Pages: 1019-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Strategy to Combat Opportunistic Infections after Umbilical Cord Blood Transplantation (UCBT)-Monitoring of Multiple Pathogens with a Novel Multiplex PCR System and Infusion of Ex-vivo Expanded CD4 T-Cells (CD4-DLI).2007

    • Author(s)
      Morio T.
    • Journal Title

      Biol Blood Marrow Transplant. 13

      Pages: 1400-1

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of human herpesvirus 6 variant A in a patient with unilateral panuveitis.2007

    • Author(s)
      Sugita S, Shimizu N, Kawaguchi T, Akao N, Morio T, Mochizuki M.
    • Journal Title

      Archives of Ophthalmology (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] E. Correction of immunodeficiency associated with NEMO mutation by umbilical cord blood transplantation using a reduced-intensity conditioning regimen.2007

    • Author(s)
      Tono C, Takahashi Y, Terui K, Sasaki S, Kamio T, Tandai S, Sato T, l Ko Kudo, Toki T, Tachibana N, Yoshioka T, Nakahata T, Morio T, Nishikomori R, Ito.
    • Journal Title

      Bone Marrow Transplant (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] N. Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2R・^<null> Mice Develop Human Lymphoid System and Induce Long-Lasting HIV-1 Infection with Specific Humoral Immune Responses.2007

    • Author(s)
      Watanabe S., Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y, Dewan Md Z, Yu Z, Ito M, Morio T, Ahimizu N, Honda M, Yamamoto N.
    • Journal Title

      Blood 109 (1)

      Pages: 212-28

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Knockdown of XAB2 enhances All-Trans Retinoic Acid-Induced Cellular Differentiation in All-Trans Retinoic Acid-Sensitive and -Resistant Cancer Cells.2007

    • Author(s)
      Ohnuma-Ishikawa K, Morio T, Yamada T, Sugawara Y, Ono M, Nagasawa M, Yasuda A, Morimoto C, Ohnuma K, Dang NH, Hosoi H, Verdin E, Mizutani S.
    • Journal Title

      Cancer Research. 67 (3)

      Pages: 1019-29

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ataxia-telangiectasia-mutated-dependent activation of Ku in human fibroblasts exposed to hydrogen peroxide.2006

    • Author(s)
      Lee JH, Kim KH, Morio T, Kim H.
    • Journal Title

      Ann NY Acad Sci. 1091

      Pages: 76-82

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The First Infant Case With Hepatosplenic gammadelta T-cell Lymphoma After Acute Disseminated Encephalomyelitis (ADEM)-like Exacerbation.2006

    • Author(s)
      Koga SY, Kumaki S, Ichinohasama R, Munakata M, Haginoya K, Ohashi Y, Tanaka Y, Sakamoto O, Minegishi M, Morio T, Iinuma K, Tsuchiya S.
    • Journal Title

      JPediatr Hematol Oncol. 28

      Pages: 741-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A. Omenn syndrome-review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan.2006

    • Author(s)
      Kato M. Kimura H. Seki M. Shimada A. Hayashi Y. Morio T. Kumaki S. Ishida Y. Kamachi Y. Yachie
    • Journal Title

      Allergology International. 55

      Pages: 115-9

    • NAID

      10019169596

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.2006

    • Author(s)
      Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H.
    • Journal Title

      Immunity. 25

      Pages: 745-55

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation: its usefulness as a marker of graft-versus-host reaction.2006

    • Author(s)
      Nagasawa M. Isoda T. Itoh S. Kajiwara M. Morio T. Shimizu N. Ogawa K. Nagata K. Nakamura M. Mizutani S.
    • Journal Title

      American Journal of Hematology 81

      Pages: 340-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ataxia-telangiectasia-mutated-dependent activation of Ku in human fibroblasts exposed to hydrogen peroxide2006

    • Author(s)
      Lee JH, Kim KH, Morio T, Kim H.
    • Journal Title

      Ann N Y Acad Sci 1091

      Pages: 76-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The First Infant Case With Hepatosplenic gammadelta T-cell Lymphoma After Acute Disseminated Encephalomyelitis(ADEM)-like Exacerbation2006

    • Author(s)
      Koga SY, Kumaki S, Ichinohasama R, Munakata M, Haginoya K, Ohashi Y, Tanaka Y, Sakamoto O, Minegishi M, Morio T, Iinuma K, Tsuchiya S.
    • Journal Title

      J Pediatr Hematol Oncol 28

      Pages: 741-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Omenn syndrome-review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan2006

    • Author(s)
      Kato M. Kimura H. Seki M. Shimada A. Hayashi Y. Morio T. Kumaki S. Ishida Y. Kamachi Y. Yachie A.
    • Journal Title

      Allergology International 55

      Pages: 115-9

    • NAID

      10019169596

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity2006

    • Author(s)
      Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H.
    • Journal Title

      Immunity 25

      Pages: 745-755

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation : its usefulness as a marker of graft-versus-host reaction2006

    • Author(s)
      Nagasawa M. Isoda T. Itoh S. Kajiwara M. Morio T. Shimizu N. Ogawa K. Nagata K. Nakamura M. Mizutani S.
    • Journal Title

      Am. J. Hematol 81

      Pages: 340-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ataxia-telangiectasia-mutated-dependent activation of Ku in human fibroblasts exposed to hydrogen peroxide.2006

    • Author(s)
      Lee JH, Kim KH, Morio T, Kim H.
    • Journal Title

      Ann N Y Acad Sci 1091

      Pages: 76-82

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The First Infant Case With Hepatosplenic gammadelta T-cell Lymphoma After Acute Disseminated Encephalomyelitis (ADEM)-like Exacerbation.2006

    • Author(s)
      Koga SY, Kumaki S, Ichinohasama R, Numakata M, Haginoya K, Ohashi Y, Tanaka Y, Sakamoto O, Minegishi M, Morio T, Iinuma K, Tsuchiya S.
    • Journal Title

      J Pediatr Hematol Oncol 28

      Pages: 741-45

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity2006

    • Author(s)
      Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, RennerED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H.
    • Journal Title

      Immunity 25

      Pages: 745-55

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Outcome in patients with Wiskott-Aldrich syndrome following stem cell transplantation : an analysis of 57 patients in Japan.2006

    • Author(s)
      Kobayashi R., Ariga T., Nonoyama S., Kanegane H., Tsuchiya S., Morio T., Yabe H., Nagatoshi Y., Kawa K., Tabuchi K., Tsuchida M., Miyawaki T., Kato S
    • Journal Title

      Br. J. Haematol 135 (3)

      Pages: 362-66

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation : its usefulness as a marker of graft-versus-host reaction.2006

    • Author(s)
      Nagasawa M., Isoda T., Itoh S., Kajiwara M., Morio T., Shimizu N., Ogawa K., Nagata K., Nakamura M., Mizutani S.
    • Journal Title

      Am. J. Hematol 81

      Pages: 340-8

    • Related Report
      2006 Annual Research Report
  • [Presentation] 関連学会合同シンポジウム「細胞移植・再生医療における品質管理のあり方」細胞移植の立場から(増殖リンパ球治療を中心として)2008

    • Author(s)
      森尾友宏、清水則夫、伊藤仁也
    • Organizer
      第30回日本造血細胞移植学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 造血幹細胞移植後難治性感染症に対するCD4-DLI療法(臨床第I-II相試験)2008

    • Author(s)
      森尾友宏、清水則夫、梶原道子、落合央、峯岸志津子、伊藤仁也、土田昌宏、加藤剛二、小寺良尚、大隅一興、関根輝彬
    • Organizer
      第30回日本造血細胞移植学会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Follicular dendritic cells (FDC), expressing ependymin related protein (ERP) and GM1, are of pluripotent mesencymal stem cells (pMSC) interfacing immune system and nervous system2007

    • Author(s)
      寺嶋一夫、持丸葉子、渡邊健、森尾友宏、松本一朗、渡辺哲、大場賢治、垂石みどり、岸千絵子、山本直樹、清水則夫
    • Organizer
      日本生化学会、日本分子生物学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] DNA損傷応答におけるArtemisのリン酸化の生物学的意義2007

    • Author(s)
      渡邊文晶、森尾友宏, 清野透, 水谷修紀
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Follicular dendritic cells (FDC), expressing ependymin related protein (ERP) and GM1, are of pluripotent mesencymal stem cells (pMSC) interfacing immune system and nerous system2007

    • Author(s)
      寺嶋一夫、持丸葉子、渡邊健、森尾友宏、松本一朗、渡辺哲、大場賢治、垂石みどり、岸千絵子、山本直樹、清水則夫
    • Organizer
      BMB2007(日本生化学会、日本分子生物学会学術集会)
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自己免疫疾患を伴ったICOS欠損症患者姉弟例の解析2007

    • Author(s)
      高橋尚美, 森尾友宏, 松本健治, 齋藤博久, 南木敏宏, 宮坂信之, 東みゆき, 水谷修紀
    • Organizer
      第35回日本臨床免疫学会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNA損傷応答におけるArtemisのリン酸化の生物学的意義(Biological significance of Artemis phosphorylation in DNA damage response)2007

    • Author(s)
      渡邉文晶, 森尾友宏, 清野透, 水谷修紀
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 出生時よりPAIgG高値を示し移行抗体消退期に診断に至ったWiskott-Aldrich症候群の1例2007

    • Author(s)
      本多正和、三浦信之、山崎太郎、石井佐織、皆川孝子、善利裕實、宮路太、森尾友宏、佐々木望
    • Organizer
      第110回日本小児科学会学術集会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 毛細血管拡張性小脳失調症(Ataxia telangiectasia)の全国調査結果報告2007

    • Author(s)
      森尾友宏、長澤正之、水谷修紀、高木正稔、宮脇利男、中村琴華、Gatti Richard
    • Organizer
      第110回日本小児科学会学術集会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 日本における重症複合免疫不全症に対する造血幹細胞移植の検討とガイドラインの策定2007

    • Author(s)
      今井耕輔、金兼弘和、久聞木悟、有賀正、森尾友宏、蒲池吉朗、上松一永、高田英俊、野々山恵章、宮脇利男
    • Organizer
      第110回日本小児科学会学術集会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 慢性糸球体腎炎を合併したIgGサブクラス欠損症の2例2007

    • Author(s)
      亀井宏一、中山真紀子、鈴木輝明、飯島一誠、小林信一、松岡健太郎、中川温子、長澤正之、森尾友宏、水谷修紀
    • Organizer
      第110回日本小児科学会学術集会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Norio Shimizu Follicular dendritic cells(FDC), expressing ependymin related protein(ERP) and GM1, are of pluripotent mesencymal stem cells(pMSC) interfacing immune system and nerous system2007

    • Author(s)
      Kazuo Terashima, Yoko Mochimaru, Ken Watanabe, Tomohiro Morio, Ichiro Matsumoto, Satoru Watanabe, Kenji Ooba, Midori Taruishi, Chieko Kishi, Naoki Yamamoto
    • Organizer
      Biochemistry and Molecular Biology
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 舞踏アテトーゼで診断したataxia-telangiectasia(A-T)の3歳女児例2006

    • Author(s)
      梶本まどか、末永尚子、市山高志、原知代、古川漸、森尾友宏
    • Organizer
      第38回日本小児感染症学会総会
    • Place of Presentation
      高知
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 慢性活動性EBV感染症に対する造血幹細胞移植2006

    • Author(s)
      森尾友宏
    • Organizer
      第38回日本小児感染症学会総会
    • Place of Presentation
      高知
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 造血細胞・リンパ球とリンパ組織の発生分化 WASP欠損B細胞株の作製とPTDを用いたWASPタンパク導入による表現形の修復2006

    • Author(s)
      佐藤力哉、本田富美子、高橋尚美, 水谷修紀、LeeSang-Kyou、森尾友宏
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨髄異形成症候群(MDS)の白血病への進展過程におけるDNA損傷チェックポイントの役割の解析2006

    • Author(s)
      高木正稔、森尾友宏、北川昌伸、水谷修紀
    • Organizer
      第65回日本がん学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨髄異形成症候群(MDS)の白血病への進展過程におけるDNA損傷応答の関与2006

    • Author(s)
      高木正稔、堀部志保、森尾友宏、北川昌伸、水谷修紀
    • Organizer
      第68回日本血液学会総会・第48回日本臨床血液学会総会
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] XAB2を標的とした癌の分化誘導療法2006

    • Author(s)
      大沼久美子、森尾友宏、長澤正之、細井創、大沼圭、水谷修紀
    • Organizer
      第68回日本血液学会総会・第48回日本臨床血液学会総会
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 常染色体劣性高IgE症候群の原因遺伝子の検討2006

    • Author(s)
      峯岸克行、齋藤雅子、森尾友宏、上松一永、原寿郎、近藤直美、有賀正、谷内江明宏、土屋滋、柘植郁哉、岩田力、水谷修紀、宮脇利男、野々山恵章
    • Organizer
      第18回日本アレルギー学会春季臨床大会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨髄異形成症候群(MDS)の白血病(overt leukemia)への進展過程におけるDNA損傷応答経路の関与について2006

    • Author(s)
      高木正稔、堀部志保、森尾友宏、北川昌伸、水谷修紀
    • Organizer
      第109回日本小児科学会学術集会
    • Place of Presentation
      金沢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 先天性免疫不全症候群研究の進歩2006

    • Author(s)
      森尾友宏
    • Organizer
      第109回日本小児科学会学術集会
    • Place of Presentation
      金沢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 日本医師会雑誌「最新臨床検査のABC」T細胞・B細胞サブセット、リンパ球芽球化反応、NK細胞活性、好中球機能2006

    • Author(s)
      森尾 友宏
    • Total Pages
      4
    • Publisher
      日本医師会雑誌
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi